Sun, A., Simsek Papur, O., Dirkx, E., Wong, L., Sips, T., Wang, S., Strzelecka, A., Nabben, M., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2021). Phosphatidylinositol 4-kinase III beta mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes. Cellular and Molecular Life Sciences, 78(6), 2839-2856. https://doi.org/10.1007/s00018-020-03669-7

Dufeys, C., Daskalopoulos, E. P., Castanares-Zapatero, D., Conway, S. J., Ginion, A., Bouzin, C., Ambroise, J., Bearzatto, B., Gala, J. L., Heymans, S., Papageorgiou, A. P., Vinckier, S., Cumps, J., Balligand, J. L., Vanhaverbeke, M., Sinnaeve, P., Janssens, S., Bertrand, L., Beauloye, C., & Horman, S. (2021). AMPKα1 deletion in myofibroblasts exacerbates post-myocardial infarction fibrosis by a connexin 43 mechanism. Basic Research in Cardiology, 116(1), Article 10. https://doi.org/10.1007/s00395-021-00846-y

Packer, M., Anker, S. D., Butler, J., Filippatos, G., Ferreira, J. P., Pocock, S. J., Brunner-La Rocca, H. P., Janssens, S., Tsutsui, H., Zhang, J., Brueckmann, M., Jamal, W., Cotton, D., Iwata, T., Schnee, J., Zannad, F., & EMPEROR‐Reduced Trial Committees and Investigators (2021). Influence of neprilysin inhibition on the efficacy and safety of empagliflozin in patients with chronic heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial. European Heart Journal, 42(6), 671-680. https://doi.org/10.1093/eurheartj/ehaa968

Cleland, J. G. F., Ferreira, J. P., Mariottoni, B., Pellicori, P., Cuthbert, J., Verdonschot, J. A. J., Petutschnigg, J., Ahmed, F. Z., Cosmi, F., Brunner-La Rocca, H. P., Mamas, M. A., Clark, A. L., Edelmann, F., Pieske, B., Khan, J., McDonald, K., Rouet, P., Staessen, J. A., Mujaj, B., ... HOMAGE Trial Committees and Investigators (2021). The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial. European Heart Journal, 42(6), 684-696. https://doi.org/10.1093/eurheartj/ehaa758

Ski, C. F., Zippel-Schultz, B., De Maesschalck, L., Hoedemakers, T., Schutt, K., Thompson, D. R., & Brunner La-Rocca, H. P. (2021). COVID-19 shapes the future for management of patients with chronic cardiac conditions. Digital health, 7, Article 2055207621991711. https://doi.org/10.1177/2055207621991711

Daskalopoulos, E. P., & Blankesteijn, W. M. (2021). Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review. Cells, 10(2), Article 207. https://doi.org/10.3390/cells10020207

Hazebroek, M. R., Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Merken, J. J., Dennert, R. M., Eurlings, C., Hamid, M. A. A., Wolffs, P. F. G., Winkens, B., Brunner-La Rocca, H. P., Knackstedt, C., van Paassen, P., van Empel, V. P. M., & Heymans, S. R. B. (2021). Intravenous immunoglobulin therapy in adult patients with idiopathic chronic cardiomyopathy and cardiac parvovirus B19 persistence: a prospective, double-blind, randomized, placebo-controlled clinical trial. European journal of heart failure, 23(2), 302-309. https://doi.org/10.1002/ejhf.2082

Simonavicius, J., & Brunner-La Rocca, H. P. (2021). Do chronic heart failure patients receive optimal decongestive interventions in a real‐life setting? Letter regarding the article ‘Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC‐EORP Heart Failure Long‐Term Registry’. European journal of heart failure, 23(2), 342-342. https://doi.org/10.1002/ejhf.1839

Meier, S., Henkens, M., Heymans, S., & Robinson, E. L. (2021). Unlocking the Value of White Blood Cells for Heart Failure Diagnosis. Journal of Cardiovascular Translational Research, 14(1), 53-62. https://doi.org/10.1007/s12265-020-10007-6

Vangrieken, P., Al-Nasiry, S., Bast, A., Leermakers, P. A., Tulen, C. B. M., Janssen, G. M. J., Kaminski, I., Geomini, I., Lemmens, T., Schiffers, P. M. H., van Schooten, F. J., & Remels, A. H. V. (2021). Hypoxia-induced mitochondrial abnormalities in cells of the placenta. PLOS ONE, 16(1), Article 0245155. https://doi.org/10.1371/journal.pone.0245155

Verdonschot, J. A. J., Merlo, M., Dominguez, F., Wang, P., Henkens, M. T. H. M., Adriaens, M. E., Hazebroek, M. R., Mase, M., Escobar, L. E., Cobas-Paz, R., Derks, K. W. J., van den Wijngaard, A., Krapels, I. P. C., Brunner, H. G., Sinagra, G., Garcia-Pavia, P., & Heymans, S. R. B. (2021). Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences. European Heart Journal, 42(2), 162-174. https://doi.org/10.1093/eurheartj/ehaa841

Amier, R. P., Marcks, N., Hooghiemstra, A. M., Nijveldt, R., van Buchem, M. A., de Roos, A., Biessels, G. J., Kappelle, L. J., van Oostenbrugge, R. J., Van der Geest, R. J., Bots, M. L., Greving, J. P., Niessen, W. J., van Osch, M. J. P., de Bresser, J., van de Ven, P. M., Van der Flier, W. M., Brunner-La Rocca, H. P., van Rossum, A. C., & Heart-Brain Connection Consortium (2021). Hypertensive Exposure Markers by MRI in Relation to Cerebral Small Vessel Disease and Cognitive Impairment. JACC-Cardiovascular Imaging, 14(1), 176-185. https://doi.org/10.1016/j.jcmg.2020.06.040

Cuijpers, I., Papageorgiou, A. P., Carai, P., Herwig, M., Mugge, A., Klein, T., Hamdani, N., Jones, E. A. V., & Heymans, S. (2021). Linagliptin prevents left ventricular stiffening by reducing titin cleavage and hypophosphorylation. Journal of Cellular and Molecular Medicine, 25(2), 729-741. https://doi.org/10.1111/jcmm.16122

Zacchigna, S., Paldino, A., Falcao-Pires, I., Daskalopoulos, E. P., Dal Ferro, M., Vodret, S., Lesizza, P., Cannata, A., Miranda-Silva, D., Lourenco, A. P., Pinamonti, B., Sinagra, G., Weinberger, F., Eschenhagen, T., Carrier, L., Kehat, I., Tocchetti, C. G., Russo, M., Ghigo, A., ... Working Group on Myocardial Function of the European Society of Cardiology (2021). Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. Cardiovascular Research, 117(1), 43-59. https://doi.org/10.1093/cvr/cvaa110

Jaarsma, T., Hill, L., Bayes-Genis, A., Brunner-La Rocca, H.-P., Castiello, T., Celutkiene, J., Marques-Sule, E., Plymen, C. M., Piper, S. E., Riegel, B., Rutten, F. H., Ben Gal, T., Bauersachs, J., Coats, A. J. S., Chioncel, O., Lopatin, Y., Lund, L. H., Lainscak, M., Moura, B., ... Stromberg, A. (2021). Self-care of heart failure patients: practical management recommendations from the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 23(1), 157-174. https://doi.org/10.1002/ejhf.2008

Zippel-Schultz, B., Palant, A., Eurlings, C., Ski, C. F., Hill, L., Thompson, D. R., Fitzsimons, D., Dixon, L. J., Brandts, J., Schuett, K. A., de Maesschalck, L., Barrett, M., da Luz, E. F., Hoedemakers, T., Helms, T. M., Brunner-La Rocca, H. P., & PASSION-HF consortium (2021). Determinants of acceptance of patients with heart failure and their informal caregivers regarding an interactive decision-making system: a qualitative study. BMJ Open, 11(6), Article e046160. https://doi.org/10.1136/bmjopen-2020-046160

Schianchi, F., Glatz, J. F. C., Navarro Gascon, A., Nabben, M., Neumann, D., & Luiken, J. J. F. P. (2020). Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance. International journal of molecular sciences, 21(24), Article 9438. https://doi.org/10.3390/ijms21249438

Anker, S. D., Butler, J., Filippatos, G., Khan, M. S., Ferreira, J. P., Bocchi, E., Bohm, M., Brunner-La Rocca, H. P., Choi, D. J., Chopra, V., Chuquiure, E., Giannetti, N., Gomez-Mesa, J. E., Janssens, S., Januzzi, J. L., Gonzalez-Juanatey, J. R., Merkely, B., Nicholls, S. J., Perrone, S. V., ... EMPEROR-Preserved Trial Committees and Investigators (2020). Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR-Preserved trial. European journal of heart failure, 22(12), 2383-2392. https://doi.org/10.1002/ejhf.2064

de Boer, R. A., Hulot, J. S., Tocchetti, C. G., Aboumsallem, J. P., Ameri, P., Anker, S. D., Bauersachs, J., Bertero, E., Coats, A. J. S., Celutkiene, J., Chioncel, O., Dodion, P., Eschenhagen, T., Farmakis, D., Bayes-Genis, A., Jager, D., Jankowska, E. A., Kitsis, R. N., Konety, S. H., ... Backs, J. (2020). Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European journal of heart failure, 22(12), 2272-2289. https://doi.org/10.1002/ejhf.2029

Robinson, E. L., Azodi, M., Heymans, S., & Heggermont, W. (2020). Anthracycline-Related Heart Failure: Certain Knowledge and Open Questions : Where Do we Stand with Chemotherapyinduced Cardiotoxicity?Current Heart Failure Reports, 17(6), 357-364. https://doi.org/10.1007/s11897-020-00489-5

Janssen, D. J. A., Ament, S. M. C., Boyne, J., Schols, J. M. G. A., Brunner-La Rocca, H.-P., Maessen, J. M. C., & van den Beuken-van Everdingen, M. H. J. (2020). Characteristics for a tool for timely identification of palliative needs in heart failure: The views of Dutch patients, their families and healthcare professionals. European Journal of Cardiovascular Nursing, 19(8), 711-720. Article 1474515120918962. https://doi.org/10.1177/1474515120918962

Kocken, J. M. M., & da Costa Martins, P. A. (2020). Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?International journal of molecular sciences, 21(23), Article 8901. https://doi.org/10.3390/ijms21238901

Videira, R. F., Martins, P. A. D. C., & Falcao-Pires, I. (2020). Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease. International journal of molecular sciences, 21(23), Article 9285. https://doi.org/10.3390/ijms21239285

Vangrieken, P., Remels, A. H., Al-Nasiry, S., Bast, A., Janssen, G. M. J., von Rango, U., Vroomans, D., Pinckers, Y. C. W., van Schooten, F. J., & Schiffers, P. M. H. (2020). Placental hypoxia-induced alterations in vascular function, morphology, and endothelial barrier integrity. Hypertension Research, 43(12), 1361-1374. https://doi.org/10.1038/s41440-020-0528-8

Lanfear, D. E., Luzum, J. A., She, R., Gui, H., Donahue, M. P., O'Connor, C. M., Adams, K. F., Sanders-van Wijk, S., Zeld, N., Maeder, M. T., Sabbah, H. N., Kraus, W. E., Brunner-La Rocca, H.-P., Li, J., & Williams, L. K. (2020). Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure. Circulation-Heart Failure, 13(12), Article 007012. https://doi.org/10.1161/circheartfailure.119.007012

Vernooy, K., & Brunner-La Rocca, H.-P. (2020). The importance of electrocardiographic follow-up in heart failure. European journal of heart failure, 22(12), 2380-2382. https://doi.org/10.1002/ejhf.2054

Reinhold, S., Blankesteijn, W. M., & Foulquier, S. (2020). The Interplay of WNT and PPARγ Signaling in Vascular Calcification. Cells, 9(12), Article 2658. https://doi.org/10.3390/cells9122658

Ament, S. M. C., van den Beuken-Everdingen, M., Maessen, J. M. C., Boyne, J., Schols, J. M. G. A., Stoffers, H. E. J. H., Bellersen, L., Brunner-La Rocca, H.-P., Engels, Y., & Janssen, D. J. A. (2020). Professionals guidance about palliative medicine in chronic heart failure: a mixed-method study. BMJ Supportive and Palliative Care. Advance online publication. https://doi.org/10.1136/bmjspcare-2020-002580

Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernandez, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J., ... Heymans, S. (2020). LifeTime and improving European healthcare through cell-based interceptive medicine. Nature, 587(7834), 377-386. https://doi.org/10.1038/s41586-020-2715-9

Mastenbroek, T. G., Karel, M. F. A., Nagy, M., Chayoua, W., Korsten, E. I. J., Coenen, D. M., Debets, J., Konings, J., Brouns, A. E., Leenders, P. J. A., van Essen, H., van Oerle, R., Heitmeier, S., Spronk, H. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2020). Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery. Scientific Reports, 10(1), Article 19360. https://doi.org/10.1038/s41598-020-76377-8

Aimo, A., Januzzi, J. L., Vergaro, G., Richards, A. M., Lam, C. S. P., Latini, R., Anand, I. S., Cohn, J. N., Ueland, T., Gullestad, L., Aukrust, P., Brunner-La Rocca, H. P., Bayes-Genis, A., Lupon, J., de Boer, R. A., Takeishi, Y., Egstrup, M., Gustafsson, I., Gaggin, H. K., ... Emdin, M. (2020). Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. European journal of heart failure, 22(11), 2078-2088. https://doi.org/10.1002/ejhf.1701

Verdonschot, J. A. J., Merken, J. J., van Stipdonk, A. M. W., Pliger, P., Derks, K. W. J., Wang, P., Henkens, M. T. H. M., van Paassen, P., Hamid, M. A. A., van Empel, V. P. M., Knackstedt, C., Luermans, J. G. L. M., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Brunner, H. G., Poelzl, G., Vernooy, K., Heymans, S. R. B., & Hazebroek, M. R. (2020). Cardiac Inflammation Impedes Response to Cardiac Resynchronization Therapy in Patients With Idiopathic Dilated Cardiomyopathy. Circulation-Arrhythmia and Electrophysiology, 13(11), 1311-1320. Article 008727. https://doi.org/10.1161/circep.120.008727

Seferovic, P. M., Fragasso, G., Petrie, M., Mullens, W., Ferrari, R., Thum, T., Bauersachs, J., Anker, S. D., Ray, R., Cavusoglu, Y., Polovina, M., Metra, M., Ambrosio, G., Prasad, K., Seferovic, J., Jhund, P. S., Dattilo, G., Celutkiene, J., Piepoli, M., ... Rosano, G. M. C. (2020). Heart Failure Association of the European Society of Cardiology update on sodium–glucose co‐transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology). European journal of heart failure, 22(11), 1984-1986. https://doi.org/10.1002/ejhf.2026

de Abreu, R. C., Fernandes, H., Martins, P. A. D. C., Sahoo, S., Emanueli, C., & Ferreira, L. (2020). Native and bioengineered extracellular vesicles for cardiovascular therapeutics. Nature Reviews Cardiology, 17(11), 685-697. https://doi.org/10.1038/s41569-020-0389-5

Elbatreek, M. H., Sadegh, S., Anastasi, E., Guney, E., Nogales, C., Kacprowski, T., Hassan, A. A., Teubner, A., Huang, P.-H., Hsu, C.-Y., Schiffers, P. M. H., Janssen, G. M., Kleikers, P. W. M., Wipat, A., Baumbach, J., De Mey, J. G. R., & Schmidt, H. H. H. W. (2020). NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype. Plos Biology, 18(11), Article 3000885. https://doi.org/10.1371/journal.pbio.3000885

Qian, Z., Van den Eynde, J., Heymans, S., Mertens, L., & Morava, E. (2020). Vascular ring anomaly in a patient with phosphomannomutase 2 deficiency: A case report and review of the literature. JIMD reports, 56(1), 27-33. https://doi.org/10.1002/jmd2.12160

Remmelzwaal, S., van Ballegooijen, A. J., Schoonmade, L. J., Dal Canto, E., Handoko, M. L., Henkens, M. T. H. M., van Empel, V., Heymans, S. R. B., & Beulens, J. W. J. (2020). Natriuretic peptides for the detection of diastolic dysfunction and heart failure with preserved ejection fraction-a systematic review and meta-analysis. BMC Medicine, 18(1), Article 290. https://doi.org/10.1186/s12916-020-01764-x

Breetveld, N. M., Alers, R.-J., Geerts, L., van Kuijk, S. M. J., van Dijk, A. P., van der Vlugt, M. J., Heidema, W. M., van Neer, J., van Empel, V. P. M., Brunner-La Rocca, H.-P., Scholten, R. R., Ghossein-Doha, C., & Spaanderman, M. E. A. (2020). Low Plasma Volume and Increased Pressure Load Relate to Concentric Left Ventricular Remodeling After Preeclampsia: A Longitudinal Study. Journal of the American Heart Association, 9(19), Article 015043. https://doi.org/10.1161/JAHA.119.015043

Selevsek, N., Caiment, F., Nudischer, R., Gmuender, H., Agarkova, I., Atkinson, F. L., Bachmann, I., Baier, V., Barel, G., Bauer, C., Boerno, S., Bosc, N., Clayton, O., Cordes, H., Deeb, S., Gotta, S., Guye, P., Hersey, A., Hunter, F. M. I., ... Kleinjans, J. (2020). Network integration and modelling of dynamic drug responses at multi-omics levels. Communications Biology, 3(1), Article 573. https://doi.org/10.1038/s42003-020-01302-8

Packer, M., Anker, S. D., Butler, J., Filippatos, G., Pocock, S. J., Carson, P., Januzzi, J., Verma, S., Tsutsui, H., Brueckmann, M., Jamal, W., Kimura, K., Schnee, J., Zeller, C., Cotton, D., Bocchi, E., Boehm, M., Choi, D.-J., Chopra, V., ... EMPEROR-Reduced Trial Investigators (2020). Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. New England Journal of Medicine, 383(15), 1413-1424. https://doi.org/10.1056/NEJMoa2022190

Ski, C. F., Thompson, D. R., & Brunner-La Rocca, H. P. (2020). Putting AI at the centre of heart failure care. Esc heart failure, 7(5), 3257-3258. https://doi.org/10.1002/ehf2.12813

Verdonschot, J. A. J., Hazebroek, M. R., Krapels, I. P. C., Henkens, M. T. H. M., Raafs, A., Wang, P., Merken, J. J., Claes, G. R. F., Vanhoutte, E. K., van den Wijngaard, A., Heymans, S. R. B., & Brunner, H. G. (2020). Implications of Genetic Testing in Dilated Cardiomyopathy. Circulation: Genomic and Precision Medicine, 13(5), 476-487. Article 003031. https://doi.org/10.1161/circgen.120.003031

Timmermans, P., Barradas-Pires, A., Ali, O., Henkens, M., Heymans, S., & Negishi, K. (2020). Prednisone and azathioprine in patients with inflammatory cardiomyopathy: systematic review and meta-analysis. Esc heart failure, 7(5), 2278-2296. https://doi.org/10.1002/ehf2.12762

Kesidou, D., Martins, P. A. D. C., de Windt, L. J., Brittan, M., Beqqali, A., & Baker, A. H. (2020). Extracellular Vesicle miRNAs in the Promotion of Cardiac Neovascularisation. Frontiers in physiology, 11, Article 579892. https://doi.org/10.3389/fphys.2020.579892

Cuijpers, I., Carai, P., Mendes-Ferreira, P., Simmonds, S. J., Mulder, P., Miranda-Silva, D., De Giorgio, D., Pokreisz, P., Heymans, S., & Jones, E. A. (2020). The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model. Scientific Reports, 10(1), Article 15701. https://doi.org/10.1038/s41598-020-72924-5

Verdonschot, J. A. J., Derks, K. W. J., Hazebroek, M. R., Wang, P., Robinson, E. L., Adriaens, M. E., Krapels, I. P. C., van den Wijngaard, A., Brunner, H. G., & Heymans, S. R. B. (2020). Distinct Cardiac Transcriptomic Clustering in Titin and Lamin A/C-Associated Dilated Cardiomyopathy Patients. Circulation, 142(12), 1230-1232. https://doi.org/10.1161/circulationaha.119.045118

Olivotto, I., Oreziak, A., Barriales-Villa, R., Abraham, T. P., Masri, A., Garcia-Pavia, P., Saberi, S., Lakdawala, N. K., Wheeler, M. T., Owens, A., Kubanek, M., Wojakowski, W., Jensen, M. K., Gimeno-Blanes, J., Afshar, K., Myers, J., Hegde, S. M., Solomon, S. D., Sehnert, A. J., ... Brunner-La Rocca, H. P. (2020). Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet, 396(10253), 759-769. https://doi.org/10.1016/S0140-6736(20)31792-X

Videira, R. F., & da Costa Martins, P. A. (2020). Non-coding RNAs in Cardiac Intercellular Communication. Frontiers in physiology, 11, Article 738. https://doi.org/10.3389/fphys.2020.00738

Tocchetti, C. G., Ameri, P., de Boer, R. A., D'Alessandra, Y., Russo, M., Sorriento, D., Ciccarelli, M., Kiss, B., Bertrand, L., Dawson, D., Falcao-Pires, I., Giacca, M., Hamdani, N., Linke, W. A., Mayr, M., van der Velden, J., Zacchigna, S., Ghigo, A., Hirsch, E., ... Thum, T. (2020). Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovascular Research, 116(11), 1820-1834. https://doi.org/10.1093/cvr/cvaa222