Marleen van Greevenbroek

Associate professor

Dr Marleen van Greevenbroek is Medical Biologist (University of Utrecht, 1992) and Epidemiologist (Maastricht University, 2012). She received her PhD degree in 1997 at the University of Utrecht, on a thesis concerning the effects of fatty acids on the production of intestinal triglyceride-rich lipoproteins. In September 1997, she was appointed at the University of Maastricht (Dept. of Internal Medicine), where she was involved in studies on the metabolic and genetic aspects of obesity and cardiometabolic diseases.

Her main area of research is the identification of early events in the development of insulin resistance, type 2 diabetes, and cardiovascular disease. In recent years, her research activities specifically focused on the role of the complement system herein. This research encompasses both cohort studies and experimental work.

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

2012
- van Greevenbroek, M. M. J., Jacobs, M., van der Kallen, C. J. H., Blaak, E. E., Jansen, E., Schalkwijk, C. G., Feskens, E. J. M., & Stehouwer, C. D. A. (2012). Human plasma complement C3 is independently associated with coronary heart disease, but only in heavy smokers (the CODAM study). International Journal of Cardiology, 154(2), 158-162. https://doi.org/10.1016/j.ijcard.2010.09.017
- Wlazlo, N., van Greevenbroek, M. M. J., Ferreira, I., Bravenboer, B., & Stehouwer, C. D. A. (2012). The diagnosis of non-alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics, 35(1), 204-205. https://doi.org/10.1111/j.1365-2036.2011.04909.x
2011
- van Tienen, F. H. J., van der Kallen, C. J. H., Lindsey, P. J., Wanders, R. J., van Greevenbroek, M. M. J., & Smeets, H. J. M. (2011). Preadipocytes of type 2 diabetes subjects display an intrinsic gene expression profile of decreased differentiation capacity. International Journal of Obesity, 35(9), 1154-1164. https://doi.org/10.1038/ijo.2010.275
- Breyer, M. K., Rutten, E. P., Vernooy, J. H. J., Spruit, M. A., Dentener, M. A., van der Kallen, C. J., van Greevenbroek, M. M., & Wouters, E. F. M. (2011). Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): A pivotal role of leptin. Respiratory Medicine, 105(7), 1046-1053. https://doi.org/10.1016/j.rmed.2011.02.001
- Jacobs, M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Ferreira, I., Feskens, E. J., Jansen, E. H., Schalkwijk, C. G., & Stehouwer, C. D. (2011). The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the Cohort on Diabetes and Atherosclerosis Maastricht [CODAM] study).Metabolism-Clinical and Experimental, 60(7), 969-975. https://doi.org/10.1016/j.metabol.2010.09.006
- van Greevenbroek, M. M. J., Jacobs, M., van der Kallen, C. J. H., Vermeulen, V. M., Jansen, E. H., Schalkwijk, C. G., Ferreira, I., Feskens, E. J., & Stehouwer, C. D. A. (2011). The cross-sectional association between insulin resistance and circulating complement C3 is partly explained by plasma alanine aminotransferase, independent of central obesity and general inflammation (the CODAM study).European Journal of Clinical Investigation, 41(4), 372-379. https://doi.org/10.1111/j.1365-2362.2010.02418.x
- Thewissen, M. M. G. L., Damoiseaux, J. G. M. C., Duijvestijn, A. M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Feskens, E. J., Blaak, E. E., Schalkwijk, C. G., Stehouwer, C. D. A., Tervaert, J. W., & Ferreira, I. (2011). Abdominal Fat Mass Is Associated With Adaptive Immune Activation: The CODAM Study. Obesity, 19(8), 1690-1698. https://doi.org/10.1038/oby.2010.337
- Brouwers, M. C., van Greevenbroek, M. M. J., Troutt, J., Bonner Freeman, A., Lu, A., Schaper, N. C., Konrad, R. J., & Stehouwer, C. D. A. (2011). Plasma proprotein convertase subtilisin kexin type 9 is a heritable trait of familial combined hyperlipidemia. Clinical Science, 121(9), 397-403. https://doi.org/10.1042/CS20110129
- Brouwers, M. C., Troutt, J. S., van Greevenbroek, M. M. J., Ferreira, I., Feskens, E. J., van der Kallen, C. J. H., Schaper, N. C., Schalkwijk, C. G., Konrad, R. J., & Stehouwer, C. D. A. (2011). Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study. Atherosclerosis, 217(1), 263-267. https://doi.org/10.1016/j.atherosclerosis.2011.03.023
- Jacobs, M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Ferreira, I., Blaak, E. E., Feskens, E. J., Jansen, E. H., Schalkwijk, C. G., & Stehouwer, C. D. A. (2011). The association between the metabolic syndrome and peripheral, but not coronary, artery disease is partly mediated by endothelial dysfunction: the CODAM study.European Journal of Clinical Investigation, 41(2), 167-175. https://doi.org/10.1111/j.1365-2362.2010.02392.x
2010
- Brouwers, M. C. G. J., van der Kallen, C. J. H., Schaper, N. C., van Greevenbroek, M. M. J., & Stehouwer, C. D. A. (2010). Five-year incidence of type 2 diabetes mellitus in patients with familial combined hyperlipidaemia. Netherlands Journal of Medicine, 68(4), 163-167. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20421657
- Engelen, L., Ferreira, I., Gaens, K. H. J., Henry, R. M. A., Dekker, J. M., Nijpels, G., Heine, R. J., 't Hart, L. M., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Blaak, E. E., Feskens, E. J. M., ten Cate, H., Stehouwer, C. D. A., & Schalkwijk, C. G. (2010). The association between the-374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies. Journal of Hypertension, 28(2), 285-293. https://doi.org/10.1097/HJH.0b013e3283330931
- Brouwers, M. C., de Graaf, J., van Greevenbroek, M. M. J., Schaper, N. C., Stehouwer, C. D. A., & Stalenhoef, A. F. (2010). Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus.Current Opinion in Lipidology, 21(6), 530-538. https://doi.org/10.1097/MOL.0b013e32833ea9ec
2009
- Gaens, K. H., Ferreira, I., van der Kallen, C. J., van Greevenbroek, M. M., Blaak, E. E., Feskens, E. J., Dekker, J. M., Nijpels, G., Heine, R. J., 't Hart, L. M., de Groot, P. G., Stehouwer, C. D., & Schalkwijk, C. G. (2009). Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels.Journal of Clinical Endocrinology & Metabolism, 94(12), 5174-5180. https://doi.org/10.1210/jc.2009-1067
- van der Kallen, C. J., van Greevenbroek, M. M., Stehouwer, C. D., & Schalkwijk, C. G. (2009). Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?Apoptosis, 14(12), 1424-1434. https://doi.org/10.1007/s10495-009-0400-4
- Brouwers, M. C., Reesink, K. D., van Greevenbroek, M. M., Meinders, J. M., van der Kallen, C. J., Schaper, N., Hoeks, A. P., & Stehouwer, C. D. (2009). Increased arterial stiffness in familial combined hyperlipidemia. Journal of Hypertension, 27(5), 1009-16. https://doi.org/10.1097/HJH.0b013e32832991fa
- Jacobs, M., van Greevenbroek, M. M., van der Kallen, C. J., Ferreira, I., Blaak, E. E., Feskens, E. J., Jansen, E. H., Schalkwijk, C. G., & Stehouwer, C. D. (2009). Low-grade inflammation can partly explain the association between the metabolic syndrome and either coronary artery disease or severity of peripheral arterial disease: the CODAM study.European Journal of Clinical Investigation, 39(6), 437-444. https://doi.org/10.1111/j.1365-2362.2009.02129.x
- Theuwissen, E., Plat, J., van der Kallen, C. J., van Greevenbroek, M. M., & Mensink, R. P. (2009). Plant stanol supplementation decreases serum triacylglycerols in subjects with overt hypertriglyceridemia.Lipids, 44(12), 1131-1140. https://doi.org/10.1007/s11745-009-3367-6
2008
- Du, H., van der A, D. L., van Bakel, M. M., van der Kallen, C. J., Blaak, E. E., van Greevenbroek, M. M., Jansen, E. H., Nijpels, G., Stehouwer, C. D., Dekker, J. M., & Feskens, E. J. M. (2008). Glycemic index and glycemic load in relation to food and nutrient intake and metabolic risk factors in a Dutch population. American Journal of Clinical Nutrition, 87(3), 655-61. https://doi.org/10.1093/ajcn/87.3.655
- van den Berg, S. W., Jansen, E. H., Kruijshoop, M., Beekhof, P. K., Blaak, E., van der Kallen, C. J., van Greevenbroek, M. M., & Feskens, E. J. (2008). Paraoxonase 1 phenotype distribution and activity differs in subjects with newly diagnosed Type 2 diabetes (the CODAM Study). Diabetic Medicine, 25(2), 186-93. https://doi.org/10.1111/j.1464-5491.2007.02328.x
- Wang, P., Smit, E., Brouwers, M., Goossens, G. H., van der Kallen, C. J. H., van Greevenbroek, M. M. J., & Mariman, E. (2008). Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot.European Journal of Endocrinology, 159(6), 713-718. https://doi.org/10.1530/EJE-08-0521
- Brouwers, M. C., Dekker, J. M., van Greevenbroek, M. M., van der Kallen, C. J., Heine, R. J., de Bruin, T. W., & Stehouwer, C. D. (2008). Plasma triglycerides and LDL cholesterol are related in a parabolic fashion in the general population and patients with Type 2 diabetes mellitus: long-term follow-up results from the Hoorn study. Diabetic Medicine, 25(9), 1121-4. https://doi.org/10.1111/j.1464-5491.2008.02524.x
- Meex, S. J., van Vliet-Ostaptchouk, J. V., van der Kallen, C. J. H., van Greevenbroek, M. M. J., Schalkwijk, C. G., Feskens, E. J. M., Blaak, E. E., Wijmenga, C., Hofker, M. H., Stehouwer, C. D., & de Bruin, T. W. (2008). Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: Association study in 2000 Dutch Caucasians. Molecular Genetics and Metabolism, 94(3), 352-355. https://doi.org/10.1016/j.ymgme.2008.03.011
2007
- Meex, S. J., van Greevenbroek, M. M. J., Ayoubi, T. A., Vlietinck, R., van Vliet-Ostaptchouk, J. V., Hofker, M. H., Vermeulen, V. M., Schalkwijk, C. G., Feskens, E. J., Boer, J. M., Stehouwer, C. D., van der Kallen, C. J. H., & de Bruin, T. W. (2007). Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians. Journal of Clinical Endocrinology & Metabolism, 92(7), 2720-2725. https://doi.org/10.1210/jc.2006-2280
- van Greevenbroek, M. M., Vermeulen, V. M., Feskens, E. J., Evelo, C. T., Kruijshoop, M., Hoebee, B., van der Kallen, C. J., & de Bruin, T. W. (2007). Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus. Diabetic Medicine, 24(5), 498-504. https://doi.org/10.1111/j.1464-5491.2007.02109.x
- Wang, P., van Greevenbroek, M. M., Bouwman, F. G., Brouwers, M. C., van der Kallen, C. J. H., Smit, E., Keijer, J., & Mariman, E. C. (2007). The circulating PBEF/NAMPT/visfatin level is associated with a beneficial blood lipid profile. Pflugers Archiv-European Journal of Physiology, 454(6), 971-976. https://doi.org/10.1007/s00424-007-0262-y
2005
- Meex, S. J. R., van der Kallen, C. J. H., van Greevenbroek, M. M., Eurlings, P. M., El Hasnaoui, M. M., Evelo, C. T., Lindsey, P. J., Luiken, J. J. F. P., Glatz, J. F., & de Bruin, T. W. (2005). Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia. Faseb Journal, 19(14), 2063-2065. https://doi.org/10.1096/fj.04-2403fje
2002
- van Greevenbroek, M. M. J., Vermeulen, V. M. M. J., & de Bruin, T. W. A. (2002). Familial combined hyperlipidemia plasma stimulates protein secretion by HepG2 cells: identification of fibronectin in the differential secretion proteome. Journal of Lipid Research, 43(11), 1846-1854. https://doi.org/10.1194/jlr.M100441-JLR200
2000
- van Greevenbroek, M. M. J., van der Kallen, C. J. H., & de Bruin, T. W. A. (2000). Caco-2 cells secrete two independent classes of lipoproteins with distinct density: effect of the ratio of unsaturated to saturated fatty acid. Atherosclerosis, 149(1), 25-31. https://doi.org/10.1016/S0021-9150(99)00289-0
- van der Kallen, C. J. H., Cantor, R. M., van Greevenbroek, M. M. J., Geurts, J. M. W., Bouwman, F. G., Aouizerat, B. E., Allayee, H., Buurman, W. A., Lusis, A. J., Rotter, J. L., & de Bruin, T. W. A. (2000). Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. International Journal of Obesity, 24(11), 1381-1391. https://doi.org/10.1038/sj.ijo.0801412
- Geurts, J. M. W., Janssen, R. G. J. H., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Cantor, R. M., Bu, X., Aouizerat, B. E., Allayee, H., Lanning, C. D., Buurman, W. A., Rotter, J. L., & de Bruin, T. W. A. (2000). Identification of TNFRSF-1B as a novel modifier gene in familial combined hyperlipidemia. Human Molecular Genetics, 9(14), 2067-2074. https://doi.org/10.1093/hmg/9.14.2067
- van Greevenbroek, M. M. J., van der Kallen, C. J. H., Geurts, J. M. W., Janssen, R. G. J. H., Buurman, W. A., & de Bruin, T. W. A. (2000). Soluble receptors for tumor necrosis factor alpha (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia. Atherosclerosis, 153(1), 1-8. https://doi.org/10.1016/S0021-9150(00)00375-0
1998
- van Greevenbroek, M. M. J., & de Bruin, T. W. A. (1998). Chylomicron synthesis by intestinal cells in vitro and in vivo.Atherosclerosis, 141(Suppl.), S9-S16. https://doi.org/10.1016/S0021-9150(98)00212-3
- van Greevenbroek, M. M. J., Robertus-Teunissen, M. G., Erkelens, D. W., & de Bruin, T. W. A. (1998). Lipoprotein secretion by intestinal Caco-2 cells is affected differently by trans and cis unsaturated fatty acids: effect of carbon chain length and position of the double bond.American Journal of Clinical Nutrition, 68(3), 561-567. https://doi.org/10.1093/ajcn/68.3.561
- van Greevenbroek, M. M. J., Robertus-Teunissen, M. G., Erkelens, D. W., & de Bruin, T. W. A. (1998). Participation of the microsomal triglyceride transfer protein in lipoprotein assembly in Caco-2 cells: interaction with saturated and unsaturated dietary fatty acids.Journal of Lipid Research, 39(1), 173-185. https://doi.org/10.1016/S0022-2275(20)34213-9

Overview

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NWO Faculty of Impact grant awarded to Hongxing Luo

12 March 2026

Recap Anna Maria van Schurman Symposium 2026

11 March 2026

Marleen van Greevenbroek

Associate professor