• 2025
    • Koolwijk, J., van de Kar, M., van der Woude, B. A., van 't Veer, M., de Grooth, H.-J., Crijns, H. J. G. M., Dekker, L. R. C., Bouwman, R. A., Cremer, O. L., de Bie, A. J. R., & Otterspoor, L. C. (2025). Anticoagulation and thromboembolic risk in critically ill patients with trigger-induced atrial fibrillation-A systematic review and meta-analysis. Netherlands Heart Journal, 33(10), 290-298. https://doi.org/10.1007/s12471-025-01978-9
    • Kantharia, B. K., Tabary, M., Wu, L., Wang, X., Narasimhan, B., Linz, D., Heijman, J., & Wehrens, X. H. T. (2025). Diabetes and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management. Journal of Cardiovascular Electrophysiology, 36(10), 2755-2766. https://doi.org/10.1111/jce.16655
    • Kantharia, B. K., Zhao, S., Linz, D., Heijman, J., & Wehrens, X. H. T. (2025). Hypertension and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management. Journal of Cardiovascular Electrophysiology, 36(10), 2712-2719. https://doi.org/10.1111/jce.16632
    • D'Italia, G., Coenen, D. M., Lemmens, T. P., Brandts, L., Wielders, S. J. H., Nagy, M., Mourmans, S. G. J., Achten, A., Al-Abadi, A., Weerts, J., Aizpurua, A. B., van Empel, V., Schroen, B., & Cosemans, J. M. E. M. (2025). Immuno-haemostatic dysregulation in heart failure with preserved ejection fraction. Esc heart failure, 12(5), 3444-3460. https://doi.org/10.1002/ehf2.15361
    • van Koll, J., Engels, M. D. E. A., Rijks, J. H. J., Salari, M., Luijten, J., Lumens, J., van Empel, V. P. M., Westra, S. W., van Stipdonk, A. M. W., Lankveld, T. A. R., Chaldoupi, S. M., Joza, J., Beukema, R. J., Luermans, J. G. L. M., Linz, D. K., & Vernooy, K. (2025). Long-term outcomes of pace-and-ablate strategy in patients with atrial fibrillation. Journal of Interventional Cardiac Electrophysiology, 68(7), 1487-1495. Article 100786. https://doi.org/10.1007/s10840-025-02038-3
    • Giudici, A., Robberechts, T., Kadziela, J., Stoenoiu, M. S., Delmotte, P., Donkers, K. M., van Leeuwen, J. E., Toubiana, L., Januszewicz, A., Januszewicz, M., Persu, A., & Spronck, B. (2025). Non-invasive evaluation of the hemodynamic significance of renal artery stenosis in fibromuscular dysplasia through quantitative image analysis. Kardiologia Polska. Advance online publication. https://doi.org/10.33963/v.phj.108870
    • Frausing, M. H. J. P., Rienstra, M., Kronborg, M. B., De Melis, M., Schotten, U., Nielsen, J. C., Tieleman, R., Crijns, H. J. G. M., Van Gelder, I. C., & Samuel, M. (2025). Association between circulating biomarkers and atrial fibrillation burden in patients with paroxysmal atrial fibrillation: a subanalysis of the RACE V study. Open Heart, 12(2), Article e003433. https://doi.org/10.1136/openhrt-2025-003433
    • Lee, X. A., Raschzok, S., Desjardins, J.-F., Van Loon, T., Plavetic, A., Kanny, O., Kabir, G., Nghiem, L., Dauz, J., Kapus, A., Lumens, J., Connelly, K. A., & Friedberg, M. K. (2025). Left ventricular pressure-loading improves pressure-induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling. Physiological Reports, 13(18), Article e70546. https://doi.org/10.14814/phy2.70546
    • van der Bruggen, M. M., van Greevenbroek, M. M. J., Spronck, B., Stehouwer, C. D. A., Delhaas, T., Reesink, K. D., & Schalkwijk, C. G. (2025). Plasma reactive dicarbonyls are not independently associated with arterial stiffness: The Maastricht Study. American Journal of Hypertension, 38(10), 777-787. https://doi.org/10.1093/ajh/hpaf068
    • Klein, D. O., Waardenburg, S. F., Janssen, E. B. N. J., Wintjens, M. S. J. N., Imkamp, M., Heemskerk, S. C. M., Birnie, E., Bonsel, G. J., Warlé, M. C., Jacobs, L. M. C., Hemmen, B., Verbunt, J., van Bussel, B. C. T., van Santen, S., Kietelaer, B. L. J. H., Jansen, G., Klok, F. A., de Kruif, M. D., Vernooy, K., ... CAPACITY-COVID collaborative consortium (2025). Two years and counting: a prospective cohort study on the scope and severity of post-COVID symptoms across diverse patient groups in the Netherlands-insights from the CORFU study. BMJ Open, 15(9), Article e093639. https://doi.org/10.1136/bmjopen-2024-093639
    • Gold, C., Pratz, P., Falagkari, A., Johnson, V., Post, F., Roth, E., Kupusovic, J., Erath-Honold, J. W., Linz, D., Leistner, D., Wakil, R., & Rottner, L. (2025). Haemolysis and myocardial and neural injury after monopolar pulsed field ablation using a novel lattice-tip catheter to treat atrial fibrillation. EP Europace, 27(9), Article euaf210. https://doi.org/10.1093/europace/euaf210
    • van Osta, N., van Loon, T., & Lumens, J. (2025). Individual hearts: computational models for improved management of cardiovascular disease. Heart. Advance online publication. https://doi.org/10.1136/heartjnl-2024-324177
    • Fu, J., Cameron, B. A., Schonleitner, P., Schiatti, T., Kuiper, M., Kittel, A.-S., Simon-Chica, A., Madl, J., Kreutz, C., Filgueiras-Rama, D., Schotten, U., Roemer, W., Ravens, U., Kohl, P., Rog-Zielinska, E. A., Antoons, G., & Peyronnet, R. (2025). Stretch-Induced Increase in Ca<SUP>2+</SUP>-Spark Rate in Rabbit Atrial Cardiomyocytes Requires TRPA1 and Intact Microtubule Network. Journal of the American Heart Association, 14(17), Article e040495. https://doi.org/10.1161/JAHA.124.040495
    • Kantharia, B. K., Wehrens, X. H. T., & Linz, D. (2025). Superior Vena Cava And Atrial Cardiomyopathy: Role of Adjunctive Superior Vena Cava Isolation Ablation in Atrial Fibrillation. EP Europace, 27(9), Article euaf204. https://doi.org/10.1093/europace/euaf204
    • Onder, R., Desteghe, L., Vijgen, J., Collins, R., Dabrowski, R., Farkowski, M. M., de Oliveira Figueiredo, M. J., Hereijgers, M. J. M., Hofer, D., Lau, C.-P., Lee, G., Linz, D., Lobeek, M., Lopez, T., McAuliffe, C., Merino, J. L., Potpara, T., Sanders, P., Shamloo, A. S., ... Heidbuchel, H. (2025). Development of three-step holistic care pathways to detect and manage comorbidities in patients with atrial fibrillation: the Horizon 2020 EHRA-PATHS consortium. European heart journal open, 5(5), Article oeaf120. https://doi.org/10.1093/ehjopen/oeaf120
    • Metzner, A., Willems, S., Borof, K., Breithardt, G., Camm, A. J., Crijns, H. J. G. M., Eckardt, L., Fabritz, L., Gessler, N., Goette, A., Reissmann, B., Schnabel, R. B., Schotten, U., Zapf, A., Rillig, A., & Kirchhof, P. (2025). Diabetes and Obesity and Treatment Effect of Early Rhythm Control vs Usual Care in Patients With Atrial Fibrillation: A Secondary Analysis of the EAST-AFNET 4 Randomized Clinical Trial. JAMA Cardiology, 10(9), 932-941. https://doi.org/10.1001/jamacardio.2025.2374
    • Hereijgers, M. J. M., van der Velden, R. M. J., Reinders, L. G., Weerts, Z., Kuijpers, S., Luermans, J., Chaldoupi, S. M., Vernooy, K., Hermans, A. N. L., Posthuma, R., Franssen, F. M. E., Linz, D., & Simons, S. O. (2025). Feasibility and diagnostic yield of a photoplethysmography-based arrhythmia screening and integrated management pathway in a COPD outpatient clinic. ERJ Open Research, 11(5), Article 01192-2024. https://doi.org/10.1183/23120541.01192-2024
    • Schalla, S., Wildberger, J. E., Ramaekers, M. J. F. G., Mihl, C., McDermott, M. C., Stammen, L., Vernooy, K., & Flohr, T. G. (2025). Imaging of Cardiovascular Implantable Electronic Device Leads With Photon-Counting Detector Computed Tomography. Investigative Radiology, 60(9), 616-625. https://doi.org/10.1097/RLI.0000000000001177
    • Joza, J., van Koll, J., Ramalingam, V., Tai, P., Essebag, V., Hadjis, T. A., Lankveld, T. A. R., van Stipdonk, A. M. W., Rijks, J. H. J., Nguyên, U. C., Luermans, J., Verma, A., & Vernooy, K. (2025). Implementation of lead V8 as a simple non-invasive tool to improve patient selection in cardiac resynchronization therapy and guide left ventricular lead placement. EP Europace, 27(9), Article euaf194 . https://doi.org/10.1093/europace/euaf194
    • Martens, B., van der Meulen, L. R., Crawley, R. J., van Cauteren, Y. J. M., Smulders, M. W., Streukens, S., Hendriks, B. M. F., Houben, I. P. L., Gommers, S., Frey, S. M., Brandts, L., Wildberger, J. E., Chiribiri, A., & Holtackers, R. J. (2025). Influence of Reader Expertise on Myocardial Infarction Detection: A Comparative Study of Dark-Blood and Bright-Blood Late Gadolinium Enhancement MRI. Investigative Radiology, 60(9), 561-568. https://doi.org/10.1097/RLI.0000000000001161
    • Jastrzebski, M., Kielbasa, G., Cano, O., Curila, K., Zanon, F., Pestrea, C., De Pooter, J., Luermans, J., Rademakers, L. M., Zizek, D., Grieco, D., Huybrechts, W., Krisai, P., Whinnett, Z., Moskal, P., Valiton, V., Navarrete-Navarro, J., Stros, P., Deluca, F., ... Burri, H. (2025). Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study. European Heart Journal, Article ehaf699. https://doi.org/10.1093/eurheartj/ehaf699
    • Bruining, N., van der Boon, R., Kardys, I., Cummins, P., & Lumens, J. (2025). Reviewers and awards. European Heart Journal - Digital Health. Advance online publication. https://doi.org/10.1093/ehjdh/ztaf098
    • Kawczynski, M. J., Gilbers, M. D., Winters, J., Maesen, B., Isaacs, A., Linz, D., Rienstra, M., van Gelder, I., Maessen, J. G., Bidar, E., & Schotten, U. (2025). Right atrial endomysial fibrosis is associated with increased postoperative atrial fibrillation burden during 2.5 years of continuous rhythm monitoring after cardiac surgery including atrial arrhythmia surgery: RACE V Tissue Bank Study. EP Europace, 27(9), Article euaf207. https://doi.org/10.1093/europace/euaf207
    • Swinnen, B., Kawczynski, M. J., Mingels, A. M. A., Wildberger, J. E., Mihl, C., Smulders, M. W., Maessen, J. G., Gollmann-Tepeköylü, C., & Heuts, S. (2025). The prognostic impact of prevailing definitions of periprocedural myocardial infarction in patients undergoing coronary artery bypass grafting. European heart journal - Quality of care & clinical outcomes, 11(6), 847-856. https://doi.org/10.1093/ehjqcco/qcaf043
    • Holtackers, R. J., Varga-Szemes, A., & Smulders, M. W. (2025). Editorial for “Improved and Automated Detection of Papillary Muscle Infarction Using Joint Bright- and Black-Blood Late Gadolinium Enhancement MRI”. Journal of Magnetic Resonance Imaging, 62(3), 840-841. https://doi.org/10.1002/jmri.29794
    • Mizner, J., Beela, A., Linkova, H., Vesela, J., Sussenbek, O., Stros, P., Smisek, R., Jurak, P., Leinveber, P., Lipoldova, J., Nagy, A., Waldauf, P., Lumens, J., Vernooy, K., Prinzen, F., & Curila, K. (2025). Electrical and mechanical interventricular dyssynchrony coupling in patients with bradycardia: A UHF-ECG validation trial. Heart Rhythm, 22(9), 2382-2390. https://doi.org/10.1016/j.hrthm.2025.02.031
    • Sandgren, E., Betz, K., Gawalko, M., Hermans, A., Habibi, Z., Verhaert, D., Philippens, S., Vorstermans, B., Uijl, D. D., Chaldoupi, S.-M., Luermans, J., Lankveld, T., Schotten, U., Vernooy, K., & Linz, D. (2025). Feasibility of repeated on-demand smartphone app-based approximation of time spent with atrial fibrillation and symptoms in patients after catheter ablation: Data from the ISOLATION study. Heart Rhythm, 22(9), 2269-2276. https://doi.org/10.1016/j.hrthm.2025.03.165
    • Van den Eynde, M. D. G., van der Bruggen, M. M., Houben, A. J. H. M., Reesink, K. D., Spronck, B., Delhaas, T., Scheijen, J. J. L. J. M., Miyata, T., & Schalkwijk, C. G. (2025). Pyridoxamine does not reduce arterial stiffness in an 8-week randomized double-blind placebo-controlled intervention trial with abdominally obese individuals. Diabetes Obesity & Metabolism, 27(9), 5332-5336. https://doi.org/10.1111/dom.16524
    • Szabo, B. R., Stein, J., Savchenko, A., Hutschalik, T., Van Nieuwerburgh, F., Meese, T., Kosmidis, G., Volders, P. G. A., & Matsa, E. (2025). Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds. Frontiers in Toxicology, 7, Article 1644119. https://doi.org/10.3389/ftox.2025.1644119
    • Isaksen, J. L., Linz, D., & Kanters, J. K. (2025). Clinically useful evaluation of reconstruction techniques and use of Einthoven's Law. Journal of Electrocardiology, 92, Article 154090. https://doi.org/10.1016/j.jelectrocard.2025.154090
    • Merino, J. L., Tamargo, J., Blomström-Lundqvist, C., Boriani, G., Crijns, H. J. G. M., Dobrev, D., Goette, A., Hohnloser, S. H., Naccarelli, G. V., Reiffel, J. A., Tfelt-Hansen, J., Martínez Cossiani, M., & Camm, A. J. (2025). Practical Compendium of Antiarrhythmic Drugs: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology. EP Europace, 27(8), Article euaf076. https://doi.org/10.1093/europace/euaf076
    • Rivera, S., Ricapito, M. D. L. P., Ronderos, R., & Volders, P. G. A. (2025). Anatomical Determinants of Papillary Muscle Arrhythmias in Apparently Normal Hearts. Arrhythmia & Electrophysiology Review, 14, Article e16. https://doi.org/10.15420/aer.2025.10
    • van Cauteren, Y. J. M., Lemmens, M. J. D. K., Bekkers, S. C. A. M., Kietselaer, B. L. J. H., Heijman, J., Theunissen, R. A. L. J., Rahel, B., Voorn, T., van Kuijk, S. M. J., Nijveldt, R., Vernooy, K., Wildberger, J. E., Mihl, C., & Smulders, M. W. (2025). Computed tomography angiography in the diagnosis of non-ST-elevation myocardial infarction: redefining our first line of defense. IJC Heart and Vasculature, 59, Article 101690. https://doi.org/10.1016/j.ijcha.2025.101690
    • Hadaya, J., Boukens, B. J. D., Janse, M. J., Cha, S., Dajani, A.-H., Challita, R., Coronel, R., Ardell, J. L., Shivkumar, K., & Meijborg, V. M. F. (2025). Right stellate ganglion stimulation modulates arrhythmogenesis in acute left lateral ventricular ischaemia. Cardiovascular Research, 121(9), 1385-1391. https://doi.org/10.1093/cvr/cvaf121
    • ter Bekke, R. M. A., van Rooij, T., Volders, P. G. A., & Hocini, M. (2025). Targeted ablation of the distal Purkinje-myocardium interface for premature ventricular complex-induced cardiomyopathy by delayed Purkinje conduction-induced re-excitation: a case report. European Heart Journal - Case Reports, 9(8), Article ytaf335. https://doi.org/10.1093/ehjcr/ytaf335
    • Farnir, F., Chaldoupi, S.-M., Hermans, B. J., Farnir, F., Habibi, Z., Jerltorp, K., Verhaert, D., Schotten, U., Maesen, B., Vernooy, K., Luermans, J., & Linz, D. (2025). A tailored substrate-based approach using focal pulsed field catheter ablation in patients with atrial fibrillation and advanced atrial substrate: Procedural data and 6-month success rates. Heart Rhythm, 22(8), 1957-1968. https://doi.org/10.1016/j.hrthm.2025.01.015
    • Tönnis, T., Birkemeyer, R., Duncker, D., Eckardt, L., Groeschel, K., Linz, D., Meyer, C., Richter, S., Straube, F., Sultan, A., Wachter, R., Kirchhof, P., & Zylla, M. M. (2025). DGK-Positionspapier zum Umgang mit Device-detektiertem Vorhofflimmern (DDAF): Aus der Kommission für Klinische Kardiovaskuläre Medizin. Die Kardiologie, 19(4), 270-284. https://doi.org/10.1007/s12181-025-00750-y
    • Oebel, S., Garcia, J. G., Arya, A., Jahnke, C., Paetsch, I., Loebe, S., Bode, K., ter Bekke, R. M. A., Vernooy, K., Dagres, N., Hindricks, G., & Darma, A. (2025). Late gadolinium enhancement imaging for the prediction of ventricular tachycardia ablation outcome. Journal of Interventional Cardiac Electrophysiology, 68(5), 1075-1085. https://doi.org/10.1007/s10840-025-02017-8
    • Morcos, R., Vijayaraman, P., Cano, Ó., Zanon, F., Ponnusamy, S. S., Herweg, B., Sharma, P. S., Jastrzebski, M., Molina-Lerma, M., Whinnett, Z. I., Vernooy, K., Zou, J., Nair, G. M., Pathak, R. K., Tung, R., Upadhyay, G. A., Curila, K., Chelu, M. G., & Ellenbogen, K. A. (2025). Left bundle branch area pacing compared with biventricular pacing for cardiac resynchronization therapy in patients with left ventricular ejection fraction ≤50%: Results from the International Collaborative LBBAP Study (I-CLAS). Heart Rhythm, 22(8), 2028-2037. https://doi.org/10.1016/j.hrthm.2025.04.005
    • Prinzen, F. W. (2025). Left Ventricular Mechanics During Left Ventricular Septal Pacing are Similar to Those During Left Bundle Branch Pacing. JACC: Clinical Electrophysiology, 11(8), 1862-1865. https://doi.org/10.1016/j.jacep.2025.04.036
    • Sciacca, V., Feldt, J., Rottner, L., Heeger, C.-H., Sohns, C., Reissmann, B., Saguner, A. M., Santoro, F., Tilz, R. R., Maurer, T., Rillig, A., Ouyang, F., Linz, D., Vernooy, K., Sommer, P., Sultan, A., Willems, S., Kuck, K.-H., Metzner, A., & Fink, T. (2025). Periprocedural Safety of Interventional Electrophysiological Procedures in Octogenarians and Nonagenarians. Journal of Cardiovascular Electrophysiology, 36(8), 1721-1732. https://doi.org/10.1111/jce.16689
    • Duytschaever, M., Grimaldi, M., De Potter, T., Verma, A., Macle, L., Kautzner, J., Linz, D., Anic, A., Van Herendael, H., Rackauskas, G., Neuzil, P., Chun, J., Schmidt, B., Knecht, S., Almorad, A., Berte, B., Reddy, V. Y., & Vijgen, J. (2025). PVI With CF-Sensing Large-Tip Focal PFA Catheter With 3D Mapping for Paroxysmal AF: Omny-IRE 3-Month Results. JACC: Clinical Electrophysiology, 11(8), 1769-1782. https://doi.org/10.1016/j.jacep.2025.04.008
    • Weerts, J., Schroen, B. L. M., Barandiaran Aizpurua, A., Berendschot, T. T. J. M., Brandts, L., Webers, C. A. B., Simons, S. O., Meex, S. J. R., Henry, R., van der Kallen, C. J. H., Brunner-La Rocca, H.-P., Knackstedt, C., Heymans, S. R. B., de Boer, R. A., van Empel, V. P. M., & Houben, A. J. H. M. (2025). Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study. Cardiovascular Diabetology, 24(1), Article 310. https://doi.org/10.1186/s12933-025-02850-1
    • Ren, H., Qin, Q., Dong, Q., Ainiwaer, A., Yuan, H., Zhu, H., Cao, Z., Chen, Y., Wesselius, A., Zeegers, M. P., Prinzen, F. W., Chen, L., Yu, E. Y.-W., Luo, H., & TREND Cohort Study Investigators (2025). Smartphone-Measured Heart Sounds for Atrial Fibrillation Screening in Community Populations. Circulation, 152(4), 283-285. https://doi.org/10.1161/CIRCULATIONAHA.125.073828
    • Velt, M. J. H., van Gelder, I. C., Crijns, H. J. G. M., Rienstra, M., & Mulder, B. A. (2025). Duration of atrial fibrillation and cardiac biomarkers are associated with cardiovascular outcomes in early permanent atrial fibrillation: Data from the RACE II study. International Journal of Cardiology, 439, Article 133669. https://doi.org/10.1016/j.ijcard.2025.133669
    • Olde Nordkamp, L. R. A., de Veld, J. A., Ghani, A., Kuschyk, J., Bonnemeier, H., Bode, K., Boersma, L. V. A., de Weger, A., de Jong, J. S. S. G., Jansen, W. P. J., Alings, M., Bijsterveld, N., El-Chami, M. F., Beukema, R. J., Vernooy, K., Philbert, B. T., Neuzil, P., Nordbeck, P., van Opstal, J. M., ... PRAETORIAN-XL Investigators (2025). Device-related Complications in Transvenous Versus Subcutaneous Defibrillator Therapy During Long-term Follow-up: the PRAETORIAN-XL Trial. Circulation, 152(3), 172-182. https://doi.org/10.1161/CIRCULATIONAHA.125.074576
    • Linz, D., Gulpen, J., Engels, M., Hendriks, J. M., Tjong, F., Mulder, B. A., Weijs, B., Pisters, R., Hemels, M., Ter Bekke, R., Beukema, R., Evens, S., Pürerfellner, H., Merino, J. L., Gunawardene, M., Chun, K.-R. J., & Yap, S.-C. (2025). Digital pulse self-measurement by a photoplethysmography smartphone application in the general population: The "#PulseDay in The Netherlands" awareness campaign. European Journal of Cardiovascular Nursing. Advance online publication. https://doi.org/10.1093/eurjcn/zvaf142
    • Clerx, M., Volders, P. G. A., & Mirams, G. R. (2025). Variability in reported midpoints of (in)activation of cardiac INa. Journal of General Physiology, 157(5), Article e202413621. https://doi.org/10.1085/jgp.202413621
    • Ganizada, B. H., Reesink, K. D., Parikh, S., Saraber, P. J. M. H., Cleutjens, J. P., Isabella, A., Krebbekx, M. Q. E., Jaminon, A. M., Maassen, C. F. M., Ramaekers, M. J. F. G., Spronck, B., van der Laan, K., Koenen, R. R., Lorusso, R., Maessen, J. G., Bidar, E., & Schurgers, L. J. (2025). Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants. The Journal of Physiology, 603(14), 3899-3922. https://doi.org/10.1113/JP288734
    • Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4