• 2024
    • Harlacher, E., Schulte, C., Vondenhoff, S., Schmitt-Kopplin, P., Diederich, P., Hemmers, C., Moellmann, J., Wollenhaupt, J., Veltrop, R., Biessen, E., Lehrke, M., Peters, B., Schlieper, G., Kuppe, C., Floege, J., Jankowski, V., Marx, N., Jankowski, J., & Noels, H. (2024). Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health. Frontiers in Cardiovascular Medicine, 11, Article 1346475. https://doi.org/10.3389/fcvm.2024.1346475
    • Wang, S., Han, Y., Liu, R., Hou, M., Neumann, D., Zhang, J., Wang, F., Li, Y., Zhao, X., Schianchi, F., Dai, C., Liu, L., Nabben, M., Glatz, J. F. C., Wu, X., Lu, X., Li, X., & Luiken, J. J. F. P. (2024). Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis. Circulation Research, 134(5), 505-525. https://doi.org/10.1161/CIRCRESAHA.123.322910
    • Cao, J., Martin-Lorenzo, M., van Kuijk, K., Wieland, E., Gijbels, M. J., Claes, B. S. R., Heredero, A., Aldamiz-Echevarria, G., Heeren, R. M. A., Goossens, P., Sluimer, J., Balluff, B., & Alvarez-Llamas, G. (2024). Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation. Arteriosclerosis Thrombosis and Vascular Biology, 44(3), 741-754. https://doi.org/10.1161/ATVBAHA.123.320278
    • Lu, C., Donners, M. M. P. C., de Baaij, J. B. J., Jin, H., Otten, J. J. T., Manca, M., van Zonneveld, A. J., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Mees, B., Sluimer, J. C., Cavill, R., Karel, J. M. H., Goossens, P., & Biessen, E. A. L. (2024). Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1286382
    • Sluiter, T. J., Tillie, R. J. H. A., de Jong, A., de Bruijn, J. B. G., Peters, H. A. B., van de Leijgraaf, R., Halawani, R., Westmaas, M., Starink, L. I. W., Quax, P. H. A., Sluimer, J. C., & de Vries, M. R. (2024). Myeloid PHD2 Conditional Knockout Improves Intraplaque Angiogenesis and Vascular Remodeling in a Murine Model of Venous Bypass Grafting. Journal of the American Heart Association, 13(3), 033109. Article e033109. https://doi.org/10.1161/JAHA.123.033109
    • Döring, Y., van der Vorst, E. P. C., Yan, Y., Neideck, C., Blanchet, X., Jansen, Y., Kemmerich, M., Bayasgalan, S., Peters, L. J. F., Hristov, M., Bidzhekov, K., Yin, C., Zhang, X., Leberzammer, J., Li, Y., Park, I., Kral, M., Nitz, K., Parma, L., ... Weber, C. (2024). Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis. Nature cardiovascular research, 3(2), 221-242. https://doi.org/10.1038/s44161-023-00413-9
    • Christ, A., Maas, S. L., Jin, H., Lu, C., Legein, B., Wijnands, E., Temmerman, L., Otten, J., Isaacs, A., Zenke, M., Stoll, M., Biessen, E. A. L., & van der Vorst, E. P. C. (2024). In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells. Free Radical Biology and Medicine, 210, 406-415. https://doi.org/10.1016/j.freeradbiomed.2023.11.044
    • McDonald, J., Hu, W., & Heeneman, S. (2024). Struggles and Joys: A Mixed Methods Study of the Artefacts and Reflections in Medical Student Portfolios. Perspectives on Medical Education, 13(1), 1-11. https://doi.org/10.5334/pme.1029
    • Lin, A., Brittan, M., Baker, A. H., Dimmeler, S., Fisher, E. A., Sluimer, J. C., & Misra, A. (2024). Clonal Expansion in Cardiovascular Pathology. JACC: Basic to Translational Science, 9(1), 120-144. https://doi.org/10.1016/j.jacbts.2023.04.008
    • Wieland, E. B., Kempen, L. J., Donners, M. M., Biessen, E. A., & Goossens, P. (2024). Macrophage heterogeneity in atherosclerosis: A matter of context. European journal of immunology, 54(1), Article 2350464. https://doi.org/10.1002/eji.202350464
  • 2023
    • Kral, M., van der Vorst, E. P. C., Surnov, A., Weber, C., & Doering, Y. (2023). ILC2-mediated immune crosstalk in chronic (vascular) inflammation. Frontiers in Immunology, 14, Article 1326440. https://doi.org/10.3389/fimmu.2023.1326440
    • Wieland, E. B., Kempen, L. J. A. P., Lu, C., Donners, M. M. P. C., Biessen, E. A. L., & Goossens, P. (2023). Protocol for multispectral imaging on cryosections to map myeloid cell heterogeneity in its spatial context. STAR protocols, 4(4), Article 102601. https://doi.org/10.1016/j.xpro.2023.102601
    • Goertzen, L., Schils, T., & Heeneman, S. (2023). Co-designing formative assessment practices: A collaboration between elementary school teachers and researchers to conceptualize and implement formative assessment as a unified practice. Teaching and Teacher Education, 134, Article 104306. https://doi.org/10.1016/j.tate.2023.104306
    • Lu, C., Donners, M. M. P. C., Karel, J., de Boer, H., van Zonneveld, A. J., den Ruijter, H., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Cavill, R., Perales-Patón, J., Ferrannini, E., Goossens, P., & Biessen, E. A. L. (2023). Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients. Atherosclerosis, 384, Article 117123. https://doi.org/10.1016/j.atherosclerosis.2023.04.005
    • Sarad, K., Stefanska, M., Kraszewska, I., Szade, K., Sluimer, J. C., Blyszczuk, P., Dulak, J., & Jazwa-Kusior, A. (2023). Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas. Frontiers in Immunology, 14, Article 1249379. https://doi.org/10.3389/fimmu.2023.1249379
    • Nagenborg, J., Jin, H., Ruder, A. V., Temmerman, L., Mees, B., Schalkwijk, C., Müller-Klieser, D., Berg, T., Goossens, P., Donners, M. M. P. C., & Biessen, E. A. L. (2023). GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis. Frontiers in Immunology, 14, Article 1165306. https://doi.org/10.3389/fimmu.2023.1165306
    • van der Weijden, J., De Hoogt, P. A., Leufkens, M. M. E., Keijbeck, A. A., van Goor, H., van den Heuvel, M. C., Cleutjens, J. P. M., Moers, C., Snoeijs, M. G., Navis, G. J., van Londen, M., Nolte, I. M., Berger, S. P., De Borst, M. H., & Peutz-Kootstra, C. J. (2023). The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors. Journal of Nephrology, 36(7), 2111-2124. https://doi.org/10.1007/s40620-023-01734-5
    • Ruder, A., Wetzels, S. M. W., Temmerman, L., Biessen, E. A. L., & Goossens, P. (2023). Monocyte heterogeneity in cardiovascular disease. Cardiovascular Research, 119(11), 2033-2045. https://doi.org/10.1093/cvr/cvad069
    • Maas, S., Jin, H., Lu, C., Nagenborg, J., Manca, M., Karel, J., Cavill, R., Sikkink, C., Yu, B., Nadeau, S., Dos Santos, J., Gijbels, M., Mees, B., Smirnov, E., Sluimer, J., Martins, G., Van der Vorst, E., & Biessen, E. (2023). Identification Of A Prdm1-Regulated T-Cell Network Which Controls T-Cell Driven Plaque Inflammation In Human And Mouse Atherosclerosis. Atherosclerosis, 379(S1), S11-S11. https://doi.org/10.1016/j.atherosclerosis.2023.06.914
    • Ganizada, B. H., Reesink, K. D., Parikh, S., Ramaekers, M. J. F. G., Akbulut, A. C., Saraber, P. J. M. H., Debeij, G. P., Jaminon, A. M., Natour, E., Lorusso, R., Wildberger, J. E., Mees, B., Schurink, G. W., Jacobs, M. J., Cleutjens, J., Krapels, I., Gombert, A., Maessen, J. G., Accord, R., ... MUMC TAA Student Team (2023). The Maastricht Acquisition Platform for Studying Mechanisms of Cell-Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease. Biomedicines, 11(8), Article 2095. https://doi.org/10.3390/biomedicines11082095
    • van Kuijk, K., McCracken, I. R., Tillie, R. J. H. A., Asselberghs, S. E. J., Kheder, D. A., Muitjens, S., Jin, H., Taylor, R. S., Schreur, R. W., Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M. J., Temmerman, L., Kirkwoord, P. M., Luyten, J., Li, Y. M., Noels, H., Goossens, P., ... Sluimer, J. C. (2023). Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol. Cardiovascular Research, 119(7), 1509-1523. https://doi.org/10.1093/cvr/cvad016
    • Kerkhofs, D., Helgers, R., Hermes, D., Steinbusch, H. P. J., Van Essen, H., Leenders, P., Prickaerts, J., Staals, J., Biessen, E. A., Van Oostenbrugge, R. J., & Foulquier, S. (2023). Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of Hypertension, 41(7), 1159-1167. https://doi.org/10.1097/HJH.0000000000003445
    • Naothavorn, W., Puranitee, P., Kaewpila, W., Sumrithe, S., Heeneman, S., van Mook, W. N. K. A., & Busari, J. O. (2023). An exploratory university-based cross-sectional study of the prevalence and reporting of mistreatment and student-related factors among Thai medical students. BMC Medical Education, 23(1), Article 473. https://doi.org/10.1186/s12909-023-04462-3
    • Skenteris, N. T., Hemme, E., Delfos, L., Karadimou, G., Karlof, E., Lengquist, M., Kronqvist, M., Zhang, X., Maegdefessel, L., Schurgers, L. J., Arnardottir, H., Biessen, E. A. L., Bot, I., & Matic, L. (2023). Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification. Vascular Pharmacology, 150(1), Article 107167. https://doi.org/10.1016/j.vph.2023.107167
    • Maas, S. L., Donners, M. M. P. C., & van der Vorst, E. P. C. (2023). ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?International Journal of Molecular Sciences, 24(8), Article 7309. https://doi.org/10.3390/ijms24087309
    • Keijbeck, A., Raaijmaakers, A., Hillen, L., Gelens, M., van Kuijk, S., Cleutjens, J. P., Peutz-Kootstra, C., & Christiaans, M. (2023). Visual interstitial fibrosis assessment as continuous variable in protocol renal transplant biopsies. Histopathology, 82(5), 713-721. https://doi.org/10.1111/his.14857
    • Ruder, A. V., Temmerman, L., van Dommelen, J. M. A., Nagenborg, J., Lu, C., Sluimer, J. C., Goossens, P., & Biessen, E. A. L. (2023). Culture density influences the functional phenotype of human macrophages. Frontiers in Immunology, 14(1), Article 1078591. https://doi.org/10.3389/fimmu.2023.1078591
    • van der Gulden, R., Timmerman, A. A., Sagasser, M. H., Kramer, A., Scherpbier-de Haan, N., Thoonen, B., & Heeneman, S. (2023). How does portfolio use support self-regulated learning during general practitioner specialty training? A qualitative focus group study. BMJ Open, 13(2), Article e066879. https://doi.org/10.1136/bmjopen-2022-066879
    • van der Vorst, E. P. C., Maas, S. L., Theodorou, K., Peters, L. J. F., Jin, H., Rademakers, T., Gijbels, M. J., Rousch, M., Jansen, Y., Weber, C., Lehrke, M., Lebherz, C., Yildiz, D., Ludwig, A., Bentzon, J. F., Biessen, E. A. L., & Donners, M. M. P. C. (2023). Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. Frontiers in Cardiovascular Medicine, 10(1), Article 974918. https://doi.org/10.3389/fcvm.2023.974918
    • Fontaine, M. A. C., Jin, H., Gagliardi, M., Rousch, M., Wijnands, E., Stoll, M., Li, X., Schurgers, L., Reutelingsperger, C., Schalkwijk, C., van den Akker, N. M. S., Molin, D. G. M., Gullestad, L., Eritsland, J., Hoffman, P., Skjelland, M., Andersen, G. Ø., Aukrust, P., Karel, J., ... Biessen, E. A. L. (2023). Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair. Advanced Science, 10(5), Article 2203053. https://doi.org/10.1002/advs.202203053
  • 2022
    • McDonald, J., Ryan, S., Heeneman, S., & Hu, W. (2022). Informed self-assessment during the transition to medical school: a longitudinal narrative study. BMJ Open, 12(12), Article e065203. https://doi.org/10.1136/bmjopen-2022-065203
    • Moshi, J. M., Ummelen, M., Broers, J. L. V., Smedts, F., Van de Vijver, K. K., Cleutjens, J. P. M., Litjens, R. J. N. T. M., Ramaekers, F. C. S., & Hopman, A. H. N. (2022). SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN. Histochemistry and Cell Biology, 158(6), 545-559. https://doi.org/10.1007/s00418-022-02145-6
    • Wang, S., Neumann, D., Westenbrink, B. D., Schianchi, F., Wong, L.-Y., Sun, A., Strzelecka, A., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2022). Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly-Rescue by Specific Amino Acid Supplementation. International journal of molecular sciences, 23(21), Article 12909. https://doi.org/10.3390/ijms232112909
    • Evans, P. C., Davidson, S. M., Wojta, J., Bäck, M., Bollini, S., Brittan, M., Catapano, A. L., Chaudhry, B., Cluitmans, M., Gnecchi, M., Guzik, T. J., Hoefer, I., Madonna, R., Monteiro, J. P., Morawietz, H., Osto, E., Padró, T., Sluimer, J. C., Tocchetti, C. G., ... Weber, C. (2022). From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. Cardiovascular Research, 118(13), 2754-2767. https://doi.org/10.1093/cvr/cvac114
    • Madrigal-Matute, J., Cuervo, A. M., & Sluimer, J. C. (2022). CHAPERONE-MEDIATED AUTOPHAGY PROTECTS AGAINST ATHEROSCLEROSIS. Autophagy, 18(10), 2505-2507. https://doi.org/10.1080/15548627.2022.2096397
    • Maas, S. L., Jin, H., Lu, C., Nagenborg, J., Karel, J. M. H., Cavill, R., Sikkink, C. J. J. M., Nadeau, S., Gijbels, M., Mees, B. M. E., Smirnov, E., Sluimer, J. C., Martins, G. A., Van der Vorst, E. P. C., & Biessen, E. A. L. (2022). Identification of a PRDM1-regulated T cell network to regulate T cell driving plaque inflammation in human and mouse atherosclerosis. European Heart Journal, 43, 3049-3049. https://doi.org/10.1093/eurheartj/ehac544.3049
    • van der Gulden, R., Timmerman, A., Muris, J. W. M., Thoonen, B. P. A., Heeneman, S., & Scherpbier-de Haan, N. D. (2022). How does portfolio use affect self-regulated learning in clinical workplace learning: What works, for whom, and in what contexts?Perspectives on Medical Education, 11(5), 247-257. https://doi.org/10.1007/s40037-022-00727-7
    • Wollenhaupt, J., Frisch, J., Harlacher, E., Wong, D. W. L., Jin, H., Schulte, C., Vondenhoff, S., Moellmann, J., Klinkhammer, B. M., Zhang, L., Baleanu-Curaj, A., Liehn, E. A., Speer, T., Kazakov, A., Werner, C., van der Vorst, E. P. C., Selejan, S.-R., Hohl, M., Böhm, M., ... Noels, H. (2022). Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease. Redox Biology, 56, Article 102459. https://doi.org/10.1016/j.redox.2022.102459
    • Heuschkel, M. A., Babler, A., Heyn, J., van der Vorst, E. P. C., Steenman, M., Gesper, M., Kappel, B. A., Magne, D., Gouëffic, Y., Kramann, R., Jahnen-Dechent, W., Marx, N., Quillard, T., & Goettsch, C. (2022). Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro. Frontiers in Cardiovascular Medicine, 9, Article 959457. https://doi.org/10.3389/fcvm.2022.959457
    • Waring, O. J., Skenteris, N. T., Biessen, E. A. L., & Donners, M. M. P. C. (2022). Two-faced Janus: The dual role of macrophages in atherosclerotic calcification. Cardiovascular Research, 118(13), 2768–2777. https://doi.org/10.1093/cvr/cvab301
    • van der Vorst, E. P. C., & Lecour, S. (2022). Finding the culprit for the failure of the immune clock as time goes by. Cardiovascular Research, 118(13), e88-e90. https://doi.org/10.1093/cvr/cvac146
    • Ganesh, N., van der Vorst, E. P. C., Spiesshöfer, J., He, S., Burgmaier, M., Findeisen, H., Lehrke, M., Swirski, F. K., Marx, N., & Kahles, F. (2022). Gut immune cells-A novel therapeutical target for cardiovascular disease?Frontiers in Cardiovascular Medicine, 9, Article 943214. https://doi.org/10.3389/fcvm.2022.943214
    • Torre, D., Schuwirth, L., Van der Vleuten, C., & Heeneman, S. (2022). An international study on the implementation of programmatic assessment: Understanding challenges and exploring solutions. Medical Teacher, 44(8), 928-937. https://doi.org/10.1080/0142159x.2022.2083487
    • Goossens, P., Lu, C., Cao, J., Gijbels, M. J., Karel, J. M. H., Wijnands, E., Claes, B. S. R., Fazzi, G. E., Hendriks, T. F. E., Wouters, K., Smirnov, E., van Zandvoort, M. J. M., Balluff, B., Cuypers, E., Donners, M. M. P. C., Heeren, R. M. A., & Biessen, E. A. L. (2022). Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context. Cell Metabolism, 34(8), 1214-1225.e6. https://doi.org/10.1016/j.cmet.2022.06.012
    • Jin, H., Maas, S. L., Lu, C., Nagenborg, J., Manca, M., Karel, J. M. H., Cavill, R., Waring, O., Sikkink, C. J. J. M., Mees, B. M. E., Daemen, M. J. A. P., Smirnov, E., Sluimer, J., Van der Vorst, E., & Biessen, E. A. L. (2022). Identification Of Cd8+T Cell Prdm1 In High-Risk Human Plaques And Its Regulatory Role In Murine Lesion Development. Atherosclerosis, 355, E9-E9.
    • Petsophonsakul, P., Burgmaier, M., Willems, B., Heeneman, S., Stadler, N., Gremse, F., Reith, S., Burgmaier, K., Kahles, F., Marx, N., Natour, E., Bidar, E., Jacobs, M., Mees, B., Reutelingsperger, C., Furmanik, M., & Schurgers, L. (2022). Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells. Cardiovascular Research, 118(9), 2196-2210. https://doi.org/10.1093/cvr/cvab244
    • Wang, S. J., Han, Y. Y., Nabben, M., Neumann, D., Luiken, J. J. F. P., & Glatz, J. F. C. (2022). Endosomal v-ATPase as a Sensor Determining Myocardial Substrate Preference. Metabolites, 12(7), Article 579. https://doi.org/10.3390/metabo12070579