• 2019
    • Geersing, G.-J., Greving, J. P., Folkeringa, R., Hemels, M. E. W., Ten Cate, H., & Huisman, M. V. (2019). Oerwoud van antitrombotica: een overzicht van recente literatuur. Nederlands Tijdschrift voor Geneeskunde, 163(46), 1-7. Article D4265. https://www.ntvg.nl/system/files/publications/d4265.pdf
    • Bohler, S., Liu, X., Krauskopf, J., Gaiment, F., Aubrecht, J., Nicolaes, G. A. F., Kleinjans, J. C. S., & Briede, J. J. (2019). Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease. Clinical Pharmacology & Therapeutics, 12(4), 609-616. https://doi.org/10.1111/cts.12663
    • Henriquez, D. D. C. A., Caram-Deelder, C., le Cessie, S., Zwart, J. J., van Roosmalen, J. J. M., Eikenboom, J. C. J., So-Osman, C., van de Watering, L. G., Zwaginga, J. J., Koopman-van Gemert, A. W. M. M., Bloemenkamp, K. W. M., van der Bom, J. G., Bank, C. M. C., Snuif-de Lange, Y. S., van Gammeren, A. J., Papatsonis, D. N. M., Klinkspoor, H., Kok, M., de Boer, B. A., ... TeMpOH-1 Research Group (2019). Association of Timing of Plasma Transfusion With Adverse Maternal Outcomes in Women With Persistent Postpartum Hemorrhage. Jama network open, 2(11), Article 1915628. https://doi.org/10.1001/jamanetworkopen.2019.15628
    • Hwang, P., Mingels, A., & Kavsak, P. A. (2019). High-sensitivity cardiac troponin testing during and after ACS: Complexed or not?Clinical Biochemistry, 73, 32-34. https://doi.org/10.1016/j.clinbiochem.2019.07.012
    • Provenzale, I., Brouns, S. L. N., van der Meijden, P. E. J., Swieringa, F., & Heemskerk, J. W. M. (2019). Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis. Micromachines, 10(11), Article 787. https://doi.org/10.3390/mi10110787
    • Claassens, D. M. F., Vos, G. J. A., Bergmeijer, T. O., Hermanides, R. S., van 't Hof, A. W. J., van der Harst, P., Barbato, E., Morisco, C., Gin, R. M. T. J., Asselbergs, F. W., Mosterd, A., Herrman, J.-P. R., Dewilde, W. J. M., Janssen, P. W. A., Kelder, J. C., Postma, M. J., de Boer, A., Boersma, C., Deneer, V. H. M., & ten Berg, J. M. (2019). A Genotype-Guided Strategy for Oral P2Y(12) Inhibitors in Primary PCI. New England Journal of Medicine, 381(17), 1621-1631. https://doi.org/10.1056/NEJMoa1907096
    • Lee, K. K., Ferry, A. V., Anand, A., Strachan, F. E., Chapman, A. R., Kimenai, D. M., Meex, S. J. R., Berry, C., Findlay, I., Reid, A., Cruickshank, A., Gray, A., Collinson, P. O., Apple, F. S., McAllister, D. A., Maguire, D., Fox, K. A. A., Newby, D. E., Tuck, C., ... High-STEACS Investigators (2019). Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome. Journal of the American College of Cardiology, 74(16), 2032-2043. https://doi.org/10.1016/j.jacc.2019.07.082
    • Henriquez, D. D. C. A., Gillissen, A., Smith, S. M., Cramer, R. A., van den Akker, T., Zwart, J. J., van Roosmalen, J. J. M., Bloemenkamp, K. W. M., van der Bom, J. G., Adriaanse, H. J., van den Akker, E. S. A., Baas, M., Bank, C. M. C., van Beek, E., de Boer, B. A., de Boer, K., van der Borden, D. M. R., Bremer, H. A., Brons, J. T. J., ... TeMpOH-1 study group (2019). Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study. BMC Pregnancy and Childbirth, 19(1), Article 361. https://doi.org/10.1186/s12884-019-2499-9
    • van Dongen, J., Zilhao, N. R., Sugden, K., Hannon, E. J., Mill, J., Caspi, A., Agnew-Blais, J., Arseneault, L., Corcoran, D. L., Moffitt, T. E., Poulton, R., Franke, B., Boomsma, D., Heijmans, B. T., t'Hoen, P. A. G., van Meurs, J., Isaacs, A., Jansen, R., Franke, L., ... BIOS Consortium (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biological Psychiatry, 86(8), 599-607. https://doi.org/10.1016/j.biopsych.2019.02.016
    • ter Beek, O., Pavlenko, D., Suck, M., Helfrich, S., Bolhuis-Versteeg, L., Snisarenko, D., Causserand, C., Bacchin, P., Aimar, P., van Oerle, R., Wetzels, R., Verhezen, P., Henskens, Y., & Stamatialis, D. (2019). New membranes based on polyethersulfone – SlipSkin™ polymer blends with low fouling and high blood compatibility. Separation and Purification Technology, 225, 60-73. https://doi.org/10.1016/j.seppur.2019.05.049
    • Hendrix, M. L. E., Palm, K. C. M., Van Kuijk, S. M. J., Bekers, O., Spaanderman, M. E. A., Bons, J. A. P., & Al-Nasiry, S. (2019). Longitudinal changes in placental biomarkers in women with early versus late placental dysfunction. Hypertension in Pregnancy, 38(4), 268-277. https://doi.org/10.1080/10641955.2019.1668948
    • Siitonen, R., Peuhu, E., Autio, A., Liljenback, H., Mattila, E., Metsala, O., Kakela, M., Saanijoki, T., Dijkgraaf, I., Jalkanen, S., Ivaska, J., & Roivainen, A. (2019). 68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice. Journal of Nuclear Medicine, 60(10), 1380-1387. https://doi.org/10.2967/jnumed.118.222026
    • Hendrix, M. L. E., Bons, J. A. P., Snellings, R. R. G., Bekers, O., van Kuijk, S. M. J., Spaanderman, M. E. A., & Al-Nasiry, S. (2019). Can Fetal Growth Velocity and First Trimester Maternal Biomarkers Improve the Prediction of Small-for-Gestational Age and Adverse Neonatal Outcome?Fetal Diagnosis and Therapy, 46(4), 274-284. https://doi.org/10.1159/000499580
    • Cimen, I., Yildirim, Z., Dogan, A. E., Yildirim, A. D., Tufanli, O., Onat, U. I., UyenThao Nguyen, Watkins, S. M., Weber, C., & Erbay, E. (2019). Double bond configuration of palmitoleate is critical for atheroprotection. Molecular Metabolism, 28, 58-72. https://doi.org/10.1016/j.molmet.2019.08.004
    • Gajjala, P. R., Bruck, H., Noels, H., Heinze, G., Ceccarelli, F., Kribben, A., Saez-Rodriguez, J., Marx, N., Zidek, W., Jankowski, J., & Jankowski, V. (2019). Novel plasma peptide markers involved in the pathology of CKD identified using mass spectrometric approach. Journal of Molecular Medicine, 97(10), 1451-1463. https://doi.org/10.1007/s00109-019-01823-8
    • Jessurun, N. T., Drent, M., van Puijenbroek, E. P., Bekers, O., Wijnen, P. A., & Bast, A. (2019). Drug-induced interstitial lung disease: role of pharmacogenetics in predicting cytotoxic mechanisms and risks of side effects. Current Opinion in Pulmonary Medicine, 25(5), 468-477. https://doi.org/10.1097/MCP.0000000000000590
    • ten Cate, V., Nagler, M., Panova-Noeva, M., Eggebrecht, L., Arnold, N., Lamparter, H., Hermanns, M. I., ten Cate, H., Prins, M. H., Espinola-Klein, C., Muenzel, T., Lackner, K. J., Wild, P. S., & Prochaska, J. H. (2019). The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of having venous thromboembolism. Haematologica-the Hematology Journal, 104(9), Article 424. https://doi.org/10.3324/haematol.2018.213322
    • Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H., & Pieters, R. J. (2019). Hybrid ligands with calixarene and thiodigalactoside groups: galectin binding and cytotoxicity. Organic Chemistry Frontiers, 6(16), 2981-2990. https://doi.org/10.1039/c9qo00810a
    • Denisov, S. S., Ippel, J. H., Heinzmann, A. C. A., Koenen, R. R., Ortega-Gomez, M., Soehnlein, O., Hackeng, T. M., & Dijkgraaf, I. (2019). Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. Journal of Biological Chemistry, 294(33), 12370-12379. https://doi.org/10.1074/jbc.RA119.008902
    • van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., ... Gieger, C. (2019). Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium. Scientific Reports, 9(1), Article 11623. https://doi.org/10.1038/s41598-019-47282-6
    • van Der Plaat, D., Vonk, J. M., Terzikhan, N., de Jong, K., de Vries, M., La Bastide-van Gemert, S., van Diemen, C. C., Lahousse, L., Brusselle, G., Nedeljkovic, I., Amin, N., Kromhout, H., Vermeulen, R. C. H., Postma, D. S., van Duijn, C. M., Boezen, H. M., Heijmans, B. T., Hoen, P. A. C. T., van Meurs, J., ... BIOS Consortium (2019). Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression. Human Molecular Genetics, 28(15), 2477-2485. https://doi.org/10.1093/hmg/ddz067
    • Busygina, K., Denzinger, V., Bernlochner, I., Weber, C., Lorenz, R., & Siess, W. (2019). Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs?Thrombosis and Haemostasis, 119(8), 1212-1221. https://doi.org/10.1055/s-0039-1687877
    • Coppin, L., Najimi, M., Bodart, J., Rouchon, M.-S., van der Smissen, P., Eeckhoudt, S., Dahlqvist, G., Castanares-Zapatero, D., Komuta, M., Brouns, S. L., Baaten, C. C., Heemskerk, J. W. M., Horman, S., Belmonte, N., Sokal, E., & Stephenne, X. (2019). Clinical Protocol to Prevent Thrombogenic Effect of Liver-Derived Mesenchymal Cells for Cell-Based Therapies. Cells, 8(8), Article 846. https://doi.org/10.3390/cells8080846
    • Petersohn, S., Ramaekers, B. L. T., Olie, R. H., ten Cate-Hoek, A. J., Daemen, J.-W. H. C., ten Cate, H., & Joore, M. A. (2019). Comparison of three generic quality-of-life metrics in peripheral arterial disease patients undergoing conservative and invasive treatments. Quality of Life Research, 28(8), 2257-2279. https://doi.org/10.1007/s11136-019-02166-0
    • Koenen, R. R. (2019). Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease. Thrombosis and Haemostasis, 119(8), 1202-1204. https://doi.org/10.1055/s-0039-1693024
    • Natarelli, L., & Weber, C. (2019). Next-Generation Therapeutic Concepts for Atherosclerosis: Focus on Cell Specificity and Noncoding RNAs. Thrombosis and Haemostasis, 119(8), 1199-1201. https://doi.org/10.1055/s-0039-1693412
    • Astuti, P., Beurskens, D., Vajen, T., Nicolaes, G., Zhang, M., & Guido, H. (2019). Protection against neutrophil extracellular trap (NET) toxicity by antioxidant monoHER. Makara Journal of Health Research, 23(2), 108-115. https://doi.org/10.7454/msk.v23i2.10453
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., Hoek - ten Cate, A., & Burden, A. (2019). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants (vol 83, pg 1835, 2017) - correction. British Journal of Clinical Pharmacology, 85(8), 1864-1864. https://doi.org/10.1111/bcp.14001
    • Heestermans, M., de Jong, A., van Tilburg, S., Reitsma, P. H., Versteeg, H. H., Spronk, H. M., & van Vlijmen, B. J. M. (2019). Use of “C9/11 Mismatch” Control siRNA Reveals Sequence-Related Off-Target Effect on Coagulation of an siRNA Targeting Mouse Coagulation Factor XII. Nucleic Acid Therapeutics, 29(4), 218-223. https://doi.org/10.1089/nat.2018.0767
    • Nagy, M., van Geffen, J. P., Stegner, D., Adams, D. J., Braun, A., de Witt, S. M., Elvers, M., Geer, M. J., Kuijpers, M. J. E., Kunzelmann, K., Mori, J., Oury, C., Pircher, J., Pleines, I., Poole, A. W., Senis, Y. A., Verdoold, R., Weber, C., Nieswandt, B., ... Baaten, C. C. F. M. J. (2019). Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Frontiers in Cardiovascular Medicine, 6, Article 99. https://doi.org/10.3389/fcvm.2019.00099
    • Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M.-J., Franke, L., ... Kutalik, Z. (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10(1), Article 3300. https://doi.org/10.1038/s41467-019-10936-0
    • Damen, S. A. J., Vroemen, W. H. M., Brouwer, M. A., Mezger, S. T. P., Suryapranata, H., van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., de Boer, D., Cramer, G. E., & Mingels, A. M. A. (2019). Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay. Journal of the American Heart Association, 8(14), Article 012602. https://doi.org/10.1161/JAHA.119.012602
    • Ketelhuth, D. F. J., Lutgens, E., Back, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C., & Evans, P. C. (2019). Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular Research, 115(9), 1385-1392. https://doi.org/10.1093/cvr/cvz166
    • Liu, C.-T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., ... Bouatia-Naji, N. (2019). Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals. Scientific Reports, 9(1), Article 9439. https://doi.org/10.1038/s41598-019-45823-7
    • Sternkopf, M., Thoroee-Boveleth, S., Beck, T., Oleschko, K., Erlenkoetter, A., Tschulena, U., Steppan, S., Speer, T., Goettsch, C., Jankowski, V., Jankowski, J., Noels, H., & European Uremic Toxin Work Group-EUTox (2019). A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients. Toxins, 11(7), Article 389. https://doi.org/10.3390/toxins11070389
    • van Doorn, P., Rosing, J., Wielders, S. J., Hackeng, T. M., & Castoldi, E. (2019). Corrigendum: The C-terminus of tissue factor pathway inhibitor-a inhibits factor V activation by protecting the Arg(1545) cleavage site (vol 15, pg 140, 2017). Journal of Thrombosis and Haemostasis, 17(7), 1195-1195. https://doi.org/10.1111/jth.14489
    • Eggebrecht, L., Prochaska, J. H., Troebs, S.-O., Schwuchow-Thonke, S., Goebel, S., Diestelmeier, S., Schulz, A., Arnold, N., Panova-Noeva, M., Koeck, T., Rapp, S., Gori, T., Lackner, K. J., ten Cate, H., Muenzel, T., & Wild, P. S. (2019). Direct oral anticoagulants and vitamin K antagonists are linked to differential profiles of cardiac function and lipid metabolism. Clinical research in cardiology, 108(7), 787-796. https://doi.org/10.1007/s00392-018-1408-y
    • Olie, R. H., van der Meijden, P. E. J., Spronk, H. M. H., van Oerle, R., Barvik, S., Bonarjee, V. V. S., Ten Cate, H., & Nilsen, D. W. T. (2019). Effects of the PAR-1 Antagonist Vorapaxar on Platelet Activation and Coagulation Biomarkers in Patients with Stable Coronary Artery Disease. TH open : companion journal to thrombosis and haemostasis, 3(3), e259-e262. https://doi.org/10.1055/s-0039-1695710
    • Heubel-Moenen, F. C. J. I., Henskens, Y. M. C., Verhezen, P. W. M., Wetzels, R. J. H., Schouten, H. C., & Beckers, E. A. M. (2019). Fibrinolysis in patients with chemotherapy-induced thrombocytopenia and the effect of platelet transfusion. Journal of Thrombosis and Haemostasis, 17(7), 1073-1084. https://doi.org/10.1111/jth.14465
    • Govers-Riemslag, J. W. P., Konings, J., Cosemans, J. M. E. M., van Geffen, J. P., de Laat, B., Heemskerk, J. W. M., Dargaud, Y., & Ten Cate, H. (2019). Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis. TH open : companion journal to thrombosis and haemostasis, 3(3), e273-e285. https://doi.org/10.1055/s-0039-1693485
    • Mezger, S. T. P., Mingels, A. M. A., Bekers, O., Cillero-Pastor, B., & Heeren, R. M. A. (2019). Trends in mass spectrometry imaging for cardiovascular diseases. Analytical and Bioanalytical Chemistry, 411(17), 3709-3720. https://doi.org/10.1007/s00216-019-01780-8
    • Boswijk, E., Sanders, K. J. C., Broeders, E. P. M., de Ligt, M., Vijgen, G. H. E. J., Havekes, B., Mingels, A. M. A., Wierts, R., van Marken Lichtenbelt, W. D., Schrauwen, P., Mottaghy, F. M., Wildberger, J. E., & Bucerius, J. (2019). TSH suppression aggravates arterial inflammation — an 18F-FDG PET study in thyroid carcinoma patients. European Journal of Nuclear Medicine and Molecular Imaging, 46(7), 1428-1438. https://doi.org/10.1007/s00259-019-04292-w
    • Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P.-C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., ... van Duijn, C. M. (2019). An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis. Nature Communications, 10(1), Article 2581. https://doi.org/10.1038/s41467-019-10487-4
    • Gulpen, A. J. W., ten Cate, H., Henskens, Y. M. C., van Oerle, R., Wetzels, R., Schalla, S., Crijns, H. J., & ten Cate-Hoek, A. J. (2019). The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study. PLOS ONE, 14(6), Article 0217302. https://doi.org/10.1371/journal.pone.0217302
    • Corbalan, R., Bassand, J. P., Illingworth, L., Ambrosio, G., Camm, A. J., Fitzmaurice, D. A., Fox, K. A. A., Goldhaber, S. Z., Goto, S., Haas, S., Kayani, G., Mantovani, L. G., Misselwitz, F., Pieper, K. S., Turpie, A. G. G., Verheugt, F. W. A., Kakkar, A. K., GARFIELD-AF Investigators, & Cate, H. T. (2019). Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients with Atrial Fibrillation: A Report from the GARFIELD-AF Registry. JAMA Cardiology, 4(6), 526-548. https://doi.org/10.1001/jamacardio.2018.4729
    • Fabris, E., van't Hof, A., Hamm, C. W., Lapostolle, F., Lassen, J. F., Goodman, S. G., ten Berg, J. M., Bolognese, L., Cequier, A., Chettibi, M., Hammett, C. J., Huber, K., Janzon, M., Merkely, B., Storey, R. F., Zeymer, U., Cantor, W. J., Kerneis, M., Diallo, A., ... ATLANTIC Investigators (2019). Pre-hospital administration of ticagrelor in diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A sub-analysis of the ATLANTIC trial. Catheterization and Cardiovascular interventions, 93(7), E369-E377. https://doi.org/10.1002/ccd.27921
    • Jooss, N. J., De Simone, I., Provenzale, I., Fernández, D. I., Brouns, S. L. N., Farndale, R. W., Henskens, Y. M. C., Kuijpers, M. J. E., Ten Cate, H., van der Meijden, P. E. J., Cavill, R., & Heemskerk, J. W. M. (2019). Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces. International journal of molecular sciences, 20(11), Article 2788. https://doi.org/10.3390/ijms20112788
    • Gomes, C. P. D. C., Agg, B., Andova, A., Arslan, S., Baker, A., Bartekova, M., Beis, D., Betsou, F., Wettinger, S. B., Bugarski, B., Condorelli, G., da Silva, G. J. J., Danilin, S., de Gonzalo-Calvo, D., Buil, A., Carmo-Fonseca, M., Enguita, F. J., Felekkis, K., Ferdinandy, P., ... Devaux, Y. (2019). Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129. Non-coding RNA research, 5(2), Article 31. https://doi.org/10.3390/ncrna5020031
    • Schutte, L. M., Cnossen, M. H., van Hest, R. M., Driessens, M. H. E., Fijnvandraat, K., Polinder, S., Beckers, E. A. M., Coppens, M., Eikenboom, J., Gorkom, B. A. P. L., Meijer, K., Nieuwenhuizen, L., Mauser-Bunschoten, E. P., Leebeek, F. W. G., Mathot, R. A. A., & Kruip, M. J. H. A. (2019). Desmopressin treatment combined with clotting factor VIII concentrates in patients with non-severe haemophilia A: protocol for a multicentre single-armed trial, the DAVID study. BMJ Open, 9(4), Article 022719. https://doi.org/10.1136/bmjopen-2018-022719