Joost Lumens

Professor

Professor Joost Lumens studied Biomedical Engineering at the Eindhoven University of Technology where he obtained his MSc degree in Medical Engineering in 2005. He obtained his PhD degree in 2010 at Maastricht University (Dept. of Biomedical Engineering and Dept. of Physiology). During his PhD, he developed and validated a computational model of left-right ventricular interaction dynamics and applied it to study right ventricular failure in patients with pulmonary arterial hypertension. He continued his academic career as a post-doctoral fellow at the LIRYC Electrophysiology and Heart Modelling Institute of CHU de Bordeaux (France), where he combined computational, experimental and clinical data to unravel the working mechanisms of cardiac pacing therapies in the dyssynchronous failing heart.

Since 2012, he is working again at CARIM, where he leads the CircAdapt Research and Education team (www.circadapt.org). In 2021, he was appointed Professor of Computational Cardiology. His research team typically combines advanced computational modelling/simulation techniques with experimental and/or clinical data to gain mechanistic insight in cardiac diseases and their treatments. Importantly, translation of novel mechanistic insights into diagnostic, therapeutic and educational improvement is always pursued. Prof Joost Lumens received prestigious personal (Dutch Heart Foundation & NWO Vidi) and EU consortium funding (H2020 ERA-NET EraCoSysMed Joint Transnational Call 2015; ERA-CVD Joint Transnational Call 2018, coordinator of EMPATHY project; Marie Curie Intelligent Ultrasound, MARCIUS) for projects focussed on computational cardiac electro-mechanics and hemodynamics. He was the chairperson of the European Society of Cardiology (ESC) working group on e-Cardiology (2018-2020) and serves as deputy editor of the European Heart Journal – Digital Health.

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.362
T: +31(0)43 388 16 66

2014
- Kuijpers, N. H. L., Hermeling, E., Lumens, J., ten Eikelder, H. M. M., Delhaas, T., & Prinzen, F. W. (2014). Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT. American Journal of Physiology-heart and Circulatory Physiology, 306(12), H1644-H1659. https://doi.org/10.1152/ajpheart.00689.2013
- Auricchio, A., Lumens, J., & Prinzen, F. W. (2014). Does Cardiac Resynchronization Therapy Benefit Patients With Right Bundle Branch Block Cardiac Resynchronization Therapy Has a Role in Patients With Right Bundle Branch Block. Circulation-Arrhythmia and Electrophysiology, 7(3), 532-542. https://doi.org/10.1161/CIRCEP.113.000628
- Bordachar, P., Eschalier, R., Lumens, J., & Ploux, S. (2014). Optimal Strategies on Avoiding CRT Nonresponse. Current treatment options in cardiovascular medicine, 16(5), Article 299. https://doi.org/10.1007/s11936-014-0299-0
- Lumens, J. (2014). Creating your own virtual patient with CircAdapt Simulator. European Heart Journal, 35(6), 335-337.
2013
- Lumens, J., Ploux, S., Strik, M., Gorcsan, J. III., Cochet, H., Derval, N., Strom, M., Ramanathan, C., Ritter, P., Haissaguerre, M., Jais, P., Arts, T., Delhaas, T., Prinzen, F. W., & Bordachar, P. (2013). Comparative Electromechanical and Hemodynamic Effects of Left Ventricular and Biventricular Pacing in Dyssynchronous Heart Failure Electrical Resynchronization Versus Left-Right Ventricular Interaction. Journal of the American College of Cardiology, 62(25), 2395-2403. https://doi.org/10.1016/j.jacc.2013.08.715
- Vonk-Noordegraaf, A., Haddad, F., Chin, K. M., Forfia, P. R., Kawut, S. M., Lumens, J., Naeije, R., Newman, J., Oudiz, R. J., Provencher, S., Torbicki, A., Voelkel, N. F., & Hassoun, P. M. (2013). Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. Journal of the American College of Cardiology, 62(25 Suppl), D22-33. https://doi.org/10.1016/j.jacc.2013.10.027
- Ploux, S., Lumens, J., Whinnett, Z., Montaudon, M., Strom, M., Ramanathan, C., Derval, N., Zemmoura, A., Denis, A., De Guillebon, M., Shah, A., Hocini, M., Jais, P., Ritter, P., Haissaguerre, M., Wilkoff, B. L., & Bordachar, P. (2013). Noninvasive Electrocardiographic Mapping to Improve Patient Selection for Cardiac Resynchronization Therapy Beyond QRS Duration and Left Bundle Branch Block Morphology. Journal of the American College of Cardiology, 61(24), 2435-2443. https://doi.org/10.1016/j.jacc.2013.01.093
- Cochet, H., Denis, A., Ploux, S., Lumens, J., Amraoui, S., Derval, N., Sacher, F., Reant, P., Lafitte, S., Jais, P., Laurent, F., Ritter, P., Montaudon, M., & Bordachar, P. (2013). Pre- and Intra-Procedural Predictors of Reverse Remodeling After Cardiac Resynchronization Therapy: An MRI Study. Journal of Cardiovascular Electrophysiology, 24(6), 682-691. https://doi.org/10.1111/jce.12101
- van Geldorp, I. E., Bordachar, P., Lumens, J., de Guillebon, M., Whinnett, Z. I., Prinzen, F. W., Haissaguerre, M., Delhaas, T., & Thambo, J.-B. (2013). Acute hemodynamic benefits of biventricular and single-site systemic ventricular pacing in patients with a systemic right ventricle. Heart Rhythm, 10(5), 676-682. https://doi.org/10.1016/j.hrthm.2013.01.017
2012
- Lumens, J., Arts, T., Marcus, J. T., Vonk-Noordegraaf, A., & Delhaas, T. (2012). Early-diastolic left ventricular lengthening implies pulmonary hypertension-induced right ventricular decompensation. Cardiovascular Research, 96(2), 286-295. https://doi.org/10.1093/cvr/cvs251
- Lumens, J., & Delhaas, T. (2012). Cardiovascular Modeling in Pulmonary Arterial Hypertension: Focus on Mechanisms and Treatment of Right Heart Failure Using the CircAdapt Model. American Journal of Cardiology, 110(6), 39S-48S. https://doi.org/10.1016/j.amjcard.2012.06.015
- Ploux, S., Whinnett, Z., Lumens, J., Denis, A., Zemmoura, A., De Guillebon, M., Ramoul, K., Ritter, P., Jais, P., Clementy, J., Haissaguerre, M., & Bordachar, P. (2012). Acute hemodynamic response to biventricular pacing in heart failure patients with narrow, moderately, and severely prolonged QRS duration. Heart Rhythm, 9(8), 1247-1250. https://doi.org/10.1016/j.hrthm.2012.03.016
- Lumens, J., Leenders, G. E., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Prinzen, F. W., & Delhaas, T. (2012). Mechanistic Evaluation of Echocardiographic Dyssynchrony Indices Patient Data Combined With Multiscale Computer Simulations. Circulation-Cardiovascular Imaging, 5(4), 491-499. https://doi.org/10.1161/CIRCIMAGING.112.973446
- Koeken, Y., Kuijpers, N. H. L., Lumens, J., Arts, T., & Delhaas, T. (2012). Atrial septostomy benefits severe pulmonary hypertension patients by increase of left ventricular preload reserve. American Journal of Physiology-heart and Circulatory Physiology, 302(12), H2654-H2662. https://doi.org/10.1152/ajpheart.00072.2012
- Arts, T., Lumens, J., Kroon, W., & Delhaas, T. (2012). Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study. PLoS Computational Biology, 8(2). https://doi.org/10.1371/journal.pcbi.1002369
- Leenders, G. E., Lumens, J., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Delhaas, T., & Prinzen, F. W. (2012). Septal Deformation Patterns Delineate Mechanical Dyssynchrony and Regional Differences in Contractility Analysis of Patient Data Using a Computer Model. Circulation-Heart Failure, 5(1), 87-96. https://doi.org/10.1161/CIRCHEARTFAILURE.111.962704
2010
- Lumens, J., Blanchard, D. G., Arts, T., Mahmud, E., & Delhaas, T. (2010). Left ventricular underfilling and not septal bulging dominates abnormal left ventricular filling hemodynamics in chronic thromboembolic pulmonary hypertension. American Journal of Physiology-heart and Circulatory Physiology, 299(4), H1083-H1091. https://doi.org/10.1152/ajpheart.00607.2010

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Joost Lumens

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