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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Joost Lumens

Professor

Professor Joost Lumens studied Biomedical Engineering at the Eindhoven University of Technology where he obtained his MSc degree in Medical Engineering in 2005. He obtained his PhD degree in 2010 at Maastricht University (Dept. of Biomedical Engineering and Dept. of Physiology). During his PhD, he developed and validated a computational model of left-right ventricular interaction dynamics and applied it to study right ventricular failure in patients with pulmonary arterial hypertension. He continued his academic career as a post-doctoral fellow at the LIRYC Electrophysiology and Heart Modelling Institute of CHU de Bordeaux (France), where he combined computational, experimental and clinical data to unravel the working mechanisms of cardiac pacing therapies in the dyssynchronous failing heart.

Since 2012, he is working again at CARIM, where he leads the CircAdapt Research and Education team (www.circadapt.org). In 2021, he was appointed Professor of Computational Cardiology. His research team typically combines advanced computational modelling/simulation techniques with experimental and/or clinical data to gain mechanistic insight in cardiac diseases and their treatments. Importantly, translation of novel mechanistic insights into diagnostic, therapeutic and educational improvement is always pursued. Prof Joost Lumens received prestigious personal (Dutch Heart Foundation & NWO Vidi) and EU consortium funding (H2020 ERA-NET EraCoSysMed Joint Transnational Call 2015; ERA-CVD Joint Transnational Call 2018, coordinator of EMPATHY project; Marie Curie Intelligent Ultrasound, MARCIUS) for projects focussed on computational cardiac electro-mechanics and hemodynamics. He was the chairperson of the European Society of Cardiology (ESC) working group on e-Cardiology (2018-2020) and serves as deputy editor of the European Heart Journal – Digital Health.

Joost-lumens

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.362
T: +31(0)43 388 16 66

  • 2026
    • Buonocunto, M., Delhaas, T., Lyon, A., Heijman, J., & Lumens, J. (2026). Spatiotemporal determinants of stretch-activated channel-induced re-entry in ventricular tissue: An in-silico study. Journal of Molecular and Cellular Cardiology, 210, 150-164. https://doi.org/10.1016/j.yjmcc.2025.11.007
    • van den Acker, G. P. H., Dhont, S., van Loon, T., Churchill, T. W., Timmermans, F., Delhaas, T., Bertrand, P. B., & Lumens, J. (2026). Impact of left-heart myopathy on mitral valve stenosis assessment and interventional outcomes: an in-silico trial. European Heart Journal - Digital Health, 7(1), Article ztaf097. https://doi.org/10.1093/ehjdh/ztaf097
  • 2025
    • Prinzen, F. W., & Lumens, J. (2025). Atrioventricular Interval Modulation: Looking Beyond Blood Pressure Needed?JACC: Clinical Electrophysiology, 11(11), 2505-2508. https://doi.org/10.1016/j.jacep.2025.07.022
    • van Koll, J., Engels, M. D. E. A., Rijks, J. H. J., Salari, M., Luijten, J., Lumens, J., van Empel, V. P. M., Westra, S. W., van Stipdonk, A. M. W., Lankveld, T. A. R., Chaldoupi, S. M., Joza, J., Beukema, R. J., Luermans, J. G. L. M., Linz, D. K., & Vernooy, K. (2025). Long-term outcomes of pace-and-ablate strategy in patients with atrial fibrillation. Journal of Interventional Cardiac Electrophysiology, 68(7), 1487-1495. Article 100786. https://doi.org/10.1007/s10840-025-02038-3
    • Lee, X. A., Raschzok, S., Desjardins, J.-F., Van Loon, T., Plavetic, A., Kanny, O., Kabir, G., Nghiem, L., Dauz, J., Kapus, A., Lumens, J., Connelly, K. A., & Friedberg, M. K. (2025). Left ventricular pressure-loading improves pressure-induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling. Physiological Reports, 13(18), Article e70546. https://doi.org/10.14814/phy2.70546
    • van Osta, N., van Loon, T., & Lumens, J. (2025). Individual hearts: computational models for improved management of cardiovascular disease. Heart. Advance online publication. https://doi.org/10.1136/heartjnl-2024-324177
    • Bruining, N., van der Boon, R., Kardys, I., Cummins, P., & Lumens, J. (2025). Reviewers and awards. European Heart Journal - Digital Health. Advance online publication. https://doi.org/10.1093/ehjdh/ztaf098
    • Mizner, J., Beela, A., Linkova, H., Vesela, J., Sussenbek, O., Stros, P., Smisek, R., Jurak, P., Leinveber, P., Lipoldova, J., Nagy, A., Waldauf, P., Lumens, J., Vernooy, K., Prinzen, F., & Curila, K. (2025). Electrical and mechanical interventricular dyssynchrony coupling in patients with bradycardia: A UHF-ECG validation trial. Heart Rhythm, 22(9), 2382-2390. https://doi.org/10.1016/j.hrthm.2025.02.031
    • Lempers, T. E. M., Smits, K. C., van Koll, J., Dural, M., van Stipdonk, A. M. W., Lumens, J., Luermans, J. G. L. M., Vernooy, K., Prinzen, F. W., van Dam, P., & Nguyên, U. C. (2025). An in-silico analysis of the influence of left bundle branch block and myocardial fibrosis on electrocardiographic QRS duration and morphology and vectorcardiographic QRS area. Journal of Electrocardiology, 91, Article 154043. https://doi.org/10.1016/j.jelectrocard.2025.154043
    • van Loon, T., Vernooy, K., & Lumens, J. (2025). Rate acceleration in heart failure with preserved ejection fraction: towards different strokes for different folks. European Heart Journal, 46(21), 2029-2030. https://doi.org/10.1093/eurheartj/ehaf110
    • Manetti, C. A., van Osta, N., Beela, A. S., Herbots, L., Prinzen, F. W., Delhaas, T., & Lumens, J. (2025). Impact of myocardial phenotype on optimal atrioventricular delay settings during biventricular and left bundle-branch pacing at rest and during exercise: insights from a virtual patient study. EP Europace, 27(4), Article euaf082. https://doi.org/10.1093/europace/euaf082
    • Van Osta, N., Van Den Acker, G., Van Loon, T., Arts, T., Delhaas, T., & Lumens, J. (2025). Numerical accuracy of closed-loop steady state in a zero-dimensional cardiovascular model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 383(2293), Article 20240208. https://doi.org/10.1098/rsta.2024.0208
    • Lumens, J. (2025). The Double Dyssynchrony Paradox: When Cardiac Discord Signals Hope. JACC-Cardiovascular Imaging, 18(4), 433-435. https://doi.org/10.1016/j.jcmg.2025.01.003
    • Beela, A. S., Manetti, C. A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2025). The mechanistic interaction between mechanical dyssynchrony and filling pressure in cardiac resynchronization therapy candidates. European Heart Journal Cardiovascular Imaging, 26(3), 424-434. Article jeae286. https://doi.org/10.1093/ehjci/jeae286
    • Munneke, A. G., Lumens, J., & Delhaas, T. (2025). Diagnostic value of reversed differential cyanosis in (supra)cardiac total anomalous pulmonary venous return. Pediatric Research, 97(2), 809-817. Article 113366. https://doi.org/10.1038/s41390-024-03355-5
  • 2024
    • van Loon, T., Rijks, J., van Koll, J., Wolffs, J., Cornelussen, R., van Osta, N., Luermans, J., Prinzen, F., Linz, D., van Empel, V., Delhaas, T., Vernooy, K., & Lumens, J. (2024). Accelerated atrial pacing reduces left-heart filling pressure: a combined clinical-computational study. European Heart Journal, 45(46), 4953-4964. https://doi.org/10.1093/eurheartj/ehae718
    • Rijks, J. H. J., Heckman, L., Westra, S., Cornelussen, R., Ghosh, S., Curila, K., Smisek, R., Grieco, D., Bressi, E., Nguyen, U. C., Lumens, J., van Stipdonk, A. M. W., Linz, D., Prinzen, F. W., Luermans, J. G. L. M., & Vernooy, K. (2024). Assessment of ventricular electrical heterogeneity in left bundle branch pacing and left ventricular septal pacing by using various electrophysiological methods. Journal of Cardiovascular Electrophysiology, 35(12), 2282-2292. Article 16435. https://doi.org/10.1111/jce.16435
    • Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2024). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology, 602(18), 4585-4604. https://doi.org/10.1113/JP284439
    • Beela, A. S., Rijks, J. H. J., Manetti, C. A., Vernooy, K., van Stipdonk, A. M. W., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2024). Left bundle branch block criteria in the 2021 ESC guidelines on CRT: A step back in identifying CRT candidates?European Heart Journal Cardiovascular Imaging, 25(9), e213-e215. https://doi.org/10.1093/ehjci/jeae164
    • Koopsen, T., van Osta, N., van Loon, T., Meiburg, R., Huberts, W., Beela, A. S., Kirkels, F. P., van Klarenbosch, B. R., Teske, A. J., Cramer, M. J., Bijvoet, G. P., van Stipdonk, A., Vernooy, K., Delhaas, T., & Lumens, J. (2024). Parameter subset reduction for imaging-based digital twin generation of patients with left ventricular mechanical discoordination. Biomedical Engineering Online, 23(1), Article 46. https://doi.org/10.1186/s12938-024-01232-0
    • Arts, T., Lyon, A., Delhaas, T., Kuster, D. W. D., van der Velden, J., & Lumens, J. (2024). Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model. Journal of Molecular and Cellular Cardiology, 190, 13-23. https://doi.org/10.1016/j.yjmcc.2024.03.001
    • Dhont, S., van den Acker, G., van Loon, T., Verbrugge, F. H., Verwerft, J., Deferm, S., Churchill, T. W., Mullens, W., Lumens, J., & Bertrand, P. B. (2024). Mitral regurgitation in heart failure with preserved ejection fraction: The interplay of valve, ventricle, and atrium. European journal of heart failure, 26(4), 974-983. https://doi.org/10.1002/ejhf.3231
    • Ložek, M., Kovanda, J., Kubuš, P., Vrbík, M., Lhotská, L., Lumens, J., Delhaas, T., & Janoušek, J. (2024). How to assess and treat right ventricular electromechanical dyssynchrony in post-repair tetralogy of Fallot: insights from imaging, invasive studies and computational modelling. EP Europace, 26(2), Article euae024. https://doi.org/10.1093/europace/euae024
    • Koopsen, T., Gerrits, W., van Osta, N., van Loon, T., Wouters, P., Prinzen, F. W., Vernooy, K., Delhaas, T., Teske, A. J., Meine, M., Cramer, M. J., & Lumens, J. (2024). Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. EP Europace, 26(1), Article euae009. https://doi.org/10.1093/europace/euae009
    • Eerenberg, F., Luermans, J., Lumens, J., Nguyên, U. C., Vernooy, K., & van Stipdonk, A. (2024). Exploring QRS Area beyond Patient Selection in CRT-Can It Guide Left Ventricular Lead Placement?Journal of Cardiovascular Development and Disease, 11(1), Article 18. https://doi.org/10.3390/jcdd11010018
    • Stankovic, I., Voigt, J.-U., Burri, H., Muraru, D., Sade, L. E., Haugaa, K. H., Lumens, J., Biffi, M., Dacher, J.-N., Marsan, N. A., Bakelants, E., Manisty, C., Dweck, M. R., Smiseth, O. A., & Donal, E. (2024). Imaging in patients with cardiovascular implantable electronic devices: part 2-imaging after device implantation. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal Cardiovascular Imaging, 25(1), E33-E54. Article jead273. https://doi.org/10.1093/ehjci/jead273
    • Stankovic, I., Voigt, J.-U., Burri, H., Muraru, D., Sade, L. E., Haugaa, K. H., Lumens, J., Biffi, M., Dacher, J.-N., Marsan, N. A., Bakelants, E., Manisty, C., Dweck, M. R., Smiseth, O. A., & Donal, E. (2024). Imaging in patients with cardiovascular implantable electronic devices: part 1-imaging before and during device implantation. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal Cardiovascular Imaging, 25(1), e1–e32. https://doi.org/10.1093/ehjci/jead272
    • HENKENS, MICHIEL. T. H. M., RAAFS, ANNE. G., VANLOON, T. I. M., VOS, JACQUELINE. L., VANDENWIJNGAARD, ARTHUR., BRUNNER, HAN. G., KRAPELS, INGRID. P. C., KNACKSTEDT, CHRISTIAN., GERRETSEN, SUZANNE., HAZEBROEK, MARK. R., VERNOOY, KEVIN., NIJVELDT, ROBIN., LUMENS, JOOST., & VERDONSCHOT, JOB. A. J. (2024). Left Atrial Function in Patients with Titin Cardiomyopathy. Journal of Cardiac Failure, 30(1), 51-60. https://doi.org/10.1016/j.cardfail.2023.05.013
    • Burman, N., Alessandra Manetti, C., Heymans, S. V., Ingram, M., Lumens, J., & D'Hooge, J. (2024). Large-Scale Simulation of Realistic Cardiac Ultrasound Data With Clinical Appearance: Methodology and Open-Access Database. IEEE Access, 12, 117040-117055. https://doi.org/10.1109/ACCESS.2024.3447528
  • 2023
    • Tamargo, M., Martínez-Legazpi, P., Espinosa, M. Á., Lyon, A., Méndez, I., Gutiérrez-Ibañes, E., Fernández, A. I., Prieto-Arévalo, R., González-Mansilla, A., Arts, T., Delhaas, T., Mombiela, T., Sanz-Ruiz, R., Elízaga, J., Yotti, R., Tschöpe, C., Fernández-Avilés, F., Lumens, J., & Bermejo, J. (2023). Increased Chamber Resting Tone Is a Key Determinant of Left Ventricular Diastolic Dysfunction. Circulation-Heart Failure, 16(12), E010673. Article 010673. https://doi.org/10.1161/CIRCHEARTFAILURE.123.010673
    • Kirkels, F. P., Rootwelt-Norberg, C., Bosman, L. P., Aabel, E. W., Muller, S., Castrini, A. I., Taha, K., van Osta, N., Lie, Ø. H., Asselbergs, F. W., Lumens, J., Te Riele, A. S. J. M., Hasselberg, N. E., Cramer, M. J., Haugaa, K., & Teske, A. J. (2023). The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy. European heart journal. Cardiovascular Imaging, 24(12), 1710-1718. Article jead174. https://doi.org/10.1093/ehjci/jead174
    • Weerts, J., Amin, H., Barandiarán Aizpurua, A., Gevaert, A. B., Handoko, M. L., Dauw, J., Tun, H. N., Rommel, K.-P., Verbrugge, F. H., Kresoja, K.-P., Sanders-van Wijk, S., Brunner-La Rocca, H.-P., Bayés-Genís, A., Lumens, J., Knackstedt, C., & van Empel, V. P. M. (2023). Webtool to enhance the accuracy of diagnostic algorithms for HFpEF: a prospective cross-over study. Esc heart failure, 10(6), 3493 - 3503. https://doi.org/10.1002/ehf2.14525
    • Munneke, A. G., Lumens, J., Arts, T., Prinzen, F. W., & Delhaas, T. (2023). Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model. Journal of Applied Physiology, 135(3), 489-499. https://doi.org/10.1152/japplphysiol.00181.2023
    • Kirkels, F. P., van Osta, N., Rootwelt-Norberg, C., Chivulescu, M., van Loon, T., Aabel, E. W., Castrini, A. I., Lie, Ø. H., Asselbergs, F. W., Delhaas, T., Cramer, M. J., Teske, A. J., Haugaa, K. H., & Lumens, J. (2023). Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. Journal of the American College of Cardiology, 82(9), 785-797. https://doi.org/10.1016/j.jacc.2023.05.065
    • Beela, A. S., Manetti, C. A., Lyon, A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2023). Impact of Estimated Left Atrial Pressure on Cardiac Resynchronization Therapy Outcome. Journal of Clinical Medicine, 12(15), Article 4908. https://doi.org/10.3390/jcm12154908
    • van Mourik, M. J. W., Linz, D., Verwijs, H. J. A., Bekkers, S. C. A. M., Weerts, J., Schotten, U., Rocca, H. B.-L., Lumens, J., Crijns, H. J. G. M., Weijs, B., & Knackstedt, C. (2023). Evaluating subclinical left ventricular and left atrial dysfunction in idiopathic atrial fibrillation: A speckle-tracking based strain-analysis. International Journal of Cardiology, 383(1), 159-165. https://doi.org/10.1016/j.ijcard.2023.04.024
    • Meiburg, R., Rijks, J. H. J., Beela, A. S., Bressi, E., Grieco, D., Delhaas, T., Luermans, J. G. L. M., Prinzen, F. W., Vernooy, K., & Lumens, J. (2023). Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform. EP Europace, 25(6), 1-11. Article euad144. https://doi.org/10.1093/europace/euad144
    • Knackstedt, C., Schummers, G., Schroder, J., Marx, N., Lumens, J., Sanders-van Wijk, S., Ramaekers, B., Becker, M., van Empel, V., Brunner-La Rocca, H. P., & PsychEcho study group (2023). A graphical analysis of aspects contributing to the spreading of measurements of left ventricular function. International Journal of Cardiovascular Imaging, 39(5), 915-927. https://doi.org/10.1007/s10554-023-02796-z
    • Hermans, A. N. L., Isaksen, J. L., Gawalko, M., Pluymaekers, N. A. H. A., van der Velden, R. M. J., Snippe, H., Evens, S., De Witte, G., Luermans, J. G. L. M., Manninger, M., Lumens, J., Kanters, J. K., & Linz, D. (2023). Accuracy of continuous photoplethysmography-based 1 min mean heart rate assessment during atrial fibrillation. EP Europace, 25(3), 835-844. https://doi.org/10.1093/europace/euad011
    • De Jaegere, P., Van Der Boon, R., Lumens, J., & Bruining, N. (2023). PubMed indexation for the European Heart Journal - Digital Health: a small step for the European Heart Journal family, a giant leap in the digital future of cardiovascular disease management. European Heart Journal - Digital Health, 4(2), 63-64. Article ztad013. https://doi.org/10.1093/ehjdh/ztad013
    • Prinzen, F. W., Lumens, J., Duchenne, J., & Vernooy, K. (2023). Erratum to: Electro-energetics of Biventricular, Septal and Conduction System Pacing. Arrhythmia & Electrophysiology Review, 12, Article e19. https://doi.org/10.15420/aer.2023.12.er1
    • Akdeniz, M., Manetti, C. A., Koopsen, T., Mirar, H. N., Snare, S. R., Aase, S. A., Lumens, J., Sprem, J., & McLeod, K. S. (2023). Deep Learning for Multi-Level Detection and Localization of Myocardial Scars Based on Regional Strain Validated on Virtual Patients. IEEE Access, 11(1), 15788-15798. https://doi.org/10.1109/ACCESS.2023.3243254
  • 2022
    • van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., ... Thum, T. (2022). Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC working group on myocardial function and the ESC Working Group on Cellular Biology of the Heart. Cardiovascular Research, 118(15), 3016-3051. https://doi.org/10.1093/cvr/cvab370
    • Guasti, L., Dilaveris, P., Mamas, M. A., Richter, D., Christodorescu, R., Lumens, J., Schuuring, M. J., Carugo, S., Afilalo, J., Ferrini, M., Asteggiano, R., & Cowie, M. R. (2022). Digital health in older adults for the prevention and management of cardiovascular diseases and frailty. A clinical consensus statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e-Cardiology. Esc heart failure, 9(5), 2808-2822. https://doi.org/10.1002/ehf2.14022
    • Dilaveris, P. E., Antoniou, C. K., Caiani, E. G., Casado-Arroyo, R., Climent, A. Μ., Cluitmans, M., Cowie, M. R., Doehner, W., Guerra, F., Jensen, M. T., Kalarus, Z., Locati, E. T., Platonov, P., Simova, I., Schnabel, R. B., Schuuring, M., Tsivgoulis, G., & Lumens, J. (2022). ESC Working Group on e-Cardiology Position Paper: accuracy and reliability of electrocardiogram monitoring in the detection of atrial fibrillation in cryptogenic stroke patients : In collaboration with the Council on Stroke, the European Heart Rhythm Association, and the Digital Health Committee. European Heart Journal - Digital Health, 3(3), 341-358. https://doi.org/10.1093/ehjdh/ztac026
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