• 2022
    • Heubel-Moenen, F. C. J. I., Brouns, S. L. N., Herfs, L., Boerenkamp, L. S., Jooss, N. J., Wetzels, R. J. H., Verhezen, P. W. M., Machiels, P., Megy, K., Downes, K., Heemskerk, J. W. M., Beckers, E. A. M., & Henskens, Y. M. C. (2022). Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time. British Journal of Haematology, 196(6), 1388-1400. https://doi.org/10.1111/bjh.18003
    • Panova-Noeva, M., Wagner, B., Nagler, M., Koeck, T., Ten Cate, V., Eggebrecht, L., Prochaska, J. H., Meyer, I., Gerdes, C., Spronk, H. M., Lackner, K. J., Ten Cate, H., Leineweber, K., Heitmeier, S., Konstantinides, S., & Wild, P. S. (2022). Variation of platelet function in clinical phenotypes of acute venous thromboembolism - Results from the GMP-VTE project. Journal of Thrombosis and Haemostasis, 20(3), 705-715. https://doi.org/10.1111/jth.15595
    • Post, D. S., van der Veer, A., Schijns, O. E. M. G., Klinkenberg, S., Rijkers, K., Wagner, G. L., van Kranen-Mastenbroek, V. H. J. M., Willems, P. C. P. H., Verhezen, P. W. M., Beckers, E. A. M., Heubel-Moenen, F. C. J. I., & Henskens, Y. M. C. (2022). Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study. PLOS ONE, 17(2), Article e0264351. https://doi.org/10.1371/journal.pone.0264351
    • Hrdinova, J., Fernández, D. I., Ercig, B., Tullemans, B. M. E., Suylen, D. P. L., Agten, S. M., Jurk, K., Hackeng, T. M., Vanhoorelbeke, K., Voorberg, J., Reutelingsperger, C. P. M., Wichapong, K., Heemskerk, J. W. M., & Nicolaes, G. A. F. (2022). Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear. International journal of molecular sciences, 23(4), Article 2046. https://doi.org/10.3390/ijms23042046
    • Cosemans, J. M. E. M. (2022). Platelet-derived MMP-2 in the prevention of plaque formation: how many strokes is par?European Heart Journal, 43(6), 515–517. https://doi.org/10.1093/eurheartj/ehab665
    • De With, R. R., Artola Arita, V., Nguyen, B.-O., Linz, D., Ten Cate, H., Spronk, H., Schotten, U., van Zonneveld, A. J., Erküner, Ö., Bayón, M. A., Schmidt, A. S., Luermans, J. G. L. M., Crijns, H. J. G. M., Van Gelder, I. C., & Rienstra, M. (2022). Different circulating biomarkers in women and men with paroxysmal atrial fibrillation: results from the AF-RISK and RACE V studies. EP Europace, 24(2), 193-201. https://doi.org/10.1093/europace/euab179
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., Girbes, A. R. J., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., ... Elbers, P. W. G. (2022). Targeted Temperature Management in Out-of-Hospital Cardiac Arrest With Shockable Rhythm: A Post Hoc Analysis of the Coronary Angiography After Cardiac Arrest Trial. Critical Care Medicine, 50(2), e129-e142. https://doi.org/10.1097/CCM.0000000000005271
    • Karel, M. F. A., Lemmens, T. P., Tullemans, B. M. E., Wielders, S. J. H., Gubbins, E., van Beurden, D., van Rijt, S., & Cosemans, J. M. E. M. (2022). Characterization of Atherosclerotic Plaque Coating for Thrombosis Microfluidics Assays. Cellular and Molecular Bioengineering, 15(1), 55-65. https://doi.org/10.1007/s12195-021-00713-9
    • Grabowski, K., Herlan, L., Witten, A., Qadri, F., Eisenreich, A., Lindner, D., Schadlich, M., Schulz, A., Subrova, J., Mhatre, K. N., Primessnig, U., Plehm, R., van Linthout, S., Escher, F., Bader, M., Stoll, M., Westermann, D., Heinzel, F. R., & Kreutz, R. (2022). Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Hypertension Research, 45(2), 292-307. https://doi.org/10.1038/s41440-021-00826-8
    • Maag, A., van Rein, N., Schuijt, T. J., Kopatz, W. F., Kruijswijk, D., Thomassen, S., Hackeng, T. M., Camire, R. M., van der Poll, T., Meijers, J. C. M., Bos, M. H. A., & van't Veer, C. (2022). Major bleeding during oral anticoagulant therapy associated with factor V activation by factor Xa. Journal of Thrombosis and Haemostasis, 20(2), 328-338. https://doi.org/10.1111/jth.15589
    • Brouns, S. L. N., Tullemans, B. M. E., Bulato, C., Perrella, G., Campello, E., Spiezia, L., van Geffen, J. P., Kuijpers, M. J. E., van Oerle, R., Spronk, H. M. H., van der Meijden, P. E. J., Simioni, P., & Heemskerk, J. W. M. (2022). Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow. Research and practice in thrombosis and haemostasis, 6(2), Article e12678. https://doi.org/10.1002/rth2.12678
    • Boswijk, E., de Ligt, M., Habets, M. F. J., Mingels, A. M. A., van Marken Lichtenbelt, W. D., Mottaghy, F. M., Schrauwen, P., Wildberger, J. E., & Bucerius, J. (2022). Resveratrol treatment does not reduce arterial inflammation in males at risk of type 2 diabetes: a randomized crossover trial. Nuklearmedizin, 61(01), 33-41. https://doi.org/10.1055/a-1585-7215
    • Fernandez, D. I., Provenzale, I., Cheung, H. Y. F., van Groningen, J., Tullemans, B. M. E., Veninga, A., Dunster, J. L., Honarnejad, S., van den Hurk, H., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2022). Ultra-high-throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein-coupled receptor activation. iScience, 25(1), Article 103718. https://doi.org/10.1016/j.isci.2021.103718
    • Spaetgens, B., Nagy, M., & ten Cate, H. (2022). Antiplatelet Therapy in Patients With COVID-19-More Is Less?JAMA-Journal of the American Medical Association, 327(3), 223-224. https://doi.org/10.1001/jama.2021.23866
    • Heuts, S., Denessen, E. J. S., Daemen, J. H. T., Vroemen, W. H. M., Sels, J. W., Segers, P., Bekers, O., Hof, A. W. J. V., Maessen, J. G., van der Horst, I. C. C., & Mingels, A. M. A. (2022). Meta-Analysis Evaluating High-Sensitivity Cardiac Troponin T Kinetics after Coronary Artery Bypass Grafting in Relation to the Current Definitions of Myocardial Infarction. American Journal of Cardiology, 163, 25-31. https://doi.org/10.1016/j.amjcard.2021.09.049
    • Meijs, D. A. M., van Bussel, B. C. T., Stessel, B., Mehagnoul-Schipper, J., Hana, A., Scheeren, C. I. E., Peters, S. A. E., van Mook, W. N. K. A., van der Horst, I. C. C., Marx, G., Mesotten, D., Ghossein-Doha, C., CoDaP Investigators, Heijnen, N. F. L., Raafs, A., van Kuijk, S. M. J., Smits, L. J. M., Janssen, E. B. N. J., Mulder, M. M. G., ... Florack, M. C. D. M. (2022). Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment. Scientific Reports, 12(1), Article 734. https://doi.org/10.1038/s41598-021-04531-x
    • Dongelmans, D. A., Termorshuizen, F., Brinkman, S., Bakhshi-Raiez, F., Arbous, M. S., de Lange, D. W., van Bussel, B. C. T., de Keizer, N. F., & Dutch COVID-19 Research Consortium (2022). Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the first and the consecutive upsurges of the second wave of the COVID-19 pandemic in the Netherlands. Annals of Intensive Care, 12(1), Article 5. https://doi.org/10.1186/s13613-021-00978-3
    • Simons, C. C. J. M., Schouten, L. J., Godschalk, R. W. L., Van Schooten, F. J., Stoll, M., Van Steen, K., van den Brandt, P. A., & Weijenberg, M. P. (2022). Polymorphisms in the mTOR-PI3K-Akt pathway, energy balance-related exposures and colorectal cancer risk in the Netherlands Cohort Study. Biodata Mining, 15(1), Article 2. https://doi.org/10.1186/s13040-021-00286-3
    • Heijnen, N. F. L., Hagens, L. A., van Schooten, F.-J., Bos, L. D. J., van der Horst, I. C. C., Mommers, A., Schultz, M. J., Smit, M. R., Bergmans, D. C. J. J., Smolinska, A., & Schnabel, R. M. (2022). Breath octane and acetaldehyde as markers for acute respiratory distress syndrome in invasively ventilated patients suspected to have ventilator-associated pneumonia. ERJ Open Research, 8(1), Article 00624. https://doi.org/10.1183/23120541.00624-2021
    • Kaczor, D. M., Kramann, R., Hackeng, T. M., Schurgers, L. J., & Koenen, R. R. (2022). Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells. International Journal of Molecular Sciences, 23(2), Article 580. https://doi.org/10.3390/ijms23020580
    • Willems, L. H., Nagy, M., Ten Cate, H., Spronk, H. M. H., Groh, L. A., Leentjens, J., Janssen, N. A. F., Netea, M. G., Thijssen, D. H. J., Hannink, G., van Petersen, A. S., & Warle, M. C. (2022). Sustained inflammation, coagulation activation and elevated endothelin-1 levels without macrovascular dysfunction at 3 months after COVID-19. Thrombosis Research, 209, 106-114. https://doi.org/10.1016/j.thromres.2021.11.027
    • Navarro, S., Stegner, D., Nieswandt, B., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2022). Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation. International journal of molecular sciences, 23(1), Article 358. https://doi.org/10.3390/ijms23010358
    • Heuts, S., van der Horst, I. C. C., & Mingels, A. (2022). Towards an improved definition of periprocedural myocardial infarction: The role of high-sensitivity cardiac troponins. Journal of Cardiac Surgery, 37(1), 162-164. https://doi.org/10.1111/jocs.16107
    • Tullemans, B. M. E., Fernandez, D. I., Veninga, A., Baaten, C. C. F. M. J., Peters, L. J. F., Aarts, M. J. B., Eble, J. A., Campello, E., Spiezia, L., Simioni, P., van der Vorst, E. P. C., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2022). Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin. Thrombosis and Haemostasis, 122(01), 92-104. https://doi.org/10.1055/s-0041-1730312
    • Uengwetwanit, T., Chutiwitoonchai, N., Wichapong, K., & Karoonuthaisiri, N. (2022). Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity. Computational and Structural Biotechnology Journal, 20, 882-890. https://doi.org/10.1016/j.csbj.2022.02.001
    • Vignoli, A., Gamba, S., van der Meijden, P. E. J., Marchetti, M., Russo, L., Tessarolo, S., Giaccherini, C., Swieringa, F., Cate, H. T., Finazzi, G., Heemskerk, J. W. M., & Falanga, A. (2022). Increased platelet thrombus formation under flow conditions in whole blood from polycythaemia vera patients. Blood Transfusion, 20(2), 143-151. https://doi.org/10.2450/2021.0456-20
  • 2021
    • Hulshof, A.-M., Olie, R. H., Vries, M. J. A., Verhezen, P. W. M., van der Meijden, P. E. J., Ten Cate, H., & Henskens, Y. M. C. (2021). Rotational Thromboelastometry in High-Risk Patients on Dual Antithrombotic Therapy After Percutaneous Coronary Intervention. Frontiers in Cardiovascular Medicine, 8, Article 788137. https://doi.org/10.3389/fcvm.2021.788137
    • Sanjurjo, L., Schulkens, I. A., Touarin, P., Heusschen, R., Aanhane, E., Castricum, K. C. M., De Gruijl, T. D., Nilsson, U. J., Leffler, H., Griffioen, A. W., Elantak, L., Koenen, R. R., & Thijssen, V. L. J. L. (2021). Chemokines modulate glycan binding and the immunoregulatory activity of galectins. Communications Biology, 4(1), Article 1415. https://doi.org/10.1038/s42003-021-02922-4
    • Maciuszek, M., Ortega-Gomez, A., Maas, S. L., Garrido-Mesa, J., Ferraro, B., Perretti, M., Merritt, A., Nicolaes, G. A. F., Soehnlein, O., & Chapman, T. M. (2021). Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. European Journal of Medicinal Chemistry, 226, Article 113805. https://doi.org/10.1016/j.ejmech.2021.113805
    • Aengevaeren, V. L., Baggish, A. L., Chung, E. H., George, K., Kleiven, Ø., Mingels, A. M. A., Ørn, S., Shave, R. E., Thompson, P. D., & Eijsvogels, T. M. H. (2021). Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance. Circulation, 144(24), 1955-1972. https://doi.org/10.1161/CIRCULATIONAHA.121.056208
    • Willems, L. H., Nagy, M., Ten Cate, H., Spronk, H. M. H., Jacobs, L. M. C., Kranendonk, J., van Leeuwen, M., Meijer, D., Middeldorp, S., Groh, L. A., & Warle, M. C. (2021). ChAdOx1 vaccination, blood coagulation, and inflammation: No effect on coagulation but increased interleukin-6. Research and practice in thrombosis and haemostasis, 5(8), Article e12630. https://doi.org/10.1002/rth2.12630
    • Bidar, E., Zeemering, S., Gilbers, M., Isaacs, A., Verheule, S., Zink, M. D., Maesen, B., Bramer, S., Kawczynski, M., Van Gelder, I. C., Crijns, H. J. G. M., Maessen, J. G., & Schotten, U. (2021). Clinical and electrophysiological predictors of device-detected new-onset atrial fibrillation during 3 years after cardiac surgery. EP Europace, 23(12), 1922-1930. https://doi.org/10.1093/europace/euab136
    • Sun, S. Y., Urbanus, R. T., ten Cate, H., de Groot, P. G., de Laat, B., Heemskerk, J. W. M., & Roest, M. (2021). Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia. Cells, 10(12), Article 3386. https://doi.org/10.3390/cells10123386
    • van Haaps, T. F. V., Collard, D., van Osch, F. H. M. V., Middeldorp, S., Coppens, M., de Kruif, M. D., Vlot, E. A., Douma, R. A., ten Cate, H., Juffermans, N. P., Gritters, N., Vlaar, A. P., Reidinga, A. C., Heuvelmans, M. A., Oudkerk, M., Buller, H. R., van den Bergh, J. P. W. V., Maas, A., Ten Wolde, M., ... Dutch COVID & Thrombosis Coalition (2021). Pre-admission anticoagulant therapy and mortality in hospitalized COVID-19 patients: A retrospective cohort study. Thrombosis Research, 208, 35-38. https://doi.org/10.1016/j.thromres.2021.10.006
    • Dofferhoff, A. S. M., Piscaer, I., Schurgers, L. J., Visser, M. P. J., van den Ouweland, J. M. W., de Jong, P. A., Gosens, R., Hackeng, T. M., van Daal, H., Lux, P., Maassen, C., Karssemeijer, E. G. A., Vermeer, C., Wouters, E. F. M., Kistemaker, L. E. M., Walk, J., & Janssen, R. (2021). Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019. Clinical Infectious Diseases, 73(11), E4039-E4046. https://doi.org/10.1093/cid/ciaa1258
    • von Hundelshausen, P., Wichapong, K., Gabius, H. J., & Mayo, K. H. (2021). The marriage of chemokines and galectins as functional heterodimers. Cellular and Molecular Life Sciences, 78(24), 8073-8095. https://doi.org/10.1007/s00018-021-04010-6
    • Amer, A. Y. A., Wouters, F., Vranken, J., Dreesen, P., Boer, D. D., van Rosmalen, F., van Bussel, B. C. T., Smit-Fun, V., Duflot, P., Guiot, J., van der Horst, I. C. C., Mesotten, D., Vandervoort, P., Aerts, J. M., & Vanrumste, B. (2021). Vital Signs Prediction for COVID-19 Patients in ICU. Sensors, 21(23), Article 8131. https://doi.org/10.3390/s21238131
    • Wan, J., Konings, J., de Laat, B., Hackeng, T. M., & Roest, M. (2021). Added Value of Blood Cells in Thrombin Generation Testing. Thrombosis and Haemostasis, 121(12), 1574-1587. https://doi.org/10.1055/a-1450-8300
    • D'Alessandro, E., Scaf, B., van Oerle, R., van Nieuwenhoven, F. A., van Hunnik, A., Verheule, S., Schotten, U., Ten Cate, H., & Spronk, H. M. H. (2021). Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay. Research and practice in thrombosis and haemostasis, 5(8), Article e12620. https://doi.org/10.1002/rth2.12620
    • Montague, S. J., Patel, P., Martin, E. M., Slater, A., Quintanilla, L. G., Perrella, G., Kardeby, C., Nagy, M., Mezzano, D., Mendes, P. M., & Watson, S. P. (2021). Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors. Platelets, 32(8), 1018-1030. https://doi.org/10.1080/09537104.2021.1945571
    • Nguyen, U. C., Vernemmen, A. I. P., Segers, P., zur Hausen, A., Driessen, R. G. H., Pluijmen, M. J. H. M., & Bekkers, S. C. A. M. (2021). Case Report: An Unusual Cause for Recurrent Hemopericardium in a Patient With Dyspnea. Frontiers in Cardiovascular Medicine, 8, Article 755106. https://doi.org/10.3389/fcvm.2021.755106
    • Cox, E. G. M., Onrust, M., Vos, M. E., Paans, W., Dieperink, W., Koeze, J., van der Horst, I. C. C., Wiersema, R., SICS Study Group, & SOCCS Student Team (2021). The simple observational critical care studies: estimations by students, nurses, and physicians of in-hospital and 6-month mortality. Critical Care, 25(1), Article 393. https://doi.org/10.1186/s13054-021-03809-w
    • Bervoets, L., Ippel, J. H., Smolinska, A., van Best, N., Savelkoul, P. H. M., Mommers, M. A. H., & Penders, J. (2021). Practical and Robust NMR-Based Metabolic Phenotyping of Gut Health in Early Life. Journal of Proteome Research, 20(11), 5079-5087. https://doi.org/10.1021/acs.jproteome.1c00617
    • van der Bruggen, M. M., Kremers, B., van Oerle, R., van Oostenbrugge, R. J., & ten Cate, H. (2021). Potential value of the calibrated automated thrombogram in patients after a cerebral venous sinus thrombosis; an exploratory study. Thrombosis Journal, 19(1), Article 81. https://doi.org/10.1186/s12959-021-00335-1
    • Driessen, R. G. H., Groven, R. V. M., van Koll, J., Oudhuis, G. J., Posthouwer, D., van der Horst, I. C. C., Bergmans, D. C. J. J., & Schnabel, R. M. (2021). Appropriateness of empirical antibiotic therapy and added value of adjunctive gentamicin in patients with septic shock: a prospective cohort study in the ICU. Infectious Diseases, 53(11), 830-838. https://doi.org/10.1080/23744235.2021.1942543
    • D'Alessandro, E., Scaf, B., Munts, C., van Hunnik, A., Trevelyan, C. J., Verheule, S., Spronk, H. M. H., Turner, N. A., ten Cate, H., Schotten, U., & van Nieuwenhoven, F. A. (2021). Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1. Cells, 10(11), Article 2958. https://doi.org/10.3390/cells10112958