• 2021
    • van der Heide, F. C. T., Steens, I. L. M., Geraets, A. F. J., Foreman, Y. D., Henry, R. M. A., Kroon, A. A., van der Kallen, C. J. H., van Sloten, T. T., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Koster, A., Schaper, N. C., Schram, M. T., ... Stehouwer, C. D. A. (2021). Association of Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration, With Depressive Symptoms Over Time. Jama network open, 4(11), e2134753. https://doi.org/10.1001/jamanetworkopen.2021.34753
    • Bogie, J. F. J., Vanmierlo, T., Vanmol, J., Timmermans, S., Mailleux, J., Nelissen, K., Wijnands, E., Wouters, K., Stinissen, P., Gustafsson, J. A., Steffensen, K. R., Mulder, M., Zelcer, N., & Hendriks, J. J. A. (2021). Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner. Journal of Autoimmunity, 124, [102723]. https://doi.org/10.1016/j.jaut.2021.102723
    • Tang, X. Y., Zhao, W., Lu, M., Zhang, X., Zhang, P., Xin, Z., Sun, R., Tian, W., Cardoso, M. A., Yang, J. K., Sim, R., Zhou, J. B., & Stehouwer, C. D. A. (2021). Relationship between Central Obesity and the incidence of Cognitive Impairment and Dementia from Cohort Studies Involving 5,060,687 Participants. Neuroscience and Biobehavioral Reviews, 130, 301-313. https://doi.org/10.1016/j.neubiorev.2021.08.028
    • Strikwerda, M., Beulens, J. W., Remmelzwaal, S., Schoonmade, L. J., van Straten, A., Schram, M. T., Elders, P. J., & Rutters, F. (2021). The Association of Burnout and Vital Exhaustion With Type 2 Diabetes: A Systematic Review and Meta-Analysis. Psychosomatic Medicine, 83(9), 1013-1030. https://doi.org/10.1097/PSY.0000000000000995
    • Doola, R., Deane, A. M., Barrett, H. L., Okano, S., Tolcher, D. M., Gregory, K., Coombes, J. S., Schalkwijk, C., Todd, A. S., Forbes, J. M., & Sturgess, D. J. (2021). The impact of a modified carbohydrate formula, and its constituents, on glycaemic control and inflammatory markers: A nested mechanistic sub-study. Journal of Human Nutrition and Dietetics. https://doi.org/10.1111/jhn.12959
    • Bakker, L., Ramakers, I. H. G. B., van Boxtel, M. P. J., Schram, M. T., Stehouwer, C. D. A., van der Kallen, C. J. H., Dagnelie, P. C., van Greevenbroek, M. M. J., Wesselius, A., Midttun, Ø., Ueland, P. M., Verhey, F. R. J., Eussen, S. J. P. M., & Köhler, S. (2021). Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. Diabetologia, 64(11), 2445-2457. https://doi.org/10.1007/s00125-021-05521-4
    • van Dalem, J., Driessen, J. H. M., Burden, A. M., Stehouwer, C. D. A., Klungel, O. H., de Vries, F., & Brouwers, M. C. G. J. (2021). Thiazolidinediones and Glucagon-Like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study. Hepatology, 74(5), 2467-2477. https://doi.org/10.1002/hep.32012
    • Kremers, S. H. M., Remmelzwaal, S., Schalkwijk, C. G., Elders, P. J. M., Stehouwer, C. D. A., van Ballegooijen, A. J., & Beulens, J. W. J. (2021). The role of serum and dietary advanced glycation endproducts in relation to cardiac function and structure: The Hoorn Study. Nutrition Metabolism and Cardiovascular Diseases, 31(11), 3167-3175. https://doi.org/10.1016/j.numecd.2021.07.020
    • Remmelzwaal, S., Beulens, J. W. J., Elders, P. J. M., Stehouwer, C. D. A., Handoko, M. L., Appelman, Y., van Empel, V., Heymans, S. R. B., & van Ballegooijen, A. J. (2021). Sex-specific associations of body composition measures with cardiac function and structure after 8 years of follow-up. Scientific Reports, 11(1), [21046]. https://doi.org/10.1038/s41598-021-00541-x
    • Wu, W., Bours, M., Koole, A., Kenkhuis, M. F., Eussen, S., Breukink, S., van Schooten, F., Weijenberg, M., & Hageman, G. (2021). Cross-Sectional Associations between Dietary Daily Nicotinamide Intake and Patient-Reported Outcomes in Colorectal Cancer Survivors, 2 to 10 Years Post-Diagnosis. Nutrients. https://doi.org/10.3390/nu13113707
    • Beulens, J. W. J., Dal Canto, E., Stehouwer, C. D. A., Rennenberg, R. J. M. W., Elders, P. J. M., & van Ballegooijen, A. J. (2021). High vitamin K status is prospectively associated with decreased left ventricular mass in women: the Hoorn Study. Nutrition Journal, 20(1), [85]. https://doi.org/10.1186/s12937-021-00742-0
    • Røikjer, J., Werkman, N. C. C., Ejskjaer, N., van den Bergh, J. P. W., Vestergaard, P., Schaper, N. C., Jensen, M. H., Klungel, O., de Vries, F., Nielen, J. T. H., & Driessen, J. H. M. (2021). Incidence, hospitalization and mortality and their changes over time in people with a first ever diabetic foot ulcer. Diabetic Medicine, [e14725]. https://doi.org/10.1111/dme.14725
    • Safipour, Z., van Der Zanden, R., van den Bergh, J., Janssen, P., Vestergaard, P., de Vries, F., & Driessen, J. H. M. (2021). The use of oral glucocorticoids and the risk of major osteoporotic fracture in patients with myasthenia gravis. Osteoporosis International. https://doi.org/10.1007/s00198-021-06101-3
    • Gianfredi, V., Beran, M., Koster, A., Eussen, S. J. P. M., Odone, A., Signorelli, C., Schaper, N. C., Kohler, S., Bosma, H., Dagnelie, P. C., Stehouwer, C. D. A., Wesselius, A., Amerio, A., Brinkhues, S., Dukers-Muijrers, N., & Schram, M. T. (2021). Association between social network characteristics and prevalent and incident depression: The Maastricht Study. Journal of Affective Disorders, 293, 338-346. https://doi.org/10.1016/j.jad.2021.06.046
    • Janssen, E. P. C. J., Kohler, S., Geraets, A. F. J., Stehouwer, C. D. A., Schaper, N. C., Sep, S. J. S., Henry, R. M. A., van der Kallen, C. J. H., Schalkwijk, C. G., Koster, A., Verhey, F. R., & Schram, M. T. (2021). Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: The Maastricht study. Brain Behavior and Immunity, 97, 61-67. https://doi.org/10.1016/j.bbi.2021.06.013
    • Molto-Puigmarti, C., Obeid, R., Mommers, M., Eussen, S. J. P. M., & Thijs, C. (2021). Maternal plasma choline and betaine in late pregnancy and child growth up to age 8 years in the KOALA Birth Cohort Study. American Journal of Clinical Nutrition, 114(4), 1438-1446. https://doi.org/10.1093/ajcn/nqab177
    • van der Sande, L. J. T. M., Jöbsis, Q., Bannier, M. A. G. E., van de Garde, E. M. W., Coremans, J. J. M., de Vries, F., Dompeling, E., & Driessen, J. H. M. (2021). The risk of community-acquired pneumonia in children using gastric acid suppressants. European Respiratory Journal, 58(4), [2003229]. https://doi.org/10.1183/13993003.03229-2020
    • van Gennip, A. C. E., Stehouwer, C. D. A., van Boxtel, M. P. J., Verhey, F. R. J., Koster, A., Kroon, A. A., Köhler, S., van Greevenbroek, M. M. J., Wesselius, A., Eussen, S. J. P. M., Backes, W. H., Jansen, J. F., Schram, M. T., Henry, R. M. A., Singh-Manoux, A., & van Sloten, T. T. (2021). Association of Type 2 Diabetes, According to the Number of Risk Factors Within Target Range, With Structural Brain Abnormalities, Cognitive Performance, and Risk of Dementia. Diabetes Care. https://doi.org/10.2337/dc21-0149
    • Heger, I. S., Deckers, K., Schram, M. T., Stehouwer, C. DA., Dagnelie, P. C., van der Kallen, C. J., Koster, A., Eussen, S. J., Jansen, J. F., Verhey, F. R., van Boxtel, M. P., & Köhler, S. (2021). Associations of the Lifestyle for Brain Health Index With Structural Brain Changes and Cognition: Results From the Maastricht Study. Neurology, 97(13), E1300-E1312. https://doi.org/10.1212/WNL.0000000000012572
    • Linkens, A. M. A., Houben, A. J. H. M., Kroon, A. A., Schram, M. T., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M., Henry, R. M. A., de Galan, B., Stehouwer, C. D. A., Eussen, S. J. M. P., & Schalkwijk, C. G. (2021). Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab302
    • Simons, P. I. H. G., Cornelissen, M. E. B., Valkenburg, O., Onland-Moret, N. C., van der Schouw, Y. T., Stehouwer, C. D. A., Burgess, S., & Brouwers, M. C. G. J. (2021). Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study. Clinical Endocrinology. https://doi.org/10.1111/cen.14593
    • Veldhuizen, G. P., Alnazer, R. M., de Leeuw, P. W., & Kroon, A. A. (2021). The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof. Cardiovascular Drugs and Therapy. https://doi.org/10.1007/s10557-021-07262-3
    • Beran, M., Muzambi, R., Geraets, A., Albertorio-Diaz, J. R., Adriaanse, M. C., Iversen, M. M., Kokoszka, A., Nefs, G., Nouwen, A., Pouwer, F., Huber, J. W., Schmitt, A., Schram, M. T., & European Depression in Diabetes (EDID) Research Consortium (2021). The bidirectional longitudinal association between depressive symptoms and HbA(1c): A systematic review and meta-analysis. Diabetic Medicine, [e14671]. https://doi.org/10.1111/dme.14671
    • Aglago, E. K., Mayen, A. L., Knaze, V., Freisling, H., Fedirko, V., Hughes, D. J., Jiao, L., Eriksen, A. K., Tjonneland, A., Boutron-Ruault, M. C., Rothwell, J. A., Severi, G., Kaaks, R., Katzke, V., Schulze, M. B., Birukov, A., Palli, D., Sieri, S., de Magistris, M. S., ... Jenab, M. (2021). Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Nutrients, 13(9), [3132]. https://doi.org/10.3390/nu13093132
    • Geraets, A. F. J., Kohler, S., Jansen, J. F. A., Eussen, S. J. P. M., Stehouwer, C. D. A., Schaper, N. C., Wesselius, A., Verhey, F. R. J., & Schram, M. T. (2021). The association of markers of cerebral small vessel disease and brain atrophy with incidence and course of depressive symptoms-the maastricht study. Journal of Affective Disorders, 292, 439-447. https://doi.org/10.1016/j.jad.2021.05.096
    • van Dongen, K. C. W., Linkens, A. M. A., Wetzels, S. M. W., Wouters, K., Vanmierlo, T., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., de Vos, W. M., Belzer, C., & Schalkwijk, C. G. (2021). Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility. Food Research International, 147, [110547]. https://doi.org/10.1016/j.foodres.2021.110547
    • ESH Working Group on Device-Based Treatment of Hypertension (2021). European Society of Hypertension position paper on renal denervation 2021. Journal of Hypertension, 39(9), 1733-1741. https://doi.org/10.1097/HJH.0000000000002933
    • Piazza, M., Hanssen, N. M. J., Persson, F., Scheijen, J. L., van de Waarenburg, M. P. H., van Greevenbroek, M. M. J., Rossing, P., Hovind, P., Stehouwer, C. D. A., Parving, H-H., & Schalkwijk, C. G. (2021). Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study. Diabetic Medicine, 38(9), [14405]. https://doi.org/10.1111/dme.14405
    • Vosa, U., Claringbould, A., Westra, H. J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., Brugge, H., Oelen, R., de Vries, D. H., van der Wijst, M. G. P., Kasela, S., Pervjakova, N., Alves, I., Fave, M. J., Agbessi, M., ... Stehouwer, C. D. A. (2021). Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nature Genetics, 53(9), 1300-1310. https://doi.org/10.1038/s41588-021-00913-z
    • Schram, M. T., Assendelft, W. J. J., van Tilburg, T. G., & Dukers-Muijrers, N. H. T. M. (2021). Social networks and type 2 diabetes: a narrative review. Diabetologia, 64(9), 1905-1916. https://doi.org/10.1007/s00125-021-05496-2
    • De Clerck, E. E. B., Schouten, J. S. A. G., Berendschot, T. T. J. M., Goezinne, F., Liesenborghs, I., Dagnelie, P. C., Schaper, N. C., Kroon, A. A., Henry, R. M. A., Reesink, K. D., Schram, M. T., Stehouwer, C. D. A., & Webers, C. A. B. (2021). Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study. Acta Ophthalmologica, 99(6), e860-e868. https://doi.org/10.1111/aos.14677
    • Wouters, K., Cento, A. S., Gaens, K. H., Teunissen, M., Scheijen, J. L. J. M., Barutta, F., Chiazza, F., Collotta, D., Aragno, M., Gruden, G., Collino, M., Schalkwijk, C. G., & Mastrocola, R. (2021). Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems. Scientific Reports, 11(1), [17373]. https://doi.org/10.1038/s41598-021-96859-7
    • Mayen, A-L., Aglago, E. K., Knaze, V., Cordova, R., Schalkwijk, C. G., Wagner, K-H., Aleksandrova, K., Fedirko, V., Keski-Rahkonen, P., Leitzmann, M. F., Katzke, V., Srour, B., Schulze, M. B., Masala, G., Krogh, V., Panico, S., Tumino, R., Bueno-de-Mesquita, B., Brustad, M., ... Freisling, H. (2021). Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study. International Journal of Cancer, 149(4), 854-864. https://doi.org/10.1002/ijc.33612
    • Empana, J. P., Boutouyrie, P., Lemogne, C., Jouven, X., & van Sloten, T. T. (2021). Microvascular Contribution to Late-Onset Depression: Mechanisms, Current Evidence, Association With Other Brain Diseases, and Therapeutic Perspectives. Biological Psychiatry, 90(4), 214-225. https://doi.org/10.1016/j.biopsych.2021.04.012
    • Monereo-Sanchez, J., de Jong, J. J. A., Drenthen, G. S., Beran, M., Backes, W. H., Stehouwer, C. D. A., Schram, M. T., Linden, D. E. J., & Jansen, J. F. A. (2021). Quality control strategies for brain MRI segmentation and parcellation: Practical approaches and recommendations- insights from the Maastricht study. Neuroimage, 237, [118174]. https://doi.org/10.1016/j.neuroimage.2021.118174
    • Lisan, Q., van Sloten, T., Boutouyrie, P., Laurent, S., Danchin, N., Thomas, F., Guibout, C., Perier, M-C., Dagnelie, P., Henry, R. M., Schram, M. T., Heinzer, R., Marques-Vidal, P., van der Kallen, C. J., Crijns, H. J., van Greevenbroek, M., Reesink, K., Kohler, S., Sastry, M., ... Empana, J-P. (2021). Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community-Based Cohort Studies. Journal of the American Heart Association, 10(15), [021318]. https://doi.org/10.1161/JAHA.120.021318
    • Aragones, G., Rowan, S., Francisco, S. G., Whitcomb, E. A., Yang, W. X., Perini-Villanueva, G., Schalkwijk, C. G., Taylor, A., & Bejarano, E. (2021). The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy. Cells, 10(8), [1852]. https://doi.org/10.3390/cells10081852
    • van der Heide, F. C. T., Zhou, T. L., Henry, R. M. A., Houben, A. J. H. M., Kroon, A. A., Dagnelie, P. C., van Dongen, M. C. J. M., Eussen, S. J. P. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Savelberg, H. H. C. M., Schaper, N. C., Reesink, K. D., & Stehouwer, C. D. A. (2021). Carotid stiffness is associated with retinal microvascular dysfunction- The Maastricht Study. Microcirculation, 28(6), [e12702]. https://doi.org/10.1111/micc.12702
    • Foreman, Y. D., van Doorn, W. P. T. M., Schaper, N. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Henry, R. M. A., Koster, A., Eussen, S. J. P. M., Wesselius, A., Reesink, K. D., Schram, M. T., Dagnelie, P. C., Kroon, A. A., Brouwers, M. C. G. J., & Stehouwer, C. D. A. (2021). Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study. Diabetologia, 64(8), 1880-1892. https://doi.org/10.1007/s00125-021-05474-8
    • Houghton, R., van den Bergh, J., Law, K., Liu, Y., & de Vries, F. (2021). Risperidone versus aripiprazole fracture risk in children and adolescents with autism spectrum disorders. Autism Research, 14(8), 1800-1814. https://doi.org/10.1002/aur.2541
    • Simons, P. I. H. G., Valkenburg, O., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2021). Sex hormone-binding globulin: biomarker and hepatokine?Trends in Endocrinology and Metabolism, 32(8), 544-553. https://doi.org/10.1016/j.tem.2021.05.002
    • Brouwers, M. C. G. J. (2021). When to Consider an Inborn Error of Metabolism in Adults?Journal of Endocrinology and Metabolism, 11(3-4), 65-68. https://doi.org/10.14740/jem750
    • Hoogeveen, R. M., Hanssen, N. M. J., Brouwer, J. R., Mosterd, A., Tack, C. J., Kroon, A. A., De Borst, G. J., Ten Berg, J., Van Trier, T., Van Lennep, J. R., Liem, A., Serne, E., Visseren, F. L. J., Cornel, J. H., Peters, R. J. G., Jukema, J. W., Stroes, E. S. G., & PANORAMA working group (2021). The challenge of choosing in cardiovascular risk management. Netherlands Heart Journal. https://doi.org/10.1007/s12471-021-01599-y
    • Abtahi, S., Driessen, J. H. M., Burden, A. M., Souverein, P. C., van den Bergh, J. P., van Staa, T. P., Boonen, A., & de Vries, F. (2021). Low-dose oral glucocorticoid therapy and risk of osteoporotic fractures in patients with rheumatoid arthritis: a cohort study using the Clinical Practice Research Datalink. Rheumatology. https://doi.org/10.1093/rheumatology/keab548
    • Veugen, M. G. J., Linssen, P. B. C., Henry, R. M. A., Koster, A., Kroon, A. A., Stehouwer, C. D. A., & Brunner-La Rocca, H-P. (2021). Measures of Left Ventricular Diastolic Function and Cardiorespiratory Fitness According to Glucose Metabolism Status: The Maastricht Study. Journal of the American Heart Association, 10(13), [020387]. https://doi.org/10.1161/jaha.120.020387
    • Monereo-Sanchez, J., Schram, M. T., Frei, O., O'Connell, K., Shadrin, A. A., Smeland, O. B., Westlye, L. T., Andreassen, O. A., Kaufmann, T., Linden, D. E. J., & van der Meer, D. (2021). Genetic Overlap Between Alzheimer's Disease and Depression Mapped Onto the Brain. Frontiers in Neuroscience, 15, [653130]. https://doi.org/10.3389/fnins.2021.653130
    • Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Taskinen, M. R., Boren, J., Schrauwen, P., Rutten, J. H. W., Cassiman, D., Schalkwijk, C. G., Stehouwer, C. D. A., Schrauwen-Hinderling, V. B., Hodson, L., & Brouwers, M. C. G. J. (2021). Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. Clinical Endocrinology, 95(1), 101-106. https://doi.org/10.1111/cen.14459
    • Driessen, R. G. H., Kiers, D., Schalkwijk, C. G., Scheijen, J. L. J. M., Gerretsen, J., Pickkers, P., van de Poll, M. C. G., van der Horst, I. C. C., Bergmans, D. C. J. J., Kox, M., & van Bussel, B. C. T. (2021). Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. Bioscience Reports, 41(7), [BSR20210954]. https://doi.org/10.1042/BSR20210954
    • Van den Eynde, M. D. G., Scheijen, J. L. J. M., Stehouwer, C. D. A., Miyata, T., & Schalkwijk, C. G. (2021). Quantification of the B6 vitamers in human plasma and urine in a study with pyridoxamine as an oral supplement; pyridoxamine as an alternative for pyridoxine. Clinical Nutrition, 40(7), 4624-4632. https://doi.org/10.1016/j.clnu.2021.05.028
    • Borg, D. J., Faridi, P., Giam, K. L., Reeves, P., Fotheringham, A. K., McCarthy, D. A., Leung, S., Ward, M. S., Harcourt, B. E., Ayala, R., Scheijen, J. L., Briskey, D., Dudek, N. L., Schalkwijk, C. G., Steptoe, R., Purcell, A. W., & Forbes, J. M. (2021). Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model. Metabolites, 11(7), [426]. https://doi.org/10.3390/metabo11070426