Mark Post

Professor

Mark Post is professor of Physiology and from 2004 until April 2019, Chair of Physiology. Prof. Mark Post received his medical degree from the University of Utrecht in 1982 and, at the same University, his PhD in 1989. As a post-doc, he joined Experimental Cardiology (Prof. C. Borst) to set up a Vascular Biology programme. From 1989 to 1996, he was senior investigator at the Royal Dutch Academy of Science. In 1996, Prof. Mark Post was appointed full time assistant professor in Medicine at Harvard Medical School, Boston, MA and continued research in Vascular Biology and more specifically neovascularisation. In 2001, he was appointed associate professor of Medicine and of Physiology at Dartmouth Medical School, Hanover, NH.

A year later, in July 2002, Mark Post returned to the Netherlands as a Professor of Vascular Physiology at the Maastricht University and Professor of Angiogenesis in Tissue Engineering at the Technical University Eindhoven. He was the Chair of the Department of Physiology at Maastricht UMC+ from 2004-2019 and is Chairman of the Dutch Society of Physiology. His main research interests are vascular biology and tissue engineering of blood vessels and skeletal muscle. These subjects are studied from their basic molecular aspects and cellular mechanisms up to preclinical models and eventually, patients and consumers. In addition, he pioneered the creation of meat from stem cells and presented the world’s first hamburger from cultured beef in 2013. As a result, he was awarded the World Technology Award for solutions that benefit the environment at the World Technology Network summit in 2013. Prof. Mark Post co-authored 175 papers in leading peer-reviewed scientific journals (Hirsch-index: 55, 10,700 citations) and received during his career close to 45 M€ in funding and awards from different sources including government, charity and industry.

He recently co-founded and is CSO of Qorium and MosaMeat, two start-ups respectively commercialising the technologies to produce bovine leather and cultured meat using tissue engineering. He is CEO of Cell2Tissue, a company that aims to develop technology platforms to support a variety of applications of tissue engineering

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.132
T: +31(0)43 388 10 85

2023
- Melzener, L., Spaans, S., Hauck, N., Pötgens, A. J. G., Flack, J. E., Post, M. J., & Dogan, A. (2023). Short-Stranded Zein Fibers for Muscle Tissue Engineering in Alginate-Based Composite Hydrogels. Gels, 9(11), Article 914. https://doi.org/10.3390/gels9110914
- Messmer, T., Dohmen, R. G. J., Schaeken, L., Melzener, L., Hueber, R., Godec, M., Didoss, C., Post, M. J., & Flack, J. E. (2023). Single-cell analysis of bovine muscle-derived cell types for cultured meat production. Frontiers in nutrition, 10, Article 1212196. https://doi.org/10.3389/fnut.2023.1212196
- Hubalek, S., Melke, J., Pawlica, P., Post, M. J., & Moutsatsou, P. (2023). Non-ammoniagenic proliferation and differentiation media for cultivated adipose tissue. Frontiers in bioengineering and biotechnology, 11(1), Article 1202165. https://doi.org/10.3389/fbioe.2023.1202165
- Caponi, J. J., Shmushkis, J., Geissler, H., Post, M. J., Jackisch, L., & Mall, E. M. (2023). Protocol for differentiation of bovine adipogenic progenitor cells embedded in alginate sheets. STAR protocols, 4(2), Article 102143. https://doi.org/10.1016/j.xpro.2023.102143
- Mitić, R., Cantoni, F., Börlin, C. S., Post, M. J., & Jackisch, L. (2023). A simplified and defined serum-free medium for cultivating fat across species. iScience, 26(1), Article 105822. https://doi.org/10.1016/j.isci.2022.105822
2022
- Hubalek, S., Post, M. J., & Moutsatsou, P. (2022). Towards resource-efficient and cost-efficient cultured meat. Current Opinion in Food Science, 47, Article 100885. https://doi.org/10.1016/j.cofs.2022.100885
- Kolkmann, A. M., Van Essen, A., Post, M. J., & Moutsatsou, P. (2022). Development of a Chemically Defined Medium for in vitro Expansion of Primary Bovine Satellite Cells. Frontiers in bioengineering and biotechnology, 10, Article 895289. https://doi.org/10.3389/fbioe.2022.895289
- Zhu, H., Wu, Z., Ding, X., Post, M. J., Guo, R., Wang, J., Wu, J., Tang, W., Ding, S., & Zhou, G. (2022). Production of cultured meat from pig muscle stem cells. Biomaterials, 287, Article 121650. https://doi.org/10.1016/j.biomaterials.2022.121650
- Park, S., Gagliardi, M., Swennen, G., Dogan, A., Kim, Y., Park, Y., Park, G., Oh, S., Post, M., & Choi, J. (2022). Effects of Hypoxia on Proliferation and Differentiation in Belgian Blue and Hanwoo Muscle Satellite Cells for the Development of Cultured Meat. Biomolecules, 12(6), Article 838. https://doi.org/10.3390/biom12060838
- Dohmen, R. G. J., Hubalek, S., Melke, J., Messmer, T., Cantoni, F., Mei, A., Hueber, R., Mitic, R., Remmers, D., Moutsatsou, P., Post, M. J., Jackisch, L., & Flack, J. E. (2022). Muscle-derived fibro-adipogenic progenitor cells for production of cultured bovine adipose tissue. npj Science of Food, 6(1), Article 6. https://doi.org/10.1038/s41538-021-00122-2
- Messmer, T., Klevernic, I., Furquim, C., Ovchinnikova, E., Dogan, A., Cruz, H., Post, M. J., & Flack, J. E. (2022). A serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation. Nature food, 3(1), 74-85. https://doi.org/10.1038/s43016-021-00419-1
2021
- de Graaf, J. A., Nijsse, B., Schepers, V. P. M., van Heugten, C. M., Post, M. W. M., & Visser-Meily, J. M. A. (2021). Which approach to measure cognitive functioning should be preferred when exploring the association between cognitive functioning and participation after stroke?Neuropsychological Rehabilitation, 31(8), 1207-1223. https://doi.org/10.1080/09602011.2020.1769687
- van Haare, J., Kooi, M. E., van Teeffelen, J. W. G. E., Vink, H., Slenter, J., Cobelens, H., Strijkers, G. J., Koehn, D., Post, M. J., & van Bilsen, M. (2021). Correction to: Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet‑induced obese rats. Cardiovascular Diabetology, 20(1), Article 53. https://doi.org/10.1186/s12933-021-01240-7
- van Haare, J., Kooi, M. E., Vink, H., Post, M. J., van Teeffelen, J. W. G. E., Slenter, J., Munts, C., Cobelens, H., Strijkers, G. J., Koehn, D., & van Bilsen, M. (2021). Correction to: Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet. Cardiovascular Diabetology, 20(1), Article 51. https://doi.org/10.1186/s12933-021-01239-0
- Melzener, L., Verzijden, K. E., Buijs, A. J., Post, M. J., & Flack, J. E. (2021). Cultured beef: from small biopsy to substantial quantity. Journal of the Science of Food and Agriculture, 101(1), 7-14. https://doi.org/10.1002/jsfa.10663
- Hamdan, M. N., Post, M., Ramli, M. A., Kamarudin, M. K., Ariffin, M. F. M., & Huri, N. M. F. Z. (2021). Cultured Meat: Islamicand Other Religious Perspectives. UMRAN - International Journal of Islamic and Civilizational Studies, 8(2), 11-19. https://doi.org/10.11113/umran2021.8n2.475
- Ding, S., Post, M., & Zhou, G. (2021). Perspectives on cultured meat. Food Materials Research, 1, Article 3. https://doi.org/10.48130/FMR-2021-0003
2020
- Rolland, N. C. M., Markus, C. R., & Post, M. J. (2020). Correction: The effect of information content on acceptance of cultured meat in a tasting context. PLOS ONE, 15(10), Article e0240630. https://doi.org/10.1371/journal.pone.0240630
- Post, M. J., Levenberg, S., Kaplan, D. L., Genovese, N., Fu, J., Bryant, C. J., Negowetti, N., Verzijden, K., & Moutsatsou, P. (2020). Scientific, sustainability and regulatory challenges of cultured meat. Nature food, 1(7), 403-415. https://doi.org/10.1038/s43016-020-0112-z
- Rolland, N. C. M., Markus, C. R., & Post, M. J. (2020). The effect of information content on acceptance of cultured meat in a tasting context. PLOS ONE, 15(4), Article 0231176. https://doi.org/10.1371/journal.pone.0231176
- Bodiou, V., Moutsatsou, P., & Post, M. J. (2020). Microcarriers for Upscaling Cultured Meat Production. Frontiers in nutrition, 7, Article 10. https://doi.org/10.3389/fnut.2020.00010
- Denisov, S. S., Heinzmann, A. C. A., Vajen, T., Vries, M. H. M., Megens, R. T. A., Suylen, D., Koenen, R. R., Post, M. J., Ippel, J. H., Hackeng, T. M., & Dijkgraaf, I. (2020). Tick Saliva Protein Evasin-3 Allows for Visualization of Inflammation in Arteries through Interactions with CXC-Type Chemokines Deposited on Activated Endothelium. Bioconjugate Chemistry, 31(3), 948-955. https://doi.org/10.1021/acs.bioconjchem.0c00095
- Kolkmann, A. M., Post, M. J., Rutjens, M. A. M., van Essen, A. L. M., & Moutsatsou, P. (2020). Serum-free media for the growth of primary bovine myoblasts. Cytotechnology, 72(1), 111–120. https://doi.org/10.1007/s10616-019-00361-y
2019
- Smulders, M. W., Kietselaer, B. L. J. H., Wildberger, J. E., Dagnelie, P. C., Brunner-La Rocca, H.-P., Mingels, A. M. A., van Cauteren, Y. J. M., Theunissen, R. A. L. J., Post, M. J., Schalla, S., van Kuijk, S. M. J., Das, M., Kim, R. J., Crijns, H. J. G. M., & Bekkers, S. C. A. M. (2019). Initial Imaging-Guided Strategy Versus Routine Care in Patients With Non-ST-Segment Elevation Myocardial Infarction. Journal of the American College of Cardiology, 74(20), 2466-2477. https://doi.org/10.1016/j.jacc.2019.09.027
- Foulquier, S., Caolo, V., Swennen, G., Milanova, I., Reinhold, S., Recarti, C., Alenina, N., Bader, M., Steckelings, U. M., Vanmierlo, T., Post, M. J., Jones, E. A., van Oostenbrugge, R. J., & Unger, T. (2019). The role of receptor MAS in microglia-driven retinal vascular development. Angiogenesis, 22(4), 481-489. https://doi.org/10.1007/s10456-019-09671-3
2018
- Hamdan, M. N., Post, M. J., Ramli, M. A., & Mustafa, A. R. (2018). Cultured Meat in Islamic Perspective. Journal of Religion & Health, 57(6), 2193-2206. https://doi.org/10.1007/s10943-017-0403-3
- Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M. J., Blankesteijn, W. M., Rutten, B. P., Prickaerts, J., Van Oostenbrugge, R. J., & Unger, T. (2018). Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice. Hypertension Research, 41(10), 817-827. https://doi.org/10.1038/s41440-018-0090-9
- Caolo, V., Peacock, H. M., Kasaai, B., Swennen, G., Gordon, E., Claesson-Welsh, L., Post, M. J., Verhamme, P., & Jones, E. A. V. (2018). Shear Stress and VE-Cadherin: The Molecular Mechanism of Vascular Fusion. Arteriosclerosis Thrombosis and Vascular Biology, 38(9), 2174-2183. https://doi.org/10.1161/ATVBAHA.118.310823
- Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Bock, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., ... Griffioen, A. W. (2018). Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis, 21(3), 425-532. https://doi.org/10.1007/s10456-018-9613-x
- Ding, S., Swennen, G. N. M., Messmer, T., Gagliardi, M., Molin, D. G. M., Li, C., Zhou, G., & Post, M. J. (2018). Maintaining bovine satellite cells stemness through p38 pathway. Scientific Reports, 8, Article 10808. https://doi.org/10.1038/s41598-018-28746-7
- Verbruggen, S., Daan, L., van Essen, A., & Post, M. J. (2018). Bovine myoblast cell production in a microcarriers-based system. Cytotechnology, 70(2), 503-512. https://doi.org/10.1007/s10616-017-0101-8
2017
- Hakimzadeh, N., Elias, J., Wijntjens, G. W. M., Theunissen, R., van Weert, A., Smulders, M. W., van den Akker, N., Moerland, P. D., Verberne, H. J., Hoebers, L. P., Henriques, J. P. S., van der Laan, A. M., Ilhan, M., Post, M., Bekkers, S. C. A. M., & Piek, J. J. (2017). Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients. Scientific Reports, 7, Article 1532. https://doi.org/10.1038/s41598-017-01695-3
- van Haare, J., Kooi, M. E., van Teeffelen, J. W. G. E., Vink, H., Slenter, J., Cobelens, H., Strijkers, G. J., Koehn, D., Post, M. J., & van Bilsen, M. (2017). Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats. Cardiovascular Diabetology, 16, Article 47. https://doi.org/10.1186/s12933-017-0525-7
- Hendrikx, G., Hackeng, T. M., van Gorp, R., Bauwens, M., Schurgers, L. J., Mottaghy, F. M., Post, M. J., & Dijkgraaf, I. (2017). Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging. Contrast Media & Molecular Imaging, 2017, Article 8638549. https://doi.org/10.1155/2017/8638549
2016
- Hendrikx, G., Vöö, S., Bauwens, M., Post, M., & Mottaghy, F. (2016). SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease. European Journal of Nuclear Medicine and Molecular Imaging, 43(13), 2433-2447. https://doi.org/10.1007/s00259-016-3480-8
- Caolo, V., Vries, M., Zupancich, J., Houben, M., Mihov, G., Wagenaar, A., Swennen, G., Nossent, Y., Quax, P., Suylen, D., Dijkgraaf, I., Molin, D., Hackeng, T., & Post, M. (2016). CXCL1 microspheres: a novel tool to stimulate arteriogenesis. Drug Delivery, 23(8), 2919-2926. https://doi.org/10.3109/10717544.2015.1120366
- Brouwers, O., Yu, L., Niessen, P., Slenter, J., Jaspers, K., Wagenaar, A., Post, M., Miyata, T., Backes, W., Stehouwer, C., Huijberts, M., & Schalkwijk, C. (2016). Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model. Glycoconjugate Journal, 33(4), 627-630. https://doi.org/10.1007/s10719-016-9681-3
- Smulders, M. W., Kietselaer, B. L. J. H., Schalla, S., Bucerius, J., Jaarsma, C., van Dieijen-Visser, M. P., Mingels, A. M. A., Brunner-La Rocca, H., Post, M., Das, M., Crijns, H. J. G. M., Wildberger, J. E., & Bekkers, B. (2016). Acute chest pain in the high-sensitivity cardiac troponin era: A changing role for noninvasive imaging?American Heart Journal, 177, 102-111. https://doi.org/10.1016/j.ahj.2016.03.025
- Vries, M. H., & Post, M. (2016). Delivering therapeutics in peripheral artery disease: challenges and future perspectives. Therapeutic Delivery, 7(7), 483-493. https://doi.org/10.4155/tde-2016-0024
- Hendrikx, G., Vries, M. H., Bauwens, M., De Saint-Hubert, M., Wagenaar, A., Landry, G., Boonen, L., Post, M. J., & Mottaghy, F. M. (2016). Comparison of LDPI to SPECT perfusion imaging using Tc-99m-sestamibi and Tc-99m-pyrophosphate in a murine ischemic hind limb model of neovascularization. EJNMMI Research, 6(1), Article 44. https://doi.org/10.1186/s13550-016-0199-2
- Geenen, I. L., Kolk, F. F., Molin, D. G., Wagenaar, A., Compeer, T., Tordoir, J., Schurink, G., de Mey, J., & Post, M. J. (2016). Nitric Oxide Resistance Reduces Arteriovenous Fistula Maturation in Chronic Kidney Disease in Rats. PLOS ONE, 11(1), Article e0146212. https://doi.org/10.1371/journal.pone.0146212
- Wagenaar, A., Wiegerinck, R. F., Heijnen, V. V. T., & Post, M. J. (2016). Percutaneous microembolization of the left coronary artery to model ischemic heart disease in rats. Lab Animal, 45(1), 20-27. https://doi.org/10.1038/laban.909
- Hendrikx, G., Bauwens, M., Wierts, R., Mottaghy, F. M., & Post, M. J. (2016). Left ventricular function measurements in a mouse myocardial infarction model Comparison between 3D-echocardiography and ECG-gated SPECT. Nuklearmedizin, 55(3), 115-122. https://doi.org/10.3413/Nukmed-0776-15-11
2015
- van Haare, J., Kooi, M. E., Vink, H., Post, M. J., van Teeffelen, J. W. G. E., Slenter, J., Munts, C., Cobelens, H., Strijkers, G. J., Koehn, D., & van Bilsen, M. (2015). Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet. Cardiovascular Diabetology, 14, Article 150. https://doi.org/10.1186/s12933-015-0312-2
- Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A. M., van Wely, M., Bloemenkamp, K. W. M., Hoek - ten Cate, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C. J., Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O. B., Post, M., Papatsonis, D. N. M., Verberg, M. F. G., ... Goddijn, M. (2015). Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study). Contemporary Clinical Trials, 44, 134-138. https://doi.org/10.1016/j.cct.2015.08.005
- Geenen, I. L. A., Molin, D. G. M., van den Akker, N. M. S., Jeukens, F., Spronk, H. M., Schurink, G. W. H., & Post, M. J. (2015). Endothelial cells (ECs) for vascular tissue engineering: venous ECs are less thrombogenic than arterial ECs. Journal of Tissue Engineering and Regenerative Medicine, 9(5), 564-576. https://doi.org/10.1002/term.1642
- Vries, M. H. M., Wagenaar, A., Verbruggen, S. E. L., Molin, D. G. M., Dijkgraaf, I., Hackeng, T., & Post, M. J. (2015). CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. Angiogenesis, 18(2), 163-171. https://doi.org/10.1007/s10456-014-9454-1
- Hendrikx, G., De Saint-Hubert, M., Dijkgraaf, I., Bauwens, M., Douma, K., Wierts, R., Pooters, I., van den Akker, N. M., Hackeng, T. M., Post, M. J., & Mottaghy, F. M. (2015). Molecular imaging of angiogenesis after myocardial infarction by (111)In-DTPA-cNGR and (99m)Tc-sestamibi dual-isotope myocardial SPECT. EJNMMI Research, 5, 13-22. Article 2. https://doi.org/10.1186/s13550-015-0081-7
- Caolo, V., Swennen, G., Chalaris, A., Wagenaar, A., Verbruggen, S., Rose-John, S., Molin, D. G. M., Vooijs, M., & Post, M. J. (2015). ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis. Angiogenesis, 18(1), 13-22. https://doi.org/10.1007/s10456-014-9443-4

Overview

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ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Longer and better lives for patients with atrial fibrillation

15 April 2024

Mark Post

Professor