• 2019
    • Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H., & Pieters, R. J. (2019). Hybrid ligands with calixarene and thiodigalactoside groups: galectin binding and cytotoxicity. Organic Chemistry Frontiers, 6(16), 2981-2990. https://doi.org/10.1039/c9qo00810a
    • Denisov, S. S., Ippel, J. H., Heinzmann, A. C. A., Koenen, R. R., Ortega-Gomez, M., Soehnlein, O., Hackeng, T. M., & Dijkgraaf, I. (2019). Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. Journal of Biological Chemistry, 294(33), 12370-12379. https://doi.org/10.1074/jbc.RA119.008902
    • van der Spek, A., Broer, L., Draisma, H. H. M., Pool, R., Albrecht, E., Beekman, M., Mangino, M., Raag, M., Nyholt, D. R., Dharuri, H. K., Codd, V., Amin, N., de Geus, E. J. C., Deelen, J., Demirkan, A., Yet, I., Fischer, K., Haller, T., Henders, A. K., ... Gieger, C. (2019). Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium. Scientific Reports, 9, Article 11623. https://doi.org/10.1038/s41598-019-47282-6
    • van Der Plaat, D., Vonk, J. M., Terzikhan, N., de Jong, K., de Vries, M., La Bastide-van Gemert, S., van Diemen, C. C., Lahousse, L., Brusselle, G., Nedeljkovic, I., Amin, N., Kromhout, H., Vermeulen, R. C. H., Postma, D. S., van Duijn, C. M., Boezen, H. M., Heijmans, B. T., Hoen, P. A. C. T., van Meurs, J., ... BIOS Consortium (2019). Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression. Human Molecular Genetics, 28(15), 2477-2485. https://doi.org/10.1093/hmg/ddz067
    • Petersohn, S., Ramaekers, B. L. T., Olie, R. H., ten Cate-Hoek, A. J., Daemen, J.-W. H. C., ten Cate, H., & Joore, M. A. (2019). Comparison of three generic quality-of-life metrics in peripheral arterial disease patients undergoing conservative and invasive treatments. Quality of Life Research, 28(8), 2257-2279. https://doi.org/10.1007/s11136-019-02166-0
    • Koenen, R. R. (2019). Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease. Thrombosis and Haemostasis, 119(8), 1202-1204. https://doi.org/10.1055/s-0039-1693024
    • Van Kuijk, K., Theelen, T., Demandt, J., Marsch, E., Gijbels, M., Jin, H., Reutelingsperger, C., Cosemans, J., Schurgers, L., Carmeliet, P., Biessen, E., Daemen, M., & Sluimer, J. (2019). MYELOID PHD2 KNOCKDOWN DRIVES MACROPHAGE APOPTOSIS AND PARACRINE FIBROBLAST/SMOOTH MUSCLE CELL COLLAGEN SECRETION LEADING TO ATHEROSCLEROTIC PLAQUE FIBROSIS. Atherosclerosis, 287, E10-E10. https://doi.org/10.1016/j.atherosclerosis.2019.06.027
    • Astuti, P., Beurskens, D., Vajen, T., Nicolaes, G., Zhang, M., & Guido, H. (2019). Protection against neutrophil extracellular trap (NET) toxicity by antioxidant monoHER. Makara Journal of Health Research, 23(2), 108-115. https://doi.org/10.7454/msk.v23i2.10453
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., Hoek - ten Cate, A., & Burden, A. (2019). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants (vol 83, pg 1835, 2017). British Journal of Clinical Pharmacology, 85(8), 1864-1864. https://doi.org/10.1111/bcp.14001
    • Heestermans, M., de Jong, A., van Tilburg, S., Reitsma, P. H., Versteeg, H. H., Spronk, H. M., & van Vlijmen, B. J. M. (2019). Use of “C9/11 Mismatch” Control siRNA Reveals Sequence-Related Off-Target Effect on Coagulation of an siRNA Targeting Mouse Coagulation Factor XII. Nucleic Acid Therapeutics, 29(4), 218-223. https://doi.org/10.1089/nat.2018.0767
    • Nagy, M., van Geffen, J. P., Stegner, D., Adams, D. J., Braun, A., de Witt, S. M., Elvers, M., Geer, M. J., Kuijpers, M. J. E., Kunzelmann, K., Mori, J., Oury, C., Pircher, J., Pleines, I., Poole, A. W., Senis, Y. A., Verdoold, R., Weber, C., Nieswandt, B., ... Baaten, C. C. F. M. J. (2019). Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Frontiers in Cardiovascular Medicine, 6, Article 99. https://doi.org/10.3389/fcvm.2019.00099
    • Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M. J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M.-J., Franke, L., ... Kutalik, Z. (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10, Article 3300. https://doi.org/10.1038/s41467-019-10936-0
    • Damen, S. A. J., Vroemen, W. H. M., Brouwer, M. A., Mezger, S. T. P., Suryapranata, H., van Royen, N., Bekers, O., Meex, S. J. R., Wodzig, W. K. W. H., Verheugt, F. W. A., de Boer, D., Cramer, G. E., & Mingels, A. M. A. (2019). Multi-Site Coronary Vein Sampling Study on Cardiac Troponin T Degradation in Non-ST-Segment-Elevation Myocardial Infarction: Toward a More Specific Cardiac Troponin T Assay. Journal of the American Heart Association, 8(14), Article 012602. https://doi.org/10.1161/JAHA.119.012602
    • Liu, C.-T., Merino, J., Rybin, D., DiCorpo, D., Benke, K. S., Bragg-Gresham, J. L., Canouil, M., Corre, T., Grallert, H., Isaacs, A., Kutalik, Z., Lahti, J., Marullo, L., Marzi, C., Rasmussen-Torvik, L. J., Rocheleau, G., Rueedi, R., Scapoli, C., Verweij, N., ... Bouatia-Naji, N. (2019). Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals. Scientific Reports, 9(1), Article 9439. https://doi.org/10.1038/s41598-019-45823-7
    • Eggebrecht, L., Prochaska, J. H., Troebs, S.-O., Schwuchow-Thonke, S., Goebel, S., Diestelmeier, S., Schulz, A., Arnold, N., Panova-Noeva, M., Koeck, T., Rapp, S., Gori, T., Lackner, K. J., ten Cate, H., Muenzel, T., & Wild, P. S. (2019). Direct oral anticoagulants and vitamin K antagonists are linked to differential profiles of cardiac function and lipid metabolism. Clinical research in cardiology, 108(7), 787-796. https://doi.org/10.1007/s00392-018-1408-y
    • Olie, R. H., van der Meijden, P. E. J., Spronk, H. M. H., van Oerle, R., Barvik, S., Bonarjee, V. V. S., Ten Cate, H., & Nilsen, D. W. T. (2019). Effects of the PAR-1 Antagonist Vorapaxar on Platelet Activation and Coagulation Biomarkers in Patients with Stable Coronary Artery Disease. TH open : companion journal to thrombosis and haemostasis, 3(3), e259-e262. https://doi.org/10.1055/s-0039-1695710
    • Heubel-Moenen, F. C. J. I., Henskens, Y. M. C., Verhezen, P. W. M., Wetzels, R. J. H., Schouten, H. C., & Beckers, E. A. M. (2019). Fibrinolysis in patients with chemotherapy-induced thrombocytopenia and the effect of platelet transfusion. Journal of Thrombosis and Haemostasis, 17(7), 1073-1084. https://doi.org/10.1111/jth.14465
    • Govers-Riemslag, J. W. P., Konings, J., Cosemans, J. M. E. M., van Geffen, J. P., de Laat, B., Heemskerk, J. W. M., Dargaud, Y., & Ten Cate, H. (2019). Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis. TH open : companion journal to thrombosis and haemostasis, 3(3), e273-e285. https://doi.org/10.1055/s-0039-1693485
    • Mezger, S. T. P., Mingels, A. M. A., Bekers, O., Cillero-Pastor, B., & Heeren, R. M. A. (2019). Trends in mass spectrometry imaging for cardiovascular diseases. Analytical and Bioanalytical Chemistry, 411(17), 3709-3720. https://doi.org/10.1007/s00216-019-01780-8
    • Boswijk, E., Sanders, K. J. C., Broeders, E. P. M., de Ligt, M., Vijgen, G. H. E. J., Havekes, B., Mingels, A. M. A., Wierts, R., van Marken Lichtenbelt, W. D., Schrauwen, P., Mottaghy, F. M., Wildberger, J. E., & Bucerius, J. (2019). TSH suppression aggravates arterial inflammation — an 18F-FDG PET study in thyroid carcinoma patients. European Journal of Nuclear Medicine and Molecular Imaging, 46(7), 1428-1438. https://doi.org/10.1007/s00259-019-04292-w
    • Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P.-C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., ... van Duijn, C. M. (2019). An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis. Nature Communications, 10, Article 2581. https://doi.org/10.1038/s41467-019-10487-4
    • Gulpen, A. J. W., ten Cate, H., Henskens, Y. M. C., van Oerle, R., Wetzels, R., Schalla, S., Crijns, H. J., & ten Cate-Hoek, A. J. (2019). The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study. PLOS ONE, 14(6), Article 0217302. https://doi.org/10.1371/journal.pone.0217302
    • Jooss, N. J., De Simone, I., Provenzale, I., Fernández, D. I., Brouns, S. L. N., Farndale, R. W., Henskens, Y. M. C., Kuijpers, M. J. E., Ten Cate, H., van der Meijden, P. E. J., Cavill, R., & Heemskerk, J. W. M. (2019). Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces. International journal of molecular sciences, 20(11), Article 2788. https://doi.org/10.3390/ijms20112788
    • Gomes, C. P. D. C., Agg, B., Andova, A., Arslan, S., Baker, A., Bartekova, M., Beis, D., Betsou, F., Wettinger, S. B., Bugarski, B., Condorelli, G., da Silva, G. J. J., Danilin, S., de Gonzalo-Calvo, D., Buil, A., Carmo-Fonseca, M., Enguita, F. J., Felekkis, K., Ferdinandy, P., ... Devaux, Y. (2019). Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129. Non-coding RNA research, 5(2), Article 31. https://doi.org/10.3390/ncrna5020031
    • van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikainen, L.-P., Mei, H., Mueller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., ... Isaacs, A. (2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. European Journal of Human Genetics, 27(6), 952-962. https://doi.org/10.1038/s41431-018-0295-z
    • van Geffen, A., Brouns, S., Batista, J., McKinney, H., Kempster, C., Nagy, M., Sivapalaratnam, S., Baaten, C., Bourry, N., Frontini, M., Jurk, K., Krause, M., Pilliteri, D., Swieringa, F., Verdoold, R., Cavill, R., Kuijpers, M., Ouwehand, W. H., Downes, K., & Heemskerk, J. (2019). High-throughput elucidation of thrombus formation reveals sources of platelet function variability. Haematologica-the Hematology Journal, 104(6), 1256-1267. https://doi.org/10.3324/haematol.2018.198853
    • ten Cate, H., Kontny, F., & Nilsen, D. W. (2019). Editorial: Novel and potential markers for prediction of outcome in patients with acute and chronic coronary heart disease. Frontiers in Cardiovascular Medicine, 6, 1-3. Article 66. https://doi.org/10.3389/fcvm.2019.00066
    • Silvestre-Roig, C., Braster, Q., Wichapong, K., Lee, E. Y., Marie Teulon, J., Berrebeh, N., Winter, J., Adrover, J. M., Santos, G. S., Froese, A., Lemnitzer, P., Ortega-Gomez, A., Chevre, R., Marschner, J., Schumski, A., Winter, C., Perez-Olivares, L., Pan, C., Paulin, N., ... Soehnlein, O. (2019). Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature, 569(7755), 236-240. https://doi.org/10.1038/s41586-019-1167-6
    • Heestermans, M., Salloum-Asfar, S., Streef, T., Laghmani, E. H., Salvatori, D., Luken, B. M., Zeerleder, S. S., Spronk, H. M. H., Korporaal, S. J., Kirchhofer, D., Wagenaar, G. T. M., Versteeg, H. H., Reitsma, P. H., Renne, T., & van Vlijmen, B. J. M. (2019). Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils. Blood, 133(19), 2090-2099. https://doi.org/10.1182/blood-2018-06-853762
    • Klotz, L., Eschborn, M., Lindner, M., Liebmann, M., Herold, M., Janoschka, C., Garrido, B. T., Schulte-Mecklenbeck, A., Gross, C. C., Breuer, J., Hundehege, P., Posevitz, V., Pignolet, B., Nebel, G., Glander, S., Freise, N., Austermann, J., Wirth, T., Campbell, G. R., ... Wiendl, H. (2019). Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Science Translational Medicine, 11(490), Article 5563. https://doi.org/10.1126/scitranslmed.aao5563
    • Wichapong, K., Poelman, H., Ercig, B., Hrdinova, J., Liu, X., Lutgens, E., & Nicolaes, G. A. F. (2019). Rational modulator design by exploitation of protein-protein complex structures. Future Medicinal Chemistry, 11(9), 1015-1033. https://doi.org/10.4155/fmc-2018-0433
    • Gurbel, P. A., Fox, K. A. A., Tantry, U. S., ten Cate, H., & Weitz, J. (2019). Combination Antiplatelet and Oral Anticoagulant Therapy in Patients With Coronary and Peripheral Artery Disease Focus on the COMPASS Trial. Circulation, 139(18), 2170-2185. https://doi.org/10.1161/CIRCULATIONAHA.118.033580
    • Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., Stoel, M., ... van Royen, N. (2019). Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. New England Journal of Medicine, 380(15), 1397-1407. https://doi.org/10.1056/NEJMoa1816897
    • Streefkerk, D. E., Schmidt, M., Ippel, J. H., Hackeng, T. M., Nuijens, T., Timmerman, P., & van Maarseveen, J. H. (2019). Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation. Organic Letters, 21(7), 2095-2100. https://doi.org/10.1021/acs.orglett.9b00378
    • Slater, A., Perrella, G., Onselaer, M.-B., Martin, E. M., Gauer, J. S., Xu, R.-G., Heemskerk, J. W. M., Ariens, R. A. S., & Watson, S. P. (2019). Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?Platelets, 30(3), 281-289. https://doi.org/10.1080/09537104.2018.1508649
    • Kremers, B. M. M., Birocchi, S., van Oerle, R., Zeerleder, S., Spronk, H. M. H., Mees, B. M. E., Luken, B. M., ten Cate, H., & ten Cate-Hoek, A. J. (2019). Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease. Frontiers in Cardiovascular Medicine, 6, 1-11. Article 33. https://doi.org/10.3389/fcvm.2019.00033
    • Panova-Noeva, M., Neu, M. A., Eckerle, S., Spix, C., Schneider, A., Schmidtmann, I., Spronk, H. M., Pfeiffer, N., Beutel, M., Lackner, K. J., Muenzel, T., ten Cate, H., Merzenich, H., Faber, J., & Wild, P. S. (2019). Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer. Clinical research in cardiology, 108(4), 438-447. https://doi.org/10.1007/s00392-018-1374-4
    • Noels, H., Weber, C., & Koenen, R. R. (2019). Chemokines as Therapeutic Targets in Cardiovascular Disease The Road Behind, The Road Ahead. Arteriosclerosis Thrombosis and Vascular Biology, 39(4), 583-592. https://doi.org/10.1161/ATVBAHA.118.312037
    • Henriquez, D. D. C. A., Bloemenkamp, K. W. M., Loeff, R. M., Zwart, J. J., van Roosmalen, J. J. M., Zwaginga, J. J., van der Bom, J. G., Adriaanse, H. J., van den Akker, E. S. A., Baas, M. I., Bank, C. M. C., van Beek, E., de Boer, B. A., de Boer, K., van der Borden, D. M. R., Bremer, H. A., Brons, J. T. J., Burggraaff, J. M., Ceelie, H., ... TeMpOH-1 study group (2019). Fluid resuscitation during persistent postpartum haemorrhage and maternal outcome: A nationwide cohort study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 235, 49-56. https://doi.org/10.1016/j.ejogrb.2019.01.027
    • Posthuma, J. J., Posma, J. J. N., Schep, G., Bender, M. M. H., van Oerle, R., van der Wal, A. C., Ten Cate, H., & Spronk, H. M. H. (2019). Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes. Journal of Vascular Surgery, 69(4), 1243-1250. https://doi.org/10.1016/j.jvs.2018.05.220
    • Brouwers, M. C. G. J., Simons, N., Stehouwer, C. D. A., Koek, G. H., Schaper, N. C., & Isaacs, A. (2019). Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease. Hepatology communications, 3(4), 587-596. https://doi.org/10.1002/hep4.1319
    • Schulz, A., Mueller, N. V., van de Lest, N. A., Eisenreich, A., Schmidbauer, M., Barysenka, A., Purfuerst, B., Sporbert, A., Lorenzen, T., Meyer, A. M., Herlan, L., Witten, A., Ruehle, F., Zhou, W., de Heer, E., Scharpfenecker, M., Panakova, D., Stoll, M., & Kreutz, R. (2019). Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. Elife, 8, Article 42068. https://doi.org/10.7554/eLife.42068
    • Krekels, J. P. M., Verhezen, P. W. M., & Henskens, Y. M. C. (2019). Platelet Aggregation in Healthy Participants is Not Affected by Smoking, Drinking Coffee, Consuming a High-Fat Meal, or Performing Physical Exercise. Clinical and Applied Thrombosis-Hemostasis, 25, 1-9. Article 1076029618782445. https://doi.org/10.1177/1076029618782445
    • Posthuma, J. J., Posma, J. J. N., van Oerle, R., Leenders, P., van Gorp, R. H., Jaminon, A. M. G., Mackman, N., Heitmeier, S., Schurgers, L. J., ten Cate, H., & Spronk, H. M. H. (2019). Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice. Scientific Reports, 9, Article 3909. https://doi.org/10.1038/s41598-019-40602-w
    • Ibrahim-Kosta, M., Suchon, P., Couturaud, F., Smadja, D., Olaso, R., Germain, M., Saut, N., Goumidi, L., Derbois, C., Thibord, F., Debette, S., Amouyel, P., Deleuze, J. F., van Doorn, P., Castoldi, E., Patin, E., Alessi, M. C., Tregouet, D. A., & Morange, P. E. (2019). Minor allele of the factor V K858R variant protects from venous thrombosis only in non-carriers of factor V Leiden mutation. Scientific Reports, 9, Article 3750. https://doi.org/10.1038/s41598-019-40172-x
    • Wijnen, P., Drent, M., Bekers, O., Verschakelen, J., & Bast, A. (2019). VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis. International journal of molecular sciences, 20(5), Article 1160. https://doi.org/10.3390/ijms20051160
    • Vroemen, W. H. M., Mezger, S. T. P., Masotti, S., Clerico, A., Bekers, O., de Boer, D., & Mingels, A. (2019). Cardiac Troponin T: Only Small Molecules in Recreational Runners After Marathon Completion. Journal of Applied Laboratory Medicine, 3(5), 909-911. https://doi.org/10.1373/jalm.2018.027144
    • Gandhi, S., Ruehle, F., & Stoll, M. (2019). Evolutionary Patterns of Non-Coding RNA in Cardiovascular Biology. Non-coding RNA, 5(1), Article 15. https://doi.org/10.3390/ncrna5010015
    • van der Meijden, P. E. J., & Heemskerk, J. W. M. (2019). Platelet biology and functions: new concepts and clinical perspectives. Nature Reviews Cardiology, 16(3), 166-179. https://doi.org/10.1038/s41569-018-0110-0
    • Donkel, S. J., Benaddi, B., Dippel, D. W. J., ten Cate, H., & de Maat, M. P. M. (2019). Prognostic Hemostasis Biomarkers in Acute Ischemic Stroke: A Systematic Review. Arteriosclerosis Thrombosis and Vascular Biology, 39(3), 360-372. https://doi.org/10.1161/ATVBAHA.118.312102