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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Miranda Nabben

Assistant Professor

Dr. Miranda Nabben obtained her MSc in Pharmaceutical Sciences (Utrecht University) and PhD in Human Biology (Maastricht University). She performed postdoctoral research at the University of Washington, Seattle, and at Eindhoven University of Technology, before returning to Maastricht University, where she was appointed Assistant Professor in 2019 and since 2025 holds a joint position in Cardiology and Clinical Genetics.

Her research team investigates cardiac substrate metabolism and metabolic remodeling in heart failure, with a particular focus on fuel flexibility, patterns of substrate utilization, and sex-specific mechanisms, aiming to uncover novel therapeutic targets to improve patient outcomes. She has received multiple grants and awards, including the Kootstra Talent Award, VENI fellowship, NWO Off Road Award, and the Dekker Senior Scientist Award from the Dutch Heart Foundation. Current projects focus on cellular regulation of cardiomyocyte metabolism, metabolic changes in cardiomyopathies, and identification of novel drivers of heart failure.

Dr. Nabben actively contributes to national and European research networks, including the DCVA Double Dose consortium and the ERA4Health Cardinnov project. She has been a board member of the International Society for Heart and Vascular Metabolism (SHVM), is board member of CARIM Division Heart, and serves on the editorial boards of Frontiers in Cardiovascular Medicine and the International Journal of Molecular Sciences. She is committed to mentoring young researchers and has supervised multiple PhD students, postdoctoral fellows, and technicians.

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  • 2014
    • Nabben, M., van Bree, B. W., Lenaers, E., Hoeks, J., Hesselink, M. K., Schaart, G., Gijbels, M. J., Glatz, J. F., da Silva, G. J., De Windt, L. J., Tian, R., Mike, E., Skapura, D. G., Wehrens, X. H., & Schrauwen, P. (2014). Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.Basic Research in Cardiology, 109(6), Article 447. https://doi.org/10.1007/s00395-014-0447-4
    • Abdurrachim, D., Ciapaite, J., Wessels, B., Nabben, M., Luiken, J. J. F. P., Nicolay, K., & Prompers, J. J. (2014). Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1841(10), 1525-1537. https://doi.org/10.1016/j.bbalip.2014.07.016
  • 2012
    • Timmers, S., Nabben, M., Bosma, M., van Bree, B., Lenaers, E., Van Beurden, D., Schaart, G., Westerterp-Plantenga, M. S., Langhans, W., Hesselink, M. K. C., Schrauwen-Hinderling, V. B., & Schrauwen, P. (2012). Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America, 109(29), 11711-11716. https://doi.org/10.1073/pnas.1206868109
  • 2011
    • Nabben, M., Hoeks, J., Kornips, C. F. P., Van Beurden, D., Briedé, J. J., Hesselink, M. K. C., Glatz, J. F., & Schrauwen, P. (2011). Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure. Febs Letters, 585(24), 4010-4017. https://doi.org/10.1016/j.febslet.2011.11.012
    • Nabben, M., Shabalina, I. G., Kornips, C. F. P., Van Beurden, D., Cannon, B., Schrauwen, P., Nedergaard, J., & Hoeks, J. (2011). Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice.Biochimica et Biophysica Acta-bioenergetics, 1807(9), 1095-1105. https://doi.org/10.1016/j.bbabio.2011.04.003
  • 2010
    • van den Berg, S. A., Nabben, M., Bijland, S., Voshol, P. J., van Klinken, J. B., Havekes, L. M., Romijn, H. A., Hoeks, J., Hesselink, M. K., Schrauwen, P., & van Dijk, K. W. (2010). High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57B1/6 mice. Metabolism-Clinical and Experimental, 59(11), 1612-1618. https://doi.org/10.1016/j.metabol.2010.03.008
    • Lenaers, E., Feyter, H. M., Hoeks, J., Schrauwen, P., Schaart, G., Nabben, M., Nicolay, K., Prompers, J. J., & Hesselink, M. K. (2010). Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.Obesity, 18(6), 1100-1107. https://doi.org/10.1038/oby.2009.372
  • 2008
    • Hoeks, J., Briede, J. J., de Vogel, J., Schaart, G., Nabben, M., Kornips, E., Hesselink, M. K., & Schrauwen, P. (2008). Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding. Febs Letters, 582(4), 510-6. https://doi.org/10.1016/j.febslet.2008.01.013
    • Nabben, M., Hoeks, J., Briede, J. J., Glatz, J. F., Kornips, E., Hesselink, M. K., & Schrauwen, P. (2008). The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice. Febs Letters, 582(30), 4147-4152. https://doi.org/10.1016/j.febslet.2008.11.016
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