Publications
- 2015
- Piers, S. R. D., Everaerts, K., van der Geest, R. J., Hazebroek, M. R., Siebelink, H.-M., Pison, L. A. F. G., Schalij, M. J., Bekkers, S. C. A. M., Heymans, S., & Zeppenfeld, K. (2015). Myocardial scar predicts monomorphic ventricular tachycardia but not polymorphic ventricular tachycardia or ventricular fibrillation in nonischemic dilated cardiomyopathy. Heart Rhythm, 12(10), 2106-2114. https://doi.org/10.1016/j.hrthm.2015.05.026
- Knackstedt, C., Bekkers, S. C. A. M., Schummers, G., Schreckenberg, M., Muraru, D., Badano, L. P., Franke, A., Bavishi, C., Omar, A. M. S., & Sengupta, P. P. (2015). Fully Automated Versus Standard Tracking of Left Ventricular Ejection Fraction and Longitudinal Strain The FAST-EFs Multicenter Study. Journal of the American College of Cardiology, 66(13), 1456-1466. https://doi.org/10.1016/j.jacc.2015.07.052
- Vandersmissen, I., Craps, S., Depypere, M., Coppiello, G., van Gastel, N., Maes, F., Carmeliet, G., Schrooten, J., Jones, E. A. V., Umans, L., Devlieger, R., Koole, M., Gheysens, O., Zwijsen, A., Aranguren, X. L., & Luttun, A. (2015). Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response. Journal of Cell Biology, 210(7), 1239-56. https://doi.org/10.1083/jcb.201502003
- Deckx, S., Carai, P., Bateman, J., Heymans, S., & Papageorgiou, A.-P. (2015). Breeding Strategy Determines Rupture Incidence in Post-Infarct Healing WARPing Cardiovascular Research. PLOS ONE, 10(9), Article e0139199. https://doi.org/10.1371/journal.pone.0139199
- Hazebroek, M. R., Moors, S., Dennert, R., van den Wijngaard, A., Krapels, I., Hoos, M., Verdonschot, J., Merken, J. J., de Vries, B., Wolffs, P. F., Crijns, H. J. G. M., Brunner-La Rocca, H. P., & Heymans, S. (2015). Prognostic Relevance of Gene-Environment Interactions in Patients With Dilated Cardiomyopathy: Applying the MOGE(S) Classification. Journal of the American College of Cardiology, 66(12), 1313-1323. https://doi.org/10.1016/j.jacc.2015.07.023
- Blankesteijn, W. M., & Hermans, K. C. M. (2015). Wnt signaling in atherosclerosis. European Journal of Pharmacology, 763, 122-130. https://doi.org/10.1016/j.ejphar.2015.05.023
- Knackstedt, C., Hildebrandt, U., Schmidt, K., Syrocki, L., Lang, A., Bjarnason-Wehrens, B., Schummers, G., Stapf, D., Becker, M., & Predel, H. G. (2015). Analysis of right and left ventricular deformation in former world class swimmers: evaluation using speckle tracking. Journal of Sports Medicine and Physical Fitness, 55(9), 978-987. https://www.scopus.com/record/display.uri?eid=2-s2.0-84962505145&origin=inward
- Cannon, M. V., Sillje, H. H. W., Sijbesma, J. W. A., Vreeswijk-Baudoin, I., Ciapaite, J., van der Sluis, B., van Deursen, J., Silva, G. J. J., de Windt, L. J., Gustafsson, J.-A., van der Harst, P., van Gilst, W. H., & de Boer, R. A. (2015). Cardiac LXR protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization. EMBO Molecular Medicine, 7(9), 1229-1243. https://doi.org/10.15252/emmm.201404669
- el Azzouzi, H., Leptidis, S., Doevendans, P. A., & De Windt, L. J. (2015). HypoxamiRs: regulators of cardiac hypoxia and energy metabolism. Trends in Endocrinology and Metabolism, 26(9), 502-508. https://doi.org/10.1016/j.tem.2015.06.008
- Heymans, S., Gonzalez, A., Pizard, A., Papageorgiou, A. P., Lopez-Andres, N., Jaisser, F., Thum, T., Zannad, F., & Diez, J. (2015). Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential. European journal of heart failure, 17(8), 764-771. https://doi.org/10.1002/ejhf.312
- Kaufmann, B. A., Goetschalckx, K., Min, S. Y., Maeder, M. T., Bucher, U., Nietlispach, F., Bernheim, A. M., Pfisterer, M. E., Brunner-La Rocca, H. P., & TIME-CHF Investigators, T. (2015). Improvement in left ventricular ejection fraction and reverse remodeling in elderly heart failure patients on intense NT-proBNP-guided therapy. International Journal of Cardiology, 191, 286-293. https://doi.org/10.1016/j.ijcard.2015.04.282
- Papageorgiou, A.-P., Heggermont, W., Rienks, M., Carai, P., Langouche, L., Verhesen, W., De Boer, R. A., & Heymans, S. (2015). Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis. Cardiovascular Research, 107(1), 78-88. https://doi.org/10.1093/cvr/cvv157
- Tchaikovski, V., Tchaikovski, S., Olieslagers, S., & Waltenberger, J. (2015). Monocyte dysfunction as a previously unrecognized pathophysiological mechanism in ApoE-/- mice contributing to impaired arteriogenesis. International Journal of Cardiology, 190(1), 214-216. https://doi.org/10.1016/j.ijcard.2015.04.188
- Devaux, Y., Zangrando, J., Schroen, B., Creemers, E. E., Pedrazzini, T., Chang, C.-P., Dorn, G. W. . II., Thum, T., & Heymans, S. (2015). Long noncoding RNAs in cardiac development and ageing. Nature Reviews Cardiology, 12(7), 415-425. https://doi.org/10.1038/nrcardio.2015.55
- Hermansand, K. C. M., & Blankesteijn, W. M. (2015). Wnt Signaling in Cardiac Disease. Comprehensive Physiology, 5(3), 1183-1209. https://doi.org/10.1002/cphy.c140060
- van Empel, V., & Brunner-La Rocca, H. P. (2015). Inflammation in HFpEF: Key or circumstantial?International Journal of Cardiology, 189(1), 259-263. https://doi.org/10.1016/j.ijcard.2015.04.110
- Neumann, D., Luiken, J. J. F. P., Nabben, M., & Glatz, J. F. C. (2015). Letter by Neumann et al Regarding Article, "Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure". Circulation Research, 116(10), E95-E96. https://doi.org/10.1161/CIRCRESAHA.115.306463
- Abdurrachim, D., Luiken, J. J. F. P., Nicolay, K., Glatz, J. F. C., Prompers, J. J., & Nabben, M. (2015). Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models. Cardiovascular Research, 106(2), 194-205. https://doi.org/10.1093/cvr/cvv105
- Knackstedt, C., Schmidt, K., Syrocki, L., Lang, A., Bjarnason-Wehrens, B., Hildebrandt, U., & Predel, H.-G. (2015). Long-term follow-up of former world-class swimmers: evaluation of cardiovascular function. Heart and Vessels, 30(3), 369-378. https://doi.org/10.1007/s00380-014-0481-z
- Altara, R., Manca, M., Hermans, K. C., Daskalopoulos, E. P., Brunner-La Rocca, H. P., Hermans, R. J., Struijker-Boudier, H. A. J., & Blankesteijn, M. W. (2015). Diurnal rhythms of serum and plasma cytokine profiles in healthy elderly individuals assessed using membrane based multiplexed immunoassay. Journal of Translational Medicine, 13(1), Article 129. https://doi.org/10.1186/s12967-015-0477-1
- Poels, E. M., Martins, P. A. D. C., & van Empel, V. P. M. (2015). Adaptive capacity of the right ventricle: why does it fail?American Journal of Physiology-heart and Circulatory Physiology, 308(8), H803-H813. https://doi.org/10.1152/ajpheart.00573.2014
- Zurek, M., Maeder, M. T., Rickli, H., Muzzarelli, S., Sanders-van Wijk, S., Abbühl, H., Handschin, R., Jeker, U., Pfisterer, M. E., Brunner-La Rocca, H. P., & TIME-CHF Investigators, T. (2015). Differential Prognostic Impact of Resting Heart Rate in Older Compared With Younger Patients With Chronic Heart Failure: Insights From TIME-CHF. Journal of Cardiac Failure, 21(4), 347-354. https://doi.org/10.1016/j.cardfail.2014.12.014
- Schalla, S., Jaarsma, C., Bekkers, S. C., Waltenberger, J., Dennert, R., Crijns, H. J., Wildberger, J., Heymans, S., & Brunner-La Rocca, H. P. (2015). Right ventricular function in dilated cardiomyopathy and ischemic heart disease: assessment with non-invasive imaging. Netherlands Heart Journal, 23(4), 232-240. https://doi.org/10.1007/s12471-015-0673-x
- Diaz-Munoz, M. D., Bell, S. E., Fairfax, K., Monzon-Casanova, E., Cunningham, A. F., Gonzalez-Porta, M., Andrews, S. R., Bunik, V. I., Zarnack, K., Curk, T., Heggermont, W. A., Heymans, S., Gibson, G. E., Kontoyiannis, D. L., Ule, J., & Turner, M. (2015). The RNA-binding protein HuR is essential for the B cell antibody response. Nature Immunology, 16(4), 415-425. https://doi.org/10.1038/ni.3115
- Brunner-La Rocca, H. P., & Crijns, H. J. (2015). Iron i.v. in heart failure: ready for implementation?European Heart Journal, 36(11), 645-647. https://doi.org/10.1093/eurheartj/ehu392
- Gandhi, P. U., Motiwala, S. R., Belcher, A. M., Gaggin, H. K., Weiner, R. B., Baggish, A. L., Fiuzat, M., Rocca, H.-P. B.-L., & Januzzi, J. L. . J. (2015). Galectin-3 and mineralocorticoid receptor antagonist use in patients with chronic heart failure due to left ventricular systolic dysfunction. American Heart Journal, 169(3), 404-411. https://doi.org/10.1016/j.ahj.2014.12.012
- Berry, M., Galinier, M., Delmas, C., Fournier, P., Desmoulin, F., Turkieh, A., Mischak, H., Mullen, W., Barutaut, M., Eurlings, L. W., Van Wijk, S., Rocca, H.-P. B.-L., Caubere, C., Butler, J., Roncalli, J., Evaristi, M. F., Cohen-Solal, A., Seronde, M.-F., Escamilla, R., ... Rouet, P. (2015). Proteomics analysis reveals IGFBP2 as a candidate diagnostic biomarker for heart failure. International Journal of Cardiology - Metabolic & Endocrine, 6, 5-12. https://doi.org/10.1016/j.ijcme.2014.11.003
- Ounzain, S., Micheletti, R., Beckmann, T., Schroen, B., Alexanian, M., Pezzuto, I., Crippa, S., Nemir, M., Sarre, A., Johnson, R., Dauvillier, J., Burdet, F., Ibberson, M., Guigo, R., Xenarios, I., Heymans, S., & Pedrazzini, T. (2015). Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs. European Heart Journal, 36(6), 353–368. https://doi.org/10.1093/eurheartj/ehu180
- Van Wijk, S., Van Empel, V., Davarzani, N., Maeder, M. T., Muzzarelli, S., Jeker, U., Dieterle, T., Handschin, R., Kiencke, S., Pfisterer, M. E., Brunner-La Rocca, H. P., & investigators, F. T. TIME.-CHF. (2015). Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction. European journal of heart failure, 17(10), 1006-1014. https://doi.org/10.1002/ejhf.414
- Cardinaels, E. P. M., Daamen, M. A. M. J., Bekers, O., ten Kate, J., Niens, M., van Suijlen, J. D. E., van Dieijen-Visser, M. P., Brunner-La Rocca, H. P., Schols, J. M. G. A., & Mingels, A. M. A. (2015). Clinical Interpretation of Elevated Concentrations of Cardiac Troponin T, but Not Troponin I, in Nursing Home Residents. Journal of the American Medical Directors Association, 16(10), 884-891. https://doi.org/10.1016/j.jamda.2015.06.026
- Brunner-La Rocca, H. P., Knackstedt, C., Eurlings, L., Rolny, V., Krause, F., Pfisterer, M. E., Tobler, D., Rickenbacher, P., Maeder, M. T., & TIME-CHF Investigators, T. (2015). Impact of worsening renal function related to medication in heart failure. European journal of heart failure, 17(2), 159-168. https://doi.org/10.1002/ejhf.210
- van Aelst, L. N., Voss, S., Carai, P., van Leeuwen, R., Vanhoutte, D., Sanders-van Wijk, S., Eurlings, L., Swinnen, M., Verheyen, F. K., Verbeken, E., Nef, H., Troidl, C., Cook, S. A., Brunner-La Rocca, H. P., Möllmann, H., Papageorgiou, A. P., & Heymans, S. (2015). Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening. Circulation Research, 116(3), 425-436. https://doi.org/10.1161/CIRCRESAHA.116.304599
- Varon, C., Alao, M., Mintert, J., Stapleton, M., Thomson, S., Jaecques, S., Brunner-La Rocca, H. P., & Huffel, S. V. (2015). Telehealth on heart failure: results of the Recap project. Journal of Telemedicine and Telecare, 21(6), 340-347. https://doi.org/10.1177/1357633X15577310
- Bryant, C. E., Gay, N. J., Heymans, S., Sacre, S., Schaefer, L., & Midwood, K. S. (2015). Advances in Toll-like receptor biology: Modes of activation by diverse stimuli. Critical Reviews in Biochemistry and Molecular Biology, 50(5), 359-379. https://doi.org/10.3109/10409238.2015.1033511
- Daskalopoulos, E. P., Vilaeti, A. D., Barka, E., Mantzouratou, P., Kouroupis, D., Kontonika, M., Tourmousoglou, C., Papalois, A., Pantos, C., Blankesteijn, W. M., Agathopoulos, S., & Kolettis, T. M. (2015). Attenuation of post-infarction remodeling in rats by sustained myocardial growth hormone administration. Growth Factors, 33(4), 250-258. https://doi.org/10.3109/08977194.2015.1072527
- Brunner-La Rocca, H., & Bektas, S. (2015). Biomarker guided therapy in chronic heart failure. Cardiac Failure Review, 1(2), 96-101. https://doi.org/10.15420/cfr.2015.1.2.96
- Jahnsen, E. D., Trindade, A., Zaun, H. C., Lehoux, S., Duarte, A., & Jones, E. A. V. (2015). Notch1 is pan-endothelial at the onset of flow and regulated by flow. PLOS ONE, 10(4), e0122622. https://doi.org/10.1371/journal.pone.0122622
- 2014
- van Empel, V. P. M., Mariani, J., Borlaug, B. A., & Kaye, D. M. (2014). Impaired myocardial oxygen availability contributes to abnormal exercise hemodynamics in heart failure with preserved ejection fraction. Journal of the American Heart Association, 3(6), Article e001293. https://doi.org/10.1161/JAHA.114.001293
- Emmens, R. W., Woudstra, L., Papageorgiou, A., Carai, P., Smit, S., Seven-Deniz, S., Rozendaal, L., Paulus, W. J., Wouters, D., Zeerleder, S., Murk, J.-L., van Ham, M. S., Heymans, S., van Rossum, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2014). Lymphocytes Infiltrate the Quadriceps Muscle in Lymphocytic Myocarditis Patients: A Potential New Diagnostic Tool. Canadian Journal of Cardiology, 30(12), 1547-1554. https://doi.org/10.1016/j.cjca.2014.07.018
- Eurlings, L. W., Sanders-van Wijk, S., van Kraaij, D. J. W., van Kimmenade, R., Meeder, J. G., Kamp, O., van Dieijen-Visser, M. P., Tijssen, J. G. P., Brunner-La Rocca, H.-P., & Pinto, Y. M. (2014). Risk stratification with the use of serial N-terminal pro-B-type natriuretic peptide measurements during admission and early after discharge in heart failure patients: post hoc analysis of the PRIMA study. Journal of Cardiac Failure, 20(12), 881-90. https://doi.org/10.1016/j.cardfail.2014.08.014
- Reinhardt, B., Godfrey, R., Fellbrich, G., Frank, H., Lueske, A., Olieslagers, S., Mertens, T., & Waltenberger, J. (2014). Human cytomegalovirus infection impairs endothelial cell chemotaxis by disturbing VEGF signalling and actin polymerization. Cardiovascular Research, 104(2), 315-325. https://doi.org/10.1093/cvr/cvu204
- Skobel, E., Martinez-Romero, A., Scheibe, B., Schauerte, P., Marx, N., Luprano, J., & Knackstedt, C. (2014). Evaluation of a newly designed shirt-based ECG and breathing sensor for home-based training as part of cardiac rehabilitation for coronary artery disease. European Journal of Preventive Cardiology, 21(11), 1332-1340. https://doi.org/10.1177/2047487313493227
- Nabben, M., van Bree, B. W., Lenaers, E., Hoeks, J., Hesselink, M. K., Schaart, G., Gijbels, M. J., Glatz, J. F., da Silva, G. J., De Windt, L. J., Tian, R., Mike, E., Skapura, D. G., Wehrens, X. H., & Schrauwen, P. (2014). Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.Basic Research in Cardiology, 109(6), Article 447. https://doi.org/10.1007/s00395-014-0447-4
- Kaye, D. M., Mariani, J. A., van Empel, V., & Maeder, M. T. (2014). Determinants and implications of elevated soluble ST2 levels in heart failure. International Journal of Cardiology, 176(3), 1242-3. https://doi.org/10.1016/j.ijcard.2014.07.206
- Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., Mahrholdt, H., McKenna, W. J., Mogensen, J., Nihoyannopoulos, P., Nistri, S., Pieper, P. G., Pieske, B., Rapezzi, C., Rutten, F. H., Tillmanns, C., ... Watkins, H. (2014). 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). European Heart Journal, 35(39), 2733-2779. https://doi.org/10.1093/eurheartj/ehu284
- Tijsen, A. J., van der Made, I., van den Hoogenhof, M. M., Wijnen, W. J., van Deel, E. D., de Groot, N. E., Alekseev, S., Fluiter, K., Schroen, B., Goumans, M.-J., van der Velden, J., Duncker, D. J., Pinto, Y. M., & Creemers, E. E. (2014). The microRNA-15 family inhibits the TGF beta-pathway in the heart. Cardiovascular Research, 104(1), 61-71. https://doi.org/10.1093/cvr/cvu184
- Abdurrachim, D., Ciapaite, J., Wessels, B., Nabben, M., Luiken, J. J. F. P., Nicolay, K., & Prompers, J. J. (2014). Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1841(10), 1525-1537. https://doi.org/10.1016/j.bbalip.2014.07.016
- Jacobs, L., Thijs, L., Jin, Y., Zannad, F., Mebazaa, A., Rouet, P., Pinet, F., Bauters, C., Pieske, B., Tomaschitz, A., Mamas, M., Diez, J., McDonald, K., Cleland, J. G. F., Brunner-La Rocca, H.-P., Heymans, S., Latini, R., Masson, S., Sever, P., ... Staessen, J. A. (2014). Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. Journal of Biomedical Research, 28(5), 349-59. https://doi.org/10.7555/JBR.28.20140045
- Westermann, D., & Heymans, S. (2014). Fibrosis or hypertrophy: let TIMPs decide. Cardiovascular Research, 103(2), 196-197. https://doi.org/10.1093/cvr/cvu160



