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MUMC+ Award Prof. Michael Jacobs

MUMC+ Award Prof. Michael Jacobs

3 May 2024

With a symposium in the St. Janskerk and a farewell lecture in the aula, vascular surgeon and professor Michael Jacobs bid farewell last Friday. From board chairman Helen Mertens, he received the MUMC+ Award, the highest distinction within the MUMC+, in recognition of all he has meant for Maastricht UMC+ and its patients.

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Prof. Kevin Vernooy Director HVC

Prof. Kevin Vernooy Director HVC

30 April 2024

Prof. Kevin Vernooy will become the medical director of the Heart+Vascular Center (HVC) at Maastricht UMC+.

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Carim Maastricht
Carim Maastricht

Guido Haenen

Assistant Professor

Prof/ Guido Haenen is currently Professor in 'Redox Modulation of Pharmacological and Toxicological Processes'. He was registered as Pharmacist in 1985 (with honours), and he obtained his PhD in Medicinal Chemistry in 1989. He was awarded the ‘Shell Prize’ for his thesis entitled ‘Thiols in Oxidative Stress’. Prof. Haenen is registered as Toxicologist and Clinical Pharmacologist. In 2015, he received the 'Grote Onderwijsprijs' (education prize) for being the best teacher in Biomedical Sciences at Maastricht University. He is Editor-in-Chief of the Molecular Toxicology section of the International Journal of Molecular Sciences.

Guido-haenen

Department of Pharmacology & Personalised Medicine
Universiteitsingel 40, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: C3.572
T: +31 (0)43 388 21 09

  • 2014
    • Haenen, G. R. M., & Bast, A. (2014). Glutathione revisited: a better scavenger than previously thought. Frontiers in Pharmacology, 5, Article 260. https://doi.org/10.3389/fphar.2014.00260
    • Lemmens, K. J., van de Wier, B., Vaes, N., Ghosh, M., van Zandvoort, M. A., van der Vijgh, W., Bast, A., & Haenen, G. R. (2014). The flavonoid 7-mono-O-(beta-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect. Toxicology in Vitro, 28(4), 538-543. https://doi.org/10.1016/j.tiv.2013.12.019
    • Milenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szarc Vel Szic, K., Heyninck, K., Laukens, K., Bizet, M., Defrance, M., Dedeurwaerder, S., Calonne, E., Fuks, F., Haegeman, G., Haenen, G. R., Bast, A., & Weseler, A. R. (2014). Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State. PLOS ONE, 9(4), Article e95527. https://doi.org/10.1371/journal.pone.0095527
    • Kelly, E. R., Plat, J., Haenen, G. R., Kijlstra, A., & Berendschot, T. T. (2014). The effect of modified eggs and an egg-yolk based beverage on serum lutein and zeaxanthin concentrations and macular pigment optical density: results from a randomized trial. PLOS ONE, 9(3), Article 92659. https://doi.org/10.1371/journal.pone.0092659
    • Sthijns, M. M., Randall, M. J., Bast, A., & Haenen, G. R. (2014). Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept.Biochemical and Biophysical Research Communications, 446(4), 1029-1034. https://doi.org/10.1016/j.bbrc.2014.03.081
    • Hazewindus, M., Haenen, G. R., Weseler, A. R., & Bast, A. (2014). Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup. PLOS ONE, 9(12), Article e114387. https://doi.org/10.1371/journal.pone.0114387
    • Marsch, E., Theelen, T. L., Demandt, J. A., Jeurissen, M., van Gink, M., Verjans, R., Janssen, A., Cleutjens, J. P., Meex, S. J., Donners, M. M., Haenen, G., Schalkwijk, C. G., Dubois, L. J., Lambin, P., Mallat, Z., Gijbels, M. J., Heemskerk, J. W., Fisher, E. A., Biessen, E. A., ... Sluimer, J. C. (2014). Reversal of hypoxia in murine atherosclerosis prevents necrotic core expansion by enhancing efferocytosis. Arteriosclerosis Thrombosis and Vascular Biology, 34(12), 2545-2553. https://doi.org/10.1161/ATVBAHA.114.304023
    • Ruijters, E. J., Haenen, G. R., Weseler, A. R., & Bast, A. (2014). The cocoa flavanol (-)-epicatechin protects the cortisol response.Pharmacological Research, 79, 28-33. https://doi.org/10.1016/j.phrs.2013.11.004
    • Lemmens, K. J., Vrolijk, M. F., Bouwman, F. G., van der Vijgh, W. J., Bast, A., & Haenen, G. R. (2014). The Minor Structural Difference between the Antioxidants Quercetin and 4'O-Methylquercetin Has a Major Impact on Their Selective Thiol. International journal of molecular sciences, 15(5), 7475-7484. https://doi.org/10.3390/ijms15057475
  • 2013
    • Ruijters, E. J. B., Weseler, A. R., Kicken, C., Haenen, G. R. M. M., & Bast, A. (2013). The flavanol (-)-epicatechin and its metabolites protect against oxidative stress in primary endothelial cells via a direct antioxidant effect.European Journal of Pharmacology, 715(1-3), 147-153. https://doi.org/10.1016/j.ejphar.2013.05.029
    • van de Wier, B., Balk, J. M., Haenen, G. R. M. M., Giamouridis, D., Bakker, J. A., Bast, B. C., den Hartog, G. J. M., Koek, G. H., & Bast, A. (2013). Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production. Febs Letters, 587(15), 2461-2466. https://doi.org/10.1016/j.febslet.2013.06.019
    • Res, P. T., Cermak, N. M., Stinkens, R. E., Tollakson, T. J., Haenen, G. R. M. M., Bast, A., & van Loon, L. J. C. (2013). Astaxanthin supplementation does not augment fat use or improve endurance performance.Medicine and Science in Sports and Exercise, 45(6), 1158-1165. https://doi.org/10.1249/MSS.0b013e31827fddc4
    • Vanhees, K., van Schooten, F. J., van Waalwijk van Doorn-Khosrovani, S. B., van Helden, S. H., Munnia, A., Peluso, M., Briedé, J. J., Haenen, G. R. M. M., & Godschalk, R. W. L. (2013). Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage. Free Radical Biology and Medicine, 57, 154-161. https://doi.org/10.1016/j.freeradbiomed.2012.12.021
    • Nergiz-Unal, R., Kuijpers, M. J. E., de Witt, S. M., Heeneman, S., Feijge, M. A. H., Garcia Caraballo, S., Biessen, E. A., Haenen, G. R. M. M., Cosemans, J. M., & Heemskerk, J. W. (2013). Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.Thrombosis Research, 131(5), 411-417. https://doi.org/10.1016/j.thromres.2013.01.003
    • Klinkenberg, L. J., Res, P. T., Haenen, G. R., Bast, A., van Loon, L. J., van Dieijen-Visser, M. P., & Meex, S. J. (2013). Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial. PLOS ONE, 8(11), Article e79280. https://doi.org/10.1371/journal.pone.0079280
    • Bast, A., & Haenen, G. R. M. M. (2013). Ten misconceptions about antioxidants. Trends in Pharmacological Sciences, 34(8), 430-436. https://doi.org/10.1016/j.tips.2013.05.010
  • 2012
    • Boots, A. W., Gerloff, K., Bartholomé, R., van Berlo, D., Ledermann, K., Haenen, G. R. M. M., Bast, A., van Schooten, F. J., Albrecht, C., & Schins, R. P. (2012). Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells. Biochimica et Biophysica Acta-Molecular Cell Research, 1823(7), 1151-1162. https://doi.org/10.1016/j.bbamcr.2012.04.012
    • Hazewindus, M., Haenen, G. R. M. M., Weseler, A. R., & Bast, A. (2012). The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and alpha-tocopherol. Food Chemistry, 132(2), 954-958. https://doi.org/10.1016/j.foodchem.2011.11.075
    • Moalin, M., van Strijdonck, G. P., Bast, A., & Haenen, G. R. M. M. (2012). Competition between Ascorbate and Glutathione for the Oxidized Form of Methylated Quercetin Metabolites and Analogues: Tamarixetin, 4'O-Methylquercetin, Has the Lowest Thiol Reactivity. Journal of Agricultural and Food Chemistry, 60(36), 9292-9297. https://doi.org/10.1021/jf302068v
    • Mateo Anson, N., Hemery, Y. M., Bast, A., & Haenen, G. R. M. M. (2012). Optimizing the bioactive potential of wheat bran by processing. Food & Function, 3(4), 362-375. https://doi.org/10.1039/c2fo10241b
    • van den Heuvel, M. G. W., Bast, A., Haenen, G. R. M. M., Ambergen, A. W., Mermans, J. F., & van der Hulst, R. R. W. J. (2012). The role of antioxidants in ischaemia-reperfusion in a human DIEP flap model. Journal of Plastic Reconstructive and Aesthetic Surgery, 65(12), 1706-1711. https://doi.org/10.1016/j.bjps.2012.06.010
  • 2011
    • Weseler, A. R., Ruijters, E. J. B., Reesink, K. D., Haenen, G. R. M. M., & Bast, A. (2011). Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health - a randomized controlled clinical pilot study. PLOS ONE, 6(12), Article 28460. https://doi.org/10.1371/journal.pone.0028460
    • Jacobs, H., Moalin, M., van Gisbergen, M. W., Bast, A., van der Vijgh, W. J. F., & Haenen, G. R. M. M. (2011). An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoher and quercetin. Free Radical Biology and Medicine, 51(11), 2118-2123. https://doi.org/10.1016/j.freeradbiomed.2011.09.013
    • Jacobs, H., Koek, G. H., Peters, R., Moalin, M., Tack, J., van der Vijgh, W. J. F., Bast, A., & Haenen, G. R. M. M. (2011). Differences in pharmacological activities of the antioxidant flavonoid monoher in humans and mice are caused by variations in its metabolic profile. Clinical Pharmacology & Therapeutics, 90(6), 852-859. https://doi.org/10.1038/clpt.2011.200
    • Moalin, M., van Strijdonck, G. P., Beckers, M., Hageman, G., Borm, P., Bast, A., & Haenen, G. R. M. M. (2011). A planar conformation and the hydroxyl groups in the b and c rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives. Molecules, 16(11), 9636-9650. https://doi.org/10.3390/molecules16119636
    • Anson, N. M., Havenaar, R., Vaes, W., Coulier, L., Venema, K., Selinheimo, E., Bast, A., & Haenen, G. R. M. M. (2011). Effect of bioprocessing of wheat bran in wholemeal wheat breads on the colonic SCFA production in vitro and postprandial plasma concentrations in men. Food Chemistry, 128(2), 404-409. https://doi.org/10.1016/j.foodchem.2011.03.043
    • Snoeijs, M. G., van Bijnen, A., Swennen, E. L., Haenen, G. R. M. M., Roberts, L. J., Christiaans, M. H., Peppelenbosch, A. G., Buurman, W. A., & van Heurn, L. W. E. (2011). Tubular Epithelial Injury and Inflammation After Ischemia and Reperfusion in Human Kidney Transplantation. Annals of Surgery, 253(3), 598-604. https://doi.org/10.1097/SLA.0b013e31820d9ae9
    • Jacobs, H., Bast, A., Peters, G. J., van der Vijgh, W. J. F., & Haenen, G. R. M. M. (2011). The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-kappaB. British Journal of Cancer, 104(3), 437-440. https://doi.org/10.1038/sj.bjc.6606065
    • Snoeijs, M. G., Vaahtera, L., de Vries, E. E., Schurink, G. W. H., Haenen, G. R. M. M., Peutz-Kootstra, C. J., Buurman, W. A., van Heurn, L. W. E., & Parkkinen, J. (2011). Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation. Transplantation, 92(3), 296-302. https://doi.org/10.1097/TP.0b013e3182247b78
    • Mateo Anson, N., Aura, A. M., Selinheimo, E., Mattila, I., Poutanen, K., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. R. M. M. (2011). Bioprocessing of Wheat Bran in Whole Wheat Bread Increases the Bioavailability of Phenolic Acids in Men and Exerts Antiinflammatory Effects ex Vivo.Journal of Nutrition, 141(1), 137-143. https://doi.org/10.3945/jn.110.127720
    • Jacobs, H., Peters, R., den Hartog, G. J. M., van der Vijgh, W. J. F., Bast, A., & Haenen, G. R. M. M. (2011). Identification of the Metabolites of the Antioxidant Flavonoid 7-Mono-O-({beta}-hydroxyethyl)-rutoside in Mice.Drug Metabolism and Disposition, 39(5), 750-756. https://doi.org/10.1124/dmd.110.036525
    • Linschooten, J. O., Laubenthal, J., Cemeli, E., Baumgartner, A., Anderson, D., Sipinen, V. E., Brunborg, G., Haenen, G. R. M. M., Fthenou, E., Briedé, J. J., van Schooten, F. J., & Godschalk, R. W. L. (2011). Incomplete protection of genetic integrity of mature spermatozoa against oxidative stress.Reproductive Toxicology, 32(1), 106-111. https://doi.org/10.1016/j.reprotox.2011.05.004
    • Boots, A. W., Drent, M., de Boer, V. C., Bast, A., & Haenen, G. R. M. M. (2011). Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clinical Nutrition, 30(4), 506-512. https://doi.org/10.1016/j.clnu.2011.01.010
  • 2010
    • Mensink, R. P., Jong, A., Lutjohann, D., Haenen, G. R. M., & Plat, J. (2010). Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. American Journal of Clinical Nutrition, 92(1), 24-33. https://doi.org/10.3945/ajcn.2009.29143
    • Hemery, Y. M., Anson, N. M., Havenaar, R., Haenen, G. R. M. M., Noort, M. W. J., & Rouau, X. (2010). Dry-fractionation of wheat bran increases the bioaccessibility of phenolic acids in breads made from processed bran fractions. Food Research International, 43(5), 1429-1438. https://doi.org/10.1016/j.foodres.2010.04.013
    • Brouwers, O., Niessen, P. M., Haenen, G. R. M. M., Miyata, T., Brownlee, M., Stehouwer, C. D. A., de Mey, J. G. R., & Schalkwijk, C. G. (2010). Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.Diabetologia, 53(5), 989-1000. https://doi.org/10.1007/s00125-010-1677-0
    • Beljaars, C. P., Balk, J. M., Bast, A., & Haenen, G. R. (2010). Prevention of a systematic underestimation of antioxidant activity in competition assays. The impact of unspecific reactions of the reactive species.Biochemical and Biophysical Research Communications, 392(3), 346-350. https://doi.org/10.1016/j.bbrc.2010.01.022
    • Jacobs, H., Moalin, M., Bast, A., van der Vijgh, W. J., & Haenen, G. R. M. M. (2010). An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network. PLOS ONE, 5(11), Article e13880. https://doi.org/10.1371/journal.pone.0013880
    • Bartholomé, R., Haenen, G. R. M. M., Hollman, C. H., Bast, A., Dagnelie, P. C., Roos, D., Keijer, J., Kroon, P. A., Needs, P. W., & Arts, C. W. (2010). Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by beta-glucuronidase from Neutrophils. Drug metabolism and pharmacokinetics, 25(4), 379-87. https://doi.org/10.2133/dmpk.DMPK-10-RG-002
    • den Hartog, G. J., Boots, A. W., Adam Perrot, A., Brouns, F. J. P. H., Verkooijen, I. W., Weseler, A. R., Haenen, G. R., & Bast, A. (2010). Erythritol is a sweet antioxidant. Nutrition, 26(4), 449-458. https://doi.org/10.1016/j.nut.2009.05.004
    • Gungor, N., Knaapen, A. M., Munnia, A., Peluso, M., Haenen, G. R., Chiu, R. K., Godschalk, R. W., & van Schooten, F. J. (2010). Genotoxic effects of neutrophils and hypochlorous acid. Mutagenesis, 25(2), 149-154. https://doi.org/10.1093/mutage/gep053
    • Bast, A., Weseler, A. R., Haenen, G. R. M. M., & den Hartog, G. J. M. (2010). Oxidative stress and antioxidants in interstitial lung disease.Current Opinion in Pulmonary Medicine, 16(5), 516-520. https://doi.org/10.1097/MCP.0b013e32833c645d
    • Wijnen, P. A., Linssen, C. F., Haenen, G. R., Bekers, O., & Drent, M. (2010). Variant VKORC1 and CYP2C9 Alleles in Patients with Diffuse Alveolar Hemorrhage Caused by Oral Anticoagulants. Molecular Diagnosis & Therapy, 14(1), 23-30. https://doi.org/10.1007/BF03256350
    • Anson, N. M., Havenaar, R., Bast, A., & Haenen, G. R. M. M. (2010). Antioxidant and anti-inflammatory capacity of bioaccessible compounds from wheat fractions after gastrointestinal digestion. Journal of Cereal Science, 51(1), 110-114. https://doi.org/10.1016/j.jcs.2009.10.005
  • 2009
    • de Jongh, R., Dambros, M., Haenen, G. R., den Hartog, G. J., Bast, A., van Kerrebroeck, P. E., & van Koeveringe, G. A. (2009). Partial bladder outlet obstruction reduces the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder. Neurourology and Urodynamics, 28(5), 461-467. https://doi.org/10.1002/nau.20677
    • Boots, A. W., Drent, M., Swennen, E. L., Moonen, H. J., Bast, A., & Haenen, G. R. (2009). Antioxidant status associated with inflammation in sarcoidosis: A potential role for antioxidants. Respiratory Medicine, 103(3), 364-372. https://doi.org/10.1016/j.rmed.2008.10.007
    • Boots, A. W., Hristova-Dijkstra, M. J., Kasahara, D. I., Haenen, G. R., Bast, A., & van der Vliet, A. (2009). ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.Journal of Biological Chemistry, 284(26), 17858-17867. https://doi.org/10.1074/jbc.M809761200
    • Mateo Anson, N., van den Berg, R., Havenaar, R., Bast, A., & Haenen, G. (2009). Bioavailability of ferulic acid is determined by its bioaccessibility. Journal of Cereal Science, 49(2), 296-300. https://doi.org/10.1016/j.jcs.2008.12.001
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