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Korver-Keularts, I. M. L. W., Wang, P., Waterval, H. W. A. H., Kluijtmans, L. A. J., Wevers, R. A., Langhans, C.-D., Scott, C., Habets, D. D. J., & Bierau, J. (2018). Fast and accurate quantitative organic acid analysis with LC-QTOF/MS facilitates screening of patients for inborn errors of metabolism. Journal of Inherited Metabolic Disease, 41(3), 415-424. https://doi.org/10.1007/s10545-017-0129-0

De Ruysscher, D., Dingemans, A.-M., Vooijs, M., & Heymans, S. (2018). PD-(L)1 Inhibition and Cardiac Damage: A Relevant Toxicity?Journal of Thoracic Oncology, 13(4), 478-479. https://doi.org/10.1016/j.jtho.2018.02.008

Loebel, M., Holzhauser, L., Hartwig, J. A., Shukla, P. C., Savvatis, K., Jenke, A., Gast, M., Escher, F., Becker, S. C., Bauer, S., Stroux, A., Beling, A., Kespohl, M., Pinkert, S., Fechner, H., Kuehl, U., Lassner, D., Poller, W., Schultheiss, H.-P., ... Skurk, C. (2018). The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance inmyocarditis. European Heart Journal, 39(10), 876-887. https://doi.org/10.1093/eurheartj/ehx624

Verdonschot, J. A. J., Hazebroek, M. R., Derks, K. W. J., Aizpurua, A. B., Merken, J. J., Wang, P., Bierau, J., van den Wijngaard, A., Schalla, S. M., Hamid, M. A. A., van Bilsen, M., van Empel, V. P. M., Knackstedt, C., Brunner-La Rocca, H.-P., Brunner, H. G., Krapels, I. P. C., & Heymans, S. R. B. (2018). Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias. European Heart Journal, 39(10), 864-873. https://doi.org/10.1093/eurheartj/ehx808

Aizpurua, A. B., Franssen, F. M. E., van Empel, V., & Brunner-La Rocca, H.-P. (2018). An old debate still in the beta-phase?European journal of heart failure, 20(3), 557-559. https://doi.org/10.1002/ejhf.1086

Deckx, S., Heggermont, W., Carai, P., Rienks, M., Dresselaers, T., Himmelreich, U., van Leeuwen, R., Lommen, W., van der Velden, J., Gonzalez, A., Diez, J., Papageorgiou, A.-P., & Heymans, S. (2018). Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation. Matrix Biology, 66, 110-124. https://doi.org/10.1016/j.matbio.2017.09.002

Hazebroek, M. R., Krapels, I., Verdonschot, J., van den Wijngaard, A., Vanhoutte, E., Hoos, M., Snijders, L., van Montfort, L., Witjens, M., Dennert, R., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Brunner, H. G., & Heymans, S. (2018). Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy. Circulation-Heart Failure, 11(3), Article e004682 . https://doi.org/10.1161/CIRCHEARTFAILURE.117.004682

Frantz, S., Falcao-Pires, I., Balligand, J.-L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G., & Heymans, S. (2018). The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. European journal of heart failure, 20(3), 445-459. https://doi.org/10.1002/ejhf.1138

De Majo, F., & Calore, M. (2018). Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart. Non-coding RNA research, 3(1), 20-28. https://doi.org/10.1016/j.ncrna.2018.02.003

Lourenco, A. P., Leite-Moreira, A. F., Balligand, J.-L., Bauersachs, J., Dawson, D., de Boer, R. A., de Windt, L. J., Falcao-Pires, I., Fontes-Carvalho, R., Franz, S., Giacca, M., Hilfiker-Kleiner, D., Hirsch, E., Maack, C., Mayr, M., Pieske, B., Thum, T., Tocchetti, C. G., Brutsaert, D. L., & Heymans, S. (2018). An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure, 20(2), 216-227. https://doi.org/10.1002/ejhf.1059

Merken, J., Hazebroek, M., Van Paassen, P., Verdonschot, J., Van Empel, V., Knackstedt, C., Hamid, M. A., Seiler, M., Kolb, J., Hoermann, P., Ensinger, C., Brunner-La Rocca, H.-P., Poelzl, G., & Heymans, S. (2018). Immunosuppressive Therapy Improves Both Short- and Long-Term Prognosis in Patients With Virus-Negative Nonfulminant Inflammatory Cardiomyopathy. Circulation-Heart Failure, 11(2), Article 004228. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004228

Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A., & Schroen, B. (2018). MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure. Hypertension, 71(2), 280-288. https://doi.org/10.1161/HYPERTENSIONAHA.117.10094

Ferreira, J. P., Machu, J.-L., Girerd, N., Jaisser, F., Thum, T., Butler, J., Gonzalez, A., Diez, J., Heymans, S., McDonald, K., Gyongyosi, M., Firat, H., Rossignol, P., Pizard, A., & Zannad, F. (2018). Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis. Esc heart failure, 5(1), 139-148. https://doi.org/10.1002/ehf2.12218

Zhang, M., Schiffers, P., Janssen, G., Vrolijk, M., Vangrieken, P., & Haenen, G. R. M. M. (2018). The cardiovascular side effects of Ma Huang due to its use in isolation in the Western world. European Journal of Integrative Medicine, 18, 18-22. https://doi.org/10.1016/j.eujim.2018.01.007

Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B., & Nabben, M. (2018). Assessing fatty acid oxidation flux in rodent cardiomyocyte models. Scientific Reports, 8(1), Article 1505. https://doi.org/10.1038/s41598-018-19478-9

Aimo, A., Januzzi, J. L., Vergaro, G., Ripoli, A., Latini, R., Masson, S., Magnoli, M., Anand, I. S., Cohn, J. N., Tavazzi, L., Tognoni, G., Gravning, J., Ueland, T., Nymo, S. H., Brunner-La Rocca, H.-P., Genis, A. B., Lupon, J., de Boer, R. A., Yoshihisa, A., ... Emdin, M. (2018). Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure An Individual Patient Data Meta-Analysis. Circulation, 137(3), 286-297. https://doi.org/10.1161/CIRCULATIONAHA.117.031560

Kuepfer, L., Clayton, O., Thiel, C., Cordes, H., Nudischer, R., Blank, L. M., Baier, V., Heymans, S., Caiment, F., Roth, A., Fluri, D. A., Kelm, J. M., Castell, J., Selevsek, N., Schlapbach, R., Keun, H., Hynes, J., Sarkans, U., Gmuender, H., ... Kleinjans, J. (2018). A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity. Archives of Toxicology, 92(1), 553-555. https://doi.org/10.1007/s00204-017-2041-7

Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V.-P., Heymans, S., Hill, L., Lainscak, M., Lam, C. S. P., Lund, L. H., Lyon, A. R., Mebazaa, A., Mueller, C., Paulus, W. J., Pieske, B., ... de Boer, R. A. (2018). Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 20(1), 16-37. https://doi.org/10.1002/ejhf.1029

Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2018). WNT Signaling in Cardiac and Vascular Disease. Pharmacological Reviews, 70(1), 68-141. https://doi.org/10.1124/pr.117.013896

Smulders, M., Bekkers, B., VAN Cauteren, Y., Liefhebber, A., Vermeer, J. R., Vervuurt, J., van Dieijen - Visser, M. P., Mingels, A., Brunner-La Rocca, H., Dagnelie, P., Wildberger, J., Crijns, H., & Kietselaer, B. (2018). Acute pijn op de borst zonder afwijkend troponine: Is aanvullende niet-invasieve diagnostiek zinvol?Nederlands Tijdschrift voor Geneeskunde, 162(51-52), 1-7. Article D3568. https://www.ntvg.nl/system/files/publications/d3568.pdf

Giamouridis, D., Gao, M., Lai, N. C., Tan, Z., Kim, B. C., Guo, T., Miyanohara, A., Blankesteijn, M., Biessen, E., & Hammond, H. K. (2018). Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC: Basic to Translational Science, 3(2), 249-264. https://doi.org/10.1016/j.jacbts.2017.12.004

Nabben, M., Luiken, J. J. F. P., & Glatz, J. F. C. (2018). Metabolic remodelling in heart failure revisited. Nature Reviews Cardiology, 15(12), 780-780. https://doi.org/10.1038/s41569-018-0115-8

Falkenberg, K. D., Braverman, N. E., Moser, A. B., Steinberg, S. J., Klouwer, F. C. C., Schluter, A., Ruiz, M., Pujol, A., Engvall, M., Naess, K., van Spronsen, F., Korver-Keularts, I., Rubio-Gozalbo, M. E., Ferdinandusse, S., Wanders, R. J. A., & Waterham, H. R. (2017). Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder. American Journal of Human Genetics, 101(6), 965-976. https://doi.org/10.1016/j.ajhg.2017.11.007

van Vark, L. C., Lesman-Leegte, I., Baart, S. J., Postmus, D., Pinto, Y. M., de Boer, R. A., Asselbergs, F. W., Wajon, E. M. C. J., Orsel, J. G., Boersma, E., Hillege, H. L., Martijn Akkerhuis, K., Nagelsmit, M. J., Brunner-La Rocca, H. P., Linssen, G. C. M., Terpstra, W. F., Liem, A. H., Wardeh, A. J., van Miltenburg, A. J. M., ... TRIUMPH Investigators (2017). Prognostic value of serial galectin-3 measurements in patients with acute heart failure. Journal of the American Heart Association, 6(12), Article e003700. https://doi.org/10.1161/JAHA.116.003700

Rickenbacher, P., Kaufmann, B. A., Maeder, M. T., Bernheim, A., Goetschalckx, K., Pfister, O., Pfisterer, M., Brunner-La Rocca, H.-P., & Investigators, TIME.-CHF. (2017). Heart failure with mid-range ejection fraction: a distinct clinical entity? Insights from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF). European journal of heart failure, 19(12), 1586-1596. https://doi.org/10.1002/ejhf.798

Baldewijns, K., Bektas, S., Boyne, J., Rohde, C., De Maesschalck, L., De Bleser, L., Brandenburg, V., Knackstedt, C., Deville, A., Sanders-Van Wijk, S., & La Rocca, H.-P. B. (2017). Improving kNowledge Transfer to Efficaciously RAise the level of Contemporary Treatment in Heart Failure (INTERACT-in-HF): Study protocol of a mixed methods study. International Journal of Care Coordination, 20(4), 171-182. https://doi.org/10.1177/2053434517726318

van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B., & van Bilsen, M. (2017). Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling. Scientific Reports, 7(1), Article 16042. https://doi.org/10.1038/s41598-017-16201-y

Dahlmans, D., Houzelle, A., Andreux, P., Jorgensen, J. A., Wang, X., de Windt, L. J., Schrauwen, P., Auwerx, J., & Hoeks, J. (2017). An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism. Molecular Metabolism, 6(11), 1429-1442. https://doi.org/10.1016/j.molmet.2017.08.007

Afsar, B., Rossignol, P., van Heerebeek, L., Paulus, W. J., Damman, K., Heymans, S., van Empel, V., Sag, A., Maisel, A., & Kanbay, M. (2017). Heart failure with preserved ejection fraction: a nephrologist-directed primer. Heart Failure Reviews, 22(6), 765-773. https://doi.org/10.1007/s10741-017-9619-2

van Vark, L. C., Lesman-Leegte, I., Baart, S. J., Postmus, D., Pinto, Y. M., Orsel, J. G., Westenbrink, B. D., Rocca, H. P. B., van Miltenburg, A. J. M., Boersma, E., Hillege, H. L., Akkerhuis, K. M., & TRIUMPH Investigators (2017). Prognostic Value of Serial ST2 Measurements in Patients With Acute Heart Failure. Journal of the American College of Cardiology, 70(19), 2378-2388. https://doi.org/10.1016/j.jacc.2017.09.026

Riemersma, M., Hazebroek, M. R., Helderman-van den Enden, A. T. J. M., Salomons, G. S., Ferdinandusse, S., Brouwers, M. C. G. J., van der Ploeg, L., Heymans, S., Glatz, J. F. C., van den Wijngaard, A., Krapels, I. P. C., Bierau, J., & Brunner, H. G. (2017). Propionic acidemia as a cause of adult-onset dilated cardiomyopathy. European Journal of Human Genetics, 25(11), 1195-1201. https://doi.org/10.1038/ejhg.2017.127

van Bilsen, M., Patel, H. C., Bauersachs, J., Boehm, M., Borggrefe, M., Brutsaert, D., Coats, A. J. S., de Boer, R. A., de Keulenaer, G., Filippatos, G. S., Floras, J., Grassi, G., Jankowska, E. A., Kornet, L., Lunde, I. G., Maack, C., Mahfoud, F., Pollesello, P., Ponikowski, P., ... Lyon, A. R. (2017). The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 19(11), 1361-1378. https://doi.org/10.1002/ejhf.921

Caforio, A. L. P., Adler, Y., Agostini, C., Allanore, Y., Anastasakis, A., Arad, M., Boehm, M., Charron, P., Elliott, P. M., Eriksson, U., Felix, S. B., Garcia-Pavia, P., Hachulla, E., Heymans, S., Imazio, M., Klingel, K., Marcolongo, R., Cerinic, M. M., Pantazis, A., ... Linhart, A. (2017). Diagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease. European Heart Journal, 38(35), 2649-2662. https://doi.org/10.1093/eurheartj/ehx321

Nanayakkara, S., Haykowsky, M., Mariani, J., Van Empel, V., Maeder, M. T., Vizi, D., & Kaye, D. M. (2017). Hemodynamic Profile of Patients With Heart Failure and Preserved Ejection Fraction Vary by Age. Journal of the American Heart Association, 6(9), Article e005434. https://doi.org/10.1161/JAHA.116.005434

Lorenzon, A., Calore, M., Poloni, G., De Windt, L. J., Braghetta, P., & Rampazzo, A. (2017). Wnt/beta-catenin pathway in arrhythmogenic cardiomyopathy. Oncotarget, 8(36), 60640-60655. https://doi.org/10.18632/oncotarget.17457

Heggermont, W. A., Papageorgiou, A.-P., Quaegebeur, A., Deckx, S., Carai, P., Verhesen, W., Eelen, G., Schoors, S., van Leeuwen, R., Alekseev, S., Elzenaar, I., Vinckier, S., Pokreisz, P., Walravens, A.-S., Gijsbers, R., Van Den Haute, C., Nickel, A., Schroen, B., van Bilsen, M., ... Heymans, S. (2017). Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. Circulation, 136(8), 747-761. https://doi.org/10.1161/CIRCULATIONAHA.116.024171

Abdurrachim, D., Nabben, M., Hoerr, V., Kuhlmann, M. T., Bovenkamp, P., Ciapaite, J., Geraets, I. M. E., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., Schaefers, M., Nicolay, K., Faber, C., Hermann, S., & Prompers, J. J. (2017). Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovascular Research, 113(10), 1148-1160. https://doi.org/10.1093/cvr/cvx100

Uszko-Lencer, N. H. M. K., Mesquita, R., Janssen, E., Werter, C., Rocca, H.-P. B.-L., Pitta, F., Wouters, E. F. M., & Spruit, M. A. (2017). Reliability, construct validity and determinants of 6-minute walk test performance in patients with chronic heart failure. International Journal of Cardiology, 240, 285-290. https://doi.org/10.1016/j.ijcard.2017.02.109

van der Harst, P., de Windt, L. J., & Chambers, J. C. (2017). Translational Perspective on Epigenetics in Cardiovascular Disease. Journal of the American College of Cardiology, 70(5), 590-606. https://doi.org/10.1016/j.jacc.2017.05.067

Ghaffari, S., Leask, R. L., & Jones, E. A. V. (2017). Blood flow can signal during angiogenesis not only through mechanotransduction, but also by affecting growth factor distribution. Angiogenesis, 20(3), 373-384. https://doi.org/10.1007/s10456-017-9553-x

Calore, M. (2017). The PRKAG2 gene and hypertrophic cardiomyopathy: an energetically imbalanced relationship. American Journal of Physiology-heart and Circulatory Physiology, 313(2), H248-H250. https://doi.org/10.1152/ajpheart.00316.2017

Zucker, I. H., Lindsey, M. L., Delmar, M., De Windt, L. J., Rosiers, C. D., Diz, D. I., Hester, R. L., Jones, S. P., Kanagy, N. L., Kitakaze, M., Liao, R., Lopaschuk, G. D., Patel, K. P., Recchia, F. A., Sadoshima, J., Shah, A. M., Ungvari, Z., Benjamin, I. J., Blaustein, M. P., ... Wolin, M. S. (2017). Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?American Journal of Physiology-heart and Circulatory Physiology, 313(2), H221-H223. https://doi.org/10.1152/ajpheart.00329.2017

Steinbusch, M. M. F., Caron, M. M. J., Surtel, D. A. M., Friedrich, F., Lausch, E., Pruijn, G. J. M., Verhesen, W., Schroen, B. L. M., van Rhijn, L. W., Zabel, B., & Welting, T. J. M. (2017). Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation. Scientific Reports, 7(1), Article 6440. https://doi.org/10.1038/s41598-017-06809-5

Sharma, U. C., Mosleh, W., Chaudhari, M. R., Katkar, R., Weil, B., Evelo, C., Cimato, T. R., Pokharel, S., Blankesteijn, W. M., & Suzuki, G. (2017). Myocardial and Serum Galectin-3 Expression Dynamics Marks Post-Myocardial Infarction Cardiac Remodelling. Heart Lung and Circulation, 26(7), 736-745. https://doi.org/10.1016/j.hlc.2016.11.007

Harjola, V.-P., Mullens, W., Banaszewski, M., Bauersachs, J., Brunner-La Rocca, H.-P., Chioncel, O., Collins, S. P., Doehner, W., Filippatos, G. S., Flammer, A. J., Fuhrmann, V., Lainscak, M., Lassus, J., Legrand, M., Masip, J., Mueller, C., Papp, Z., Parissis, J., Platz, E., ... Mebazaa, A. (2017). Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European journal of heart failure, 19(7), 821-836. https://doi.org/10.1002/ejhf.872

Rienks, M., Carai, P., Bitsch, N., Schellings, M., Vanhaverbeke, M., Verjans, J., Cuijpers, I., Heymans, S., & Papageorgiou, A. (2017). Sema3A promotes the resolution of cardiac inflammation after myocardial infarction. Basic Research in Cardiology, 112(4), Article 42. https://doi.org/10.1007/s00395-017-0630-5

Micheletti, R., Plaisance, I., Abraham, B. J., Sarre, A., Ting, C.-C., Alexanian, M., Maric, D., Maison, D., Nemir, M., Young, R. A., Schroen, B., Gonzalez, A., Ounzain, S., & Pedrazzini, T. (2017). The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Science Translational Medicine, 9(395), Article eaai9118. https://doi.org/10.1126/scitranslmed.aai9118

Perrino, C., Barabasi, A.-L., Condorelli, G., Davidson, S. M., De Windt, L., Dimmeler, S., Engel, F. B., Hausenloy, D. J., Hill, J. A., Van Laake, L. W., Lecour, S., Leor, J., Madonna, R., Mayr, M., Prunier, F., Sluijter, J. P. G., Schulz, R., Thum, T., Ytrehus, K., & Ferdinandy, P. (2017). Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heartd. Cardiovascular Research, 113(7), 725-736. https://doi.org/10.1093/cvr/cvx070