Publications
- 2018
- Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(5), 1960-1967. https://doi.org/10.1016/j.bbadis.2017.12.025
- Coene, K. L. M., Kluijtmans, L. A. J., van der Heeft, E., Engelke, U. F. H., de Boer, S., Hoegen, B., Kwast, H. J. T., van de Vorst, M., Huigen, M. C. D. G., Keularts, I. M. L. W., Schreuder, M. F., van Karnebeek, C. D. M., Wortmann, S. B., de Vries, M. C., Janssen, M. C. H., Gilissen, C., Engel, J., & Wevers, R. A. (2018). Next-generation metabolic screening: targeted and untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patients. Journal of Inherited Metabolic Disease, 41(3), 337-353. https://doi.org/10.1007/s10545-017-0131-6
- Brugts, J. J., Linssen, G. C. M., Hoes, A. W., Brunner-La Rocca, H. P., & CHECK-HF Investigators (2018). Real-world heart failure management in 10,910 patients with chronic heart failure in the Netherlands: Design and rationale of the Chronic Heart failure ESC guideline-based Cardiology practice Quality project (CHECK-HF) registry. Netherlands Heart Journal, 26(5), 272-279. https://doi.org/10.1007/s12471-018-1103-7
- Korver-Keularts, I. M. L. W., Wang, P., Waterval, H. W. A. H., Kluijtmans, L. A. J., Wevers, R. A., Langhans, C.-D., Scott, C., Habets, D. D. J., & Bierau, J. (2018). Fast and accurate quantitative organic acid analysis with LC-QTOF/MS facilitates screening of patients for inborn errors of metabolism. Journal of Inherited Metabolic Disease, 41(3), 415-424. https://doi.org/10.1007/s10545-017-0129-0
- De Ruysscher, D., Dingemans, A.-M., Vooijs, M., & Heymans, S. (2018). PD-(L)1 Inhibition and Cardiac Damage: A Relevant Toxicity?Journal of Thoracic Oncology, 13(4), 478-479. https://doi.org/10.1016/j.jtho.2018.02.008
- Loebel, M., Holzhauser, L., Hartwig, J. A., Shukla, P. C., Savvatis, K., Jenke, A., Gast, M., Escher, F., Becker, S. C., Bauer, S., Stroux, A., Beling, A., Kespohl, M., Pinkert, S., Fechner, H., Kuehl, U., Lassner, D., Poller, W., Schultheiss, H.-P., ... Skurk, C. (2018). The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance inmyocarditis. European Heart Journal, 39(10), 876-887. https://doi.org/10.1093/eurheartj/ehx624
- Verdonschot, J. A. J., Hazebroek, M. R., Derks, K. W. J., Aizpurua, A. B., Merken, J. J., Wang, P., Bierau, J., van den Wijngaard, A., Schalla, S. M., Hamid, M. A. A., van Bilsen, M., van Empel, V. P. M., Knackstedt, C., Brunner-La Rocca, H.-P., Brunner, H. G., Krapels, I. P. C., & Heymans, S. R. B. (2018). Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias. European Heart Journal, 39(10), 864-873. https://doi.org/10.1093/eurheartj/ehx808
- Aizpurua, A. B., Franssen, F. M. E., van Empel, V., & Brunner-La Rocca, H.-P. (2018). An old debate still in the beta-phase?European journal of heart failure, 20(3), 557-559. https://doi.org/10.1002/ejhf.1086
- Deckx, S., Heggermont, W., Carai, P., Rienks, M., Dresselaers, T., Himmelreich, U., van Leeuwen, R., Lommen, W., van der Velden, J., Gonzalez, A., Diez, J., Papageorgiou, A.-P., & Heymans, S. (2018). Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation. Matrix Biology, 66, 110-124. https://doi.org/10.1016/j.matbio.2017.09.002
- Hazebroek, M. R., Krapels, I., Verdonschot, J., van den Wijngaard, A., Vanhoutte, E., Hoos, M., Snijders, L., van Montfort, L., Witjens, M., Dennert, R., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Brunner, H. G., & Heymans, S. (2018). Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy. Circulation-Heart Failure, 11(3), Article e004682 . https://doi.org/10.1161/CIRCHEARTFAILURE.117.004682
- Frantz, S., Falcao-Pires, I., Balligand, J.-L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G., & Heymans, S. (2018). The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. European journal of heart failure, 20(3), 445-459. https://doi.org/10.1002/ejhf.1138
- De Majo, F., & Calore, M. (2018). Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart. Non-coding RNA research, 3(1), 20-28. https://doi.org/10.1016/j.ncrna.2018.02.003
- Lourenco, A. P., Leite-Moreira, A. F., Balligand, J.-L., Bauersachs, J., Dawson, D., de Boer, R. A., de Windt, L. J., Falcao-Pires, I., Fontes-Carvalho, R., Franz, S., Giacca, M., Hilfiker-Kleiner, D., Hirsch, E., Maack, C., Mayr, M., Pieske, B., Thum, T., Tocchetti, C. G., Brutsaert, D. L., & Heymans, S. (2018). An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure, 20(2), 216-227. https://doi.org/10.1002/ejhf.1059
- Merken, J., Hazebroek, M., Van Paassen, P., Verdonschot, J., Van Empel, V., Knackstedt, C., Hamid, M. A., Seiler, M., Kolb, J., Hoermann, P., Ensinger, C., Brunner-La Rocca, H.-P., Poelzl, G., & Heymans, S. (2018). Immunosuppressive Therapy Improves Both Short- and Long-Term Prognosis in Patients With Virus-Negative Nonfulminant Inflammatory Cardiomyopathy. Circulation-Heart Failure, 11(2), Article 004228. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004228
- Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A., & Schroen, B. (2018). MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure. Hypertension, 71(2), 280-288. https://doi.org/10.1161/HYPERTENSIONAHA.117.10094
- Ferreira, J. P., Machu, J.-L., Girerd, N., Jaisser, F., Thum, T., Butler, J., Gonzalez, A., Diez, J., Heymans, S., McDonald, K., Gyongyosi, M., Firat, H., Rossignol, P., Pizard, A., & Zannad, F. (2018). Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis. Esc heart failure, 5(1), 139-148. https://doi.org/10.1002/ehf2.12218
- Zhang, M., Schiffers, P., Janssen, G., Vrolijk, M., Vangrieken, P., & Haenen, G. R. M. M. (2018). The cardiovascular side effects of Ma Huang due to its use in isolation in the Western world. European Journal of Integrative Medicine, 18, 18-22. https://doi.org/10.1016/j.eujim.2018.01.007
- Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B., & Nabben, M. (2018). Assessing fatty acid oxidation flux in rodent cardiomyocyte models. Scientific Reports, 8(1), Article 1505. https://doi.org/10.1038/s41598-018-19478-9
- Aimo, A., Januzzi, J. L., Vergaro, G., Ripoli, A., Latini, R., Masson, S., Magnoli, M., Anand, I. S., Cohn, J. N., Tavazzi, L., Tognoni, G., Gravning, J., Ueland, T., Nymo, S. H., Brunner-La Rocca, H.-P., Genis, A. B., Lupon, J., de Boer, R. A., Yoshihisa, A., ... Emdin, M. (2018). Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure An Individual Patient Data Meta-Analysis. Circulation, 137(3), 286-297. https://doi.org/10.1161/CIRCULATIONAHA.117.031560
- Kuepfer, L., Clayton, O., Thiel, C., Cordes, H., Nudischer, R., Blank, L. M., Baier, V., Heymans, S., Caiment, F., Roth, A., Fluri, D. A., Kelm, J. M., Castell, J., Selevsek, N., Schlapbach, R., Keun, H., Hynes, J., Sarkans, U., Gmuender, H., ... Kleinjans, J. (2018). A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity. Archives of Toxicology, 92(1), 553-555. https://doi.org/10.1007/s00204-017-2041-7
- Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V.-P., Heymans, S., Hill, L., Lainscak, M., Lam, C. S. P., Lund, L. H., Lyon, A. R., Mebazaa, A., Mueller, C., Paulus, W. J., Pieske, B., ... de Boer, R. A. (2018). Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 20(1), 16-37. https://doi.org/10.1002/ejhf.1029
- Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2018). WNT Signaling in Cardiac and Vascular Disease. Pharmacological Reviews, 70(1), 68-141. https://doi.org/10.1124/pr.117.013896
- Zhang, M., Vrolijk, M., & Haenen, G. R. M. M. (2018). The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine. International journal of molecular sciences, 19(1), Article 18. https://doi.org/10.3390/ijms19010018
- Smulders, M., Bekkers, B., VAN Cauteren, Y., Liefhebber, A., Vermeer, J. R., Vervuurt, J., van Dieijen - Visser, M. P., Mingels, A., Brunner-La Rocca, H., Dagnelie, P., Wildberger, J., Crijns, H., & Kietselaer, B. (2018). Acute pijn op de borst zonder afwijkend troponine: Is aanvullende niet-invasieve diagnostiek zinvol?Nederlands Tijdschrift voor Geneeskunde, 162(51-52), 1-7. Article D3568. https://www.ntvg.nl/system/files/publications/d3568.pdf
- Giamouridis, D., Gao, M., Lai, N. C., Tan, Z., Kim, B. C., Guo, T., Miyanohara, A., Blankesteijn, M., Biessen, E., & Hammond, H. K. (2018). Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC: Basic to Translational Science, 3(2), 249-264. https://doi.org/10.1016/j.jacbts.2017.12.004
- Nabben, M., Luiken, J. J. F. P., & Glatz, J. F. C. (2018). Metabolic remodelling in heart failure revisited. Nature Reviews Cardiology, 15(12), 780-780. https://doi.org/10.1038/s41569-018-0115-8
- 2017
- Falkenberg, K. D., Braverman, N. E., Moser, A. B., Steinberg, S. J., Klouwer, F. C. C., Schluter, A., Ruiz, M., Pujol, A., Engvall, M., Naess, K., van Spronsen, F., Korver-Keularts, I., Rubio-Gozalbo, M. E., Ferdinandusse, S., Wanders, R. J. A., & Waterham, H. R. (2017). Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder. American Journal of Human Genetics, 101(6), 965-976. https://doi.org/10.1016/j.ajhg.2017.11.007
- van Vark, L. C., Lesman-Leegte, I., Baart, S. J., Postmus, D., Pinto, Y. M., de Boer, R. A., Asselbergs, F. W., Wajon, E. M. C. J., Orsel, J. G., Boersma, E., Hillege, H. L., Martijn Akkerhuis, K., Nagelsmit, M. J., Brunner-La Rocca, H. P., Linssen, G. C. M., Terpstra, W. F., Liem, A. H., Wardeh, A. J., van Miltenburg, A. J. M., ... TRIUMPH Investigators (2017). Prognostic value of serial galectin-3 measurements in patients with acute heart failure. Journal of the American Heart Association, 6(12), Article e003700. https://doi.org/10.1161/JAHA.116.003700
- Rickenbacher, P., Kaufmann, B. A., Maeder, M. T., Bernheim, A., Goetschalckx, K., Pfister, O., Pfisterer, M., Brunner-La Rocca, H.-P., & Investigators, TIME.-CHF. (2017). Heart failure with mid-range ejection fraction: a distinct clinical entity? Insights from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF). European journal of heart failure, 19(12), 1586-1596. https://doi.org/10.1002/ejhf.798
- Baldewijns, K., Bektas, S., Boyne, J., Rohde, C., De Maesschalck, L., De Bleser, L., Brandenburg, V., Knackstedt, C., Deville, A., Sanders-Van Wijk, S., & La Rocca, H.-P. B. (2017). Improving kNowledge Transfer to Efficaciously RAise the level of Contemporary Treatment in Heart Failure (INTERACT-in-HF): Study protocol of a mixed methods study. International Journal of Care Coordination, 20(4), 171-182. https://doi.org/10.1177/2053434517726318
- van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B., & van Bilsen, M. (2017). Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling. Scientific Reports, 7(1), Article 16042. https://doi.org/10.1038/s41598-017-16201-y
- Baumgartner, S., Mensink, R. P., Haenen, G. R., Bast, A., Binder, C. J., Bekers, O., Husche, C., Luetjohann, D., & Plat, J. (2017). The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial. Scientific Reports, 7(1), Article 15288. https://doi.org/10.1038/s41598-017-15615-y
- Dahlmans, D., Houzelle, A., Andreux, P., Jorgensen, J. A., Wang, X., de Windt, L. J., Schrauwen, P., Auwerx, J., & Hoeks, J. (2017). An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism. Molecular Metabolism, 6(11), 1429-1442. https://doi.org/10.1016/j.molmet.2017.08.007
- Afsar, B., Rossignol, P., van Heerebeek, L., Paulus, W. J., Damman, K., Heymans, S., van Empel, V., Sag, A., Maisel, A., & Kanbay, M. (2017). Heart failure with preserved ejection fraction: a nephrologist-directed primer. Heart Failure Reviews, 22(6), 765-773. https://doi.org/10.1007/s10741-017-9619-2
- van Vark, L. C., Lesman-Leegte, I., Baart, S. J., Postmus, D., Pinto, Y. M., Orsel, J. G., Westenbrink, B. D., Rocca, H. P. B., van Miltenburg, A. J. M., Boersma, E., Hillege, H. L., Akkerhuis, K. M., & TRIUMPH Investigators (2017). Prognostic Value of Serial ST2 Measurements in Patients With Acute Heart Failure. Journal of the American College of Cardiology, 70(19), 2378-2388. https://doi.org/10.1016/j.jacc.2017.09.026
- Riemersma, M., Hazebroek, M. R., Helderman-van den Enden, A. T. J. M., Salomons, G. S., Ferdinandusse, S., Brouwers, M. C. G. J., van der Ploeg, L., Heymans, S., Glatz, J. F. C., van den Wijngaard, A., Krapels, I. P. C., Bierau, J., & Brunner, H. G. (2017). Propionic acidemia as a cause of adult-onset dilated cardiomyopathy. European Journal of Human Genetics, 25(11), 1195-1201. https://doi.org/10.1038/ejhg.2017.127
- van Bilsen, M., Patel, H. C., Bauersachs, J., Boehm, M., Borggrefe, M., Brutsaert, D., Coats, A. J. S., de Boer, R. A., de Keulenaer, G., Filippatos, G. S., Floras, J., Grassi, G., Jankowska, E. A., Kornet, L., Lunde, I. G., Maack, C., Mahfoud, F., Pollesello, P., Ponikowski, P., ... Lyon, A. R. (2017). The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 19(11), 1361-1378. https://doi.org/10.1002/ejhf.921
- D'Souza, A., Pearman, C. M., Wang, Y., Nakao, S., Logantha, S. J. R. J., Cox, C., Bennett, H., Zhang, Y., Johnsen, A. B., Linscheid, N., Poulsen, P. C., Elliott, J., Coulson, J., McPhee, J., Robertson, A., Martins, P. A. D. C., Kitmitto, A., Wisloff, U., Cartwright, E. J., ... Boyett, M. R. (2017). Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia. Circulation Research, 121(9), 1058-1068. https://doi.org/10.1161/CIRCRESAHA.117.311607
- da Costa Martins, P. A. (2017). Mononuclear Diploidy at the Heart of Cardiomyocyte Proliferation. Cell Stem Cell, 21(4), 421-422. https://doi.org/10.1016/j.stem.2017.09.012
- Vrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Hageman, G. J., Bast, A., & Haenen, G. R. M. M. (2017). The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicology in Vitro, 44, 206-212. https://doi.org/10.1016/j.tiv.2017.07.009
- Sthijns, M. M. J. P. E., den Hartog, G. J. M., Scasso, C., Haenen, J. P., Bast, A., & Haenen, G. R. M. M. (2017). Activation versus inhibition of microsomal glutathione S-transferase activity by acrolein. Dependence on the concentration and time of acrolein exposure. Chemico-Biological Interactions, 275, 116-120. https://doi.org/10.1016/j.cbi.2017.08.001
- Caforio, A. L. P., Adler, Y., Agostini, C., Allanore, Y., Anastasakis, A., Arad, M., Boehm, M., Charron, P., Elliott, P. M., Eriksson, U., Felix, S. B., Garcia-Pavia, P., Hachulla, E., Heymans, S., Imazio, M., Klingel, K., Marcolongo, R., Cerinic, M. M., Pantazis, A., ... Linhart, A. (2017). Diagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease. European Heart Journal, 38(35), 2649-2662. https://doi.org/10.1093/eurheartj/ehx321
- Lorenzon, A., Calore, M., Poloni, G., De Windt, L. J., Braghetta, P., & Rampazzo, A. (2017). Wnt/beta-catenin pathway in arrhythmogenic cardiomyopathy. Oncotarget, 8(36), 60640-60655. https://doi.org/10.18632/oncotarget.17457
- Heggermont, W. A., Papageorgiou, A.-P., Quaegebeur, A., Deckx, S., Carai, P., Verhesen, W., Eelen, G., Schoors, S., van Leeuwen, R., Alekseev, S., Elzenaar, I., Vinckier, S., Pokreisz, P., Walravens, A.-S., Gijsbers, R., Van Den Haute, C., Nickel, A., Schroen, B., van Bilsen, M., ... Heymans, S. (2017). Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. Circulation, 136(8), 747-761. https://doi.org/10.1161/CIRCULATIONAHA.116.024171
- van Gisbergen, M. W., Voets, A. M., Biemans, R., Hoffmann, R. F., Drittij-Reijnders, M.-J., Haenen, G. R. M. M., Heijink, I. H., Rouschop, K. M. A., Dubois, L. J., & Lambin, P. (2017). Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress. PLOS ONE, 12(8), Article 0182508. https://doi.org/10.1371/journal.pone.0182508
- Abdurrachim, D., Nabben, M., Hoerr, V., Kuhlmann, M. T., Bovenkamp, P., Ciapaite, J., Geraets, I. M. E., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., Schaefers, M., Nicolay, K., Faber, C., Hermann, S., & Prompers, J. J. (2017). Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovascular Research, 113(10), 1148-1160. https://doi.org/10.1093/cvr/cvx100
- Uszko-Lencer, N. H. M. K., Mesquita, R., Janssen, E., Werter, C., Rocca, H.-P. B.-L., Pitta, F., Wouters, E. F. M., & Spruit, M. A. (2017). Reliability, construct validity and determinants of 6-minute walk test performance in patients with chronic heart failure. International Journal of Cardiology, 240, 285-290. https://doi.org/10.1016/j.ijcard.2017.02.109
- van der Harst, P., de Windt, L. J., & Chambers, J. C. (2017). Translational Perspective on Epigenetics in Cardiovascular Disease. Journal of the American College of Cardiology, 70(5), 590-606. https://doi.org/10.1016/j.jacc.2017.05.067




