PI group Tammo Delhaas
- 2026
- Buonocunto, M., Delhaas, T., Lyon, A., Heijman, J., & Lumens, J. (2026). Spatiotemporal determinants of stretch-activated channel-induced re-entry in ventricular tissue: An in-silico study. Journal of Molecular and Cellular Cardiology, 210, 150-164. https://doi.org/10.1016/j.yjmcc.2025.11.007
- van den Acker, G. P. H., Dhont, S., van Loon, T., Churchill, T. W., Timmermans, F., Delhaas, T., Bertrand, P. B., & Lumens, J. (2026). Impact of left-heart myopathy on mitral valve stenosis assessment and interventional outcomes: an in-silico trial. European Heart Journal - Digital Health, 7(1), Article ztaf097. https://doi.org/10.1093/ehjdh/ztaf097
- 2025
- Okoro, C., van der Kallen, C. J. H., Mokhtar, S. B. A., Zhou, T. L., Berendschot, T. T. J. M., Koster, A., Reesink, K., Reulen, J., Mess, W. H., Webers, C. A. B., Kroon, A., & Stehouwer, C. D. A. (2025). Arterial stiffness is associated with small and large fiber neuropathy: The Maastricht Study. Journal of Hypertension, 43(12), 1945-1952. https://doi.org/10.1097/HJH.0000000000004126
- Parikh, S., Reesink, K. D., Spronck, B., Delhaas, T., & Giudici, A. (2025). Impact of Dynamic Axial Stretching on the Arterial Pulse Wave Velocity: Physical Foundation and Clinical Implications. Annals of Biomedical Engineering. https://doi.org/10.1007/s10439-025-03940-7
- Prinzen, F. W., & Lumens, J. (2025). Atrioventricular Interval Modulation: Looking Beyond Blood Pressure Needed?JACC: Clinical Electrophysiology, 11(11), 2505-2508. https://doi.org/10.1016/j.jacep.2025.07.022
- Neuen, S. M. L., Ophelders, D. R. M. G., Widowski, H., Hütten, M. C., Brokken, T., van Gorp, C., de Lange, I. H., Zimmermann, L. J. I., Nikkels, P. G. J., Severens-Rijvers, C. A. H., Sthijns, M. M. J. P. E., LaPointe, V. L. S., Jolani, S., Pillow, J. J., Delhaas, T., Seiler, C., Reynaert, N. L., & Wolfs, T. G. A. M. (2025). Multipotent adult progenitor cell therapy: Effect of timing and frequency on lung health in preterm lambs during inflammation. Pharmacological Research, 221, Article 107979. https://doi.org/10.1016/j.phrs.2025.107979
- van der Laan, K. W. F., Neutel, C. H. G., Pencheva, M. G., Wesley, C. D., Krüger, D. N., Schalwijk, C. G., De Meyer, G. R. Y., Martinet, W., Reesink, K. D., Delhaas, T., Giudici, A., Guns, P.-J., & Spronck, B. (2025). Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells. American Journal of Physiology-Cell Physiology, 329(5), C1398-C1410. https://doi.org/10.1152/ajpcell.00387.2025
- Bruno, R. M., Badhwar, S., Abid, L., Agharazii, M., Anastasio, F., Bellien, J., Burghuber, O., Faconti, L., Filipovsky, J., Ghiadoni, L., Giannattasio, C., Hametner, B., Hughes, A. D., Jeroncic, A., Ikonomidis, I., Lonnebakken, M. T., Maloberti, A., Mayer, C. C., Muiesan, M. L., ... CARTESIAN Investigators (2025). Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study. European Heart Journal, 46(39), 3905-3918. Article ehaf7019. https://doi.org/10.1093/eurheartj/ehaf430
- van Koll, J., Engels, M. D. E. A., Rijks, J. H. J., Salari, M., Luijten, J., Lumens, J., van Empel, V. P. M., Westra, S. W., van Stipdonk, A. M. W., Lankveld, T. A. R., Chaldoupi, S. M., Joza, J., Beukema, R. J., Luermans, J. G. L. M., Linz, D. K., & Vernooy, K. (2025). Long-term outcomes of pace-and-ablate strategy in patients with atrial fibrillation. Journal of Interventional Cardiac Electrophysiology, 68(7), 1487-1495. Article 100786. https://doi.org/10.1007/s10840-025-02038-3
- Giudici, A., Robberechts, T., Kadziela, J., Stoenoiu, M. S., Delmotte, P., Donkers, K. M., van Leeuwen, J. E., Toubiana, L., Januszewicz, A., Januszewicz, M., Persu, A., & Spronck, B. (2025). Non-invasive evaluation of the hemodynamic significance of renal artery stenosis in fibromuscular dysplasia through quantitative image analysis. Kardiologia Polska. Advance online publication. https://doi.org/10.33963/v.phj.108870
- Lee, X. A., Raschzok, S., Desjardins, J.-F., Van Loon, T., Plavetic, A., Kanny, O., Kabir, G., Nghiem, L., Dauz, J., Kapus, A., Lumens, J., Connelly, K. A., & Friedberg, M. K. (2025). Left ventricular pressure-loading improves pressure-induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling. Physiological Reports, 13(18), Article e70546. https://doi.org/10.14814/phy2.70546
- van der Bruggen, M. M., van Greevenbroek, M. M. J., Spronck, B., Stehouwer, C. D. A., Delhaas, T., Reesink, K. D., & Schalkwijk, C. G. (2025). Plasma reactive dicarbonyls are not independently associated with arterial stiffness: The Maastricht Study. American Journal of Hypertension, 38(10), 777-787. https://doi.org/10.1093/ajh/hpaf068
- van Osta, N., van Loon, T., & Lumens, J. (2025). Individual hearts: computational models for improved management of cardiovascular disease. Heart. Advance online publication. https://doi.org/10.1136/heartjnl-2024-324177
- Bruining, N., van der Boon, R., Kardys, I., Cummins, P., & Lumens, J. (2025). Reviewers and awards. European Heart Journal - Digital Health. Advance online publication. https://doi.org/10.1093/ehjdh/ztaf098
- Mizner, J., Beela, A., Linkova, H., Vesela, J., Sussenbek, O., Stros, P., Smisek, R., Jurak, P., Leinveber, P., Lipoldova, J., Nagy, A., Waldauf, P., Lumens, J., Vernooy, K., Prinzen, F., & Curila, K. (2025). Electrical and mechanical interventricular dyssynchrony coupling in patients with bradycardia: A UHF-ECG validation trial. Heart Rhythm, 22(9), 2382-2390. https://doi.org/10.1016/j.hrthm.2025.02.031
- Van den Eynde, M. D. G., van der Bruggen, M. M., Houben, A. J. H. M., Reesink, K. D., Spronck, B., Delhaas, T., Scheijen, J. J. L. J. M., Miyata, T., & Schalkwijk, C. G. (2025). Pyridoxamine does not reduce arterial stiffness in an 8-week randomized double-blind placebo-controlled intervention trial with abdominally obese individuals. Diabetes Obesity & Metabolism, 27(9), 5332-5336. https://doi.org/10.1111/dom.16524
- Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
- Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
- Lempers, T. E. M., Smits, K. C., van Koll, J., Dural, M., van Stipdonk, A. M. W., Lumens, J., Luermans, J. G. L. M., Vernooy, K., Prinzen, F. W., van Dam, P., & Nguyên, U. C. (2025). An in-silico analysis of the influence of left bundle branch block and myocardial fibrosis on electrocardiographic QRS duration and morphology and vectorcardiographic QRS area. Journal of Electrocardiology, 91, Article 154043. https://doi.org/10.1016/j.jelectrocard.2025.154043
- Tavolinejad, H., Boczar, K. E., Spronck, B., Maynard, H., Bertoni, A. G., Shah, S. J., & Chirinos, J. A. (2025). Determinants of Cardio-Ankle Vascular Index and Heart-Thigh β Index in the MESA: The MESA. Hypertension, 82(6), 1081-1094. https://doi.org/10.1161/HYPERTENSIONAHA.124.23970
- van Loon, T., Vernooy, K., & Lumens, J. (2025). Rate acceleration in heart failure with preserved ejection fraction: towards different strokes for different folks. European Heart Journal, 46(21), 2029-2030. https://doi.org/10.1093/eurheartj/ehaf110
- van Willigen, B. G., van Osta, N., van der Hout-van der Jagt, M. B., van de Vosse, F. N., & Huberts, W. (2025). A virtual population cohort approach for fetal cardiac valve modeling. Journal of Computational Science, 88, Article 102606. https://doi.org/10.1016/j.jocs.2025.102606
- Saraber, P., Bica, L., Reesink, K., Mees, B., Bidar, E., Schurger, L., & Heuts, S. (2025). The clinical relevance of the decelerating effect of angiotensin receptor blockers on aortic growth in Marfan patients; a Bayesian perspective. International Journal of Cardiology, 433, Article 133318. https://doi.org/10.1016/j.ijcard.2025.133318
- Manetti, C. A., van Osta, N., Beela, A. S., Herbots, L., Prinzen, F. W., Delhaas, T., & Lumens, J. (2025). Impact of myocardial phenotype on optimal atrioventricular delay settings during biventricular and left bundle-branch pacing at rest and during exercise: insights from a virtual patient study. EP Europace, 27(4), Article euaf082. https://doi.org/10.1093/europace/euaf082
- Van Osta, N., Van Den Acker, G., Van Loon, T., Arts, T., Delhaas, T., & Lumens, J. (2025). Numerical accuracy of closed-loop steady state in a zero-dimensional cardiovascular model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 383(2293), Article 20240208. https://doi.org/10.1098/rsta.2024.0208
- Giudici, A., Grillo, A., Scalise, F., Reesink, K. D., Delhaas, T., Salvi, P., Spronck, B., & Parati, G. (2025). Beat-to-beat variability of aortic pulse wave velocity: Implications for aortic stiffness measurements. Journal of Hypertension, 43(4), 589-597. Article 3935. https://doi.org/10.1097/HJH.0000000000003935
- Lumens, J. (2025). The Double Dyssynchrony Paradox: When Cardiac Discord Signals Hope. JACC-Cardiovascular Imaging, 18(4), 433-435. https://doi.org/10.1016/j.jcmg.2025.01.003
- Beela, A. S., Manetti, C. A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2025). The mechanistic interaction between mechanical dyssynchrony and filling pressure in cardiac resynchronization therapy candidates. European Heart Journal Cardiovascular Imaging, 26(3), 424-434. Article jeae286. https://doi.org/10.1093/ehjci/jeae286
- Munneke, A. G., Lumens, J., & Delhaas, T. (2025). Diagnostic value of reversed differential cyanosis in (supra)cardiac total anomalous pulmonary venous return. Pediatric Research, 97(2), 809-817. Article 113366. https://doi.org/10.1038/s41390-024-03355-5
- van Loo, C., Toonen, S. M. R. L., Schurgers, L. J., Delhaas, T., & Spronck, B. (2025). Human Aortic Vasoreactivity in Response to Various Stimuli: A Review. Pulse, 13(1), 121-139. https://doi.org/10.1159/000547617
- Parikh, S., Wehrens, A., Giudici, A., Ganizada, B., Saraber, P., Schurgers, L., Debeij, G., Natour, E., Maessen, J., Huberts, W., Delhaas, T., Reesink, K., & Bidar, E. (2025). Interpretation of intra-operative strain differences in ascending thoracic aortic repair patients. Journal of Biomechanics, 179, Article 112447. https://doi.org/10.1016/j.jbiomech.2024.112447
- Neutel, C. H. G., van der Laan, K. W. F., Wesley, C. D., Krueger, D. N., Pencheva, M. G., Schalkwijk, C. G., De Meyer, G. R. Y., Martinet, W., Delhaas, T., Reesink, K. D., Giudici, A., Guns, P.-J., & Spronck, B. (2025). The MAASWERP Study: An International, Comparative Case Study on Measuring Biomechanics of the Aged Murine Aorta. Pulse, 13(1), 1-10. https://doi.org/10.1159/000542694
- Heinen, S. G. H., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T., & Huberts, W. (2025). Corrigendum to “A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenosis” [J. Biomech. 92 (2019) 67–75]. Journal of Biomechanics, 178, Article 112248. https://doi.org/10.1016/j.jbiomech.2024.112248
- 2024
- van Loon, T., Rijks, J., van Koll, J., Wolffs, J., Cornelussen, R., van Osta, N., Luermans, J., Prinzen, F., Linz, D., van Empel, V., Delhaas, T., Vernooy, K., & Lumens, J. (2024). Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study. European Heart Journal, 45(46), 4953-4964. https://doi.org/10.1093/eurheartj/ehae718
- Zanelli, S., Agnoletti, D., Alastruey, J., Allen, J., Bianchini, E., Bikia, V., Boutouyrie, P., Bruno, R. M., Climie, R., Djamaleddine, D., Gkaliagkousi, E., Giudici, A., Gopcevic, K., Grillo, A., Guala, A., Hametner, B., Joseph, J., Karimpour, P., Kodithuwakku, V., ... Charlton, P. H. (2024). Developing technologies to assess vascular ageing: a roadmap from VascAgeNet. Physiological Measurement, 45(12), Article 121001. https://doi.org/10.1088/1361-6579/ad548e
- Neuen, S. M. L., Ophelders, D. R. M. G., Widowski, H., Hütten, M. C., Brokken, T., van Gorp, C., Nikkels, P. G. J., Severens-Rijvers, C. A. H., Sthijns, M. M. J. P. E., van Blitterswijk, C. A., Troost, F. J., LaPointe, V. L. S., Jolani, S., Seiler, C., Pillow, J. J., Delhaas, T., Reynaert, N. L., & Wolfs, T. G. A. M. (2024). Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs. Regenerative Therapy, 27, 207-217. https://doi.org/10.1016/j.reth.2024.03.014
- van Willigen, B. G., van der Hout-van der Jagt, M. B., Bovendeerd, P. H. M., Huberts, W., & van de Vosse, F. N. (2024). A Multiscale Mathematical Model for the Fetal Blood Circulation of the Second Half of Pregnancy. International Journal for Numerical Methods in Biomedical Engineering, 40(12), Article e3877. https://doi.org/10.1002/cnm.3877
- Rijks, J. H. J., Heckman, L., Westra, S., Cornelussen, R., Ghosh, S., Curila, K., Smisek, R., Grieco, D., Bressi, E., Nguyen, U. C., Lumens, J., van Stipdonk, A. M. W., Linz, D., Prinzen, F. W., Luermans, J. G. L. M., & Vernooy, K. (2024). Assessment of ventricular electrical heterogeneity in left bundle branch pacing and left ventricular septal pacing by using various electrophysiological methods. Journal of Cardiovascular Electrophysiology, 35(12), 2282-2292. Article 16435. https://doi.org/10.1111/jce.16435
- Bressi, E., Sedlacek, K., Curila, K., Cano, O., Luermans, J. G. L. M., Rijks, J. H. J., Meiburg, R., Smits, K. C., Nguyen, U. C., De Ruvo, E., Calo, L., Kron, J., Ellenbogen, K. A., Prinzen, F., Vernooy, K., & Grieco, D. (2024). Clinical impact and predictors of periprocedural myocardial injury among patients undergoing left bundle branch area pacing. Journal of Interventional Cardiac Electrophysiology, 67(9), 2039-2050. Article e17. https://doi.org/10.1007/s10840-024-01863-2
- van der Sluijs, K. M., Bakker, E. A., Kerstens, T. P., Stens, N. A., de Koning, I. A., Thannhauser, J., Malik, A. E. F., Reesink, K. D., Nabeel, P. M., Raj, K. V., Joseph, J., Eijsvogels, T. M. H., Thijssen, D. H. J., & Nijmegen Exercise Study collaboration (2024). Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study. Scandinavian Journal of Medicine & Science in Sports, 34(11), Article e14757. https://doi.org/10.1111/sms.14757
- Forrest, M., Matossian, M., Valdes Sustaita, B., Papacostas Quintanilla, H., Spronck, B., Sharman, J., & Daskalopoulou, S. S. (2024). Arterial stiffness as a novel tool for the early prediction of preeclampsia: a perspective. Journal of Human Hypertension, 38(11), 745-749. https://doi.org/10.1038/s41371-024-00967-6
- Neutel, C. H. G., Wesley, C. D., van Loo, C., Civati, C., Mertens, F., Zurek, M., Verhulst, A., Pintelon, I., De Vos, W. H., Spronck, B., Roth, L., De Meyer, G. R. Y., Martinet, W., & Guns, P. J. (2024). Calciprotein particles induce arterial stiffening ex vivo and impair vascular cell function. Communications Biology, 7(1), Article 1241. https://doi.org/10.1038/s42003-024-06895-y
- Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2024). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology, 602(18), 4585-4604. https://doi.org/10.1113/JP284439
- Paulussen, E., Van Steenkiste, G., Hermans, B. J. M., Decloedt, A., van Loon, G., & Delhaas, T. (2024). Einthoven's triangle adapted for horses: Proposal for the Delta configuration. Journal of Veterinary Internal Medicine, 38(5), 2698-2706. https://doi.org/10.1111/jvim.17179
- Beela, A. S., Rijks, J. H. J., Manetti, C. A., Vernooy, K., van Stipdonk, A. M. W., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2024). Left bundle branch block criteria in the 2021 ESC guidelines on CRT: A step back in identifying CRT candidates?European Heart Journal Cardiovascular Imaging, 25(9), e213-e215. https://doi.org/10.1093/ehjci/jeae164
- van Vliet, L. V., Zonnebeld, N., Tordoir, J. H., Huberts, W., Bouwman, L. H., Cuypers, P. W., Heinen, S. G., Huisman, L. C., Lemson, S., Mees, B. M. E., Schlosser, F. J., de Smet, A. A., Toorop, R. J., Delhaas, T., & Snoeijs, M. G. (2024). Guideline recommendations on minimal blood vessel diameters and arteriovenous fistula outcomes. Journal of vascular access, 25(5), 1584-1592. https://doi.org/10.1177/11297298231180627




