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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Tilman Hackeng

Professor

Prof. Tilman Hackeng studied biochemistry at the University of Utrecht and obtained his PhD at the same University in 1993 on protein C/protein S anticoagulant mechanisms. Shortly after, he left for The Scripps Research Institute, La Jolla, CA, USA, were he worked on translational chemistry in the laboratories of Molecular and Experimental Medicine and Cell Biology.

In 1998, he returned to the Netherlands as a Research Fellow of the Royal Netherlands Academy of Arts and Sciences (KNAW) at the Department of Biochemistry of the University Maastricht. He is past president of the Netherlands Society on Thrombosis and Hemostasis (NVTH), and elected member of the Royal Holland Society of Sciences and Humanities (KHMW). In addition, he is chair of the Scientific Advisory Board of the Netherlands Thrombosis Foundation, acts as reviewer for major journals in the Thrombosis & Haemostasis and Chemistry fields and serves on grant reviewing boards of national and international granting agencies. Currently he is chairman of the Department of Biochemistry of the University Maastricht and Scientific Director of CARIM. He is co-founder of ACS Biomarker BV and Coagulation Profile BV.

His research on chemistry and structure function relationships of blood coagulation proteins explores the involvement of blood coagulation proteins in developing cardiovascular disease. With an emphasis on anticoagulant regulatory pathways, a multidisciplinary approach is used in unraveling functional properties of proteins involved in the regulation of thrombin formation. Functional impairments of coagulation proteins can lead to development of venous and arterial thrombosis, and a fundamental understanding of inter-protein and protein-vessel wall interactions is a prerequisite for understanding how anticoagulant proteins work in preventing thrombosis. A broad technology platform is applied to this programme, from automated thrombin generation, total chemical synthesis of proteins, to NMR protein structural analysis and development of clinical assays. Additional research programmes performed in his laboratory for total chemical protein synthesis comprise several research lines and collaborations in the field of haemostasis and thrombosis, cancer, targeted molecular imaging and synthetic vaccines. Multimodal and multivalent constructs are applied as molecular imaging agents in vitro and in vivo for the targeting and MRI, SPECT, and PET imaging of thrombosis, atherosclerosis and angiogenesis and further developed within Maastricht Imaging Valley under the evolving discipline of translational cardiovascular chemistry.

Tilman-hackeng

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.366
T: +31 (0)43 388 1674/1766

  • 2007
    • Prinzen, L., Miserus, R.-J. J. H. M., Dirksen, A., Hackeng, T. M., Deckers, N., Bitsch, N. J., Megens, R. T. A., Douma, K., Heemskerk, J. W., Kooi, M. E., Frederik, P. M., Slaaf, D. W., van Zandvoort, M. A. M. J., & Reutelingsperger, C. P. M. (2007). Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano Letters, 7(1), 93-100. https://doi.org/10.1021/nl062226r
    • Langereis, S., Dirksen, A., Hackeng, T. M., van Genderen, M. H. P., & Meijer, E. W. (2007). Dendrimers and magnetic resonance imaging. New Journal of Chemistry, 31(7), 1152-1160. https://doi.org/10.1039/b616960k
  • 2006
    • Dirksen, A., Dirksen, S., Hackeng, T. M., & Dawson, P. E. (2006). Nucleophilic catalysis of hydrazone formation and transimination: Implications for dynamic covalent chemistry. Journal of the American Chemical Society, 128(49), 15602-15603. https://doi.org/10.1021/ja067189k
    • Buehler, A., van Zandvoort, M. A. M. J., Stelt, B. J., Hackeng, T. M., Schrans-Stassen, B. H. G. J., Bennaghmouch, A., Hofstra, L., Cleutjens, J. P. M., Duijvestijn, A., Smeets, M. B., de Kleijn, D. P. V., Post, M. J., & de Muinck, E. D. (2006). cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo. Arteriosclerosis Thrombosis and Vascular Biology, 26(12), 2681-7. https://doi.org/10.1161/01.ATV.0000245807.65714.0b
    • Nicolaes, G. A. F., Hackeng, T. M., Segers, K., & Rosing, J. (2006). A structural model of the SHBG domain of human variant protein S Heerlen. Thrombosis and Haemostasis, 96(4), 538-540. https://doi.org/10.1160/TH06-07-0361
    • Hackeng, TM., Sere, KM., Tans, G., & Rosing, J. (2006). Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 103(9), 3106-3111. https://doi.org/10.1073/pnas.0504240103
    • Dirksen, A., Hackeng, T. M., & Dawson, P. E. (2006). Nucleophilic catalysis of oxime ligation. Angewandte Chemie-International Edition, 45(45), 7581-7584. https://doi.org/10.1002/anie.200602877
    • Dirksen, A., Meijer, EW., Adriaens, W., & Hackeng, TM. (2006). Strategy for the synthesis of multivalent peptide-based nonsymmetric dendrimers by native chemical ligation. Chemical Communications, (15), 1667-1669. https://doi.org/10.1039/b600286b
  • 2005
    • Denis, CV., Roberts, SJ., Hackeng, TM., & Lenting, PJ. (2005). In vivo clearance of human protein S in a mouse model - Influence of c4b-binding protein and the Heerlen polymorphism. Arteriosclerosis Thrombosis and Vascular Biology, 25(10), 2209-2215. https://doi.org/10.1161/01.ATV.0000181760.55269.6b
    • Hackeng, TM., Sere, KM., & Rosing, J. (2005). Misconceptions about protein-S multimers - Response. Blood, 106(5), 1884-1885. https://doi.org/10.1182/blood-2004-12-4706
    • Keuren, JFW., Wielders, SJH., Ulrichts, H., Hackeng, T., Heemskerk, JWM., Deckmyn, H., Bevers, EM., & Lindhout, T. (2005). Synergistic effect of thrombin on collagen-induced platelet procoagulant activity is mediated through protease-activated receptor-1. Arteriosclerosis Thrombosis and Vascular Biology, 25(7), 1499-1505. https://doi.org/10.1161/01.ATV.0000167526.31611.f6
    • Langereis, S., Dirksen, A., De Waal, BFM., Van Genderen, MHP., De Lussanet, QG., Hackeng, TM., & Meijer, EW. (2005). Solid-phase synthesis of a cyclic NGR-functionalized Gd(III)DTPA complex. European Journal of Organic Chemistry, 2005(12), 2534-2538. https://doi.org/10.1002/ejoc.200500045
    • Koenen, RR., Thomassen, MCLGD., Tans, G., Rosing, J., & Hackeng, TM. (2005). Effect of oral contraceptives on the anticoagulant activity of protein S in plasma. Thrombosis and Haemostasis, 93(5), 853-859. https://doi.org/10.1160/TH04-11-0762
    • Ravassa, S., Bennaghmouch, A., Kenis, H., Lindhout, T., Hackeng, T., Narula, J., Hofstra, L., & Reutelingsperger, C. (2005). Annexin A5 down-regulates surface expression of tissue factor. Journal of Biological Chemistry, 280(7), 6028-6035. https://doi.org/10.1074/jbc.M411710200
    • von Hundelshausen, P., Koenen, RR., Sack, M., Mause, SF., Adriaens, W., Proudfoot, AEI., Hackeng, TM., & Weber, C. (2005). Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood, 105(3), 924-930. https://doi.org/10.1182/blood-2004-06-2475
    • Hackeng, TM. (2005). Gla glances at proteins. Blood, 105(1), 1-2. https://doi.org/10.1182/blood-2004-10-3874
    • Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Hackeng, TM., & Meijer, EW. (2005). A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis. Chemical Communications, (22), 2811-2813. https://doi.org/10.1039/b502347e
    • van Baal, W. M., Malda, H., Synowsky, SA., van Dongen, JLJ., Hackeng, TM., Merkx, M., & Meijer, EW. (2005). Multivalent peptide and protein dendrimers using native chemical ligation. Angewandte Chemie-International Edition, 44(32), 5052-5057. https://doi.org/10.1002/anie.200500635
  • 2004
    • Dirksen, A., Langereis, S., de Waal, BFM., van Genderen, MHP., Meijer, EW., de Lussanet, QG., & Hackeng, TM. (2004). Design and synthesis of a bimodal target-specific contrast agent for angiogenesis. Organic Letters, 6(26), 4857-4860. https://doi.org/10.1021/ol048084u
    • Sere, KM., Rosing, J., & Hackeng, TM. (2004). Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance. Blood, 104(12), 3624-3630. https://doi.org/10.1182/blood-2004-03-1146
    • Heeb, MJ., Koenen, RR., Fernandez, JA., & Hackeng, TM. (2004). Direct anticoagulant activity of protein S-C4b binding protein complex in Heerlen heterozygotes and normals. Journal of Thrombosis and Haemostasis, 2(10), 1766-1773. https://doi.org/10.1111/j.1538-7836.2004.00901.x
    • Koenen, RR., Gomes, L., Tans, G., Rosing, J., & Hackeng, TM. (2004). The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities. Thrombosis and Haemostasis, 91(6), 1105-1114. https://doi.org/10.1160/TH04-02-0082
    • Soute, B. A. M., Jin, D.-Y., Spronk, H. M. H., Mutucumarana, V. P., Lin, P.-J., Hackeng, T. M., Stafford, D. W., & Vermeer, C. (2004). Characteristics of recombinant W501S mutated human gamma-glutamyl carboxylase. Journal of Thrombosis and Haemostasis, 2(4), 597-604. https://doi.org/10.1111/j.1538-7836.2004.00686.x
  • 2003
    • Koenen, RR., Tans, G., van Oerle, R., Hamulyak, K., Rosing, J., & Hackeng, TM. (2003). The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation. Blood, 102(5), 1686-1692. https://doi.org/10.1182/blood-2003-02-0620
  • 2001
    • Sere, KM., Janssen, MP., Willems, GM., Tans, G., Rosing, J., & Hackeng, TM. (2001). Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity. Biochemistry, 40(30), 8852-8860. https://doi.org/10.1021/bi002500a
    • Hackeng, T. M., Rosing, J., Spronk, H. M., & Vermeer, C. (2001). Total chemical synthesis of human matrix Gla protein. Protein Science, 10(4), 864-70. https://doi.org/10.1110/ps.44701
  • 2000
    • Hackeng, TM., Fernandez, JA., Dawson, PE., Kent, SBH., & Griffin, JH. (2000). Chemical synthesis and spontaneous folding of a multidomain protein: Anticoagulant microprotein S. Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14074-14078. https://doi.org/10.1073/pnas.260239797
    • Hackeng, TM., Yegneswaran, S., Johnson, AE., & Griffin, JH. (2000). Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S. Biochemical Journal, 349, 757-764. https://doi.org/10.1042/bj3490757
    • Marx, PF., Hackeng, TM., Dawson, PE., Griffin, JH., Meijers, JCM., & Bouma, BN. (2000). Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage. Journal of Biological Chemistry, 275(17), 12410-12415. https://doi.org/10.1074/jbc.275.17.12410
    • Fernandez, JA., Kojima, K., Petaja, J., Hackeng, TM., & Griffin, JH. (2000). Cardiolipin enhances protein C pathway anticoagulant activity. Blood Cells Molecules and Diseases, 26(2), 115-123. https://doi.org/10.1006/bcmd.2000.0285
    • Deguchi, H., Fernandez, JA., Hackeng, TM., Banka, CL., & Griffin, JH. (2000). Cardiolipin is a normal component of human plasma lipoproteins. Proceedings of the National Academy of Sciences of the United States of America, 97(4), 1743-1748. https://doi.org/10.1073/pnas.97.4.1743
  • 1999
    • Hackeng, TM., Griffin, JH., & Dawson, PE. (1999). Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology. Proceedings of the National Academy of Sciences of the United States of America, 96(18), 10068-10073. https://doi.org/10.1073/pnas.96.18.10068
  • 1997
    • Wang, LL., Zoppe, M., Hackeng, TM., Griffin, JH., Lee, K.-F., & Verma, IM. (1997). A factor IX-deficient mouse model for hemophilia B gene therapy. Proceedings of the National Academy of Sciences of the United States of America, 94(21), 11563-11566. https://doi.org/10.1073/pnas.94.21.11563
  • 1995
    • KOPPELMAN, SJ., HACKENG, TM., SIXMA, JJ., & BOUMA, BN. (1995). INHIBITION OF THE INTRINSIC-FACTOR-X ACTIVATING COMPLEX BY PROTEIN-S - EVIDENCE FOR A SPECIFIC BINDING OF PROTEIN-S TO FACTOR-VIII. Blood, 86(3), 1062-1071. https://doi.org/10.1182/blood.V86.3.1062.1062
    • VANTVEER, C., HACKENG, TM., BIESBROECK, D., SIXMA, JJ., & BOUMA, BN. (1995). INCREASED PROTHROMBIN ACTIVATION IN PROTEIN S-DEFICIENT PLASMA UNDER FLOW CONDITIONS ON ENDOTHELIAL-CELL MATRIX - AN INDEPENDENT ANTICOAGULANT FUNCTION OF PROTEIN-S IN PLASMA. Blood, 85(7), 1815-1821. https://doi.org/10.1182/blood.V85.7.1815.bloodjournal8571815
  • 1994
    • VANTVEER, C., HACKENG, TM., DELAHAYE, C., SIXMA, JJ., & BOUMA, BN. (1994). ACTIVATED FACTOR-X AND THROMBIN FORMATION TRIGGERED BY TISSUE FACTOR ON ENDOTHELIAL-CELL MATRIX IN A FLOW MODEL - EFFECT OF THE TISSUE FACTOR PATHWAY INHIBITOR. Blood, 84(4), 1132-1142. https://doi.org/10.1182/blood.V84.4.1132.1132
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