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MUMC+ Award Prof. Michael Jacobs

MUMC+ Award Prof. Michael Jacobs

3 May 2024

With a symposium in the St. Janskerk and a farewell lecture in the aula, vascular surgeon and professor Michael Jacobs bid farewell last Friday. From board chairman Helen Mertens, he received the MUMC+ Award, the highest distinction within the MUMC+, in recognition of all he has meant for Maastricht UMC+ and its patients.

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Prof. Kevin Vernooy Director HVC

Prof. Kevin Vernooy Director HVC

30 April 2024

Prof. Kevin Vernooy will become the medical director of the Heart+Vascular Center (HVC) at Maastricht UMC+.

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Carim Maastricht
Carim Maastricht

Guido Haenen

Assistant Professor

Prof/ Guido Haenen is currently Professor in 'Redox Modulation of Pharmacological and Toxicological Processes'. He was registered as Pharmacist in 1985 (with honours), and he obtained his PhD in Medicinal Chemistry in 1989. He was awarded the ‘Shell Prize’ for his thesis entitled ‘Thiols in Oxidative Stress’. Prof. Haenen is registered as Toxicologist and Clinical Pharmacologist. In 2015, he received the 'Grote Onderwijsprijs' (education prize) for being the best teacher in Biomedical Sciences at Maastricht University. He is Editor-in-Chief of the Molecular Toxicology section of the International Journal of Molecular Sciences.

Guido-haenen

Department of Pharmacology & Personalised Medicine
Universiteitsingel 40, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: C3.572
T: +31 (0)43 388 21 09

  • 2009
    • Mateo Anson, N., Selinheimo, E., Havenaar, R., Aura, A. M., Mattila, I., Lehtinen, P., Bast, A., Poutanen, K., & Haenen, G. R. (2009). Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds.Journal of Agricultural and Food Chemistry, 57(14), 6148-6155. https://doi.org/10.1021/jf900492h
    • Jacobs, H., van der Vijgh, W. J., Koek, G. H., Draaisma, G. J., Moalin, M., van Strijdonck, G. P., Bast, A., & Haenen, G. R. (2009). Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER. Free Radical Biology and Medicine, 46(12), 1567-1573. https://doi.org/10.1016/j.freeradbiomed.2009.02.031
    • Balk, J. M., Bast, A., & Haenen, G. R. (2009). Evaluation of the accuracy of antioxidant competition assays: incorrect assumptions with major impact.Free Radical Biology and Medicine, 47(2), 135-144. https://doi.org/10.1016/j.freeradbiomed.2009.04.009
  • 2008
    • Mateo Anson, N., van den Berg, R., Havenaar, R., Haenen, G. R., & Bast, A. (2008). Antioxidant and anti-inflammatory potency of different wheat varieties and fractions. Proceedings of the Nutrition Society, 67(OCE1), Article E56. https://doi.org/10.1017/S0029665108006654
    • Mateo Anson, N., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. R. M. (2008). Ferulic Acid from Aleurone Determines the Antioxidant Potency of Wheat Grain (Triticum aestivum L.). Journal of Agricultural and Food Chemistry, 56(14), 5589-5594. https://doi.org/10.1021/jf800445k
    • Boots, A. W., Haenen, G. R., & Bast, A. (2008). Health effects of quercetin: from antioxidant to nutraceutical.European Journal of Pharmacology, 585(2-3), 325-337. https://doi.org/10.1016/j.ejphar.2008.03.008
    • Boots, A., Wilms, L. C., Swennen, E. L., Kleinjans, J. C., Bast, A., & Haenen, G. R. (2008). In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. Nutrition, 24(7-8), 703-10. https://doi.org/10.1016/j.nut.2008.03.023
    • de Jongh, R., Haenen, G. R. M. M., van Koeveringe, G. A., Dambros, M., & van Kerrebroeck, P. E. V. (2008). Lipid peroxidation product 4-hydroxynonenal contributes to bladder smooth muscle damage.Urology, 71(5), 974-978. https://doi.org/10.1016/j.urology.2007.11.014
    • Wijnen, P. A. H. M., Drent, M., Nelemans, P. J., Kuijpers, P. M., Koek, G. H., Neef, C. K., Haenen, G. R., & Bekers, O. (2008). Role of cytochrome p450 polymorphisms in the development of pulmonary drug toxicity: a case-control study in the Netherlands. Drug Safety, 31(12), 1125-34. https://doi.org/10.2165/0002018-200831120-00008
  • 2007
    • Rezk, B. M., van der Vijgh, W. J., Bast, A., & Haenen, G. R. (2007). Alpha-tocopheryl phosphate is a novel apoptotic agent. Frontiers in Bioscience, 12, 2013-2019. https://doi.org/10.2741/2206
    • Haenen, G. R. M. M., & Bast, A. (2007). Antioxidanten overbodig? Prietpraat!Chemisch2Weekblad, 102(18), 26-27.
    • Rietjens, S. J., Beelen, M., Koopman, R., van Loon, L. J., Bast, A., & Haenen, G. R. (2007). A single session of resistance exercise induces oxidative damage in untrained men. Medicine and Science in Sports and Exercise, 39(12), 2145-2151. https://doi.org/10.1249/mss.0b013e318157936d
    • Coleman, M. D., Rimmer, G. S., & Haenen, G. R. (2007). Effects of Lipoic Acid and Dihydrolipoic Acid on Total Erythrocytic Thiols under Conditions of Restricted Glucose in vitro. Basic & Clinical Pharmacology & Toxicology, 100(2), 139-144. https://doi.org/10.1111/j.1742-7843.2006.00025.x
    • Wilms, L. C., Boots, A. W., de Boer, V. C., Maas, L. M., Pachen, D. M., Gottschalk, R. W., Ketelslegers, H., Godschalk, R. W., Haenen, G. R., van Schooten, F. J., & Kleinjans, J. C. (2007). Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis, 28(8), 1800-1806. https://doi.org/10.1093/carcin/bgm145
    • Rietjens, S. J., Bast, A., & Haenen, G. R. (2007). New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol. Journal of Agricultural and Food Chemistry, 55(18), 7609-7614. https://doi.org/10.1021/jf0706934
    • Arts, M. J., Grun, C., Jong, R. L., Voss, H. P., Bast, A., Mueller, M. J., & Haenen, G. R. (2007). Oxidative Degradation of Lipids during Mashing. Journal of Agricultural and Food Chemistry, 55(17), 7010-7014. https://doi.org/10.1021/jf070505+
    • de Jongh, R., Haenen, G. R., van Koeveringe, G. A., Dambros, M., de Mey, J. G., & van Kerrebroeck, P. E. V. A. (2007). Oxidative stress reduces the muscarinic receptor function in the urinary bladder. Neurourology and Urodynamics, 26(2), 302-308. https://doi.org/10.1002/nau.20298
    • Bast, A., Haenen, G. R., Bruynzeel, A. M., & van der Vijgh, W. J. (2007). Protection by flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials. Cardiovascular Toxicology, 7(2), 154-159. https://doi.org/10.1007/s12012-007-0018-0
    • Bast, A., Kaiserova, H., den Hartog, G. J., Haenen, G. R., & van der Vijgh, W. J. (2007). Protectors against doxorubicin-induced cardiotoxicity: Flavonoids. Cell Biology and Toxicology, 23(1), 39-47. https://doi.org/10.1007/s10565-006-0139-4
    • Rietjens, S. J., Bast, A., Vente, J. D., & Haenen, G. (2007). The olive oil antioxidant hydroxytyrosol efficiently protects against the oxidative stress induced impairment of the NO{middle dot} response of isolated rat aorta. American Journal of Physiology-heart and Circulatory Physiology, 292(4), H1931-H1936. https://doi.org/10.1152/ajpheart.00755.2006
    • Boots, A. W., Li, H., Schins, R. P., Heemskerk, J. W., Bast, A., & Haenen, G. R. (2007). The quercetin paradox. Toxicology and Applied Pharmacology, 222(1), 89-96. https://doi.org/10.1016/j.taap.2007.04.004
  • 2006
    • Coleman, M. D., Williams, C., & Haenen, G. R. (2006). Effects of Lipoic Acid and Dihydrolipoic Acid on 4-Aminophenol-Mediated Erythrocytic Toxicity in vitro*. Basic & Clinical Pharmacology & Toxicology, 99(3), 225-229. https://doi.org/10.1111/j.1742-7843.2006.pto_499.x
    • Vaisman, N., Haenen, G. R., Zaruk, Y., Verduyn, C., Bindels, J. G., Verlaan, S., & Meijer, E. P. (2006). Enteral feeding enriched with carotenoids normalizes the carotenoid status and reduces oxidative stress in long-term enterally fed patients. Clinical Nutrition, 25(6), 897-905. https://doi.org/10.1016/j.clnu.2006.06.002
    • Troost, F. J., Brummer, R. J., Haenen, G. R., Bast, A., van Haaften, R. I. M., Evelo, C. T., & Saris, W. H. (2006). Gene expression in human small intestinal mucosa in vivo is mediated by iron-induced oxidative stress. Physiological genomics, 25(2), 242-249. https://doi.org/10.1152/physiolgenomics.00114.2005
    • Haenen, G. R., Arts, M. J. T., Bast, A., & Coleman, M. D. (2006). Structure and activity in assessing antioxidant activity in vitro and in vivo. A critical appraisal illustrated with the flavenoids. Environmental Toxicology and Pharmacology, 21, 191-198. https://doi.org/10.1016/j.etap.2005.07.010
  • 2005
    • Gosker, H. R., Bast, A., Haenen, G. R. M. M., Fischer, M. A. J. G., van der Vusse, G. J., Wouters, E. F. M., & Schols, A. M. W. J. (2005). Altered antioxidant status in peripheral skeletal muscle of patients with COPD. Respiratory Medicine, 99, 118-125. https://doi.org/10.1016/j.rmed.2004.05.018
    • Fischer, M. A. J. G., Gransier, T. J., Beckers, L. M., Bekers, O., Bast, A., & Haenen, G. R. (2005). Determination of the antioxidant capacity in blood. Clinical Chemistry and Laboratory Medicine, 43(7), 735-740. https://doi.org/10.1515/CCLM.2005.125
    • Boots, A. W., Bast, A., & Haenen, G. R. (2005). No role of DT-diaphorase (NQO1) in the protection against oxidized quercetin. Febs Letters, 579(3), 677-682. https://doi.org/10.1016/j.febslet.2004.12.044
    • Boots, A. W., Balk, J. M., Bast, A., & Haenen, G. R. (2005). The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity. Biochemical and Biophysical Research Communications, 338(2), 923-929. https://doi.org/10.1016/j.bbrc.2005.10.031
  • 2004
    • Arts, M. J. T. J., Dallinga, J. W., Voss, H. P., Haenen, G. R. M. M., & Bast, A. (2004). A new approach to assess the total antioxidant capacity using the TEAC assay. Food Chemistry, 88, 567-570. https://doi.org/10.1016/j.foodchem.2004.02.008
    • Arts, M. J. T. J., Haenen, G. R., Voss, H. P., & Bast, A. (2004). Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay. Food and Chemical Toxicology, 42(1), 45-49. https://doi.org/10.1016/j.fct.2003.08.004
    • den Hartog, G. J. M., Haenen, G. R. M. M., Boven, E., van der Vijgh, W. J. F., & Bast, A. (2004). Lecithinized copper,zinc-superoxide dismutase as a protector against doxorubicin-induced cardiotoxicity in mice. Toxicology and Applied Pharmacology, 194(2), 180-188. https://doi.org/10.1016/j.taap.2003.09.008
    • Rezk, B. M., Haenen, G. R., van der Vijgh, W. J. F., & Bast, A. (2004). Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage. Journal of Biological Chemistry, 279(11), 9693-9697. https://doi.org/10.1074/jbc.M312289200
    • Rezk, B. M., Haenen, G. R., van der Vijgh, W. J. F., & Bast, A. (2004). The extraordinary antioxidant activity of vitamin E phosphate. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1683(1-3), 16-21. https://doi.org/10.1016/j.bbalip.2004.03.005
    • Michels, G., Haenen, G. R., Wätjen, W., Rietjens, S. J., & Bast, A. (2004). The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids. Toxicology Letters, 151(1), 105-111. https://doi.org/10.1016/j.toxlet.2004.01.017
  • 2003
    • Arts, M. J. T. J., Dallinga, J. W., Voss, H. P., Haenen, G. R. M. M., & Bast, A. (2003). A critical appraisal of the use of the antioxidant capacity (TEAC) assay in defining optimal structures. Food Chemistry, 80, 409-414. https://doi.org/10.1016/S0308-8146(02)00468-5
    • de Kok, T. M. C. M., Zwingman, I., Moonen, E. J. C., Schilderman-Houba, P. A. E. L., Rhijnsburger, E. H., Haenen, G. R. M. M., & Kleinjans, J. C. S. (2003). Analysis of oxidative DNA damage after human dietary supplementation with linoleic acid. Food and Chemical Toxicology, 41(3), 351-358. https://doi.org/10.1016/S0278-6915(02)00237-5
    • Abou el Hassan, M. A., Kedde, M., Zwiers, U. T., Tourn, E., Haenen, G. R. M. M., Bast, A., & van der Vijgh, W. J. F. (2003). Bioavailability and pharmacokinetics of the cardioprotecting flavonoid 7-monohydroxyethylrutoside in mice. Cancer Chemotherapy and Pharmacology, 52(5), 371-376. https://doi.org/10.1007/s00280-003-0667-z
    • van Haaften, R. I. M., Haenen, G. R. M. M., Evelo, C. T. A., & Bast, A. (2003). Effect of vitamin E on glutathione-dependent enzymes. Drug Metabolism Reviews, 35(2-3), 215-253. https://doi.org/10.1081/DMR-120024086
    • van Haaften, R. I. M., Haenen, G. R. M. M., van Bladeren, P. J., Bogaards, J. J., Evelo, C. T. A., & Bast, A. (2003). Inhibition of various glutathione S-transferase isoenzymes by RRR-alpha-tocopherol. Toxicology in Vitro, 17(3), 245-251. https://doi.org/10.1016/S0887-2333(03)00038-9
    • den Hartog, G. J. M., Boots, A. W., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2003). Lack of inhibition of endothelial nitric oxide synthase in the isolated rat aorta by doxorubicin. Toxicology in Vitro, 17(2), 165-167. https://doi.org/10.1016/S0887-2333(03)00007-9
    • Bast, A., & Haenen, G. R. M. M. (2003). Lipoic acid: a multifunctional antioxidant. Biofactors, 17(1-4), 207-213. https://doi.org/10.1002/biof.5520170120
    • Troost, F. J. J., Saris, W. H. M., Haenen, G. R. M. M., Bast, A., & Brummer, R. J. M. (2003). New method to study oxidative damage and antioxidants in the human small bowel: effects of iron application. American Journal of Physiology-Gastrointestinal and Liver Physiology, 285(2), G354-G359. https://doi.org/10.1152/ajpgi.00422.2002
    • Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2003). Oxidant metabolism in chronic obstructive pulmonary disease. European Respiratory Journal, 22(suppl 46), 14S-27S. https://doi.org/10.1183/09031936.03.00000403a
    • de Kort, J., Fischer, M., Haenen, G. R. M. M., Bast, A., & Koek, G. H. (2003). Oxidative stress in patients with active HCV infection compared to healthy volunteers. Journal of Hepatology, 38, 374. https://doi.org/10.1016/S0168-8278(03)80643-8
    • Boots, A. W., Knubben, N., Haenen, G. R. M. M., & Bast, A. (2003). Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation. Biochemical and Biophysical Research Communications, 308(3), 560-565. https://doi.org/10.1016/S0006-291X(03)01438-4
    • den Hartog, G. J. M., Haenen, G. R. M. M., Vegt, E., van der Vijgh, W. J. F., & Bast, A. (2003). Superoxide dismutase: the balance between prevention and induction of oxidative damage. Chemico-Biological Interactions, 145(1), 33-39. https://doi.org/10.1016/S0009-2797(02)00160-6
    • Hageman, G. J., Larik, I., Pennings, H. J., Haenen, G. R. M. M., Wouters, E. F. M., & Bast, A. (2003). Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients. Free Radical Biology and Medicine, 35(2), 140-148. https://doi.org/10.1016/S0891-5849(03)00237-5
    • Rezk, B. M., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2003). Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. Febs Letters, 555(3), 601-605. https://doi.org/10.1016/S0014-5793(03)01358-9
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