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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Longer and better lives for patients with atrial fibrillation

Longer and better lives for patients with atrial fibrillation

15 April 2024

An international panel of experts published recommendations to improve management of atrial fibrillation (AF).

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Carim Maastricht
Carim Maastricht

Tammo Delhaas

Professor

Tammo Delhaas is Pediatric Cardiologist and Professor of Biomedical Engineering. He obtained his MD at the University of Groningen and received his PhD degree from Maastricht University in 1993 for a thesis on cardiac mechanics. After his training in Pediatrics in Maastricht and Utrecht, he received a Fulbright grant/ICIN-Fellowship and spent one year at the Departments of Bioengineering and Medicine from the UCSD. Thereafter, he trained in Pediatric Cardiology in Aachen and Melbourne. In 2000, he returned to Maastricht as Pediatric Cardiologist and continued his research on the crossroads of (Pediatric) Cardiology, Physiology and Biomedical Engineering. In 2009, he was appointed Professor and Chair of Biomedical Engineering at Maastricht University, where he is involved in projects related to cellular and cardiac mechanics, cardiac pacing, and mathematical modeling of the heart and circulation.

Prof. Tammo Delhaas is heading the CardioVascular System Dynamics Research Group (CVSDRG). With clinical questions regarding (congenital) heart diseases in mind, his research focusses on asynchronous electrical activation, vascular and myocardial structure-function relation, and computer model-assisted diagnosis and treatment of cardiac failure, pulmonary hypertension and congenital heart diseases. Besides standard expertise, CVSDRG uses following techniques/models in which it has expertise of extraordinary quality according to international standards: 1) CircAdapt, a lumped parameter mathematical model of the human heart and circulation that enables real-time simulation of cardiovascular system dynamics in a wide variety of physiological and pathophysiological situations (www.circadapt.org); 2) Finite Element Model of the heart with left and right ventricle, simulating local stress and strain as a function of time with emphasis on adaptation of wall anatomy to local mechanical load; 3) Pulse Wave Propagation and Computational Fluid Dynamics models that predict pressure and flow waveforms after vascular interventions, such as Arterio-Venous Fistula creation for hemodialysis. Prof. Tammo Delhaas serves as a reviewer or member of the editorial board of many journals, and has received grants from, amongst others, the Dutch Heart Foundation, Maastricht UMC+, Province of Limburg, NWO, European Research Council, and the Interuniversity Cardiology Institute of the Netherlands (ICIN).

Tammo-delhaas

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.366
T:+31(0)43 388 16 67

  • 2013
    • Janousek, J., van Geldorp, I. E., Krupickova, S., Rosenthal, E., Nugent, K., Tomaske, M., Fruh, A., Elders, J., Hiippala, A., Kerst, G., Gebauer, R. A., Kubus, P., Frias, P., Gabbarini, F., Clur, S.-A., Nagel, B., Ganame, J., Papagiannis, J., Marek, J., ... Delhaas, T. (2013). Permanent Cardiac Pacing in Children: Choosing the Optimal Pacing Site A Multicenter Study. Circulation, 127(5), 613-623. https://doi.org/10.1161/CIRCULATIONAHA.112.115428
    • Delhaas, T., Van der Meer, S. F., Schaart, G., Degens, H., & Drost, M. R. (2013). Steep increase in myonuclear domain size during infancy. The Anatomical Record: advances in integrative anatomy and evolutionary biology, 296(2), 192-197. https://doi.org/10.1002/ar.22631
    • Ghossein-Doha, C., van Kuijk, S. M. J., Spaanderman, M. E. A., Delhaas, T., & Peeters, L. L. H. (2013). Age-Related Alterations in Cardiac Geometry in Formerly Preeclamptic Women and Healthy Parous Controls: An Explorative Study. Reproductive Sciences, 20(1), 39-44. https://doi.org/10.1177/1933719112459230
  • 2012
    • Lumens, J., Arts, T., Marcus, J. T., Vonk-Noordegraaf, A., & Delhaas, T. (2012). Early-diastolic left ventricular lengthening implies pulmonary hypertension-induced right ventricular decompensation. Cardiovascular Research, 96(2), 286-295. https://doi.org/10.1093/cvr/cvs251
    • Lumens, J., & Delhaas, T. (2012). Cardiovascular Modeling in Pulmonary Arterial Hypertension: Focus on Mechanisms and Treatment of Right Heart Failure Using the CircAdapt Model. American Journal of Cardiology, 110(6), 39S-48S. https://doi.org/10.1016/j.amjcard.2012.06.015
    • Lumens, J., Leenders, G. E., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Prinzen, F. W., & Delhaas, T. (2012). Mechanistic Evaluation of Echocardiographic Dyssynchrony Indices Patient Data Combined With Multiscale Computer Simulations. Circulation-Cardiovascular Imaging, 5(4), 491-499. https://doi.org/10.1161/CIRCIMAGING.112.973446
    • Pluijmert, M., Kroon, W., Rossi, A. C., Bovendeerd, P. H. M., & Delhaas, T. (2012). Why SIT Works: Normal Function Despite Typical Myofiber Pattern in Situs Inversus Totalis (SIT) Hearts Derived by Shear-induced Myofiber Reorientation. PLoS Computational Biology, 8(7), Article e1002611. https://doi.org/10.1371/journal.pcbi.1002611
    • Pluijmert, M., Kroon, W., Delhaas, T., & Bovendeerd, P. H. M. (2012). Adaptive reorientation of cardiac myofibers: The long-term effect of initial and boundary conditions. Mechanics Research Communications, 42, 60-67. https://doi.org/10.1016/j.mechrescom.2011.11.011
    • Koeken, Y., Kuijpers, N. H. L., Lumens, J., Arts, T., & Delhaas, T. (2012). Atrial septostomy benefits severe pulmonary hypertension patients by increase of left ventricular preload reserve. American Journal of Physiology-heart and Circulatory Physiology, 302(12), H2654-H2662. https://doi.org/10.1152/ajpheart.00072.2012
    • Arts, T., Reesink, K., Kroon, W., & Delhaas, T. (2012). Simulation of adaptation of blood vessel geometry to flow and pressure: Implications for arterio-venous impedance. Mechanics Research Communications, 42, 15-21. https://doi.org/10.1016/j.mechrescom.2011.10.005
    • Kuijpers, N. H. L., Hermeling, E., Bovendeerd, P. H. M., Delhaas, T., & Prinzen, F. W. (2012). Modeling Cardiac Electromechanics and Mechanoelectrical Coupling in Dyssynchronous and Failing Hearts. Journal of Cardiovascular Translational Research, 5(2), 159-169. https://doi.org/10.1007/s12265-012-9346-y
    • Arts, T., Lumens, J., Kroon, W., & Delhaas, T. (2012). Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study. PLoS Computational Biology, 8(2). https://doi.org/10.1371/journal.pcbi.1002369
    • Leenders, G. E., Lumens, J., Cramer, M. J., De Boeck, B. W. L., Doevendans, P. A., Delhaas, T., & Prinzen, F. W. (2012). Septal Deformation Patterns Delineate Mechanical Dyssynchrony and Regional Differences in Contractility Analysis of Patient Data Using a Computer Model. Circulation-Heart Failure, 5(1), 87-96. https://doi.org/10.1161/CIRCHEARTFAILURE.111.962704
    • Hermeling, E., Delhaas, T., Prinzen, F. W., & Kuijpers, N. H. L. (2012). Mechano-electrical feedback explains T-wave morphology and optimizes cardiac pump function: Insight from a multi-scale model. Progress in Biophysics & Molecular Biology, 110(2-3), 359-371. https://doi.org/10.1016/j.pbiomolbio.2012.07.008
  • 2011
    • van Geldorp, I. E., Delhaas, T., Gebauer, R. A., Frias, P., Tomaske, M., Friedberg, M. K., Tisma-Dupanovic, S., Elders, J., Fruh, A., Gabbarini, F., Kubus, P., Illikova, V., Tsao, S., Blank, A. C., Hiippala, A., Sluysmans, T., Karpawich, P., Clur, S.-A., Ganame, X., ... Janousek, J. (2011). Impact of the permanent ventricular pacing site on left ventricular function in children: a retrospective multicentre survey. Heart, 97(24), 2051-2055. https://doi.org/10.1136/heartjnl-2011-300197
    • van Loon, R. L. E., Roofthooft, M. T. R., Hillege, H. L., ten Harkel, A. D. J., van Osch-Gevers, M., Delhaas, T., Kapusta, L., Strengers, J. L. M., Rammeloo, L. A. J., Clur, S.-A. B., Mulder, B. J. M., & Berger, R. M. F. (2011). Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization During the Period 1991 to 2005. Circulation, 124(16), 1755-U136. https://doi.org/10.1161/CIRCULATIONAHA.110.969584
    • van Geldorp, I. E., Vanagt, W. Y., Prinzen, F. W., & Delhaas, T. (2011). Chronic ventricular pacing in children: toward prevention of pacing-induced heart disease. Heart Failure Reviews, 16(3), 305-314. https://doi.org/10.1007/s10741-010-9207-1
    • Prinzen, F. W., Vernooy, K., DeBoeck, B. W. L., & Delhaas, T. (2011). Mechano-energetics of the asynchronous and resynchronized heart. Heart Failure Reviews, 16(3), 215-224. https://doi.org/10.1007/s10741-010-9205-3
    • van Geldorp, I. E., Delhaas, T., Hermans, B., Vernooy, K., Broers, B., Klimusina, J., Regoli, F., Faletra, F. F., Moccetti, T., Gerritse, B., Cornelussen, R., Settels, J. J., Crijns, H. J. G. M., Auricchio, A., & Prinzen, F. W. (2011). Comparison of a non-invasive arterial pulse contour technique and echo Doppler aorta velocity-time integral on stroke volume changes in optimization of cardiac resynchronization therapy. EP Europace, 13(1), 87-95. https://doi.org/10.1093/europace/euq348
  • 2010
    • Lumens, J., Blanchard, D. G., Arts, T., Mahmud, E., & Delhaas, T. (2010). Left ventricular underfilling and not septal bulging dominates abnormal left ventricular filling hemodynamics in chronic thromboembolic pulmonary hypertension. American Journal of Physiology-heart and Circulatory Physiology, 299(4), H1083-H1091. https://doi.org/10.1152/ajpheart.00607.2010
    • Blaauw, E., van Nieuwenhoven, F. A., Willemsen, P., Delhaas, T., Prinzen, F. W., Snoeckx, L. H., van Bilsen, M., & van der Vusse, G. J. (2010). Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes. American Journal of Physiology-heart and Circulatory Physiology, 299(3), H780-H787. https://doi.org/10.1152/ajpheart.00822.2009
    • van Loon, R. L. E., Roofthooft, M. T. R., Delhaas, T., van Osch-Gevers, M., ten Harkel, A. D. J., Strengers, J. L. M., Backx, A. P. C. M., Hillege, H. L., & Berger, R. M. F. (2010). Outcome of Pediatric Patients With Pulmonary Arterial Hypertension in the Era of New Medical Therapies. American Journal of Cardiology, 106(1), 117-124. https://doi.org/10.1016/j.amjcard.2010.02.023
    • Babiker, F. A., Lorenzen-Schmidt, I., Mokelke, E., Vanagt, W. Y., Delhaas, T., Waltenberger, J., Cleutjens, J. P., & Prinzen, F. W. (2010). Long-term protection and mechanism of pacing-induced postconditioning in the heart. Basic Research in Cardiology, 105(4), 523-533. https://doi.org/10.1007/s00395-010-0095-2
    • Arts, T., Prinzen, F. W., Delhaas, T., Milles, J. R., Rossi, A. C., & Clarysse, P. (2010). Mapping Displacement and Deformation of the Heart With Local Sine-Wave Modeling. Ieee Transactions on Medical Imaging, 29(5), 1114-1123. https://doi.org/10.1109/TMI.2009.2037955
    • Delhaas, T., Sarvaas, G. J. D. M., Rijlaarsdam, M. E., Strengers, J. L. M., Eveleigh, R. M., Poulino, S. E., de Korte, C. L., & Kapusta, L. (2010). A Multicenter, Long-Term Study on Arrhythmias in Children with Ebstein Anomaly. Pediatric Cardiology, 31(2), 229-233. https://doi.org/10.1007/s00246-009-9590-3
    • van Geldorp, I. E., Vernooy, K., Delhaas, T., Prins, M. H., Crijns, H. J., Prinzen, F. W., & Dijkman, B. (2010). Beneficial effects of biventricular pacing in chronically right ventricular paced patients with mild cardiomyopathy. EP Europace, 12(2), 223-229. https://doi.org/10.1093/europace/eup378
  • 2009
    • Been, J. V., Robben, S. G., Delhaas, T., Theunissen, P., Dompeling, E. D., & Jöbsis, Q. (2009). A 3-year-old female with cough, dyspnoea and low-grade fever. European Respiratory Journal, 33(3), 690-3. https://doi.org/10.1183/09031936.00074108
  • 2008
    • Drost, M. R., Schaart, G., van Dijk, P., van Capelle, C. I., van der Vusse, G. J., Delhaas, T., van der Ploeg, A. T., & Reuser, A. J. (2008). Both type 1 and type 2a muscle fibers can respond to enzyme therapy in Pompe disease. Muscle & Nerve, 37(2), 251-5. https://doi.org/10.1002/mus.20896
  • 2002
    • Delhaas, T., van Engeland, S., Broers, J. L. V., Bouten, C., Kuijpers, N., Ramaekers, F. C. S., & Snoeckx, L. H. E. M. (2002). Quantification of cytoskeletal deformation in living cells based on hierarchical feature vector matching.American Journal of Physiology-Cell Physiology, 283, C639-C645. https://doi.org/10.1152/ajpcell.00535.2001
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