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Social and economic background influences survival in intensive care: Research with societal impact

Social and economic background influences survival in intensive care: Research with societal impact

18 August 2026

A large-scale study by researchers from Maastricht UMC+ and Amsterdam UMC demonstrates that lower socioeconomic status (SES) of patients admitted to Dutch intensive care units contributes to worse survival.

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Fatma Karapinar appointed as Professor in Medication Safety

Fatma Karapinar appointed as Professor in Medication Safety

12 August 2026

As of 1 June 2026, Dr Fatma Karapinar has been appointed Professor of Medication Safety at Maastricht University.

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Carim Maastricht
Carim Maastricht

Jean Scheijen

Technical staff

Jean Scheijen is an Analytical Scientist at the Department of Internal Medicine, where he focuses on analytical method development and the application of advanced analytical techniques in biomedical research.

His expertise lies particularly in UPLC-MS/MS, with extensive experience in developing, optimising, and validating analytical methods for the analysis of biomolecules and advanced glycation endproducts (AGEs). His work combines mass spectrometry-based approaches with clinical and translational research, supporting investigations into metabolic disorders, diabetes, and cardiovascular disease.

He obtained his PhD for his research on 'The analysis of advanced glycation endproducts, a mass spectrometry based approach and its applications'. Over the course of his career, he has developed and implemented a broad range of LC-MS and UPLC-MS/MS methods, contributing to the advancement of quantitative analytical techniques within biomedical research.

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht, B5.334-B

  • 2020
    • Zhang, C., Couppe, C., Scheijen, J. L. J. M., Schalkwijk, C. G., Kjaer, M., Magnusson, S. P., & Svensson, R. B. (2020). Regional collagen turnover and composition of the human patellar tendon. Journal of Applied Physiology, 128(4), 884-891. https://doi.org/10.1152/japplphysiol.00030.2020
    • Schutten, M. T. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Niessen, H. E., Roodt, J. O., Scheijen, J. L. J. M., van de Waardenburg, M. P., Schalkwijk, C. G., de Leeuw, P. W., & Stehouwer, C. D. A. (2020). Glucocorticoids affect metabolic but not muscle microvascular insulin sensitivity following high versus low salt intake. JCI INSIGHT, 5(6), Article 127530. https://doi.org/10.1172/jci.insight.127530
    • Bellier, J., Nokin, M. J., Caprasse, M., Tiamiou, A., Blomme, A., Scheijen, J. L., Koopmansch, B., MacKay, G. M., Chiavarina, B., Costanza, B., Rademaker, G., Durieux, F., Agirman, F., Maloujahmoum, N., Cusumano, P. G., Lovinfosse, P., Leung, H. Y., Lambert, F., Bours, V., ... Bellahcene, A. (2020). Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab. Cell Reports, 30(5), 1400-1416.e6. https://doi.org/10.1016/j.celrep.2020.01.012
  • 2019
    • Martens, R. J. H., Broers, N. J. H., Canaud, B., Christiaans, M. H. L., Cornelis, T., Gauly, A., Hermans, M. M. H., Konings, C. J. A. M., van Der Sande, F. M., Scheijen, J. L. J. M., Stifft, F., Wirtz, J. J. J. M., Kooman, J. P., & Schalkwijk, C. G. (2019). Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study. PLOS ONE, 14(8), Article 0221058. https://doi.org/10.1371/journal.pone.0221058
    • Maasen, K., van Greevenbroek, M. M. J., Scheijen, J. L. J. M., van der Kallen, C. J. H., Stehouwer, C. D. A., & Schalkwijk, C. G. (2019). High dietary glycemic load is associated with higher concentrations of urinary advanced glycation endproducts: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) Study. American Journal of Clinical Nutrition, 110(2), 358-366. https://doi.org/10.1093/ajcn/nqz119
    • Wetzels, S., Vanmierlo, T., Scheijen, J. L. J. M., van Horssen, J., Amor, S., Somers, V., Schalkwijk, C. G., Hendriks, J. J. A., & Wouters, K. (2019). Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions. Frontiers in Immunology, 10(APR), Article 855. https://doi.org/10.3389/fimmu.2019.00855
    • Nokin, M.-J., Bellier, J., Durieux, F., Peulen, O., Rademaker, G., Gabriel, M., Monseur, C., Charloteaux, B., Verbeke, L., van Laere, S., Roncarati, P., Herfs, M., Lambert, C., Scheijen, J., Schalkwijk, C., Colige, A., Caers, J., Delvenne, P., Turtoi, A., ... Bellahcene, A. (2019). Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer. Breast Cancer Research, 21(1), Article 11. https://doi.org/10.1186/s13058-018-1095-7
    • Bijnen, M., van Greevenbroek, M. M. J., van Der Kallen, C. J. H., Scheijen, J. L., van de Waarenburg, M. P. H., Stehouwer, C. D. A., Wouters, K., & Schallcwijk, C. G. (2019). Hepatic Fat Content and Liver Enzymes Are Associated with Circulating Free and Protein-Bound Advanced Glycation End Products, Which Are Associated with Low-Grade Inflammation: The CODAM Study. Journal of Diabetes Research, 2019, Article 6289831. https://doi.org/10.1155/2019/6289831
  • 2018
    • Van den Eynde, M. D. G., Geleijnse, J. M., Scheijen, J. L. J. M., Hanssen, N. M. J., Dower, J. I., Afman, L. A., Stehouwer, C. D. A., Hollman, P. C. H., & Schalkwijk, C. G. (2018). Quercetin, but Not Epicatechin, Decreases Plasma Concentrations of Methylglyoxal in Adults in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial with Pure Flavonoids. Journal of Nutrition, 148(12), 1911-1916. https://doi.org/10.1093/jn/nxy236
    • Bijnen, M., Beelen, N., Wetzels, S., van De Gaar, J., Vroomen, M., Wijnands, E., Scheijen, J. L., van de Waarenburg, M. P. H., Gijbels, M. J., Cleutjens, J. P., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2018). RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr(-/-) mice. Scientific Reports, 8(1), Article 15256. https://doi.org/10.1038/s41598-018-33661-y
    • Hanssen, N. M. J., Westerink, J., Scheijen, J. L. J. M., van der Graaf, Y., Stehouwer, C. D. A., Schalkwijk, C. G., & SMART Study Grp (2018). Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes. Diabetes Care, 41(8), 1689-1695. https://doi.org/10.2337/dc18-0159
    • Scheijen, J. L. J. M., Hanssen, N. M. J., van Greevenbroek, M. M., van der Kallen, C. J., Feskens, E. J. M., Stehouwer, C. D. A., & Schalkwijk, C. G. (2018). Dietary intake of advanced glycation endproducts is associated with higher levels of advanced glycation endproducts in plasma and urine: The CODAM study. Clinical Nutrition, 37(3), 919-925. https://doi.org/10.1016/j.clnu.2017.03.019
    • Wetzels, S., Wouters, K., Miyata, T., Scheijen, J. L. J. M., Hendriks, J. J. A., Schalkwijk, C. G., & Vanmierlo, T. (2018). Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression. International journal of molecular sciences, 19(5), Article 1311. https://doi.org/10.3390/ijms19051311
    • Schutten, M. T. J., Kusters, Y. H. A. M., Houben, A. J. H. M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Schalkwijk, C. G., Joris, P. J., Plat, J., Mensink, R. P., de Leeuw, P. W., & Stehouwer, C. D. A. (2018). Aldosterone Is Not Associated With Metabolic and Microvascular Insulin Sensitivity in Abdominally Obese Men. Journal of Clinical Endocrinology & Metabolism, 103(2), 759-767. https://doi.org/10.1210/jc.2017-01541
  • 2017
    • Hanssen, N. M. J., Scheijen, J. L. J. M., Jorsal, A., Parving, H.-H., Tarnow, L., Rossing, P., Stehouwer, C. D. A., & Schalkwijk, C. G. (2017). Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study. Diabetes, 66(8), 2278-2283. https://doi.org/10.2337/db16-1578
    • Fokkens, B. T., Mulder, D. J., Schalkwijk, C. G., Scheijen, J. L., Smit, A. J., & Los, L. I. (2017). Vitreous advanced glycation endproducts and alpha-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls. PLOS ONE, 12(3), Article e0173379. https://doi.org/10.1371/journal.pone.0173379
    • Skovgaard, D., Svensson, R. B., Scheijen, J., Eliasson, P., Mogensen, P., Hag, A. M. F., Kjær, M., Schalkwijk, C. G., Schjerling, P., Magnusson, S. P., & Couppé, C. (2017). An advanced glycation endproduct (AGE)-rich diet promotes accumulation of AGEs in Achilles tendon. Physiological Reports, 5(6), Article e13215. https://doi.org/10.14814/phy2.13215
    • Pearce, K., Hatzinikolas, A., Moran, L., de Courten, M. P. J., Forbes, J., Scheijen, J. L. J. M., Schalkwijk, C. G., Walker, K., & de Courten, B. (2017). Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity. International Journal of Food Sciences and Nutrition, 68(8), 1021-1026. https://doi.org/10.1080/09637486.2017.1319468
  • 2016
    • Fokkens, B. T., Mulder, D. J., Nugteren, M. B., Schalkwijk, C. G., Scheijen, J. L., Smit, A. J., & Los, L. I. (2016). Surface Area of Detachment, Proliferative Vitreoretinopathy, and Pulse Pressure, but not AGEs, are Associated With Retinal Redetachment. Investigative Ophthalmology & Visual Science, 57(15), 6633-6638. https://doi.org/10.1167/iovs.16-20735
    • Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Scheijen, J. L., Schalkwijk, C. G., Leenders, J., De Tullio, P., Bianchi, E., Thiry, M., Uchida, K., Spiegel, D. A., Cochrane, J. R., ... Bellahcene, A. (2016). Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. Elife, 5(OCTOBER2016), Article e19375. https://doi.org/10.7554/elife.19375
    • van Eupen, M. G. A., Schram, M. T., van Sloten, T. T., Scheijen, J., Sep, S. J. S., van der Kallen, C. J., Dagnelie, P. C., Koster, A., Schaper, N., Henry, R. M. A., Kroon, A. A., Smit, A. J., Stehouwer, C. D. A., & Schalkwijk, C. G. (2016). Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening: The Maastricht Study. Hypertension, 68(4), 956-963. https://doi.org/10.1161/HYPERTENSIONAHA.116.07446
    • Maessen, D. E., Hanssen, N. M., Lips, M. A., Scheijen, J. L., van Dijk, K. W., Pijl, H., Stehouwer, C. D., & Schalkwijk, C. G. (2016). Energy restriction and Roux-en-Y gastric bypass reduce postprandial alpha-dicarbonyl stress in obese women with type 2 diabetes. Diabetologia, 59(9), 2013-2017. https://doi.org/10.1007/s00125-016-4009-1
    • de Courten, B., de Courten, M. P. J., Soldatos, G., Dougherty, S. L., Straznicky, N., Schlaich, M., Sourris, K. C., Chand, V., Scheijen, J. L. J. M., Kingwell, B. A., Cooper, M. E., Schalkwijk, C. G., Walker, K. Z., & Forbes, J. M. (2016). Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial. American Journal of Clinical Nutrition, 103(6), 1426-1433. https://doi.org/10.3945/ajcn.115.125427
    • Scheijen, J. L. J. M., Clevers, E., Engelen, L., Dagnelie, P. C., Brouns, F., Stehouwer, C. D. A., & Schalkwijk, C. G. (2016). Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: Presentation of a dietary AGE database. Food Chemistry, 190, 1145-1150. https://doi.org/10.1016/j.foodchem.2015.06.049
  • 2015
    • Cornelis, T., Eloot, S., Vanholder, R., Glorieux, G., van der Sande, F. M., Scheijen, J. L., Leunissen, K. M., Kooman, J. P., & Schalkwijk, C. G. (2015). Protein-bound uraemic toxins, dicarbonyl stress and advanced glycation end products in conventional and extended haemodialysis and haemodiafiltration. Nephrology Dialysis Transplantation, 30(8), 1395-1402. https://doi.org/10.1093/ndt/gfv038
    • Maessen, D. E., Hanssen, N. M., Scheijen, J. L., van der Kallen, C. J., van Greevenbroek, M. M., Stehouwer, C. D., & Schalkwijk, C. G. (2015). Post-Glucose Load Plasma alpha-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study. Diabetes Care, 38(5), 913-920. https://doi.org/10.2337/dc14-2605
    • Engelen, L., Schalkwijk, C. G., Eussen, S. J. P. M., Scheijen, J. L. J. M., Soedamah-Muthu, S. S., Chaturvedi, N., Fuller, J. H., & Stehouwer, C. D. A. (2015). Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study. Cardiovascular Diabetology, 14(1), Article 67. https://doi.org/10.1186/s12933-015-0231-2
    • Hanssen, N. M. J., Beulens, J. W. J., van Dieren, S., Scheijen, J. L. J. M., van der A, D. L., Spijkerman, A. M. W., van der Schouw, Y. T., Stehouwer, C. D. A., & Schalkwijk, C. G. (2015). Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL). Diabetes, 64(1), 257-265. https://doi.org/10.2337/db13-1864
  • 2014
    • Eriksen, C., Svensson, R. B., Scheijen, J., Hag, A. M. F., Schalkwijk, C., Praet, S. F. E., Schjerling, P., Kjaer, M., Magnusson, S. P., & Couppe, C. (2014). Systemic stiffening of mouse tail tendon is related to dietary advanced glycation end products but not high-fat diet or cholesterol. Journal of Applied Physiology, 117(8), 840-847. https://doi.org/10.1152/japplphysiol.00584.2014
    • Hanssen, N. M. J., Wouters, K., Huijberts, M. S., Gijbels, M. J., Sluimer, J. C., Scheijen, J. L. J. M., Heeneman, S., Biessen, E. A. L., Daemen, M. J. A. P., Brownlee, M., de Kleijn, D. P., Stehouwer, C. D. A., Pasterkamp, G., & Schalkwijk, C. G. (2014). Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype. European Heart Journal, 35(17), 1137-1146. https://doi.org/10.1093/eurheartj/eht402
    • Gopal, P., Reynaert, N. L., Scheijen, J. L. J. M., Schalkwijk, C. G., Franssen, F. M. E., Wouters, E. F. M., & Rutten, E. P. A. (2014). Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD. Respiratory Research, 15(1), Article 24. https://doi.org/10.1186/1465-9921-15-24
    • Gopal, P., Reynaert, N. L., Scheijen, J. L. J. M., Engelen, L., Schalkwijk, C. G., Franssen, F. M. E., Wouters, E. F. M., & Rutten, E. P. A. (2014). Plasma advanced glycation end-products and skin autofluorescence are increased in COPD. European Respiratory Journal, 43(2), 430-438. https://doi.org/10.1183/09031936.00135312
    • Scheijen, J. L. J. M., & Schalkwijk, C. G. (2014). Quantification of glyoxal, methylglyoxal and 3-deoxyglucosone in blood and plasma by ultra performance liquid chromatography tandem mass spectrometry: evaluation of blood specimen. Clinical Chemistry and Laboratory Medicine, 52(1), 85-91. https://doi.org/10.1515/cclm-2012-0878
  • 2013
    • van Eupen, M. G. A., Schram, M. T., Colhoun, H. M., Scheijen, J. L. J. M., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013). Plasma levels of advanced glycation endproducts are associated with type 1 diabetes and coronary artery calcification. Cardiovascular Diabetology, 12(1), Article 149. https://doi.org/10.1186/1475-2840-12-149
    • Hanssen, N. M. J., Engelen, L., Ferreira, I., Scheijen, J. L. J. M., Huijberts, M. S., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013). Plasma Levels of Advanced Glycation Endproducts N-is an element of-(carboxymethyl)lysine, N-is an element of-(carboxyethyl)lysine, and Pentosidine Are not Independently Associated With Cardiovascular Disease in Individuals With or Without Type 2 Diabetes: The Hoorn and CODAM Studies. Journal of Clinical Endocrinology & Metabolism, 98(8), E1369-E1373. https://doi.org/10.1210/jc.2013-1068
  • 2012
    • Alkhalaf, A., Kleefstra, N., Groenier, K. H., Bilo, H. J. G., Gans, R. O. B., Heeringa, P., Scheijen, J. L., Schalkwijk, C. G., Navis, G. J., & Bakker, S. J. L. (2012). Effect of Benfotiamine on Advanced Glycation Endproducts and Markers of Endothelial Dysfunction and Inflammation in Diabetic Nephropathy. PLOS ONE, 7(7), e40427. https://doi.org/10.1371/journal.pone.0040427
    • Scheijen, J. L. J. M., Hanssen, N. M., van de Waarenburg, M. P., Jonkers, D. M. A. E., Stehouwer, C. D. A., & Schalkwijk, C. G. (2012). L(+) and d(-) lactate are increased in plasma and urine samples of type 2 diabetes as measured by a simultaneous quantification of l(+) and d(-) lactate by reversed-phase liquid chromatography tandem mass spectrometry. Experimental Diabetes Research, 2012, Article 234812. https://doi.org/10.1155/2012/234812
  • 2009
    • Scheijen, J. L. J. M., van de Waarenburg, M. P., Stehouwer, C. D., & Schalkwijk, C. G. (2009). Measurement of pentosidine in human plasma protein by a single-column high-performance liquid chromatography method with fluorescence detection.Journal of Chromatography B, 877(7), 610-614. https://doi.org/10.1016/j.jchromb.2009.01.022
  • 2008
    • Baumann, M., Stehouwer, C. D. A., Scheijen, J. L. J. M., Heemann, U., Struijker Boudier, H. A. J., & Schalkwijk, C. G. (2008). N{epsilon}-(carboxymethyl)lysine during the early development of hypertension. Annals of the New York Academy of Sciences, 1126, 201-4. https://doi.org/10.1196/annals.1433.004
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