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Social and economic background influences survival in intensive care: Research with societal impact

Social and economic background influences survival in intensive care: Research with societal impact

18 August 2026

A large-scale study by researchers from Maastricht UMC+ and Amsterdam UMC demonstrates that lower socioeconomic status (SES) of patients admitted to Dutch intensive care units contributes to worse survival.

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Fatma Karapinar appointed as Professor in Medication Safety

Fatma Karapinar appointed as Professor in Medication Safety

12 August 2026

As of 1 June 2026, Dr Fatma Karapinar has been appointed Professor of Medication Safety at Maastricht University.

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Carim Maastricht
Carim Maastricht

Jean Scheijen

Technical staff

Jean Scheijen is an Analytical Scientist at the Department of Internal Medicine, where he focuses on analytical method development and the application of advanced analytical techniques in biomedical research.

His expertise lies particularly in UPLC-MS/MS, with extensive experience in developing, optimising, and validating analytical methods for the analysis of biomolecules and advanced glycation endproducts (AGEs). His work combines mass spectrometry-based approaches with clinical and translational research, supporting investigations into metabolic disorders, diabetes, and cardiovascular disease.

He obtained his PhD for his research on 'The analysis of advanced glycation endproducts, a mass spectrometry based approach and its applications'. Over the course of his career, he has developed and implemented a broad range of LC-MS and UPLC-MS/MS methods, contributing to the advancement of quantitative analytical techniques within biomedical research.

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht, B5.334-B

  • 2026
    • Buziau, A. M., Simons, N., Tolan, D. R., Caiment, F., Scheijen, J. L. J. M., van de Waarenburg, M. P., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2026). Endogenous fructose production in patients and mice with aldolase B deficiency. Molecular Genetics and Metabolism, 149(1-2), Article 110219. https://doi.org/10.1016/j.ymgme.2026.110219
    • Ferrero, G., Mastrocola, R., Tarallo, S., Pardini, B., Scheijen, J., Van De Waarenburg, M., Gallo, G., Chatziioannou, A. C., Robinot, N., Keski-Rahkonen, P., Piccinno, G., Segata, N., Aglago, E. K., Hughes, D. J., Jenab, M., Schalkwijk, C. G., & Naccarati, A. (2026). Integrative analyses of dicarbonyls and advanced glycation end-products with multiomic profiles across tissue, plasma and stool samples reveal methylglyoxal accumulation in colon cancer. Free Radical Biology and Medicine, 246, 518-530. https://doi.org/10.1016/j.freeradbiomed.2026.01.034
    • Silvares, R. R., de Araujo, B. P., Pereira, E. N. G. D. S., Rodrigues, K. L., Barbosa, J. M. C., da Silva, J. F., da Silva, V. V. D., Van de Aarenburg, M., Scheijen, J., Wouters, K., Schalkwijk, C., & Daliry, A. (2026). Pyridoxamine reduces inflammatory and microcirculatory abnormalities in metabolic dysfunction-associated steatohepatitis and modulates key factors in the hepatic AGE/ALE signaling pathway. Frontiers in physiology, 16, Article 1736221. https://doi.org/10.3389/fphys.2025.1736221
  • 2025
    • van Oeteren, M. A. J., De Groot, D. M., Buziau, A. M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Kroon, A. A., Eussen, S. J. P. M., Dagnelie, P. C., Van Greevenbroek, M. M. J., Houben, A. J. H. M., Meex, S. J. R., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2025). The effects of dietary fructose on blood pressure are modified by the food matrix. Clinical Nutrition, 55, 134-140. https://doi.org/10.1016/j.clnu.2025.10.017
    • Lasfar, A., van Stratum, S. L. M., Imperatrice, M., van Kalkeren, C. A. J., Scheijen, J. L. J. M., Schalkwijk, C. G., La Torre, D., & Troost, F. J. (2025). Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes. Frontiers in nutrition, 12, Article 1670194. https://doi.org/10.3389/fnut.2025.1670194
    • Mayen, A.-L., Maasen, K., Hana, C., Knaze, V., Scheijen, J., Eussen, S. J. P. M., Vangrieken, P., Debras, C., Blanco, J., Dahm, C. C., Aleksandrova, K., Schulze, M. B., Dansero, L., Masala, G., Panico, S., Sieri, S., Guevara, M., Moreno Iribas, C., Petrova, D., ... Jenab, M. (2025). Higher intakes of dietary dicarbonyl compounds are associated with lower risk of cardiovascular disease. European Journal of Preventive Cardiology, 32(16), 1588-1600. Article zwaf060. https://doi.org/10.1093/eurjpc/zwaf060
    • Akinrimisi, O. I., Koning, M., Scheijen, J. L. J. M., Meijnikman, A. S., Sindhunata, D. P., Bruin, S., van de Laar, A., Franken, R., Acherman, Y., Gerdes, V. E. A., Nieuwdorp, M., Schalkwijk, C. G., & Hanssen, N. M. J. (2025). Higher plasma dicarbonyl levels are associated with liver fibrosis in obese individuals. Diabetes Obesity & Metabolism, 27(10), 5878-5888. https://doi.org/10.1111/dom.16643
    • Van den Eynde, M. D. G., van der Bruggen, M. M., Houben, A. J. H. M., Reesink, K. D., Spronck, B., Delhaas, T., Scheijen, J. J. L. J. M., Miyata, T., & Schalkwijk, C. G. (2025). Pyridoxamine does not reduce arterial stiffness in an 8-week randomized double-blind placebo-controlled intervention trial with abdominally obese individuals. Diabetes Obesity & Metabolism, 27(9), 5332-5336. https://doi.org/10.1111/dom.16524
    • Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
    • Tian, X., Scheijen, J. L. J. M., Van Pee, J., Van Royen, G., Schalkwijk, C. G., De Smet, S., & Van Hecke, T. (2025). High-moisture extruded pea balls exhibit lower (glyc)oxidative stability than pork balls following barbecuing and simulated gastrointestinal digestion. Food chemistry, 479, Article 143864. https://doi.org/10.1016/j.foodchem.2025.143864
    • Sun, D., van Greevenbroek, M. M. J., Scheijen, J. L. J. M., Kelly, J., Schalkwijk, C. G., & Wouters, K. (2025). Methylglyoxal mediates the association between 2-hour plasma glucose and HbA1c with inflammation: The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 110(7), 2047–2054. https://doi.org/10.1210/clinem/dgae640
    • Akinrimisi, O. I., Maasen, K., Scheijen, J. L. J. M., Nemet, I., Nieuwdorp, M., Schalkwijk, C. G., & Hanssen, N. M. J. (2025). Does Gut Microbial Methylglyoxal Metabolism Impact Human Physiology?Antioxidants, 14(7), Article 763. https://doi.org/10.3390/antiox14070763
    • Nokin, M.-J., Bellier, J., Durieux, F., Peulen, O., Rademaker, G., Gabriel, M., Monseur, C., Charloteaux, B., Verbeke, L., van Laere, S., Roncarati, P., Herfs, M., Lambert, C., Scheijen, J., Schalkwijk, C., Colige, A., Caers, J., Delvenne, P., Turtoi, A., ... Bellahcene, A. (2025). Correction: Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer (vol 21, 11, 2019). Breast Cancer Research, 27(1), Article 99. https://doi.org/10.1186/s13058-025-02044-3
    • Zhang, X., van Greevenbroek, M. M. J., Scheijen, J. L. J. M., Eussen, S. J. P. M., Kelly, J., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2025). Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study. Journal of Endocrinological Investigation, 48(5), 1257-1268. https://doi.org/10.1007/s40618-025-02536-1
    • Berends, E., Vangrieken, P., Amiri, N., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Schalkwijk, C. G., & Foulquier, S. (2025). Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice. Molecular Neurobiology, 62(4), 4190-4202. Article 101148. https://doi.org/10.1007/s12035-024-04552-3
    • Koene, E. J., Buziau, A. M., Cassiman, D., Cox, T. M., Bons, J., Scheijen, J. L. J. M., Schalkwijk, C. G., Meex, S. J., Saxena, A. R., Esler, W. P., Schrauwen-Hinderling, V. B., Schrauwen, P., & Brouwers, M. C. (2025). Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance. Journal of Clinical Investigation, 135(6), Article e187376. https://doi.org/10.1172/JCI187376
    • Vangrieken, P., Scheijen, J. L. J. M., Schiffers, P. M. H., van de Waarenburg, M. P. H., Foulquier, S., & Schalkwijk, C. C. G. (2025). Modelling the effects of elevated methylglyoxal levels on vascular and metabolic complications. Scientific Reports, 15(1), Article 6025. https://doi.org/10.1038/s41598-025-90661-5
  • 2024
    • Lemmens, T. P., Luo, Q., Wielders, S. J. H., Scheijen, J. L. J. M., Al-Nasiry, S., Koenen, R. R., Wenzel, P., & Cosemans, J. M. E. M. (2024). Platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates. Thrombosis Research, 244, Article 109201. https://doi.org/10.1016/j.thromres.2024.109201
    • Berends, E., Pencheva, M. G., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2024). Glyoxalase 1 overexpression improves neurovascular coupling and limits development of mild cognitive impairment in a mouse model of type 1 diabetes. Journal of Physiology, 602(22), 6209-6223. https://doi.org/10.1113/JP286723
    • Vangrieken, P., Al-Nasiry, S., Remels, A. H. V., Schiffers, P. M. H., Janssen, E., Nass, S., Scheijen, J. L. J. M., Spaanderman, M. E. A., & Schalkwijk, C. G. (2024). Placental Methylglyoxal in Preeclampsia: Vascular and Biomarker Implications. Hypertension, 81(7), 1537-1549. https://doi.org/10.1161/HYPERTENSIONAHA.123.22633
  • 2023
    • Piazza, M., Hanssen, N. M. J., Scheijen, J. L. J. M., Vd Waarenburg, M., Caroccia, B., Seccia, T. M., Stehouwer, C. D. A., Rossi, G. P., & Schalkwijk, C. G. (2023). Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma. Journal of Human Hypertension, 37(10), 919-924. https://doi.org/10.1038/s41371-022-00773-y
    • Bednarska, K., Fecka, I., Scheijen, J. L. J. M., Ahles, S., Vangrieken, P., & Schalkwijk, C. G. (2023). A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial. International Journal of Molecular Sciences, 24(17), Article 13168. https://doi.org/10.3390/ijms241713168
    • Buziau, A. M., Scheijen, J. L. J. M., Stehouwer, C. D. A., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2023). Effects of fructose added to an oral glucose tolerance test on plasma glucose excursions in healthy adults. Metabolism open, 18(1), Article 100245. https://doi.org/10.1016/j.metop.2023.100245
    • van den Eynde, M. D. G., Houben, A. J. H. M., Scheijen, J. L. J. M., Linkens, A. M. A., Niessen, P. M., Simons, N., Hanssen, N. M. J., Kusters, Y. H. A. M., Eussen, S. J. M. P., Miyata, T., Stehouwer, C. D. A., & Schalkwijk, C. G. (2023). Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial. Diabetes Obesity & Metabolism, 25(5), 1280-1291. https://doi.org/10.1111/dom.14977
    • Buziau, A. M., Blokland, G. A. M., Schalkwijk, C. G., Scheijen, J. L. J. M., Simons, P. I. H. G., Eussen, S. J. P. M., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2023). Comment on Lee et al. Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies. Diabetes Care 2022;45. Diabetes Care, 46(4), E97-E98. https://doi.org/10.2337/dc22-1930
    • Zhang, X. D., Scheijen, J. L. J. M., Stehouwer, C. D. A., Wouters, K., & Schalkwijk, C. G. (2023). Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose. Clinical Science, 137(8), 697-706. https://doi.org/10.1042/CS20220753
    • Buziau, A. M., Law, P. J., Blokland, G., Schalkwijk, C., Scheijen, J., Simons, P., van der Kallen, C., Eussen, S., Dagnelie, P. C., van Greevenbroek, M., Houlston, R. S., Wesselius, A., Went, M., Stehouwer, C., & Brouwers, M. C. (2023). Genetically proxied ketohexokinase function and risk of colorectal cancer: a Mendelian randomisation study. Gut, 72(3), 604-606. https://doi.org/10.1136/gutjnl-2021-326299
    • Hanssen, N. M. J., Tikellis, C., Pickering, R. J., Dragoljevic, D., Lee, M. K. S., Block, T., Scheijen, J. L. J. M., Wouters, K., Miyata, T., Cooper, M. E., Murphy, A. J., Thomas, M. C., & Schalkwijk, C. G. (2023). Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE-/- mice. Biomedicine & Pharmacotherapy, 158(1), Article 114211. https://doi.org/10.1016/j.biopha.2022.114211
    • de Graaf, M. C. G., Scheijen, J. L. J. M., Spooren, C. E. G. M., Mujagic, Z., Pierik, M. J., Feskens, E. J. M., Keszthelyi, D., Schalkwijk, C. G., & Jonkers, D. M. A. E. (2023). The Intake of Dicarbonyls and Advanced Glycation Endproducts as Part of the Habitual Diet Is Not Associated with Intestinal Inflammation in Inflammatory Bowel Disease and Irritable Bowel Syndrome Patients. Nutrients, 15(1), Article 83. https://doi.org/10.3390/nu15010083
  • 2022
    • Csongová, M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Gurecká, R., Koborová, I., Tábi, T., Szökö, É., Schalkwijk, C. G., & Šebeková, K. (2022). Association of α-Dicarbonyls and Advanced Glycation End Products with Insulin Resistance in Non-Diabetic Young Subjects: A Case-Control Study. Nutrients, 14(22), Article 4929. https://doi.org/10.3390/nu14224929
    • Wölfel, E. M., Schmidt, F. N., Vom Scheidt, A., Siebels, A. K., Wulff, B., Mushumba, H., Ondruschka, B., Püschel, K., Scheijen, J., Schalkwijk, C. G., Vettorazzi, E., Jähn-Rickert, K., Gludovatz, B., Schaible, E., Amling, M., Rauner, M., Hofbauer, L. C., Zimmermann, E. A., & Busse, B. (2022). Dimorphic mechanisms of fragility in diabetes mellitus - the role of reduced collagen fibril deformation. Journal of Bone and Mineral Research, 37(11), 2259-2276. https://doi.org/10.1002/jbmr.4706
    • Leung, S. S., Borg, D. J., McCarthy, D. A., Boursalian, T. E., Cracraft, J., Zhuang, A., Fotheringham, A. K., Flemming, N., Watkins, T., Miles, J. J., Groop, P.-H., Scheijen, J. L., Schalkwijk, C. G., Steptoe, R. J., Radford, K. J., Knip, M., & Forbes, J. M. (2022). Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells. Diabetes, 71(9), 1994-2008. https://doi.org/10.2337/db22-0177
    • Linkens, A. M. A., van Best, N., Niessen, P. M., Wijckmans, N. E. G., de Goei, E. E. C., Scheijen, J. L. J. M., van Dongen, M. C. J. M., van Gool, C. C. J. A. W., de Vos, W. M., Houben, A. J. H. M., Stehouwer, C. D. A., Eussen, S. J. M. P., Penders, J., & Schalkwijk, C. G. (2022). A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial. International journal of molecular sciences, 23(10), Article 5328. https://doi.org/10.3390/ijms23105328
    • Linkens, A. M. A., Houben, A. J., Niessen, P. M., Wijckmans, N., de Goei, E., Van den Eynde, M. D. G., Scheijen, J. L. J. M., Waarenburg, M., Mari, A., Berendschot, T. T. J. M., Streese, L., Hanssen, H., van Dongen, M. C. J. M., van Gool, C., Stehouwer, C. D. A., Eussen, S. J. P. M., & Schalkwijk, C. (2022). A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals. JCI INSIGHT, 7(6), Article e156950. https://doi.org/10.1172/jci.insight.156950
    • Maasen, K., Eussen, S. J. P. M., Scheijen, J. L. J. M., van der Kallen, C. J. H., Dagnelie, P. C., Opperhuizen, A., Stehouwer, C. D. A., van Greevenbroek, M. M. J., & Schalkwijk, C. G. (2022). Higher habitual intake of dietary dicarbonyls is associated with higher corresponding plasma dicarbonyl concentrations and skin autofluorescence: the Maastricht Study. American Journal of Clinical Nutrition, 115(1), 34-44. https://doi.org/10.1093/ajcn/nqab329
  • 2021
    • van Dongen, K. C. W., Linkens, A. M. A., Wetzels, S. M. W., Wouters, K., Vanmierlo, T., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., de Vos, W. M., Belzer, C., & Schalkwijk, C. G. (2021). Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility. Food Research International, 147, Article 110547. https://doi.org/10.1016/j.foodres.2021.110547
    • Piazza, M., Hanssen, N. M. J., Persson, F., Scheijen, J. L., van de Waarenburg, M. P. H., van Greevenbroek, M. M. J., Rossing, P., Hovind, P., Stehouwer, C. D. A., Parving, H.-H., & Schalkwijk, C. G. (2021). Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study. Diabetic Medicine, 38(9), Article e14405. https://doi.org/10.1111/dme.14405
    • Wouters, K., Cento, A. S., Gaens, K. H., Teunissen, M., Scheijen, J. L. J. M., Barutta, F., Chiazza, F., Collotta, D., Aragno, M., Gruden, G., Collino, M., Schalkwijk, C. G., & Mastrocola, R. (2021). Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems. Scientific Reports, 11(1), Article 17373. https://doi.org/10.1038/s41598-021-96859-7
    • Driessen, R. G. H., Kiers, D., Schalkwijk, C. G., Scheijen, J. L. J. M., Gerretsen, J., Pickkers, P., van de Poll, M. C. G., van der Horst, I. C. C., Bergmans, D. C. J. J., Kox, M., & van Bussel, B. C. T. (2021). Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. Bioscience Reports, 41(7), Article BSR20210954. https://doi.org/10.1042/BSR20210954
    • Van den Eynde, M. D. G., Scheijen, J. L. J. M., Stehouwer, C. D. A., Miyata, T., & Schalkwijk, C. G. (2021). Quantification of the B6 vitamers in human plasma and urine in a study with pyridoxamine as an oral supplement; pyridoxamine as an alternative for pyridoxine. Clinical Nutrition, 40(7), 4624-4632. https://doi.org/10.1016/j.clnu.2021.05.028
    • Borg, D. J., Faridi, P., Giam, K. L., Reeves, P., Fotheringham, A. K., McCarthy, D. A., Leung, S., Ward, M. S., Harcourt, B. E., Ayala, R., Scheijen, J. L., Briskey, D., Dudek, N. L., Schalkwijk, C. G., Steptoe, R., Purcell, A. W., & Forbes, J. M. (2021). Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model. Metabolites, 11(7), Article 426. https://doi.org/10.3390/metabo11070426
    • Maasen, K., Scheijen, J. L. J. M., Opperhuizen, A., Stehouwer, C. D. A., Van Greevenbroek, M. M., & Schalkwijk, C. G. (2021). Corrigendum to “Quantification of dicarbonyl compounds in commonly consumed foods and drinks; presentation of a food composition database for dicarbonyls” [Food Chemistry, 339 (2020) 128063]. Food Chemistry, 344, Article 128578. https://doi.org/10.1016/j.foodchem.2020.128578
    • Van den Eynde, M. D. G., Kusters, Y. H. A. M., Houben, A. J. H. M., Scheijen, J. L. J. M., van Duynhoven, J., Fazelzadeh, P., Joris, P. J., Plat, J., Mensink, R. P., Hanssen, N. M. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial. Clinical Nutrition, 40(5), 2654-2662. https://doi.org/10.1016/j.clnu.2021.03.042
    • Maasen, K., Scheijen, J. L. J. M., Opperhuizen, A., Stehouwer, C. D. A., Van Greevenbroek, M. M., & Schalkwijk, C. G. (2021). Quantification of dicarbonyl compounds in commonly consumed foods and drinks; presentation of a food composition database for dicarbonyls. Food Chemistry, 339, Article 128063. https://doi.org/10.1016/j.foodchem.2020.128063
    • Hanssen, N. M. J., Scheijen, J. L. J. M., Houben, A. J. H. M., van de Waarenburg, M., Berendschot, T. T. J. M., Webers, C. A. B., Reesink, K. D., van Greevenbroek, M. M. J., van der Kallen, C., Schaper, N. C., Schram, M. T., Henry, R. M. A., Stehouwer, C. D. A., & Schalkwijk, C. G. (2021). Fasting and post-oral-glucose-load levels of methylglyoxal are associated with microvascular, but not macrovascular, disease in individuals with and without (pre)diabetes: The Maastricht Study. Diabetes & Metabolism, 47(1), Article 101148. https://doi.org/10.1016/j.diabet.2020.02.002
    • Hanssen, N. M. J., Teraa, M., Scheijen, J. L. J. M., Van de Waarenburg, M., Gremmels, H., Stehouwer, C. D. A., Verhaar, M. C., & Schalkwijk, C. G. (2021). Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes. Diabetes Care, 44(1), 157-163. https://doi.org/10.2337/dc20-0581
  • 2020
    • Atzeni, I. M., Boersema, J., Pas, H. H., Diercks, G. F. H., Scheijen, J. L. J. M., Schalkwijk, C. G., Mulder, D. J., van der Zee, P., & Smit, A. J. (2020). Is skin autofluorescence (SAF) representative of dermal advanced glycation endproducts (AGEs) in dark skin? A pilot study. Heliyon, 6(11), Article 05364. https://doi.org/10.1016/j.heliyon.2020.e05364
    • Buziau, A. M., Scheijen, J. L. J. M., Stehouwer, C. D. A., Simons, N., Brouwers, M. C. G. J., & Schalkwijk, C. G. (2020). Development and validation of a UPLC-MS/MS method to quantify fructose in serum and urine. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1155, Article 122299. https://doi.org/10.1016/j.jchromb.2020.122299
    • Martens, R. J. H., Broers, N. J. H., Canaud, B., Christiaans, M. H. L., Cornelis, T., Gauly, A., Hermans, M. M. H., Konings, C. J. A. M., van der Sande, F. M., Scheijen, J. L. J. M., Stifft, F., Kooman, J. P., & Schalkwijk, C. G. (2020). Advanced glycation endproducts and dicarbonyls in end-stage renal disease: associations with uraemia and courses following renal replacement therapy. Clinical Kidney Journal, 13(5), 855-866. https://doi.org/10.1093/ckj/sfz099
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