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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Publications

Section Barend Mees Section Leon Schurgers Section Elham Bidar
  • 2010
    • Donners, M. P. C., Wolfs, I. M. J., Olieslagers, S., Mohammadi-Motahhari, Z., Tchaikovski, V., Heeneman, S., van Buul, J. D., Caolo, V., Molin, D. G. M., Post, M. J., & Waltenberger, J. (2010). A Disintegrin and Metalloprotease 10 Is a Novel Mediator of Vascular Endothelial Growth Factor: Induced Endothelial Cell Function in Angiogenesis and Is Associated With Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology, 30(11), 2188-U382. https://doi.org/10.1161/ATVBAHA.110.213124
    • Dargaud, Y., Spronk, H. M. H., Leenders, P., Hemker, H. C., & Ten Cate, H. (2010). Monitoring platelet dependent thrombin generation in mice. Thrombosis Research, 126(5), 436-441. https://doi.org/10.1016/j.thromres.2010.08.007
    • Peppelenbosch, A. G., Windsant, I. C. V., Jacobs, M. J., Tordoir, J. H. M., & Schurink, G. W. H. (2010). Open Repair for Ruptured Abdominal Aortic Aneurysm and the Risk of Spinal Cord Ischemia: Review of the Literature and Risk-factor Analysis. European Journal of Vascular and Endovascular Surgery, 40(5), 589-595. https://doi.org/10.1016/j.ejvs.2010.07.024
    • Ueland, T., Gullestad, L., Dahl, C. P., Aukrust, P., Aakhus, S., Solberg, O. G., Vermeer, C., & Schurgers, L. J. (2010). Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis. Journal of Internal Medicine, 268(5), 483-492. https://doi.org/10.1111/j.1365-2796.2010.02264.x
    • Cranenburg, E. C. M., Koos, R., Schurgers, L. J., Magdeleyns, E. J. P., Schoonbrood, T. H. M., Landewe, R. B., Brandenburg, V. M., Bekers, O., & Vermeer, C. (2010). Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thrombosis and Haemostasis, 104(4), 811-822. https://doi.org/10.1160/TH09-11-0786
    • Jellema, R. K., Bomans, P., Deckers, N., Ungethum, L., Reutelingsperger, C. P. M., Hofstra, L., & Frederik, P. M. (2010). Transfection efficiency of lipoplexes for site-directed delivery. Journal of Liposome Research, 20(3), 258-267. https://doi.org/10.3109/08982100903384137
    • Wallin, R., Schurgers, L. J., & Loeser, R. F. (2010). Biosynthesis of the vitamin K-dependent matrix Gla protein (MGP) in chondrocytes: a fetuin-MGP protein complex is assembled in vesicles shed from normal but not from osteoarthritic chondrocytes. Osteoarthritis and Cartilage, 18(8), 1096-1103. https://doi.org/10.1016/j.joca.2010.05.013
    • Cosemans, J. M. E. M., Van Kruchten, R., Olieslagers, S., Schurgers, L. J., Verheyen, F. K., Munnix, I. C. A., Waltenberger, J., Angelillo-Scherrer, A., Hoylaerts, M. F., Carmeliet, P., & Heemskerk, J. W. M. (2010). Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. Journal of Thrombosis and Haemostasis, 8(8), 1797-1808. https://doi.org/10.1111/j.1538-7836.2010.03935.x
    • Rennenberg, R. J. M. W., van Varik, B. J., Schurgers, L. J., Hamulyak, K., ten Cate, H., Leiner, T., Vermeer, C., de Leeuw, P. W., & Kroon, A. A. (2010). Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood, 115(24), 5121-5123. https://doi.org/10.1182/blood-2010-01-264598
    • Vanakker, O. M., Martin, L., Schurgers, L. J., Quaglino, D., Costrop, L., Vermeer, C., Pasquali-Ronchetti, I., Coucke, P. J., & De Paepe, A. (2010). Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome. Laboratory Investigation, 90(6), 895-905. https://doi.org/10.1038/labinvest.2010.68
    • Parker, B. D., Schurgers, L. J., Brandenburg, V. M., Christenson, R. H., Vermeer, C., Ketteler, M., Shlipak, M. G., Whooley, M. A., & Ix, J. H. (2010). The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study. Annals of Internal Medicine, 152(10), 640-648. https://doi.org/10.7326/0003-4819-152-10-201005180-00004
    • Vermeulen Windsant, I. C., Snoeijs, M. G., Hanssen, S. J. P., Altintas, S., Heijmans, J. H., Koeppel, T. A., Schurink, G. W. H., Buurman, W. A., & Jacobs, M. J. H. M. (2010). Hemolysis is associated with acute kidney injury during major aortic surgery.Kidney International, 77(10), 913-920. https://doi.org/10.1038/ki.2010.24
    • Parker, B. D., Schurgers, L. J., Vermeer, C., Schiller, N. B., Whooley, M. A., & Ix, J. H. (2010). The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study. Atherosclerosis, 210(1), 320-325. https://doi.org/10.1016/j.atherosclerosis.2009.11.023
    • Schlieper, G., Grotemeyer, D., Aretz, A., Schurgers, L. J., Krueger, T., Rehbein, H., Weirich, T. E., Westenfeld, R., Brandenburg, V. M., Eitner, F., Mayer, J., Floege, J., Sandmann, W., & Ketteler, M. (2010). Analysis of Calcifications in Patients with Coral Reef Aorta. Annals of Vascular Surgery, 24(3), 408-414. https://doi.org/10.1016/j.avsg.2009.11.006
    • Rennenberg, R. J. M. W., de Leeuw, P. W., Kessels, A. G. H., Schurgers, L. J., Vermeer, C., van Engelshoven, J. M. A., Kemerink, G. J., & Kroon, A. A. (2010). Calcium scores and matrix Gla protein levels: association with vitamin K status. European Journal of Clinical Investigation, 40(4), 344-349. https://doi.org/10.1111/j.1365-2362.2010.02275.x
    • Schurgers, L. J., Barreto, D. V., Barreto, F. C., Liabeuf, S., Renard, C., Magdeleyns, E. J. P., Vermeer, C., Choukroun, G., & Massy, Z. A. (2010). The Circulating Inactive Form of Matrix Gla Protein Is a Surrogate Marker for Vascular Calcification in Chronic Kidney Disease: A Preliminary Report. Clinical journal of the American Society of Nephrology, 5(4), 568-575. https://doi.org/10.2215/CJN.07081009
    • Speelman, L., Hellenthal, F. A., Pulinx, B., Bosboom, E. M. H., Breeuwer, M., Van Sambeek, M. R. H. M., de Vosse, F. N. V., Jacobs, M. J., Wodzig, W. K. W. H., & Schurink, G. W. H. (2010). The Influence of Wall Stress on AAA Growth and Biomarkers. European Journal of Vascular and Endovascular Surgery, 39(4), 410-416. https://doi.org/10.1016/j.ejvs.2009.12.021
    • De Saint-Hubert, M., Mottaghy, F. M., Vunckx, K., Nuyts, J., Fonge, H., Prinsen, K., Stroobants, S., Mortelmans, L., Deckers, N., Hofstra, L., Reutelingsperger, C. P. M., Verbruggen, A. M., & Rattat, D. (2010). Site-specific labeling of 'second generation' annexin V with Tc-99m(CO)(3) for improved imaging of apoptosis in vivo. Bioorganic & Medicinal Chemistry, 18(3), 1356-1363. https://doi.org/10.1016/j.bmc.2009.12.021
    • Rennenberg, R. J. W. M., Schurgers, L. J., Kroon, A. A., & Stehouwer, C. D. A. (2010). Arterial calcifications. Journal of Cellular and Molecular Medicine, 14(9), 2203-2210. https://doi.org/10.1111/j.1582-4934.2010.01139.x
    • Snoeijs, M. G., van Heurn, L. W. E., & Buurman, W. A. (2010). Biological modulation of renal ischemia-reperfusion injury.Current Opinion in Organ Transplantation, 15(2), 190-199. https://doi.org/10.1097/MOT.0b013e32833593eb
    • Hoogland, E. R., Snoeijs, M. G., & van Heurn, L. W. E. (2010). DCD kidney transplantation: results and measures to improve outcome. Current Opinion in Organ Transplantation, 15(2), 177-82. https://doi.org/10.1097/MOT.0b013e32833734b1
    • Snoeijs, M. G., Boonstra, L. A., Buurman, W. A., Goldschmeding, R., van Suylen, R. J., van Heurn, L. W., & Kootstra, C. J. (2010). Histological assessment of pre-transplant kidney biopsies is reproducible and representative. Histopathology, 56(2), 198-202. https://doi.org/10.1111/j.1365-2559.2009.03469.x
    • de Vries, E. E., Snoeijs, M. G., & van Heurn, L. W. E. (2010). Kidney donation from children after cardiac death. Critical Care Medicine, 38(1), 249-253. https://doi.org/10.1097/CCM.0b013e3181c025fd
    • Snoeijs, M. G., Schaubel, D. E., Hene, R., Hoitsma, A. J., Idu, M. M., Ijzermans, J. N., Ploeg, R. J., Ringers, J., Christiaans, M. H., Buurman, W. A., & van Heurn, L. W. (2010). Kidneys from donors after cardiac death provide survival benefit. Journal of the American Society of Nephrology, 21(6), 1015-21. https://doi.org/10.1681/ASN.2009121203
    • Snoeijs, M. G., Winkens, B., Heemskerk, M. B., Hoitsma, A. J., Christiaans, M. H., Buurman, W. A., & van Heurn, L. W. E. (2010). Kidney transplantation from donors after cardiac death: a 25-year experience.Transplantation, 90(10), 1106-1112. https://doi.org/10.1097/TP.0b013e3181f83b0b
    • Le Boulanger, G., Labreze, C., Croue, A., Schurgers, L. J., Chassaing, N., Wittkampf, T., Rutsch, F., & Martin, C. L. (2010). An Unusual Severe Vascular Case of Pseudoxanthoma Elasticum Presenting as Generalized Arterial Calcification of Infancy. American Journal of Medical Genetics Part A, 152A(1), 118-123. https://doi.org/10.1002/ajmg.a.33162
    • Ueland, T., Fougner, S. L., Godang, K., Lekva, T., Schurgers, L. J., Scholz, H., Halvorsen, B., Schreiner, T., Aukrust, P., & Bollerslev, J. (2010). Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly. Journal of Clinical Endocrinology & Metabolism, 95(1), 361-368. https://doi.org/10.1210/jc.2009-0422
    • Shroff, R. C., McNair, R., Skepper, J. N., Figg, N., Schurgers, L. J., Deanfield, J., Rees, L., & Shanahan, C. M. (2010). Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification. Journal of the American Society of Nephrology, 21(1), 103-112. https://doi.org/10.1681/ASN.2009060640
    • Speelman, L., Schurink, G. W. H., Bosboom, E. M. H., Buth, J., Breeuwer, M., de Vosse, F. N. V., & Jacobs, M. H. (2010). The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm. Journal of Vascular Surgery, 51(1), 19-26. https://doi.org/10.1016/j.jvs.2009.08.075
    • Megens, R. T. A., Reitsma, S., Prinzen, L., Egbrink, M. G. A. O., Engels, W., Leenders, P. J. A., Brunenberg, E. J. L., Reesink, K. D., Janssen, B. J. A., Romeny, B. M. T. H., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2010). In vivo high-resolution structural imaging of large arteries in small rodents using two-photon laser scanning microscopy. Journal of Biomedical Optics, 15(1), 10. Article 011108. https://doi.org/10.1117/1.3281672
  • 2009
    • Punt, I. M., Cleutjens, J. P. M., de Bruin, T., Willems, P. C., Kurtz, S. M., van Rhijn, L. W., Schurink, G. W. H., & van Ooij, A. (2009). Periprosthetic tissue reactions observed at revision of total intervertebral disc arthroplasty. Biomaterials, 30(11), 2079-84. https://doi.org/10.1016/j.biomaterials.2008.12.071
    • Loubele, S. T. B. G., Spek, C. A., Leenders, P., van Oerle, R., Aberson, H. L., van der Voort, D., Hamulyák, K., Petersen, L. C., Spronk, H. M. H., & ten Cate, H. (2009). Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice. Journal of Thrombosis and Haemostasis, 7(2), 290-8. https://doi.org/10.1111/j.1538-7836.2008.03232.x
    • Hellenthal, F. A., Buurman, W. A., Wodzig, W. K., & Schurink, G. W. (2009). Biomarkers of AAA progression. Part 1: extracellular matrix degeneration. Nature Reviews Cardiology, 6(7), 464-474. https://doi.org/10.1038/nrcardio.2009.80
    • Hellenthal, F. A., Buurman, W. A., Wodzig, W. K., & Schurink, G. W. (2009). Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation. Nature Reviews Cardiology, 6(8), 543-552. https://doi.org/10.1038/nrcardio.2009.102
    • Rennenberg, R. J. M. W., Kessels, A. G. H., Schurgers, L. J., van Engelshoven, J. M. A., de Leeuw, P. W., & Kroon, A. A. (2009). Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. Vascular health and risk management, 5(1), 185-97. https://doi.org/10.2147/vhrm.s4822
  • 2008
    • Vanschoonbeek, K., Wouters, K., van der Meijden, P. E., van Gorp, P. J. J., Feijge, M. A., Herfs, M., Schurgers, L. J., Hofker, M. H., de Maat, M. P., & Heemskerk, J. W. (2008). Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.Arteriosclerosis Thrombosis and Vascular Biology, 28(11), 2023-2029. https://doi.org/10.1161/ATVBAHA.107.156992
    • Snoeijs, M. G., Buurman, W. A., Christiaans, M. H., van Hooff, J. P., Goldschmeding, R., van Suylen, R. J., Kootstra, C. J., & van Heurn, L. W. (2008). Histological assessment of preimplantation biopsies may improve selection of kidneys from old donors after cardiac death. American Journal of Transplantation, 8(9), 1844-51. https://doi.org/10.1111/j.1600-6143.2008.02318.x
    • Cranenburg, E. C., Vermeer, C., Koos, R., Boumans, M. L., Hackeng, T. M., Bouwman, F. G., Kwaijtaal, M., Brandenburg, V. M., Ketteler, M., & Schurgers, L. J. (2008). The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification. Journal of Vascular Research, 45(5), 427-36. https://doi.org/10.1159/000124863
    • Hanssen, S. J., Derikx, J. P., Vermeulen Windsant, I. C., Heijmans, J. H., Koeppel, T. A., Schurink, G. W., Buurman, W. A., & Jacobs, M. J. (2008). Visceral injury and systemic inflammation in patients undergoing extracorporeal circulation during aortic surgery. Annals of Surgery, 248(1), 117-25. https://doi.org/10.1097/SLA.0b013e3181784cc5
  • 2007
    • Knapen, M. H. J., Schurgers, L. J., & Vermeer, C. (2007). Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International, 18(7), 963-72. https://doi.org/10.1007/s00198-007-0337-9
    • Schurgers, L. J., Teunissen, K. J. F., Hamulyak, K., Knapen, M. H. J., Vik, H., & Vermeer, C. (2007). Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood, 109(8), 3279-83. https://doi.org/10.1182/blood-2006-08-040709
    • Snoeijs, M. G., van Heurn, L. W. E., van Mook, W. N., Christiaans, M. H., & Cohen Tervaert, J. W. (2007). Controlled donation after cardiac death - A European perspective.Transplantation reviews, 1, 219-229. https://doi.org/10.1016/j.trre.2007.07.004
    • Snoeijs, M. G., Dekkers, A. J., Buurman, W. A., van den Akker, L., Welten, R. J., Schurink, G. W., & van Heurn, L. W. (2007). In Situ Preservation of Kidneys From Donors After Cardiac Death: Results and Complications. Annals of Surgery, 246(5), 844-852. https://doi.org/10.1097/SLA.0b013e318142cb1b
    • Snoeijs, M. G., Wiermans, B., Christiaans, M. H., van Hooff, J. P., Timmerman, B. E., Schurink, G. W., Buurman, W. A., & van Heurn, L. W. (2007). Recipient hemodynamics during non-heart-beating donor kidney transplantation are major predictors of primary nonfunction.American Journal of Transplantation, 7(5), 1158-1166. https://doi.org/10.1111/j.1600-6143.2007.01744.x
    • Hermans, M. M., Vermeer, C., Kooman, J. P., Brandenburg, V., Ketteler, M., Gladziwa, U., Rensma, P. L., Leunissen, K. M., & Schurgers, L. J. (2007). Undercarboxylated Matrix GLA Protein Levels Are Decreased in Dialysis Patients and Related to Parameters of Calcium-Phosphate Metabolism and Aortic Augmentation Index. Blood Purification, 25(5), 395-401. https://doi.org/10.1159/000108629
    • Prinzen, L., Miserus, R.-J. J. H. M., Dirksen, A., Hackeng, T. M., Deckers, N., Bitsch, N. J., Megens, R. T. A., Douma, K., Heemskerk, J. W., Kooi, M. E., Frederik, P. M., Slaaf, D. W., van Zandvoort, M. A. M. J., & Reutelingsperger, C. P. M. (2007). Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano Letters, 7(1), 93-100. https://doi.org/10.1021/nl062226r
  • 2006
    • Willems, H. P. J., den Heijer, M., Gerrits, W. B. J., Schurgers, L. J., Havekes, M., Blom, H. J., & Bos, G. M. J. (2006). Oral anticoagulant treatment with coumarin derivatives does not influence plasma homocysteine concentration. European journal of internal medicine, 17(2), 120-4. https://doi.org/10.1016/j.ejim.2005.10.009
    • Snoeijs, M. G., Schaefer, S., Christiaans, M. H., van Hooff, J. P., van den Berg-Loonen, E. M., Peutz-Kootstra, C. J., Buurman, W. A., & van Heurn, L. W. E. (2006). Kidney transplantation using elderly non-heart-beating donors: a single-center experience. American Journal of Transplantation, 6(5 Pt 1), 1066-1071. https://doi.org/10.1111/j.1600-6143.2006.01312.x