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Dekker Grant for Sam Heuts

Dekker Grant for Sam Heuts

25 July 2023

Dr Sam Heuts (Dept. of CTC) has received a Dekker grant awarded by the Dutch Heart Foundation.

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Harry Crijns Research Grant - Deadline 17 september 2023

Harry Crijns Research Grant - Deadline 17 september 2023

25 April 2023

De Harry Crijns Research Grant, in het leven geroepen door het Hart en vaat onderzoekfonds Limburg, in te stelle wordt periodiek toegekend aan jonge wetenschappers die zich bezighouden met klinisch cardiovasculair onderzoek en daarmee bijdragen aan de realisering van de doelstellingen van de foundation.

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Carim Maastricht
Carim Maastricht

Tammo Delhaas

Professor

Tammo Delhaas is Pediatric Cardiologist and Professor of Biomedical Engineering. He obtained his MD at the University of Groningen and received his PhD degree from Maastricht University in 1993 for a thesis on cardiac mechanics. After his training in Pediatrics in Maastricht and Utrecht, he received a Fulbright grant/ICIN-Fellowship and spent one year at the Departments of Bioengineering and Medicine from the UCSD. Thereafter, he trained in Pediatric Cardiology in Aachen and Melbourne. In 2000, he returned to Maastricht as Pediatric Cardiologist and continued his research on the crossroads of (Pediatric) Cardiology, Physiology and Biomedical Engineering. In 2009, he was appointed Professor and Chair of Biomedical Engineering at Maastricht University, where he is involved in projects related to cellular and cardiac mechanics, cardiac pacing, and mathematical modeling of the heart and circulation.

Prof. Tammo Delhaas is heading the CardioVascular System Dynamics Research Group (CVSDRG). With clinical questions regarding (congenital) heart diseases in mind, his research focusses on asynchronous electrical activation, vascular and myocardial structure-function relation, and computer model-assisted diagnosis and treatment of cardiac failure, pulmonary hypertension and congenital heart diseases. Besides standard expertise, CVSDRG uses following techniques/models in which it has expertise of extraordinary quality according to international standards: 1) CircAdapt, a lumped parameter mathematical model of the human heart and circulation that enables real-time simulation of cardiovascular system dynamics in a wide variety of physiological and pathophysiological situations (www.circadapt.org); 2) Finite Element Model of the heart with left and right ventricle, simulating local stress and strain as a function of time with emphasis on adaptation of wall anatomy to local mechanical load; 3) Pulse Wave Propagation and Computational Fluid Dynamics models that predict pressure and flow waveforms after vascular interventions, such as Arterio-Venous Fistula creation for hemodialysis. Prof. Tammo Delhaas serves as a reviewer or member of the editorial board of many journals, and has received grants from, amongst others, the Dutch Heart Foundation, Maastricht UMC+, Province of Limburg, NWO, European Research Council, and the Interuniversity Cardiology Institute of the Netherlands (ICIN).

Tammo-delhaas

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.366
T:+31(0)43 388 16 67

  • 2023
    • Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2023). Electrophysiological effects of stretch-activated ion channels: a systematic computational characterization. The Journal of Physiology. Advance online publication. https://doi.org/10.1113/JP284439
    • Kirkels, F. P., van Osta, N., Rootwelt-Norberg, C., Chivulescu, M., van Loon, T., Aabel, E. W., Castrini, A. I., Lie, Ø. H., Asselbergs, F. W., Delhaas, T., Cramer, M. J., Teske, A. J., Haugaa, K. H., & Lumens, J. (2023). Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. Journal of the American College of Cardiology, 82(9), 785-797. https://doi.org/10.1016/j.jacc.2023.05.065
    • Ganizada, B. H., Reesink, K. D., Parikh, S., Ramaekers, M. J. F. G., Akbulut, A. C., Saraber, P. J. M. H., Debeij, G. P., Jaminon, A. M., Natour, E., Lorusso, R., Wildberger, J. E., Mees, B., Schurink, G. W., Jacobs, M. J., Cleutjens, J., Krapels, I., Gombert, A., Maessen, J. G., Accord, R., ... MUMC TAA Student Team (2023). The Maastricht Acquisition Platform for Studying Mechanisms of Cell-Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease. Biomedicines, 11(8), Article 2095. https://doi.org/10.3390/biomedicines11082095
    • Beela, A. S., Manetti, C. A., Lyon, A., Prinzen, F. W., Delhaas, T., Herbots, L., & Lumens, J. (2023). Impact of Estimated Left Atrial Pressure on Cardiac Resynchronization Therapy Outcome. Journal of Clinical Medicine, 12(15), Article 4908. https://doi.org/10.3390/jcm12154908
    • Neumann, B., Vink, A. S., Hermans, B. J. M., Lieve, K. V. V., Cömert, D., Beckmann, B-M., Clur, S-A. B., Blom, N. A., Delhaas, T., Wilde, A. A. M., Kääb, S., Postema, P. G., & Sinner, M. F. (2023). Manual versus Automatic Assessment of the QT-Interval and QTc. EP Europace, 1-12. Article euad213. https://doi.org/10.1093/europace/euad213
    • Munneke, A. G., Lumens, J., Arts, T., Prinzen, F. W., & Delhaas, T. (2023). Myocardial perfusion and flow reserve in the asynchronous heart: mechanistic insight from a computational model. Journal of Applied Physiology, 135(3), 489-499. https://doi.org/10.1152/japplphysiol.00181.2023
    • Parikh, S., Moerman, K. M., Ramaekers, M. J. F. G., Schalla, S., Bidar, E., Delhaas, T., Reesink, K., & Huberts, W. (2023). Biomechanical Characterisation of Thoracic Ascending Aorta with Preserved Pre-Stresses. Bioengineering, 10(7), Article 846. https://doi.org/10.3390/bioengineering10070846
    • Meiburg, R., Rijks, J. H. J., Beela, A. S., Bressi, E., Grieco, D., Delhaas, T., Luermans, J. G. L. M., Prinzen, F. W., Vernooy, K., & Lumens, J. (2023). Comparison of novel ventricular pacing strategies using an electro-mechanical simulation platform. EP Europace, 25(6), 1-11. Article euad144. https://doi.org/10.1093/europace/euad144
    • van Vliet, L. V., Zonnebeld, N., Tordoir, J. H., Huberts, W., Bouwman, L. H., Cuypers, P. W., Heinen, S. G., Huisman, L. C., Lemson, S., Mees, B. M. E., Schlosser, F. J., de Smet, A. A., Toorop, R. J., Delhaas, T., & Snoeijs, M. G. (2023). Guideline recommendations on minimal blood vessel diameters and arteriovenous fistula outcomes. Journal of vascular access. Advance online publication. https://doi.org/10.1177/11297298231180627
    • van Vliet, L. V., Zonnebeld, N., Tordoir, J. H., Huberts, W., Delhaas, T., & Snoeijs, M. G. (2023). Arteriovenous Fistulas Created with the Help of Personalised Blood Flow Simulations: Clinical Outcomes of a Randomised Controlled Trial. European Journal of Vascular and Endovascular Surgery, 65(6), 907-908. https://doi.org/10.1016/j.ejvs.2023.02.072
    • Giudici, A., van der Laan, K. W. F., van der Bruggen, M. M., Parikh, S., Berends, E., Foulquier, S., Delhaas, T., Reesink, K. D., & Spronck, B. (2023). Constituent-based quasi-linear viscoelasticity: a revised quasi-linear modelling framework to capture nonlinear viscoelasticity in arteries. Biomechanics and modeling in mechanobiology. Advance online publication. https://doi.org/10.1007/s10237-023-01711-8
    • Luo, H., Westphal, P., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Cornelussen, R. N., Delhaas, T., & Prinzen, F. W. (2023). Heart sound-derived systolic time intervals for atrioventricular delay optimization in cardiac resynchronization therapy. Heart Rhythm, 20(4), 572-579. https://doi.org/10.1016/j.hrthm.2022.12.031
    • Westphal, P., Luo, H., Shahmohammadi, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2023). Machine learning–powered, device-embedded heart sound measurement can optimize AV delay in patients with CRT. Heart Rhythm, 20(9), 1316-1324. https://doi.org/10.1016/j.hrthm.2023.05.025
    • Luo, H., Weerts, J., Bekkers, A., Achten, A., Lievens, S., Smeets, K., van Empel, V., Delhaas, T., & Prinzen, F. W. (2023). Association between phonocardiography and echocardiography in heart failure patients with preserved ejection fraction. European Heart Journal - Digital Health, 4(1), 4-11. https://doi.org/10.1093/ehjdh/ztac073
    • Malik, A. E. F., Giudici, A., van der Laan, K. W. F., Op 't Roodt, J., Mess, W. H., Delhaas, T., Spronck, B., & Reesink, K. D. (2023). Detectable Bias between Vascular Ultrasound Echo-Tracking Systems: Relevance Depends on Application. Journal of Clinical Medicine, 12(1), Article 69. https://doi.org/10.3390/jcm12010069
  • 2022
    • Bol, M. E., Huckriede, J. B., van de Pas, K. G. H., Delhaas, T., Lorusso, R., Nicolaes, G. A. F., Sels, J. E. M., & van de Poll, M. C. G. (2022). Multimodal measurement of glycocalyx degradation during coronary artery bypass grafting. Frontiers in medicine, 9, 1045728. https://doi.org/10.3389/fmed.2022.1045728
    • Bol, M. E., Broddin, B. E. K., Delhaas, T., Sels, J. E. M., & van de Poll, M. C. G. (2022). Variability of microcirculatory measurements in healthy volunteers. Scientific Reports, 12(1), Article 19887. https://doi.org/10.1038/s41598-022-22947-x
    • Shahmohammadi, M., Huberts, W., Luo, H. X., Westphal, P., Cornelussen, R. N., Prinzen, F. W., & Delhaas, T. (2022). Hemodynamics-driven mathematical model of third heart sound generation. Frontiers in physiology, 13, Article 847164. https://doi.org/10.3389/fphys.2022.847164
    • Luo, H., Lamata, P., Bazin, S., Bautista, T., Barclay, N., Shahmohammadi, M., Lubrecht, J. M., Delhaas, T., & Prinzen, F. W. (2022). Smartphone as an electronic stethoscope: factors influencing heart sound quality. European Heart Journal - Digital Health, 3(3), 473-480. https://doi.org/10.1093/ehjdh/ztac044
    • Verzaal, N. J., van Deursen, C. J. M., Pezzuto, S., Wecke, L., van Everdingen, W. M., Vernooy, K., Delhaas, T., Auricchio, A., & Prinzen, F. W. (2022). Synchronization of repolarization after cardiac resynchronization therapy: A combined clinical and modeling study. Journal of Cardiovascular Electrophysiology, 33(8), 1837-1846. Advance online publication. https://doi.org/10.1111/jce.15581
    • Quicken, S., Mees, B., Zonnebeld, N., Tordoir, J., Huberts, W., & Delhaas, T. (2022). A realistic arteriovenous dialysis graft model for hemodynamic simulations. PLOS ONE, 17(7), Article e0269825. https://doi.org/10.1371/journal.pone.0269825
    • Westphal, P., Luo, H. X., Shahmohammadi, M., Heckman, L. I. B., Kuiper, M., Prinzen, F. W., Delhaas, T., & Cornelussen, R. N. (2022). Left Ventricular Pressure Estimation Using Machine Learning-Based Heart Sound Classification. Frontiers in cardiovascular medicine, 9, Article 763048. https://doi.org/10.3389/fcvm.2022.763048
    • Koopsen, T., Van Osta, N., Van Loon, T., Van Nieuwenhoven, F. A., Prinzen, F. W., Van Klarenbosch, B. R., Kirkels, F. P., Teske, A. J., Vernooy, K., Delhaas, T., & Lumens, J. (2022). A Lumped Two-Compartment Model for Simulation of Ventricular Pump and Tissue Mechanics in Ischemic Heart Disease. Frontiers in physiology, 13, Article 782592. https://doi.org/10.3389/fphys.2022.782592
    • Salden, F. C. W. M., Huntjens, P. R., Schreurs, R., Willemen, E., Kuiper, M., Wouters, P., Maessen, J. G., Bordachar, P., Delhaas, T., Luermans, J., Meine, M., Allaart, C. P., van Stipdonk, A. M. W., Prinzen, F. W., Lumens, J., & Vernooy, K. (2022). Pacing therapy for atrioventricular dromotropathy: a combined computational-experimental-clinical study. EP Europace, 24(5), 784-795. Advance online publication. https://doi.org/10.1093/europace/euab248
    • Van Steenkiste, G., Delhaas, T., Hermans, B., Vera, L., Decloedt, A., & van Loon, G. (2022). An Exploratory Study on Vectorcardiographic Identification of the Site of Origin of Focally Induced Premature Depolarizations in Horses, Part II: The Ventricles. Animals, 12(5), Article 550. https://doi.org/10.3390/ani12050550
    • Van Steenkiste, G., Delhaas, T., Hermans, B., Vera, L., Decloedt, A., & van Loon, G. (2022). An Exploratory Study on Vectorcardiographic Identification of the Site of Origin of Focally Induced Premature Depolarizations in Horses, Part I: The Atria. Animals, 12(5), Article 549. https://doi.org/10.3390/ani12050549
    • Munneke, A. G., Lumens, J., Arts, T., & Delhaas, T. (2022). A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling. Frontiers in physiology, 13, Article 830925. https://doi.org/10.3389/fphys.2022.830925
    • van der Laan, K. W. F., Reesink, K. D., van der Bruggen, M. M., Jaminon, A. M. G., Schurgers, L. J., Megens, R. T. A., Huberts, W., Delhaas, T., & Spronck, B. (2022). Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy. Frontiers in physiology, 12, Article 814434. https://doi.org/10.3389/fphys.2021.814434
    • Munneke, A. G., Lumens, J., & Delhaas, T. (2022). Cardiovascular fetal-to-neonatal transition: an in silico model. Pediatric Research, 91(1), 116-128. Advance online publication. https://doi.org/10.1038/s41390-021-01401-0
  • 2021
    • Malik, A. E. F., Delhaas, T., Spronck, B., Henry, R. M. A., Joseph, J., Stehouwer, C. D. A., Mess, W. H., & Reesink, K. D. (2021). Single M-Line Is as Reliable as Multiple M-Line Ultrasound for Carotid Artery Screening. Frontiers in physiology, 12, Article 787083. https://doi.org/10.3389/fphys.2021.787083
    • Hermans, B. J. M., Zink, M. D., Rosmalen, F. V., Crijns, H. J. G. M., Vernooy, K., Postema, P., Pison, L., Schotten, U., & Delhaas, T. (2021). Corrected QT interval prolongation after ganglionated plexus ablation: myth or reality?-Authors' reply. EP Europace, 23(12), 2047-2048. https://doi.org/10.1093/europace/euab148
    • Hermans, B. J. M., Zink, M. D., Rosmalen, F. V., Crijns, H. J. G. M., Vernooy, K., Postema, P., Pison, L., Schotten, U., & Delhaas, T. (2021). Does pulmonary vein isolation prolong QT-interval?-Authors' reply. EP Europace, 23(12), 2046-2047. https://doi.org/10.1093/europace/euab153
    • Shenthar, J., Valappil, S. P., Rai, M. K., Banavalikar, B., Padmanabhan, D., & Delhaas, T. (2021). Angiography-guided mid/high septal implantation of ventricular leads in patients with congenital heart disease. Journal of Arrhythmia, 37(6), 1512-1521. Advance online publication. https://doi.org/10.1002/joa3.12636
    • Giudici, A., Khir, A. W., Reesink, K. D., Delhaas, T., & Spronck, B. (2021). Five years of cardio-ankle vascular index (CAVI) and CAVI0: how close are we to a pressure-independent index of arterial stiffness?Journal of Hypertension, 39(11), 2128-2138. https://doi.org/10.1097/HJH.0000000000002928
    • van der Bruggen, M. M., Spronck, B., Delhaas, T., Reesink, K. D., & Schalkwijk, C. G. (2021). The Putative Role of Methylglyoxal in Arterial Stiffening: A Review. Heart Lung and Circulation, 30(11), 1681-1693. https://doi.org/10.1016/j.hlc.2021.06.527
    • Shenthar, J., Rai, M. K., Chakali, S. S., Pillai, V., & Delhaas, T. (2021). Computed tomography validated right ventricular mid-septal lead implantation using right ventricular angiography. Journal of Arrhythmia, 37(5), 1131-1138. Advance online publication. https://doi.org/10.1002/joa3.12591
    • van Osta, N., Kirkels, F. P., van Loon, T., Koopsen, T., Lyon, A., Meiburg, R., Huberts, W., Cramer, M. J., Delhaas, T., Haugaa, K. H., Teske, A. J., & Lumens, J. (2021). Uncertainty Quantification of Regional Cardiac Tissue Properties in Arrhythmogenic Cardiomyopathy Using Adaptive Multiple Importance Sampling. Frontiers in physiology, 12, Article 738926. https://doi.org/10.3389/fphys.2021.738926
    • Widowski, H., Ophelders, D. R. M. G., van Leeuwen, A. J. C. N., Nikkels, P. G. J., Severens-Rijvers, C. A. H., LaPointe, V. L. S., Cleutjens, J. P. M., Hütten, M. C., Kemp, M. W., Payne, M. S., Saito, M., Usuda, H., Newnham, J. P., Jobe, A. H., Kramer, B. W., Delhaas, T., Wolfs, T. G. A. M., & Reynaert, N. L. (2021). Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero. Pediatric Research, 90(3), 549-558. Advance online publication. https://doi.org/10.1038/s41390-020-01204-9
    • Shahmohammadi, M., Luo, H., Westphal, P., Cornelussen, R. N., Prinzen, F. W., & Delhaas, T. (2021). Hemodynamics-driven mathematical model of first and second heart sound generation. PLoS Computational Biology, 17(9), Article e1009361. https://doi.org/10.1371/journal.pcbi.1009361
    • Stevens, R. R. F., Gommer, E. D., Aries, M. J. H., Ertl, M., Mess, W. H., Huberts, W., & Delhaas, T. (2021). Optic nerve sheath diameter assessment by neurosonology: A review of methodologic discrepancies. Journal of Neuroimaging, 31(5), 814-825. Advance online publication. https://doi.org/10.1111/jon.12906
    • Vroomen, M., van Rosmalen, F., Schroeder, J., Philippens, S., Delhaas, T., Crijns, H. J., & Pison, L. (2021). Ten-year follow-up after endocardial point-by-point cryoablation for paroxysmal atrial fibrillation. Acta Cardiologica, 76(4), 425-430. Advance online publication. https://doi.org/10.1080/00015385.2020.1756087
    • van der Bruggen, M., Spronck, B., Bos, S., Heusinkveld, M. H. G., Taddei, S., Ghiadoni, L., Delhaas, T., Bruno, R. M., & Reesink, K. D. (2021). Pressure-corrected carotid stiffness and Young's modulus: evaluation in an outpatient clinic setting. American Journal of Hypertension, 34(7), 737-743. https://doi.org/10.1093/ajh/hpab028
    • Parikh, S., Ganizada, B., Debeij, G., Natour, E., Maessen, J., Spronck, B., Schurgers, L., Delhaas, T., Huberts, W., Bidar, E., & Reesink, K. (2021). Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta. Biomedicines, 9(6), Article 670. https://doi.org/10.3390/biomedicines9060670
    • ter Meulen, K. J., Hermans, B. J. M., van der Sande, F. M., Canaud, B., Konings, C. J. A. M., Kooman, J. P., & Delhaas, T. (2021). Effect of citric-acid dialysate on the QTC-interval. Scientific Reports, 11(1), Article 9909. https://doi.org/10.1038/s41598-021-89083-w
    • van Rosmalen, F., Delhaas, T., Dagres, N., Arbelo, E., Blomstrom-Lundqvist, C., Crijns, H. J. G. M., Da Costa, A., Pytkowski, M., Sharikov, N., Laroche, C., Tavazzi, L., Brugada, J., Pison, L., & ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators (2021). Adenosine usage during AF ablation in Europe and selected long-term findings from the ESC-EHRA EORP Atrial Fibrillation Ablation Long-Term registry. Journal of Interventional Cardiac Electrophysiology, 60(3), 395-406. Advance online publication. https://doi.org/10.1007/s10840-020-00744-8
    • Vink, A. S., Hermans, B. J. M., Pimenta, J., Peltenburg, P. J., Filippini, L. H. P. M., Hofman, N., Clur, S-A. B., Blom, N. A., Wilde, A. A. M., Delhaas, T., & Postema, P. G. (2021). Diagnostic accuracy of the response to the brief tachycardia provoked by standing in children suspected for long QT syndrome. Heart Rhythm O2, 2(2), 149-159. https://doi.org/10.1016/j.hroo.2021.03.005
    • van Rosmalen, F., Maesen, B., van Hunnik, A., Hermans, B. J. M., Bonizzi, P., Bidar, E., Nijs, J., Maessen, J. G., Verheule, S., Delhaas, T., Schotten, U., & Zeemering, S. (2021). Incidence, prevalence, and trajectories of repetitive conduction patterns in human atrial fibrillation. EP Europace, 23(Supplement_1), i123-i132. https://doi.org/10.1093/europace/euaa403
    • Heusinkveld, M. H. G., Holtackers, R. J., Adriaans, B. P., Op't Roodt, J., Arts, T., Delhaas, T., Reesink, K. D., & Huberts, W. (2021). Complementing sparse vascular imaging data by physiological adaptation rules. Journal of Applied Physiology, 130(3), 571-588. https://doi.org/10.1152/japplphysiol.00250.2019
Overview