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Social and economic background influences survival in intensive care: Research with societal impact

Social and economic background influences survival in intensive care: Research with societal impact

18 August 2026

A large-scale study by researchers from Maastricht UMC+ and Amsterdam UMC demonstrates that lower socioeconomic status (SES) of patients admitted to Dutch intensive care units contributes to worse survival.

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Fatma Karapinar appointed as Professor in Medication Safety

Fatma Karapinar appointed as Professor in Medication Safety

12 August 2026

As of 1 June 2026, Dr Fatma Karapinar has been appointed Professor of Medication Safety at Maastricht University.

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Carim Maastricht
Carim Maastricht

Annemariek Driessen

Post doc

Dr. Annemariek Driessen holds a Bachelor`s degree in Biomedical Sciences and a Master`s degree in Statistical Sciences for Life and Behaviourial Sciences, both from Leiden University. In 2012, she started her PhD in pharmacoepidemiology at Maastricht University within the School for Public Health and Primary Care (CAPHRI) in 2012. Her research focused on unintended effects of anti-hyperglycaemic drugs on bone health.

After completing her PhD in 2017, Annemariek continued her research at Maastricht University as a post-doctoral researcher within CARIM. Her current research focuses on effectiveness and safety of medicines, with a particular interest in diabetes and osteoporosis. In addition, she conducts research on prescribing cascades, when side effects of one medicine may lead to the prescription of another medicine. 

Annemariek driessen klin farmacie toxologie 003 pasfoto 002

Department of Clinical Pharmacy 
P. Debeyelaan 25, 6229 HX Maastricht 
Telephone: +31 (0)43 387 18 81

  • 2020
    • de Bruin, I. J. A., Wyers, C. E., Souverein, P. C., van Staa, T. P., Geusens, P. P. M. M., van den Bergh, J. P. W., de Vries, F., & Driessen, J. H. M. (2020). The risk of new fragility fractures in patients with chronic kidney disease and hip fracture-a population-based cohort study in the UK. Osteoporosis International, 31(8), 1487-1497. https://doi.org/10.1007/s00198-020-05351-x
    • Oortgiesen, B. E., Driessen, J. H. M., Hoogendoorn, M., Kibbelaar, R. E., Veeger, N. J. G. M., van den Bergh, J. P. W., Vestergaard, P., de Vries, F., & van Roon, E. N. (2020). No decrease in fracture risk despite 15 years of treatment evolution for multiple myeloma patients: A Danish nationwide case-control study. Bone, 134, Article 115299. https://doi.org/10.1016/j.bone.2020.115299
    • van Durme, C., Spaetgens, B., Driessen, J., Nielen, J., Sastry, M., Boonen, A., & de Vries, F. (2020). Obstructive sleep apnea and the risk of gout: a population-based case-control study. Arthritis Research & Therapy, 22(1), Article 92. https://doi.org/10.1186/s13075-020-02176-1
    • van Dort, M. J., Driessen, J. H. M., Geusens, P., Romme, E. A. P. M., Smeenk, F. W. J. M., Rahel, B. M., Eisman, J. A., Wouters, E. F. M., & van den Bergh, J. P. W. (2020). Association between vertebral fractures and coronary artery calcification in current and former smokers in the ECLIPSE cohort. Osteoporosis International, 31(2), 297-305. https://doi.org/10.1007/s00198-019-05218-w
    • Oshagbemi, O. A., Franssen, F. M. E., Wouters, E. F. M., Maitland-van der Zee, A. H., Driessen, J. H. M., de Boer, A., & de Vries, F. (2020). C-reactive protein as a biomarker of response to inhaled corticosteroids among patients with COPD. Pulmonary Pharmacology & Therapeutics, 60, Article 101870. https://doi.org/10.1016/j.pupt.2019.101870
    • Nielen, J. T. H., Driessen, J. H. M., Dagnelie, P. C., Boonen, A., van den Bemt, B., van Onzenoort, H. A. W., Neef, C., Henry, R. M. A., Burden, A. M., Sep, S. J. S., van der Kallen, C. J., Schram, M. T., Schaper, N., Stehouwer, C. D. A., Smits, L., & de Vries, F. (2020). Drug utilization in the Maastricht Study: A comparison with nationwide data. Medicine, 99(1), Article 18524. https://doi.org/10.1097/MD.0000000000018524
    • Abbas, H., Kurdi, M., de Vries, F., van Onzenoort, H. A. W., Driessen, J. H. M., Watfa, M., & Karam, R. (2020). Factors Associated with Antihypertensive Medication Non-Adherence: A Cross-Sectional Study Among Lebanese Hypertensive Adults. Patient Preference and Adherence, 14, 663-673. https://doi.org/10.2147/PPA.S238751
  • 2019
    • den Heijer, C. D. J., Hoebe, C. J. P. A., Driessen, J. H. M., Wolffs, P., van den Broek, I. V. F., Hoenderboom, B. M., Williams, R., de Vries, F., & Dukers-Muijrers, N. H. T. M. (2019). Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients. Clinical Infectious Diseases, 69(9), 1517-1525. https://doi.org/10.1093/cid/ciz429
    • Abtahi, S., Driessen, J. H. M., Vestergaard, P., van den Bergh, J., Boonen, A., de Vries, F., & Burden, A. M. (2019). Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010. Osteoporosis International, 30(11), 2217-2223. https://doi.org/10.1007/s00198-019-05109-0
    • Vranken, L., Wyers, C. E., van Rietbergen, B., Driessen, J. H. M., Geusens, P. P. M. M., Janzing, H. M. J., van der Velde, R. Y., & van den Bergh, J. P. W. (2019). The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service. Osteoporosis International, 30(9), 1789-1797. https://doi.org/10.1007/s00198-019-05081-9
    • van Maren, M. A., Wyers, C. E., Driessen, J. H. M., Visser, J. V., de Vries, F., van de Wijdeven, K., Gevers, S., Lems, W. F., Emmelot-Vonk, M. H., & van den Bergh, J. P. W. (2019). Two-year persistence with teriparatide improved significantly after introduction of an educational and motivational support program. Osteoporosis International, 30(9), 1837-1844. https://doi.org/10.1007/s00198-019-05052-0
    • van Dort, M. J., Driessen, J. H. M., Geusens, P., Romme, E. A. P. M., Smeenk, F. W. J. M., Wouters, E. F. M., & van den Bergh, J. P. W. (2019). Vertebral bone attenuation in Hounsfield Units and prevalent vertebral fractures are associated with the short-term risk of vertebral fractures in current and ex-smokers with and without COPD: a 3-year chest CT follow-up study. Osteoporosis International, 30(8), 1561-1571. https://doi.org/10.1007/s00198-019-04977-w
    • Abtahi, S., Driessen, J. H. M., Vestergaard, P., van den Bergh, J., Boonen, A., de Vries, F., & Burden, A. M. (2019). Retraction Note to: Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010. Archives of Osteoporosis, 14(1), Article 77. https://doi.org/10.1007/s11657-019-0614-1
    • van Dort, M. J., Driessen, J. H. M., Romme, E. A. P. M., Geusens, P., Willems, P. C., Smeenk, F. W. J. M., Wouters, E. F. M., & van den Bergh, J. P. W. (2019). Thoracic Kyphosis on Chest CT Scans Is Associated With Incident Vertebral Fractures in Smokers. Journal of Bone and Mineral Research, 34(5), 859-866. https://doi.org/10.1002/jbmr.3672
    • de Bruin, I. J. A., Klop, C., Wyers, C. E., Overbeek, J. A., Geusens, P. P. M. M., van den Bergh, J. P. W., Driessen, J. H. M., & de Vries, F. (2019). All-cause mortality with current and past use of antidepressants or benzodiazepines after major osteoporotic and hip fracture. Osteoporosis International, 30(3), 573-581. https://doi.org/10.1007/s00198-019-04851-9
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H. A. W., Schram, M. T., van der Kallen, C., Reesink, K. D., Sep, S., Stehouwer, C. D. A., Schaper, N., Kroon, A. A., Schalkwijk, C., van den Bergh, J. P. W., & Henry, R. M. A. (2019). Metformin use in type 2 diabetic patients is not associated with lower arterial stiffness: the Maastricht Study. Journal of Hypertension, 37(2), 365-371. https://doi.org/10.1097/HJH.0000000000001892
    • Oshagbemi, O. A., Franssen, F. M. E., van Kraaij, S., Braeken, D. C. W., Wouters, E. F. M., Maitland-van der Zee, A. H., Driessen, J. H. M., & de Vries, F. (2019). Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD). COPD, 16(2), 152-159. https://doi.org/10.1080/15412555.2019.1608172
  • 2018
    • Simeonova, M., de Vries, F., Pouwels, S., Driessen, J. H. M., Leufkens, H. G. M., Cadarette, S. M., & Burden, A. M. (2018). Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK. British Journal of Clinical Pharmacology, 84(11), 2551-2561. https://doi.org/10.1111/bcp.13708
    • Oshagbemi, O. A., Keene, S. J., Driessen, J. H. M., Jordan, R., Wouters, E. F. M., de Boer, A., de Vries, F., & Franssen, F. M. E. (2018). Trends in moderate and severe exacerbations among COPD patients in the UK from 2005 to 2013. Respiratory Medicine, 144, 1-6. https://doi.org/10.1016/j.rmed.2018.09.010
    • Peters, M., van Tubergen, A., Scharmga, A., Driessen, A., van Rietbergen, B., Loeffen, D., Weijers, R., Geusens, P., & van den Bergh, J. (2018). Assessment of Cortical Interruptions in the Finger Joints of Patients With Rheumatoid Arthritis Using HR-pQCT, Radiography, and MRI. Journal of Bone and Mineral Research, 33(9), 1676-1685. https://doi.org/10.1002/jbmr.3466
    • Abtahi, S., Driessen, J. H. M., Vestergaard, P., van den Bergh, J., Boonen, A., de Vries, F., & Burden, A. M. (2018). RETRACTED ARTICLE: Secular trends in major osteoporotic fractures among 50+adults in Denmark between 1995 and 2010. Archives of Osteoporosis, 13(1), Article 91. https://doi.org/10.1007/s11657-018-0503-z
    • van Dort, M. J., Geusens, P., Driessen, J. H. M., Romme, E. A. P. M., Smeenk, F. W. J. M., Wouters, E. F. M., & van den Bergh, J. P. W. (2018). High Imminent Vertebral Fracture Risk in Subjects With COPD With a Prevalent or Incident Vertebral Fracture. Journal of Bone and Mineral Research, 33(7), 1233-1241. https://doi.org/10.1002/jbmr.3429
    • Knapen, L. M., Koornstra, R. H. T., Driessen, J. H. M., van Vlijmen, B., Croes, S., Schalkwijk, S., Colbers, A., Gerritsen, W. R., Burger, D. M., de Vries, F., & van Erp, N. P. (2018). The Impact of Dose and Simultaneous Use of Acid-Reducing Agents on the Effectiveness of Vemurafenib in Metastatic BRAF V600 Mutated Melanoma: a Retrospective Cohort Study. Targeted Oncology, 13(3), 363-370. https://doi.org/10.1007/s11523-018-0564-3
    • Oshagbemi, O. A., Burden, A. M., Shudofsky, K. N., Driessen, J. H. M., Vestergaard, P., Krings, A., Franssen, F. M. E., van den Bergh, J., & de Vries, F. (2018). Use of high-dose intermittent systemic glucocorticoids and the risk of fracture in patients with chronic obstructive pulmonary disease. Bone, 110, 238-243. https://doi.org/10.1016/j.bone.2018.02.007
    • van Dalem, J., Brouwers, M. C. G. J., Stehouwer, C. D. A., Krings, A., Klungel, O. H., Driessen, J. H. M., de Vries, F., & Burden, A. M. (2018). Risk of a first-ever acute myocardial infarction and all-cause mortality with sulphonylurea treatment: A population-based cohort study. Diabetes Obesity & Metabolism, 20(4), 1056-1060. https://doi.org/10.1111/dom.13168
    • Amiche, M. A., Abtahi, S., Driessen, J. H. M., Vestergaard, P., de Vries, F., Cadarette, S. M., & Burden, A. M. (2018). Impact of cumulative exposure to high-dose oral glucocorticoids on fracture risk in Denmark: a population-based case-control study. Archives of Osteoporosis, 13(1), Article 30. https://doi.org/10.1007/s11657-018-0424-x
  • 2017
    • Oshagbemi, O. A., Driessen, J. H. M., Pieffers, A., Wouters, E. F. M., Geusens, P., Vestergaard, P., van den Bergh, J., Franssen, F. M. E., & de Vries, F. (2017). Use of systemic glucocorticoids and the risk of major osteoporotic fractures in patients with sarcoidosis. Osteoporosis International, 28(10), 2859-2866. https://doi.org/10.1007/s00198-017-4115-z
    • Driessen, J. H. M., Knapen, L. M., Geusens, P. P. M. M., & van den Bergh, J. P. W. (2017). Fracture risk reduction with use of dipeptidyl peptidase-4 inhibitors: is there immortal time bias?Osteoporosis International, 28(8), 2429-2430. https://doi.org/10.1007/s00198-017-4120-2
    • de Waard, E. A. C., Driessen, J. H. M., de Jong, J. J. A., van Geel, T. A. C. M., Henry, R. M. A., van Onzenoort, H. A. W., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Koster, A., Savelberg, H. H. C. M., Neef, C., Geusens, P. P. M. M., de Vries, F., & van den Bergh, J. P. W. (2017). The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study. Bone, 101, 156-161. https://doi.org/10.1016/j.bone.2017.05.004
    • Oshagbemi, O. A., Burden, A. M., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., Driessen, J. H. M., Maitland-van der Zee, A. H., de Vries, F., & Franssen, F. M. E. (2017). Stability of Blood Eosinophils in Patients with Chronic Obstructive Pulmonary Disease and in Control Subjects, and the Impact of Sex, Age, Smoking, and Baseline Counts. American Journal of Respiratory and Critical Care Medicine, 195(10), 1402-1404. https://doi.org/10.1164/rccm.201701-0009LE
    • Spaetgens, B., de Vries, F., Driessen, J. H. M., Leufkens, H. G., Souverein, P. C., Boonen, A., van der Meer, J. W. M., & Joosten, L. A. B. (2017). Risk of infections in patients with gout: a population-based cohort study. Scientific Reports, 7(1), Article 1429. https://doi.org/10.1038/s41598-017-01588-5
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H., Harvey, N. C., Neef, C., van den Bergh, J. P. W., Vestergaard, P., & Henry, R. M. A. (2017). The use of incretins and fractures - a meta-analysis on population-based real life data. British Journal of Clinical Pharmacology, 83(4), 923-926. https://doi.org/10.1111/bcp.13167
    • Driessen, J. H. M., van den Bergh, J. P. W., van Onzenoort, H. A. W., Henry, R. M. A., Leufkens, H. G. M., & de Vries, F. (2017). Long-term use of dipeptidyl peptidase-4 inhibitors and risk of fracture: A retrospective population-based cohort study. Diabetes Obesity & Metabolism, 19(3), 421-428. https://doi.org/10.1111/dom.12843
    • Knapen, L. M., de Jong, R. G. P. J., Driessen, J. H. M., Keulemans, Y. C., van Erp, N. P., De Bruin, M. L., Leufkens, H. G. M., Croes, S., & de Vries, F. (2017). Use of incretin agents and risk of acute and chronic pancreatitis: A population-based cohort study. Diabetes Obesity & Metabolism, 19(3), 401-411. https://doi.org/10.1111/dom.12833
    • van de Plas, A., Slikkerveer, M., Hoen, S., Schrijnemakers, R., Driessen, J., de Vries, F., & van den Bemt, P. (2017). Experiences with Lean Six Sigma as improvement strategy to reduce parenteral medication administration errors and associated potential risk of harm. BMJ Open Quality, 6(1), Article u215011.w5936. https://doi.org/10.1136/bmjquality.u215011.w5936
    • Braeken, D. C. W., Rohde, G. G. U., Franssen, F. M. E., Driessen, J. H. M., van Staa, T. P., Souverein, P. C., Wouters, E. F. M., & de Vries, F. (2017). Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom. International journal of chronic obstructive pulmonary disease, 12, 2425-2432. https://doi.org/10.2147/COPD.S138435
  • 2016
    • Dalem, J. V., Brouwers, M. C. G. J., Stehouwer, C. D. A., Krings, A., Leufkens, H. G. M., Driessen, J. H. M., Devries, F., & Burden, A. M. (2016). Het risico op hypoglykemieen bij sulfonylureum- derivaten ten opzichte van metformine in relatie tot nierfunctie en metabolietgroep. Pharmaceutisch Weekblad, 151(50), 37-41.
    • Driessen, J. H. M., Hansen, L., Eriksen, S. A., van Onzenoort, H. A. W., Henry, R. M. A., van den Bergh, J., Abrahamsen, B., Vestergaard, P., & de Vries, F. (2016). The epidemiology of fractures in Denmark in 2011. Osteoporosis International, 27(6), 2017-2025. https://doi.org/10.1007/s00198-016-3488-8
    • Knapen, L., van Dalem, J., Keulemans, J., van Erp, N. P., Bazelier, M. T., de Bruin, M. L., Leufkens, H. G., Croes, S., Neef, C., de Vries, F., & Driessen, J. H. M. (2016). Use of incretin agents and risk of pancreatic cancer: a population-based cohort study. Diabetes Obesity & Metabolism, 18(3), 258-265. https://doi.org/10.1111/dom.12605
  • 2015
    • Driessen, J. H. M., van Onzenoort, H. A. W., Starup-Linde, J., Henry, R., Burden, A. M., Neef, C., van den Bergh, J. P., Vestergaard, P., & de Vries, F. (2015). Use of Glucagon-Like-Peptide 1 Receptor Agonists and Risk of Fracture as Compared to Use of Other Anti-hyperglycemic Drugs. Calcified Tissue International, 97(5), 506-515. https://doi.org/10.1007/s00223-015-0037-y
    • Driessen, J. H. M., Henry, R. M. A., van Onzenoort, H. A. W., Lalmohamed, A., Burden, A. M., Prieto-Alhambra, D., Neef, C., Leufkens, H. G. M., & de Vries, F. (2015). Bone Fracture Risk is Not Associated with the Use of Glucagon-Like Peptide-1 Receptor Agonists: A Population-Based Cohort Analysis. Calcified Tissue International, 97(2), 104-112. https://doi.org/10.1007/s00223-015-9993-5
    • Wijnands, J. M. A., van Durme, C. M. P. G., Driessen, J. H. M., Boonen, A., Klop, C., Leufkens, B., Cooper, C., Stehouwer, C. D. A., & de Vries, F. (2015). Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This is Not Due to Diabetes: A Population-Based Cohort Study. Medicine, 94(32), Article e1358. https://doi.org/10.1097/MD.0000000000001358
    • Goossens, M. E., Buntinx, F., Zeegers, M. P., Driessen, J. H. M., de Bruin, M. L., & de Vries, F. (2015). Influence of metformin intake on the risk of bladder cancer in type 2 diabetes patients. British Journal of Clinical Pharmacology, 80(6), 1464-1472. https://doi.org/10.1111/bcp.12740
    • Driessen, J. H. M., van Onzenoort, H. A. W., Starup-Linde, J., Henry, R., Neef, C., van den Bergh, J., Vestergaard, P., de Vries, F., & Burden, A. M. (2015). Use of dipeptidyl peptidase 4 inhibitors and fracture risk compared to use of other anti-hyperglycemic drugs. Pharmacoepidemiology and Drug Safety, 24(10), 1017-1025. https://doi.org/10.1002/pds.3837
    • van der Zanden, R. W., de Vries, F., Lalmohamed, A., Driessen, J. H. M., de Boer, A., Rohde, G., Neef, C., & den Heijer, C. (2015). Use of Dipeptidyl-Peptidase-4 Inhibitors and the Risk of Pneumonia: A Population-Based Cohort Study. PLOS ONE, 10(10), Article e0139367. https://doi.org/10.1371/journal.pone.0139367
  • 2014
    • Driessen, J. H. M., van Onzenoort, H. A. W., Henry, R. M. A., Lalmohamed, A., van den Bergh, J. P., Neef, C. K., Leufkens, H. G. M., & de Vries, F. (2014). Use of dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus and risk of fracture. Bone, 68, 124-130. https://doi.org/10.1016/j.bone.2014.07.030
  • 2013
    • Klop, C., Driessen, J. H. M., & de Vries, F. (2013). Statin use and reduced cancer-related mortality...N Engl J Med. 2012 Nov 8;367(19): 1792-802. New England Journal of Medicine, 368(6), 574. https://doi.org/10.1056/NEJMc1214827
    • Buurma, A. J., Turner, R. J., Driessen, J. H. M., Mooyaart, A. L., Schoones, J. W., Bruijn, J. A., Bloemenkamp, K. W. M., Dekkers, O. M., & Baelde, H. J. (2013). Genetic variants in pre-eclampsia: a meta-analysis. Human Reproduction Update, 19(3), 289-303. https://doi.org/10.1093/humupd/dms060
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