• 2017
    • van der Velde, J. H. P. M., Savelberg, H. H. C. M., van der Berg, J. D., Sep, S. J. S., van der Kallen, C. J. H., Dagnelie, P. C., Schram, M. T., Henry, R. M. A., Reijven, P. L. M., van Geel, T. A. C. M., Stehouwer, C. D. A., Koster, A., & Schaper, N. C. (2017). Sedentary Behavior Is Only Marginally Associated with Physical Function in Adults Aged 40-75 Years - the Maastricht Study. Frontiers in physiology, 8(APR), Article 242. https://doi.org/10.3389/fphys.2017.00242
    • Kleinegris, M.-C. F., Konings, J., Daemen, J. W., Henskens, Y., de Laat, B., Spronk, H. M. H., ten Cate-Hoek, A. J., & ten Cate, H. (2017). Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case-Control Study. Frontiers in Cardiovascular Medicine, 4, Article 23. https://doi.org/10.3389/fcvm.2017.00023
    • Hobbelt, A. H., Spronk, H. M., Crijns, H. J. G. M., Ten Cate, H., Rienstra, M., & Van Gelder, I. C. (2017). Prethrombotic State in Young Very Low- Risk Patients With Atrial Fibrillation. Journal of the American College of Cardiology, 69(15), 1990-1992. https://doi.org/10.1016/j.jacc.2017.01.057
    • von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., ... Weber, C. (2017). Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Science Translational Medicine, 9(384), Article eaah6650. https://doi.org/10.1126/scitranslmed.aah6650
    • van Smaalen, T. C., Beurskens, D. M. H., Hoogland, E. R. P., Winkens, B., Christiaans, M. H. L., Reutelingsperger, C. P., van Heurn, L. W. E., & Nicolaes, G. A. F. (2017). Presence of Cytotoxic Extracellular Histones in Machine Perfusate of Donation After Circulatory Death Kidneys. Transplantation, 101(4), e93-e101. https://doi.org/10.1097/TP.0000000000001590
    • den Biggelaar, L. J. C. J., Eussen, S. J. P. M., Sep, S. J. S., Mari, A., Ferrannini, E., van Dongen, M. C. J. M., Denissen, K. F. M., Wijckmans, N. E. G., Schram, M. T., van der Kallen, C. J., Koster, A., Schaper, N., Henry, R. M. A., Stehouwer, C. D. A., & Dagnelie, P. C. (2017). Associations of Dietary Glucose, Fructose, and Sucrose with beta-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study. Nutrients, 9(4), Article 380. https://doi.org/10.3390/nu9040380
    • Martens, R. J. H., Kimenai, D. M., Kooman, J. P., Stehouwer, C. D. A., Tan, F. E. S., Bekers, O., Dagnelie, P. C., van der Kallen, C. J. H., Kroon, A. A., Leunissen, K. M. L., van der Sande, F. M., Schaper, N. C., Sep, S. J. S., Schram, M. T., van Suijlen, J. D., van Dieijen-Visser, M. P., Meex, S. J. R., & Henry, R. M. A. (2017). Estimated Glomerular Filtration Rate and Albuminuria Are Associated with Biomarkers of Cardiac Injury in a Population-Based Cohort Study: The Maastricht Study. Clinical Chemistry, 63(4), 887-897. https://doi.org/10.1373/clinchem.2016.266031
    • Soehnlein, O., Steffens, S., Hidalgo, A., & Weber, C. (2017). Neutrophils as protagonists and targets in chronic inflammation. Nature Reviews Immunology, 17(4), 248-261. https://doi.org/10.1038/nri.2017.10
    • Driessen, J. H. M., de Vries, F., van Onzenoort, H., Harvey, N. C., Neef, C., van den Bergh, J. P. W., Vestergaard, P., & Henry, R. M. A. (2017). The use of incretins and fractures - a meta-analysis on population-based real life data. British Journal of Clinical Pharmacology, 83(4), 923-926. https://doi.org/10.1111/bcp.13167
    • Asare, Y., Ommer, M., Azombo, F. A., Alampour-Rajabi, S., Sternkopf, M., Sanati, M., Gijbels, M. J., Schmitz, C., Sinitski, D., Tilstam, P. V., Lue, H., Gessner, A., Lange, D., Schmid, J. A., Weber, C., Dichgans, M., Jankowski, J., Pardi, R., de Winther, M. P. J., ... Bernhagen, J. (2017). Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proceedings of the National Academy of Sciences of the United States of America, 114(13), E2766-E2775. https://doi.org/10.1073/pnas.1618411114
    • Ruhle, F., & Stoll, M. (2017). Genetic factors in pediatric venous thromboembolism. Thrombosis Research, 151, S97-S99. https://doi.org/10.1016/S0049-3848(17)30077-4
    • Hyafil, F., Pelisek, J., Laitinen, I., Schottelius, M., Mohring, M., Doering, Y., van der Vorst, E. P. C., Kallmayer, M., Steiger, K., Poschenrieder, A., Notni, J., Fischer, J., Baumgartner, C., Rischpler, C., Nekolla, S. G., Weber, C., Eckstein, H.-H., Wester, H.-J., & Schwaiger, M. (2017). Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer (68)Ga-Pentixafor for PET. Journal of Nuclear Medicine, 58(3), 499-506. https://doi.org/10.2967/jnumed.116.179663
    • van Moorsel, D., Henry, R. M., Schaper, N. C., van Greevenbroek, M. M., van Rossum, E. F., 't Hart, L. M., Schalkwijk, C. G., van der Kallen, C. J., Dekker, J. M., Stehouwer, C. D., & Havekes, B. (2017). BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies. American Journal of Hypertension, 30(3), 286-294. https://doi.org/10.1093/ajh/hpw196
    • Mingels, A. M. A., Cardinaels, E. P. M., Broers, N. J. H., van Sleeuwen, A., Streng, A. S., van Dieijen-Visser, M. P., Kooman, J. P., & Bekers, O. (2017). Cardiac Troponin T: Smaller Molecules in Patients with End-Stage Renal Disease than after Onset of Acute Myocardial Infarction. Clinical Chemistry, 63(3), 683-690. https://doi.org/10.1373/clinchem.2016.261644
    • van der Vorst, E. P. C., Zhao, Z., Rami, M., Holdt, L. M., Teupser, D., Steffens, S., & Weber, C. (2017). Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thrombosis and Haemostasis, 117(3), 644-646. https://doi.org/10.1160/TH16-09-0674
    • Driessen, J. H. M., van den Bergh, J. P. W., van Onzenoort, H. A. W., Henry, R. M. A., Leufkens, H. G. M., & de Vries, F. (2017). Long-term use of dipeptidyl peptidase-4 inhibitors and risk of fracture: A retrospective population-based cohort study. Diabetes Obesity & Metabolism, 19(3), 421-428. https://doi.org/10.1111/dom.12843
    • Simons, N., Isaacs, A., Koek, G. H., Kuc, S., Schaper, N. C., & Brouwers, M. C. G. J. (2017). PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease. Gastroenterology, 152(4), 912-913. https://doi.org/10.1053/j.gastro.2016.12.020
    • Kapustin, A. N., Schoppet, M., Schurgers, L. J., Reynolds, J. L., McNair, R., Heiss, A., Jahnen-Dechent, W., Hackeng, T. M., Schlieper, G., Harrison, P., & Shanahan, C. M. (2017). Prothrombin Loading of Vascular Smooth Muscle Cell-Derived Exosomes Regulates Coagulation and Calcification. Arteriosclerosis Thrombosis and Vascular Biology, 37(3), E22-E32. https://doi.org/10.1161/ATVBAHA.116.308886
    • Rowinska, Z., Koeppel, T. A., Sanati, M., Schelzig, H., Jankowski, J., Weber, C., Zernecke, A., & Liehn, E. A. (2017). Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation. PLOS ONE, 12(2), Article 0170644. https://doi.org/10.1371/journal.pone.0170644
    • Kicken, C. H., Roest, M., Henskens, Y. M. C., de Laat, B., & Huskens, D. (2017). Application of an optimized flow cytometry-based quantification of Platelet Activation (PACT): Monitoring platelet activation in platelet concentrates. PLOS ONE, 12(2), Article e0172265. https://doi.org/10.1371/journal.pone.0172265
    • Ruehle, F., Witten, A., Barysenka, A., Huge, A., Arning, A., Heller, C., Kruempel, A., Mesters, R., Franke, A., Lieb, W., Riemenschneider, M., Hiersche, M., Limperger, V., Nowak-Goettl, U., & Stoll, M. (2017). Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to pediatric venous thromboembolism. Blood, 129(6), 783-790. https://doi.org/10.1182/blood-2016-07-728840
    • Winckers, K., Thomassen, S., ten Cate, H., & Hackeng, T. M. (2017). Platelet full length TFPI-alpha in healthy volunteers is not affected by sex or hormonal use. PLOS ONE, 12(2), Article 0168273. https://doi.org/10.1371/journal.pone.0168273
    • Arno, G., Carss, K. J., Hull, S., Zihni, C., Robson, A. G., Fiorentino, A., Hardcastle, A. J., Holder, G. E., Cheetham, M. E., Plagnol, V., Moore, A. T., Raymond, F. L., Matter, K., Balda, M. S., UK Inherited Retinal Dis, Henskens, Y., NIHR-BioResource Rare Dis, & Webster, A. R. (2017). Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. American Journal of Human Genetics, 100(2), 334-342. https://doi.org/10.1016/j.ajhg.2016.12.014
    • Genome of the Netherlands Consortium, & Isaacs, A. (2017). A framework for the detection of de novo mutations in family-based sequencing data. European Journal of Human Genetics, 25(2), 227-233. https://doi.org/10.1038/ejhg.2016.147
    • Braeken, D. C. W., Franssen, F. M. E., von Baum, H., Schuette, H., Pletz, M. W., Rupp, J., Stassen, F., Mooij, M. J., Rohde, G. G. U., & CAPNETZ Study Grp (2017). Bacterial aetiology and mortality in COPD patients with CAP: results from the German Competence Network, CAPNETZ. International Journal of Tuberculosis and Lung Disease, 21(2), 236-243. https://doi.org/10.5588/ijtld.16.0567
    • Beer, A. J., & Dijkgraaf, I. (2017). Editorial European Journal of Nuclear Medicine and Molecular Imaging. European Journal of Nuclear Medicine and Molecular Imaging, 44(2), 284-285. https://doi.org/10.1007/s00259-016-3559-2
    • Martens, R. J. H., Kooman, J. P., Stehouwer, C. D. A., Dagnelie, P. C., van der Kallen, C. J. H., Koster, A., Kroon, A. A., Leunissen, K. M. L., Nijpels, G., van der Sande, F. M., Schaper, N. C., Sep, S. J. S., van Boxtel, M. P. J., Schram, M. T., & Henry, R. M. A. (2017). Estimated GFR, Albuminuria, and Cognitive Performance: The Maastricht Study. American Journal of Kidney Diseases, 69(2), 179-191. https://doi.org/10.1053/j.ajkd.2016.04.017
    • Streng, A. S., de Boer, D., van Doom, W. P. T. M., Bouwman, F. G., Mariman, E. C. M., Bekers, O., van Dieijen-Visser, M. P., & Wodzig, W. K. W. H. (2017). Identification and and Characterization of Cardiac Troponin T Fragments in Serum of Patients Suffering from Acute Myocardial Infarction. Clinical Chemistry, 63(2), 563-572. https://doi.org/10.1373/clinchem.2016.261511
    • van Bussel, B. C. T., van de Poll, M. C. G., Schalkwijk, C. G., & Bergmans, D. C. J. J. (2017). Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness. International journal of molecular sciences, 18(2), Article 346. https://doi.org/10.3390/ijms18020346
    • Wolf, D., Bukosza, N., Enge, D., Poggi, M., Jehle, F., Michel, N. A., Chen, Y.-C., Colberg, C., Hoppe, N., Dufner, B., Boon, L., Blankenbach, H., Hilgendorf, I., Muhlen, C. V. Z., Reinoehl, J., Sommer, B., Marchini, T., Febbraio, M. A., Weber, C., ... Zirlik, A. (2017). Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO). Thrombosis and Haemostasis, 117(2), 325-338. https://doi.org/10.1160/TH16-07-0553
    • Doering, Y., Soehnlein, O., & Weber, C. (2017). Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis. Circulation Research, 120(4), 736-743. https://doi.org/10.1161/CIRCRESAHA.116.309692
    • de Jong, R. J., Paulin, N., Lemnitzer, P., Viola, J. R., Winter, C., Ferraro, B., Grommes, J., Weber, C., Reutelingsperger, C., Drechsler, M., & Soehnlein, O. (2017). Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report. Arteriosclerosis Thrombosis and Vascular Biology, 37(2), 312-315. https://doi.org/10.1161/ATVBAHA.116.308744
    • Elands, R. J. J., Simons, C. C. J. M., Riemenschneider, M., Isaacs, A., Schouten, L. J., Verhage, B. A., Van Steen, K., Godschalk, R. W. L., van den Brandt, P. A., Stoll, M., & Weijenberg, M. P. (2017). A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk. Scientific Reports, 7, Article 41034. https://doi.org/10.1038/srep41034
    • van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F. A., Tas, S. W., Wolfs, I. M. J., Kuijpers, M. J. E., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P. Y., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C.-C., Leitges, M., Lawrence, T., ... Donners, M. M. P. C. (2017). High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappa B/STAT1-IRF1 Signaling. Cell Metabolism, 25(1), 197-207. https://doi.org/10.1016/j.cmet.2016.10.013
    • Panova-Noeva, M., Arnold, N., Hermanns, M. I., Prochaska, J. H., Schulz, A., Spronk, H. M., Binder, H., Pfeiffer, N., Beutel, M., Blankenberg, S., Zeller, T., Lotz, J., Muenzel, T., Lackner, K. J., ten Cate, H., & Wild, P. S. (2017). Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability. Scientific Reports, 7, Article 40229. https://doi.org/10.1038/srep40229
    • Carss, K. J., Arno, G., Erwood, M., Stephens, J., Sanchis-Juan, A., Hull, S., Megy, K., Grozeva, D., Dewhurst, E., Malka, S., Plagnol, V., Penkett, C., Stirrups, K., Rizzo, R., Wright, G., Josifova, D., Bitner-Glindzicz, M., Scott, R. H., Clement, E., ... Raymond, F. L. (2017). Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. American Journal of Human Genetics, 100(1), 75-90. https://doi.org/10.1016/j.ajhg.2016.12.003
    • Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity, Chambers, J. C., Grallert, H., & Kooner, J. S. (2017). Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541(7635), 81-86. https://doi.org/10.1038/nature20784
    • Knippels, M. C. J., Essers, I. M. M., Magdelijns, F. J. H., & Van Twist, D. J. L. (2017). 'Ecstasy-light': Niet zo onschuldig als het lijkt. Nederlands Tijdschrift voor Geneeskunde, 161(27), Article d1356.
    • Spronk, H. M. H., De Jong, A. M., Verheule, S., De Boer, H. C., Maass, A. H., Lau, D. H., Rienstra, M., van Hunnik, A., Kuiper, M., Lumeij, S., Zeemering, S., Linz, D., Kamphuisen, P. W., ten Cate, H., Crijns, H. J., Van Gelder, I. C., van Zonneveld, A. J., & Schotten, U. (2017). Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation. European Heart Journal, 38(1), 38-50. https://doi.org/10.1093/eurheartj/ehw119
    • van Dooren, F. E. P., Pouwer, F., Schalkwijk, C. G., Sep, S. J. S., Stehouwer, C. D. A., Henry, R. M. A., Dagnelie, P. C., Schaper, N. C., van der Kallen, C. J. H., Koster, A., Denollet, J., Verhey, F. R. J., & Schram, M. T. (2017). Advanced Glycation End Product (AGE) Accumulation in the Skin is Associated with Depression: The Maastricht Study. Depression and Anxiety, 34(1), 59-67. https://doi.org/10.1002/da.22527
    • Kusters, R. W. J., Simons, A. P., Lance, M. D., Ganushchak, Y. M., Bekers, O., & Weerwind, P. W. (2017). Blood warming, pump heating and haemolysis in low-flow extracorporeal life support; an in vitro study using freshly donated human blood. Perfusion, 32(1), 27-34. https://doi.org/10.1177/0267659116656045
    • Winkels, H., Meiler, S., Smeets, E., Lievens, D., Engel, D., Spitz, C., Buerger, C., Rinne, P., Beckers, L., Dandl, A., Reim, S., Ahmadsei, M., Van den Bossche, J., Holdt, L. M., Megens, R. T. A., Schmitt, M. M., de Winther, M., Biessen, E. A., Borst, J., ... Gerdes, N. (2017). CD70 limits atherosclerosis and promotes macrophage function. Thrombosis and Haemostasis, 117(1), 164-175. https://doi.org/10.1160/TH16-04-0318
    • Vries, M. J. A., Bouman, H. J., Olie, R. H., Veenstra, L. F., Zwaveling, S., Verhezen, P. W. M., ten Cate-Hoek, A. J., ten Cate, H., Henskens, Y. M. C., & van der Meijden, P. E. J. (2017). Determinants of agreement between proposed therapeutic windows of platelet function tests in vulnerable patients. European Heart Journal-Cardiovascular Pharmacotherapy, 3(1), 11-17. https://doi.org/10.1093/ehjcvp/pvw026
    • Zahedi, F., Nazari-Jahantigh, M., Zhou, Z., Subramanian, P., Wei, Y., Grommes, J., Offermanns, S., Steffens, S., Weber, C., & Schober, A. (2017). Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. Cellular and Molecular Life Sciences, 74(2), 359-372. https://doi.org/10.1007/s00018-016-2349-0
    • Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J., Slieker, R. C., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Arindrarto, W., ... Franke, L. (2017). Disease variants alter transcription factor levels and methylation of their binding sites. Nature Genetics, 49(1), 131-138. https://doi.org/10.1038/ng.3721
    • Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H.-J., Bonder, M. J., van Rooij, J., Verkerk, M., Jhamai, P. M., Moed, M., Kielbasa, S. M., Bot, J., Nooren, I., Pool, R., ... Franke, L. (2017). Identification of context-dependent expression quantitative trait loci in whole blood. Nature Genetics, 49(1), 139-145. https://doi.org/10.1038/ng.3737
    • van Doorn, P., Rosing, J., Wielders, S. J., Hackeng, T. M., & Castoldi, E. (2017). The C-terminus of tissue factor pathway inhibitor-alpha inhibits factor V activation by protecting the Arg(1545) cleavage site. Journal of Thrombosis and Haemostasis, 15(1), 140-149. https://doi.org/10.1111/jth.13559
    • Houben, I. P. L., van Berlo, C. J. L. Y., Bekers, O., Nijssen, E. C., Lobbes, M. B. I., & Wildberger, J. E. (2017). Assessing the Risk of Contrast-Induced Nephropathy Using a Finger Stick Analysis in Recalls from Breast Screening: The CINFIBS Explorative Study. Contrast Media & Molecular Imaging, Article 5670384. https://doi.org/10.1155/2017/5670384
    • Hurkens, K. P. G. M., Mestres-gonzalvo, C., Wit, H. A. J. M. D., Janknegt, R., Verhey, F., Schols, J. M. G. A., Magdelijns, F., Stehouwer, C. D. A., Winkens, B., Mulder, W., & Kuy, P. H. M. V. D. (2017). Assessing the strengths and weaknesses of a computer assisted medication review in hospitalized patients. International Journal of Hospital Pharmacy, 2(6), 1-12. https://doi.org/10.28933/IJHP-2017-10-0101