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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Leon Schurgers

Professor

Initially trained in clinical chemistry and hematology at the University of Applied Science, Prof. Leon Schurgers obtained his PhD at the Department of Biochemistry within CARIM on the role of vitamin K1 and K2 on bone metabolism and cardiovascular disease. He worked as post-doc on a Dutch Heart Foundation grant on the role of matrix Gla-protein synthesized by vascular smooth muscle cell and calcification in collaboration with the group of Prof. Catherine Shanahan (Cambridge, UK).

In 2009, he was appointed on a tenured position at the Department of Biochemistry. After entering the Toptalent programme (Maastricht UMC+) in 2016, he was appointed as Professor of Biochemistry of Vascular Calcification in 2017. He is vice-chair of the department of Biochemistry. Since 2021, he chairs the stem cell research facility of the University of Maastricht (SCRUM).

The focus of his current work is elucidating the molecular mechanisms by which vascular remodelling is initiated and propagated. Key cellular events include phenotypic switching of vascular smooth muscle cells (SMCs) and the role of oxidative stress, extracellular vesicles and calcification. In this, he collaborates closely with the Cardiothoracic Surgery and Vascular Surgery departments of the Heart and Vessel Center (HVC) of the Maastricht University Medical Center. Patient derived primary SMCs are isolated from vascular tissue and induced pluripotent stem cells (iPSC) are generated from patient derived peripheral blood mononuclear cells (PBMCs). These iPSCs are used to differentiate into patient specific cardiovascular cells (i.e., cardiomyocytes, smooth muscle cells, endothelial cells and fibroblasts) to study cardiovascular disease.

The underlying causes of SMC phenotypic switching are insufficient to understand the pathogenesis of vascular ageing and calcification at a level that allows development of novel diagnostic tools and therapeutic strategies. In his project line, the Schurgers’ group aim to elucidate the molecular mechanisms of vitamin K-metabolism in health and vascular disease. Importantly, this work will help to understand the paradoxal observation that patients with low vitamin K-status during oral anticoagulant treatment develop enhanced vascular calcification and our results might provide new insights in prognostic and preventive measures to combat vascular ageing.

Professor Schurgers is Chairman of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection and member of the scientific advisory boards of the Dutch Thrombosis Society.

Leon-schurgers

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.314
T: +31(0)43 388 16 80

  • 2017
    • Kapustin, A. N., Schoppet, M., Schurgers, L. J., Reynolds, J. L., McNair, R., Heiss, A., Jahnen-Dechent, W., Hackeng, T. M., Schlieper, G., Harrison, P., & Shanahan, C. M. (2017). Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification. Arteriosclerosis Thrombosis and Vascular Biology, 37(3), E22-E32. https://doi.org/10.1161/ATVBAHA.116.308886
    • Chen, Z., Qureshi, A. R., Parini, P., Hurt-Camejo, E., Ripsweden, J., Brismar, T. B., Barany, P., Jaminon, A. M., Schurgers, L. J., Heimburger, O., Lindholm, B., & Stenvinkel, P. (2017). Does statins promote vascular calcification in chronic kidney disease?European Journal of Clinical Investigation, 47(2), 137-148. https://doi.org/10.1111/eci.12718
    • Houben, E., Neradova, A., Schurgers, L. J., & Vervloet, M. (2017). The influence of phosphate, calcium and magnesium on matrix Gla-protein and vascular calcification: a systematic review. Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, 33(6), 1-10.
    • Hendrikx, G., Hackeng, T. M., van Gorp, R., Bauwens, M., Schurgers, L. J., Mottaghy, F. M., Post, M. J., & Dijkgraaf, I. (2017). Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging. Contrast Media & Molecular Imaging, 2017, Article 8638549. https://doi.org/10.1155/2017/8638549
  • 2016
    • Donners, M. M. P. C., Bai, L., Lutgens, S., Wijnands, E., Johnson, J., Schurgers, L. J., Liu, C.-L., Daemen, M., Cleutjens, K. B. J. M., Shi, G.-P., Biessen, E. A. L., & Heeneman, S. (2016). Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE(-/-) Mice. PLOS ONE, 11(9), Article e0162595. https://doi.org/10.1371/journal.pone.0162595
    • Card, D. J., Shearer, M. J., Schurgers, L. J., Gomez, K., & Harrington, D. J. (2016). What's in a name? The pharmacy of vitamin K. British Journal of Haematology, 174(6), 989-990. https://doi.org/10.1111/bjh.13828
    • Brandenburg, V. M., Evenepoel, P., Floege, J., Goldsmith, D., Kramann, R., Massy, Z., Mazzaferro, S., Schurgers, L. J., Sinha, S., Torregrosa, V., Urena-Torres, P., Vervloet, M., & Cozzolino, M. (2016). Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis?Nephrology Dialysis Transplantation, 31(8), 1211-1219. https://doi.org/10.1093/ndt/gfw025
    • Burgmaier, M., Schurgers, L., & Reutelingsperger, C. (2016). Response to letter to the editor: annexin A5 levels or circulating microparticles: what we see depends mainly on what we look for. Journal of Internal Medicine, 279(6), 606-607. https://doi.org/10.1111/joim.12459
    • Horn, P., Erkilet, G., Veulemans, V., Kroepil, P., Schurgers, L., Zeus, T., Heiss, C., Kelm, M., & Westenfeld, R. (2016). Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis. PLOS ONE, 11(3), Article e0151499. https://doi.org/10.1371/journal.pone.0151499
    • Zaragatski, E., Grommes, J., Schurgers, L. J., Langer, S., Kennes, L., Tamm, M., Koeppel, T. A., Kranz, J., Hackhofer, T., Arakelyan, K., Jacobs, M. J., & Kokozidou, M. (2016). Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?Kidney International, 89(3), 601-611. https://doi.org/10.1038/ki.2015.298
    • Schurgers, L. J., Burgmaier, M., Ueland, T., Schutters, K., Aakhus, S., Hofstra, L., Gullestad, L., Aukrust, P., Hellmich, M., Narula, J., & Reutelingsperger, C. P. (2016). Circulating annexin A5 predicts mortality in patients with heart failure. Journal of Internal Medicine, 279(1), 89-97. https://doi.org/10.1111/joim.12396
    • Schlieper, G., Schurgers, L., Brandenburg, V., Reutelingsperger, C., & Floege, J. (2016). Vascular calcification in chronic kidney disease: an update. Nephrology Dialysis Transplantation, 31(1), 31-39. https://doi.org/10.1093/ndt/gfv111
    • E., H., Neradova, A., Schurgers, L., & Vervloet, M. (2016). L’influenza del fosforo, del calcio e del magnesio sulla proteina Gla di matrice e sul processo di calcificazione vascolare: una review sistematica. Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, 33(6). https://giornaleitalianodinefrologia.it/wp-content/uploads/sites/3/2016/12/GIN_A33V6_00248_5_en-1.pdf
  • 2015
    • Chatrou, M. L. L., Cleutjens, J. P., van der Vusse, G. J., Roijers, R. B., Mutsaers, P. H. A., & Schurgers, L. J. (2015). Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis. PLOS ONE, 10(11), Article e0142335. https://doi.org/10.1371/journal.pone.0142335
    • Vossen, L. M., Schurgers, L. J., van Varik, B. J., Kietselaer, B. L. J. H., Vermeer, C., Meeder, J. G., Rahel, B. M., van Cauteren, Y. J. M., Hoffland, G. A., Rennenberg, R. J. M. W., Reesink, K. D., de Leeuw, P. W., & Kroon, A. A. (2015). Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial). Nutrients, 7(11), 8905-8915. https://doi.org/10.3390/nu7115443
    • van Gorp, R. H., & Schurgers, L. J. (2015). New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs). Nutrients, 7(11), 9538-9557. https://doi.org/10.3390/nu7115479
    • van Niel, G., Bergam, P., Di Cicco, A., Hurbain, I., Lo Cicero, A., Dingli, F., Palmulli, R., Fort, C., Potier, M. C., Schurgers, L. J., Loew, D., Levy, D., & Raposo, G. (2015). Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells. Cell Reports, 13(1), 43-51. https://doi.org/10.1016/j.celrep.2015.08.057
    • Scheiber, D., Veulemans, V., Horn, P., Chatrou, M. L., Potthoff, S. A., Kelm, M., Schurgers, L. J., & Westenfeld, R. (2015). High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification. Nutrients, 7(8), 6991-7011. https://doi.org/10.3390/nu7085318
    • Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. (2015). Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PLOS ONE, 10(6), Article e0130484. https://doi.org/10.1371/journal.pone.0130484
    • Brandenburg, V. M., Schurgers, L. J., Kaesler, N., Puesche, K., van Gorp, R. H., Leftheriotis, G., Reinartz, S., Koos, R., & Krueger, T. (2015). Prevention of vasculopathy by vitamin K supplementation: Can we turn fiction into fact?Atherosclerosis, 240(1), 10-16. https://doi.org/10.1016/j.atherosclerosis.2015.02.040
    • Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., Furmanik, M., Sanchis, P., De Rosales, R. T. M., Alvarez-Hernandez, D., Shroff, R., Yin, X., Muller, K., Skepper, J. N., Mayr, M., Reutelingsperger, C. P., Chester, A., Bertazzo, S., Schurgers, L. J., & Shanahan, C. M. (2015). Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion. Circulation Research, 116(8), 1312-1323. https://doi.org/10.1161/CIRCRESAHA.116.305012
    • van der Vorst, E. P. C., Jeurissen, M., Wolfs, I. M. J., Keijbeck, A., Theodorou, K., Wijnands, E., Schurgers, L., Weber, S., Gijbels, M. J., Hamers, A. A. J., Dreymueller, D., Rose-John, S., de Winther, M. P. J., Ludwig, A., Saftig, P., Biessen, E. A. L., & Donners, M. M. P. C. (2015). Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis. American Journal of Pathology, 185(4), 1145-1155. https://doi.org/10.1016/j.ajpath.2014.11.028
  • 2014
    • Schurgers, L. J., & Spronk, H. M. H. (2014). Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis. Thrombosis and Haemostasis, 112(5), 909-917. https://doi.org/10.1160/TH14-03-0268
    • Burgmaier, M., Schutters, K., Willems, B., Van der Vorst, E. P. C., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A. L., Cleutjens, J., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine, 18(10), 2117-2124. https://doi.org/10.1111/jcmm.12374
    • Krueger, T., Schlieper, G., Schurgers, L., Cornelis, T., Cozzolino, M., Jacobi, J., Jadoul, M., Ketteler, M., Rump, L. C., Stenvinkel, P., Westenfeld, R., Wiecek, A., Reinartz, S., Hilgers, R.-D., & Floege, J. (2014). Vitamin K1 to slow vascular calcification in haemodialysis patients (VitaVasK trial): a rationale and study protocol. Nephrology Dialysis Transplantation, 29(9), 1633-1638. https://doi.org/10.1093/ndt/gft459
    • Willems, B. A. G., Vermeer, C., Reutelingsperger, C. P. M., & Schurgers, L. J. (2014). The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification. Molecular Nutrition & Food Research, 58(8), 1620-1635. https://doi.org/10.1002/mnfr.201300743
    • Li, Q., Brodsky, J. L., Conlin, L. K., Pawel, B., Glatz, A. C., Gafni, R. I., Schurgers, L., Uitto, J., Hakonarson, H., Deardorff, M. A., & Levine, M. A. (2014). Mutations in the ABCC6 Gene as a Cause of Generalized Arterial Calcification of Infancy: Genotypic Overlap with Pseudoxanthoma Elasticum. Journal of Investigative Dermatology, 134(3), 658-665. https://doi.org/10.1038/jid.2013.370
    • Ungethüm, L., Chatrou, M., Kusters, D., Schurgers, L., & Reutelingsperger, C. P. (2014). Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake. PLOS ONE, 9(5), e96749. https://doi.org/10.1371/journal.pone.0096749
  • 2013
    • Boraldi, F., Garcia-Fernandez, M., Paolinelli-deVincenzi, C., Annovi, G., Schurgers, L., Vermeer, C., Cianciulli, P., Ronchetti, I., & Quaglino, D. (2013). Ectopic calcification in beta-thalassemia patients is associated with increased oxidative stress and lower MGP carboxylation. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1832(12), 2077-2084. https://doi.org/10.1016/j.bbadis.2013.07.017
    • Krueger, T., Oelenberg, S., Kaesler, N., Schurgers, L. J., van de Sandt, A. M., Boor, P., Schlieper, G., Brandenburg, V. M., Fekete, B. C., Veulemans, V., Ketteler, M., Vermeer, C., Jahnen-Dechent, W., Floege, J., & Westenfeld, R. (2013). Warfarin Induces Cardiovascular Damage in Mice. Arteriosclerosis Thrombosis and Vascular Biology, 33(11), 2618-2624. https://doi.org/10.1161/ATVBAHA.113.302244
    • Brandenburg, V. M., Kramann, R., Koos, R., Krueger, T., Schurgers, L., Muehlenbruch, G., Huebner, S., Gladziwa, U., Drechsler, C., & Ketteler, M. (2013). Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study. Bmc Nephrology, 14(1), Article 219. https://doi.org/10.1186/1471-2369-14-219
    • Theuwissen, E., Teunissen, K. J., Spronk, H. M. H., Hamulyak, K., Ten Cate, H., Shearer, M. J., Vermeer, C., & Schurgers, L. J. (2013). Effect of low-dose supplements of menaquinone-7 (vitamin K-2) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. Journal of Thrombosis and Haemostasis, 11(6), 1085-1092. https://doi.org/10.1111/jth.12203
    • Dalmeijer, G. W., van der Schouw, Y. T., Vermeer, C., Magdeleyns, E. J., Schurgers, L. J., & Beulens, J. W. J. (2013). Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women. Journal of Nutritional Biochemistry, 24(4), 624-628. https://doi.org/10.1016/j.jnutbio.2012.02.012
    • Boraldi, F., Annovi, G., Vermeer, C., Schurgers, L. J., Trenti, T., Tiozzo, R., Guerra, D., & Quaglino, D. (2013). Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls. Journal of Investigative Dermatology, 133(4), 946-954. https://doi.org/10.1038/jid.2012.460
    • Kramann, R., Brandenburg, V. M., Schurgers, L. J., Ketteler, M., Westphal, S., Leisten, I., Bovi, M., Jahnen-Dechent, W., Knuechel, R., Floege, J., & Schneider, R. K. (2013). Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy. Nephrology Dialysis Transplantation, 28(4), 856-868. https://doi.org/10.1093/ndt/gfs466
    • Schurgers, L. J., Uitto, J., & Reutelingsperger, C. P. (2013). Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization. Trends in Molecular Medicine, 19(4), 217-226. https://doi.org/10.1016/j.molmed.2012.12.008
    • Li, Q., Guo, H., Chou, D. W., Harrington, D. J., Schurgers, L. J., Terry, S. F., & Uitto, J. (2013). Warfarin Accelerates Ectopic Mineralization in Abcc6(-/-) Mice Clinical Relevance to Pseudoxanthoma Elasticum. American Journal of Pathology, 182(4), 1139-1150. https://doi.org/10.1016/j.ajpath.2012.12.037
    • Schutters, K., Kusters, D. H. M., Chatrou, M. L. L., Montero-Melendez, T., Donners, M., Deckers, N. M., Krysko, D. V., Vandenabeele, P., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. P. M. (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells. Cell Death and Differentiation, 20(1), 49-56. https://doi.org/10.1038/cdd.2012.107
  • 2012
    • Brandenburg, V., Al-Fakhri, N., Nemeth, K., Goettsch, C., Schurgers, L. J., Vermeer, C., Hofbauer, L. C., & Schoppet, M. (2012). Calcification inhibitors in vascular calciphylaxis associated with normal renal function. Thrombosis and Haemostasis, 108(6), 1241-3. https://doi.org/10.1160/TH12-07-0484
    • Van de Vijver, P., Schmitt, M., Suylen, D., Scheer, L., Thomassen, M. C. L. G. D., Schurgers, L. J., Griffin, J. H., Koenen, R. R., & Hackeng, T. M. (2012). Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies against the Thrombin-Sensitive Region of Murine Protein S. Journal of the American Chemical Society, 134(47), 19318-19321. https://doi.org/10.1021/ja306993t
    • Theuwissen, E., Cranenburg, E. C., Knapen, M. H., Magdeleyns, E. J., Teunissen, K. J., Schurgers, L. J., Smit, E., & Vermeer, C. (2012). Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. British Journal of Nutrition, 108(9), 1652-1657. https://doi.org/10.1017/S0007114511007185
    • Boxma, P. Y., van den Berg, E., Geleijnse, J. M., Laverman, G. D., Schurgers, L. J., Vermeer, C., Kema, I. P., Muskiet, F. A., Navis, G., Bakker, S. J. L., & de Borst, M. H. (2012). Vitamin K Intake and Plasma Desphospho-Uncarboxylated Matrix Gla-Protein Levels in Kidney Transplant Recipients. PLOS ONE, 7(10), Article e47991. https://doi.org/10.1371/journal.pone.0047991
    • Kusters, D. H. M., Tegtmeier, J., Schurgers, L. J., & Reutelingsperger, C. P. M. (2012). Molecular Imaging to Identify the Vulnerable Plaque-From Basic Research to Clinical Practice. Molecular Imaging and Biology, 14(5), 523-533. https://doi.org/10.1007/s11307-012-0586-7
    • Knapen, M. H. J., Schurgers, L. J., Shearer, M. J., Newman, P., Theuwissen, E., & Vermeer, C. (2012). Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight. British Journal of Nutrition, 108(6), 1017-1024. https://doi.org/10.1017/S000711451100626X
    • Cranenburg, E. C. M., Schurgers, L. J., Uiterwijk, H. H., Beulens, J. W. J., Dalmeijer, G. W., Westerhuis, R., Magdeleyns, E. J., Herfs, M., Vermeer, C., & Laverman, G. D. (2012). Vitamin K intake and status are low in hemodialysis patients. Kidney International, 82(5), 605-610. https://doi.org/10.1038/ki.2012.191
    • Schurgers, L. J., Joosen, I. A., Laufer, E. M., Chatrou, M. L. L., Herfs, M., Winkens, M. H. M., Westenfeld, R., Veulemans, V., Krueger, T., Shanahan, C. M., Jahnen-Dechent, W., Biessen, E., Narula, J., Vermeer, C., Hofstra, L., & Reutelingsperger, C. P. (2012). Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype. PLOS ONE, 7(8), Article e43229. https://doi.org/10.1371/journal.pone.0043229
    • Chatrou, M. L. L., Winckers, K., Hackeng, T. M., Reutelingsperger, C. P. M., & Schurgers, L. J. (2012). Vascular calcification: The price to pay for anticoagulation therapy with vitamin K-antagonists. Blood Reviews, 26(4), 155-166. https://doi.org/10.1016/j.blre.2012.03.002
    • Westenfeld, R., Krueger, T., Schlieper, G., Cranenburg, E. C. M., Magdeleyns, E. J. P., Heidenreich, S., Holzmann, S., Vermeer, C., Jahnen-Dechent, W., Ketteler, M., Floege, J., & Schurgers, L. J. (2012). Effect of Vitamin K-2 Supplementation on Functional Vitamin K Deficiency in Hemodialysis Patients: A Randomized Trial. American Journal of Kidney Diseases, 59(2), 186-195. https://doi.org/10.1053/j.ajkd.2011.10.041
  • 2011
    • Vanakker, O. M., Leroy, B. P., Schurgers, L. J., Vermeer, C., Coucke, P. J., & De Paepe, A. (2011). Atypical Presentation of Pseudoxanthoma Elasticum With Abdominal Cutis Laxa: Evidence for a Spectrum of Ectopic Calcification Disorders?American Journal of Medical Genetics Part A, 155A(11), 2855-2859. https://doi.org/10.1002/ajmg.a.34264
    • Chatrou, M. L. L., Reutelingsperger, C. P., & Schurgers, L. J. (2011). Role of vitamin K-dependent proteins in the arterial vessel wall. Hämostaseologie, 31(4), 251-257. https://doi.org/10.5482/ha-1157
Overview