Menu

Latest news & events

Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

Read more
Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

Read more
More newsMore events
Carim Maastricht
Carim Maastricht

Joost Lumens

Professor

Professor Joost Lumens studied Biomedical Engineering at the Eindhoven University of Technology where he obtained his MSc degree in Medical Engineering in 2005. He obtained his PhD degree in 2010 at Maastricht University (Dept. of Biomedical Engineering and Dept. of Physiology). During his PhD, he developed and validated a computational model of left-right ventricular interaction dynamics and applied it to study right ventricular failure in patients with pulmonary arterial hypertension. He continued his academic career as a post-doctoral fellow at the LIRYC Electrophysiology and Heart Modelling Institute of CHU de Bordeaux (France), where he combined computational, experimental and clinical data to unravel the working mechanisms of cardiac pacing therapies in the dyssynchronous failing heart.

Since 2012, he is working again at CARIM, where he leads the CircAdapt Research and Education team (www.circadapt.org). In 2021, he was appointed Professor of Computational Cardiology. His research team typically combines advanced computational modelling/simulation techniques with experimental and/or clinical data to gain mechanistic insight in cardiac diseases and their treatments. Importantly, translation of novel mechanistic insights into diagnostic, therapeutic and educational improvement is always pursued. Prof Joost Lumens received prestigious personal (Dutch Heart Foundation & NWO Vidi) and EU consortium funding (H2020 ERA-NET EraCoSysMed Joint Transnational Call 2015; ERA-CVD Joint Transnational Call 2018, coordinator of EMPATHY project; Marie Curie Intelligent Ultrasound, MARCIUS) for projects focussed on computational cardiac electro-mechanics and hemodynamics. He was the chairperson of the European Society of Cardiology (ESC) working group on e-Cardiology (2018-2020) and serves as deputy editor of the European Heart Journal – Digital Health.

Joost-lumens

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.362
T: +31(0)43 388 16 66

  • 2022
    • Van Mourik, M. J. W., Arita, V. A., Lyon, A., Lumens, J., De With, R. R., van Melle, J. P., Schotten, U., Bekkers, S. C. A. M., Crijns, H. J. G. M., Van Gelder, I. C., Rienstra, M., & Linz, D. K. (2022). Association between comorbidities and left and right atrial dysfunction in patients with paroxysmal atrial fibrillation: Analysis of AF-RISK. International Journal of Cardiology, 360, 29-35. https://doi.org/10.1016/j.ijcard.2022.05.044
    • Bouwmeester, S., van Loon, T., Ploeg, M., Mast, T. P., Verzaal, N. J., van Middendorp, L. B., Strik, M., van Nieuwenhoven, F. A., Dekker, L. R., Prinzen, F. W., Lumens, J., & Houthuizen, P. (2022). Left atrial remodeling in mitral regurgitation: A combined experimental-computational study. PLOS ONE, 17(7), Article e0271588. https://doi.org/10.1371/journal.pone.0271588
    • Rijks, J., Luermans, J., Heckman, L., van Stipdonk, A. M. W., Prinzen, F., Lumens, J., & Vernooy, K. (2022). Physiology of Left Ventricular Septal Pacing and Left Bundle Branch Pacing. Cardiac Electrophysiology Clinics, 14(2), 181-189. https://doi.org/10.1016/j.ccep.2021.12.010
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, Article 782592. https://doi.org/10.3389/fphys.2022.782592
    • Salden, F. C. W. M., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Atrioventricular dromotropathy: an important substrate for complete resynchronization therapy-Authors' reply. EP Europace, 24(5), 868-869. https://doi.org/10.1093/europace/euac037
    • Salden, F. C. W. M., Huntjens, P. R., Schreurs, R., Willemen, E., Kuiper, M., Wouters, P., Maessen, J. G., Bordachar, P., Delhaas, T., Luermans, J., Meine, M., Allaart, C. P., van Stipdonk, A. M. W., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study. EP Europace, 24(5), 784-795. https://doi.org/10.1093/europace/euab248
    • Ribeiro, J. M., Astudillo, P., de Backer, O., Budde, R., Nuis, R. J., Goudzwaard, J., Van Mieghem, N. M., Lumens, J., Mortier, P., Mattace-Raso, F., Boersma, E., Cummins, P., Bruining, N., & de Jaegere, P. P. (2022). Artificial Intelligence and Transcatheter Interventions for Structural Heart Disease: A glance at the (near) future. Trends in Cardiovascular Medicine, 32(3), 153-159. https://doi.org/10.1016/j.tcm.2021.02.002
    • Munneke, A. G., Lumens, J., Arts, T., & Delhaas, T. (2022). A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling. Frontiers in physiology, 13, Article 830925. https://doi.org/10.3389/fphys.2022.830925
    • de Groot, N. M. S., Shah, D., Boyle, P. M., Anter, E., Clifford, G. D., Deisenhofer, I., Deneke, T., van Dessel, P., Doessel, O., Dilaveris, P., Heinzel, F. R., Kapa, S., Lambiase, P. D., Lumens, J., Platonov, P. G., Ngarmukos, T., Martinez, J. P., Sanchez, A. O., Takahashi, Y., ... Linz, D. (2022). Critical appraisal of technologies to assess electrical activity during atrial fibrillation: a position paper from the European Heart Rhythm Association and European Society of Cardiology Working Group on eCardiology in collaboration with the Heart Rhythm Society, Asia Pacific Heart Rhythm Society, Latin American Heart Rhythm Society and Computing in Cardiology. EP Europace, 24(2), 313–330. https://doi.org/10.1093/europace/euab254
    • Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A. J. S., Deharo, J. C., Delgado, V., Diller, G. P., Israel, C. W., Keren, A., Knops, R. E., Kotecha, D., ... Et al. (2022). 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA). EP Europace, 24(1), 71-164. https://doi.org/10.1093/europace/euab232
    • Villalobos Lizardi, J. C., Baranger, J., Nguyen, M. B., Asnacios, A., Malik, A., Lumens, J., Mertens, L., Friedberg, M., Simmons, C. A., Pernot, M., & Villemain, O. (2022). A guide for assessment of myocardial stiffness in health and disease. Nature cardiovascular research, 1, 8-22. https://doi.org/10.1038/s44161-021-00007-3
    • Munneke, A. G., Lumens, J., & Delhaas, T. (2022). Cardiovascular fetal-to-neonatal transition: an in silico model. Pediatric Research, 91(1), 116-128. https://doi.org/10.1038/s41390-021-01401-0
    • Weerts, J., Barandiarán Aizpurua, A., Henkens, M. T. H. M., Lyon, A., van Mourik, M. J. W., van Gemert, M. R. A. A., Raafs, A., Sanders-van Wijk, S., Bayés-Genís, A., Heymans, S. R. B., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Lumens, J., van Empel, V. P. M., & Knackstedt, C. (2022). The prognostic impact of mechanical atrial dysfunction and atrial fibrillation in heart failure with preserved ejection fraction. European Heart Journal Cardiovascular Imaging, 23(1), 74-84. https://doi.org/10.1093/ehjci/jeab222
  • 2021
    • Augustin, C. M., Gsell, M. A. F., Karabelas, E., Willemen, E., Prinzen, F. W., Lumens, J., Vigmond, E. J., & Plank, G. (2021). A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation. Computer Methods in Applied Mechanics and Engineering, 386, Article 114092. https://doi.org/10.1016/j.cma.2021.114092
    • Prinzen, F. W., Lumens, J., Duchenn, J., & Vernooy, K. (2021). Electro-energetics of Biventricular, Septal and Conduction System Pacing. Arrhythmia & Electrophysiology Review, 10(4), 250-257. https://doi.org/10.15420/aer.2021.30
    • de Jaegere, P., Lumens, J., & Bruining, N. (2021). The 1-year anniversary of the European Heart Journal – Digital Health. European Heart Journal - Digital Health, 2(4), 548–549. https://doi.org/10.1093/ehjdh/ztab100
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Understanding the effects of heart beat irregularity on ventricular function in human atrial fibrillation: simulation models may help to untie the knot-Authors' reply. EP Europace, 23(11), 1869-1869. https://doi.org/10.1093/europace/euab144
    • van Osta, N., Kirkels, F. P., van Loon, T., Koopsen, T., Lyon, A., Meiburg, R., Huberts, W., Cramer, M. J., Delhaas, T., Haugaa, K. H., Teske, A. J., & Lumens, J. (2021). Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling. Frontiers in physiology, 12, Article 738926. https://doi.org/10.3389/fphys.2021.738926
    • Lumens, J., Koopsen, T., & Beela, A. S. (2021). What Do We Gain From Septal Strain?JACC-Cardiovascular Imaging, 14(9), 1703-1706. https://doi.org/10.1016/j.jcmg.2021.05.010
    • de Jaegere, P., Lumens, J., & Bruining, N. (2021). The 12-lead surface electrocardiogram: a sheet of paper or a realm of concealed information asking for deep learning analysis. European Heart Journal - Digital Health, 2(3), 356–357. https://doi.org/10.1093/ehjdh/ztab066
    • Jensen, M. T., Treskes, R. W., Caiani, E. G., Casado-Arroyo, R., Cowie, M. R., Dilaveris, P., Duncker, D., Di Rienzo, M., Frederix, I., De Groot, N., Kolh, P. H., Kemps, H., Mamas, M., McGreavy, P., Neubeck, L., Parati, G., Platonov, P. G., Schmidt-Trucksass, A., Schuuring, M. J., ... Lumens, J. (2021). ESC working group on e-cardiology position paper: Use of commercially available wearable technology for heart rate and activity tracking in primary and secondary cardiovascular prevention - In collaboration with the European Heart Rhythm Association, European Association of Preventive Cardiology, Association of Cardiovascular Nursing and Allied Professionals, Patient Forum, and the Digital Health Committee. European Heart Journal - Digital Health, 2(1), 49-59. https://doi.org/10.1093/ehjdh/ztab011
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28. https://doi.org/10.1093/europace/euaa387
    • van Osta, N., Kirkels, F., Lyon, A., Koopsen, T., van Loon, T., Cramer, M.-J., Teske, A. J., Delhaas, T., & Lumens, J. (2021). Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations. EP Europace, 23, I153-I160. https://doi.org/10.1093/europace/euaa407
    • Dilaveris, P., & Lumens, J. (2021). The ESC Working Group on e-Cardiology. European Heart Journal, 42(2), 143-144. https://doi.org/10.1093/eurheartj/ehaa401
    • Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A. J. S., Deharo, J. C., Delgado, V., Diller, G. P., Israel, C. W., Keren, A., Knops, R. E., Kotecha, D., ... Et al. (2021). 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. European Heart Journal, 42(35), 3427-3520. https://doi.org/10.1093/eurheartj/ehab364
  • 2020
    • Sutanto, H., Lyon, A., Lumens, J., Schotten, U., Dobrev, D., & Heijman, J. (2020). Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies. Progress in Biophysics & Molecular Biology, 157, 54-75. https://doi.org/10.1016/j.pbiomolbio.2020.02.008
    • Prinzen, F. W., & Lumens, J. (2020). Investigating myocardial work as a CRT response predictor is not a waste of work. European Heart Journal, 41(39), 3824-3826. https://doi.org/10.1093/eurheartj/ehaa677
    • Dilaveris, P., Casado-Arroyo, R., & Lumens, J. (2020). A roadmap to nationwide monitoring of Cardiovascular Implantable Electronic Devices in Greece: staying safe in the era of COVID-19 pandemic. Hellenic Journal of Cardiology, 61(6), 396-397. https://doi.org/10.1016/j.hjc.2020.09.008
    • Lyon, A., Dupuis, L. J., Arts, T., Crijns, H. J. G. M., Prinzen, F. W., Delhaas, T., Heijman, J., & Lumens, J. (2020). Differentiating the effects of β-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. American Journal of Physiology-heart and Circulatory Physiology, 319(3), H519-H530. https://doi.org/10.1152/ajpheart.00275.2020
    • Lumens, J., Willemen, E., & Prinzen, F. W. (2020). Does the Right Go Wrong During Cardiac Resynchronization Therapy?JACC-Cardiovascular Imaging, 13(7), 1485-1488. https://doi.org/10.1016/j.jcmg.2020.01.009
    • van Osta, N., Lyon, A., Kirkels, F., Koopsen, T., van Loon, T., Cramer, M. J., Teske, A. J., Delhaas, T., Huberts, W., & Lumens, J. (2020). Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190347. https://doi.org/10.1098/rsta.2019.0347
    • Gauthey, A., Willemen, E., Lumens, J., Ploux, S., Bordachar, P., Ritter, P., Prinzen, F. W., Lejeune, S., Pouleur, A.-C., Garnir, Q., Marchandise, S., Scavee, C., Wauters, A., & De Waroux, J.-B. L. P. (2020). Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy. Journal of Cardiovascular Electrophysiology, 31(2), 494-502. https://doi.org/10.1111/jce.14330
    • Verdonschot, J. A. J., Merken, J. J., Brunner-La Rocca, H.-P., Hazebroek, M. R., Eurlings, C. G. M. J., Thijssen, E., Wang, P., Weerts, J., van Empel, V., Schummers, G., Schreckenberg, M., van den Wijngaard, A., Lumens, J., Brunner, H. G., Heymans, S. R. B., Krapels, I. P. C., & Knackstedt, C. (2020). Value of Speckle Tracking-Based Deformation Analysis in Screening Relatives of Patients With Asymptomatic Dilated Cardiomyopathy. JACC-Cardiovascular Imaging, 13(2), 549-558. https://doi.org/10.1016/j.jcmg.2019.02.032
    • van Loon, T., Knackstedt, C., Cornelussen, R., Reesink, K., Brunner-La Rocca, H., Delhaas, T., van Empel, V., & Lumens, J. (2020). Increased myocardial stiffness more than impaired relaxation function limits cardiac performance during exercise in heart failure with preserved ejection fraction: a virtual patient study. European Heart Journal - Digital Health, 1(1), 40-50. https://doi.org/10.1093/ehjdh/ztaa009
  • 2019
    • Gorcsan, J., & Lumens, J. (2019). Opposing Wall Pushing and Stretching: Response to Cardiac Resynchronization Therapy Requires Electrical Delay and Viability. JACC-Cardiovascular Imaging, 12(12), 2414-2416. https://doi.org/10.1016/j.jcmg.2019.01.013
    • Walmsley, J., Squara, P., Wolfhard, U., Cornelussen, R., & Lumens, J. (2019). Impact of abrupt versus gradual correction of mitral and tricuspid regurgitation: a modelling study. Eurointervention, 15(10), 902-911. https://doi.org/10.4244/EIJ-D-19-00598
    • Gorcsan, J., Anderson, C. P., Tayal, B., Sugahara, M., Walmsley, J., Starling, R. C., & Lumens, J. (2019). Systolic Stretch Characterizes the Electromechanical Substrate Responsive to Cardiac Resynchronization Therapy. JACC-Cardiovascular Imaging, 12(9), 1741-1752. https://doi.org/10.1016/j.jcmg.2018.07.013
    • Heusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D., & Reesink, K. D. (2019). Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model. Journal of Applied Physiology, 127(2), 491-500. https://doi.org/10.1152/japplphysiol.00769.2018
    • Heusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T., & Reesink, K. D. (2019). Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction. PLoS Computational Biology, 15(7), Article 1007173. https://doi.org/10.1371/journal.pcbi.1007173
    • Prinzen, F. W., Willemen, E., & Lumens, J. (2019). LBBB and High Afterload: A Dangerous Liaison?JACC-Cardiovascular Imaging, 12(6), 978-980. https://doi.org/10.1016/j.jcmg.2017.12.002
    • Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M., & Schroen, B. (2019). AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism. Molecular Therapy - Nucleic Acids, 14, 424-437. https://doi.org/10.1016/j.omtn.2018.12.010
    • Mast, T. P., Taha, K., Cramer, M. J., Lumens, J., van der Heijden, J. F., Bouma, B. J., van den Berg, M. P., Asselbergs, F. W., Doevendans, P. A., & Teske, A. J. (2019). The Prognostic Value of Right Ventricular Deformation Imaging in Early Arrhythmogenic Right Ventricular Cardiomyopathy. JACC-Cardiovascular Imaging, 12(3), 446-455. https://doi.org/10.1016/j.jcmg.2018.01.012
    • Willemen, E., Schreurs, R., Huntjens, P. R., Strik, M., Plank, G., Vigmond, E., Walmsley, J., Vernooy, K., Delhaas, T., Prinzen, F. W., & Lumens, J. (2019). The Left and Right Ventricles Respond Differently to Variation of Pacing Delays in Cardiac Resynchronization Therapy: A Combined Experimental- Computational Approach. Frontiers in physiology, 10(FEB), 1-13. Article 17. https://doi.org/10.3389/fphys.2019.00017
    • Niederer, S. A., Lumens, J., & Trayanova, N. A. (2019). Computational models in cardiology. Nature Reviews Cardiology, 16(2), 100-111. https://doi.org/10.1038/s41569-018-0104-y
    • Lumens, J., Fan, C.-P. S., Walmsley, J., Yim, D., Manlhiot, C., Dragulescu, A., Grosse-Wortmann, L., Mertens, L., Prinzen, F. W., Delhaas, T., & Friedberg, M. K. (2019). Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot. Journal of the American Heart Association, 8(2), Article 010903. https://doi.org/10.1161/JAHA.118.010903
    • Noordegraaf, A. V., Chin, K. M., Haddad, F., Hassoun, P. M., Hemnes, A. R., Hopkins, S. R., Kawut, S. M., Langleben, D., Lumens, J., & Naeije, R. (2019). Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update. European Respiratory Journal, 53(1), Article 1801900. https://doi.org/10.1183/13993003.01900-2018
    • van Mourik, M. J. W., Zaar, D. V. J., Smulders, M. W., Heijman, J., Lumens, J., Dokter, J. E., Passos, V. L., Schalla, S., Knackstedt, C., Schummers, G., Gjesdal, O., Edvardsen, T., & Bekkers, S. C. A. M. (2019). Adding Speckle-Tracking Echocardiography to Visual Assessment of Systolic Wall Motion Abnormalities Improves the Detection of Myocardial Infarction. Journal of the American Society of Echocardiography, 32(1), 65-73. https://doi.org/10.1016/j.echo.2018.09.007
  • 2018
    • Kirn, B., Walmsley, J., & Lumens, J. (2018). Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study. Biomedical Engineering Online, 17(1), Article 182. https://doi.org/10.1186/s12938-018-0614-1
    • Dupuis, L. J., Arts, T., Prinzen, F. W., Delhaas, T., & Lumens, J. (2018). Linking cross-bridge cycling kinetics to response to cardiac resynchronization therapy: a multiscale modelling study. EP Europace, 20, 87-93. https://doi.org/10.1093/europace/euy230
    • Dupuis, L. J., Lumens, J., Arts, T., & Delhaas, T. (2018). High tension in sarcomeres hinders myocardial relaxation: A computational study. PLOS ONE, 13(10), Article e0204642. https://doi.org/10.1371/journal.pone.0204642
Overview