Paola van der Meijden

Assistant Professor

Dr. Paola van der Meijden is an Associate Professor at the department of Biochemistry of Maastricht University, affiliated with the Cardiovascular Research Institute Maastricht (CARIM). Her research focuses on the mechanisms underlying thrombosis and haemostasis, with particular emphasis on platelet biology and the interplay between platelets, coagulation and the vascular system. Alongside her research activities, she is involved in teaching and student advising, supporting the personal and professional development of students.

Since 2010, she has held a bridging position within the Maastricht Thrombosis Expertise Center, connecting fundamental research on thrombosis and hemostasis with clinical research and applications. With over 20 years of experience in platelet research, she has developed extensive expertise in platelet phenotyping in haemostatic and thrombotic disorders and in the context of antithrombotic treatment. Paola her research interests include platelet priming and the functional specialisation of platelet populations. She has established a strong national and international collaborative network in the field of thrombosis and haemostasis. A key aspect of her work is the development and application of advanced experimental models, including microfluidic systems, to study thrombus formation and platelet function in human blood. As a co-founder of the platform Hemosum, she is also committed to improve bleeding risk prediction and treatment of patients with hereditary or acquired hemostatic disorders by enabling rapid assessment of the haemostatic balance. 

Through her research, she aims to advance the understanding of haemostatic and thrombotic disorders and contribute to the development of biomarkers and innovative diagnostic tools that support improved risk assessment and more personalized treatment strategies.

Paola-van-der-meijden

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room: 4.322
T: +31(0)43 388 16 84

  • 2026
    • Urlings, E. H., Heubel-Moenen, F. C. J. I., van Oerle, R., Hellenbrand, D. L. S., van der Meijden, P. E. J., Hackeng, T. M., Cate, H. T., Nagy, M., Henskens, Y. M. C., & Spronk, H. M. H. (2026). Intrinsic activated thrombin generation for treatment efficacy and monitoring of octocog alfa and emicizumab in severe hemophilia A. Research and practice in thrombosis and haemostasis, 10(4), Article 106627. https://doi.org/10.1016/j.rpth.2026.106627
  • 2025
    • Baaten, C. C. F. M. J., Wollenhaupt, J., Henning, T. M., Vondenhoff, S., Schröer, J. R., Stamellou, E., Saritas, T., Kurt, B., Boger, L., Antwerpen, A., Hermann, J., Nagy, M., Sternkopf, M., Buhl, E. M., Raffetseder, U., van der Meijden, P. E. J., Kuijpers, M. J. E., Spronk, H. M. H., Schunk, S. J., ... Noels, H. (2025). Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation. JACC: Basic to Translational Science, 10(9), Article 101355. https://doi.org/10.1016/j.jacbts.2025.101355
  • 2024
    • Monard, A., Castoldi, E., De Simone, I., Wichapong, K., van Duijl, T., van den Biggelaar, M., Spada, S., van Doorn, W., Hellenbrand, D., van der Meijden, P., Swieringa, F., Stork, A., ten Cate, H., Beckers, E., Heubel-Moenen, F., & Henskens, Y. (2024). Case Report: Laboratory detection of a thrombotic tendency in a family with hypodysfibrinogenemia and a novel FGG mutation. Frontiers in Cardiovascular Medicine, 11, Article 1488602. https://doi.org/10.3389/fcvm.2024.1488602
    • Provenzale, I., Solari, F. A., Schoenichen, C., Brouns, S. L. N., Fernandez, D. I., Kuijpers, M. J. E., van Der Meijden, P. E. J., Gibbins, J. M., Sickmann, A., Jones, C., & Heemskerk, J. W. M. (2024). Endothelium-mediated regulation of platelet activation: Involvement of multiple protein kinases. Faseb Journal, 38(4), Article e23468. https://doi.org/10.1096/fj.202300360RR
    • Baaten, C. C. F. M. J., Nagy, M., Bergmeier, W., Spronk, H. M. H., & van der Meijden, P. E. J. (2024). Platelet biology and function: plaque erosion vs. rupture. European Heart Journal, 45(1), 18-31. https://doi.org/10.1093/eurheartj/ehad720
  • 2023
    • Provenzale, I., De Simone, I., Gibbins, J. M., Heemskerk, J. W. M., van der Meijden, P. E. J., & Jones, C. I. (2023). Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. International Journal of Molecular Sciences, 24(17), Article 13352. https://doi.org/10.3390/ijms241713352
    • Akbalut, C., Arisz, R., Baaten, C., Baildildinova, G., Barakzie, A., Bauersachs, R., Ten Berg, J. M., van den Broek, W., de Boer, H. C., Broker, V., Buka, R., Ten Cate, H., Cate, A. T., De Luca, C., De Simone, I., Dignat-George, F., Freson, K., Gazzaniga, G., van Gorp, E., ... van Zonneveld, A.-J. (2023). Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 123(8), 808-839. https://doi.org/10.1055/a-2052-9175
    • De Simone, I., Baaten, C. C. F. M. J., Gibbins, J. M., Ten Cate, H., Heemskerk, J. W. M., Jones, C. I., & van der Meijden, P. E. J. (2023). Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation. Journal of Thrombosis and Haemostasis, 21(5), 1289-1306. https://doi.org/10.1016/j.jtha.2023.01.006
  • 2022
    • Baidildinova, G., Ten Cate, V., Nagler, M., Panova-Noeva, M., Rapp, S., Köck, T., Prochaska, J. H., Heitmeier, S., Gerdes, C., Schwers, S., Konstantinides, S. V., Münzel, T., Espinola-Klein, C., Lackner, K. J., Spronk, H. M. N., Ten Cate, H., van der Meijden, P. E. J., Leineweber, K., Wild, P. S., & Jurk, K. (2022). Subtype-specific plasma signatures of platelet-related protein releasate in acute pulmonary embolism. Thrombosis Research, 220, 75-87. https://doi.org/10.1016/j.thromres.2022.10.005
    • Nagy, M., van der Meijden, P. E. J., Glunz, J., Schurgers, L., Lutgens, E., Ten Cate, H., Heitmeier, S., & Spronk, H. M. H. (2022). Integrating Mechanisms in Thrombotic Peripheral Arterial Disease. Pharmaceuticals, 15(11), Article 1428. https://doi.org/10.3390/ph15111428
    • De Simone, I., Baaten, C. C. F. M. J., Jandrot-Perrus, M., Gibbins, J. M., Ten Cate, H., Heemskerk, J. W. M., Jones, C. I., & van der Meijden, P. E. J. (2022). Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1. International journal of molecular sciences, 23(18), Article 10203. https://doi.org/10.3390/ijms231810203
    • Veninga, A., Handtke, S., Aurich, K., Tullemans, B., Brouns, S., Schwarz, S. L., Heubel-Moenen, F. C., Greinacher, A., Heemskerk, J. W. M., van der Meijden, P., & Thiele, T. (2022). GPVI expression is linked to platelet size, age, and reactivity. Blood advances, 6(14), 4162-4173. https://doi.org/10.1182/bloodadvances.2021006904
    • Lundstroem, A., Sanden, P., Mitroulis, I., & van der Meijden, P. E. J. (2022). Editorial: Platelet Function in COVID-19. Frontiers in Cardiovascular Medicine, 9, Article 912472. https://doi.org/10.3389/fcvm.2022.912472
    • Veninga, A., Baaten, C. C. F. M. J., De Simone, I., Tullemans, B. M. E., Kuijpers, M. J. E., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2022). Effects of Platelet Agonists and Priming on the Formation of Platelet Populations. Thrombosis and Haemostasis, 122(05), 726-738. https://doi.org/10.1055/s-0041-1735972
    • Brouns, S. L. N., Tullemans, B. M. E., Bulato, C., Perrella, G., Campello, E., Spiezia, L., van Geffen, J. P., Kuijpers, M. J. E., van Oerle, R., Spronk, H. M. H., van der Meijden, P. E. J., Simioni, P., & Heemskerk, J. W. M. (2022). Protein C or Protein S deficiency associates with paradoxically impaired platelet-dependent thrombus and fibrin formation under flow. Research and practice in thrombosis and haemostasis, 6(2), Article e12678. https://doi.org/10.1002/rth2.12678
    • Tullemans, B. M. E., Fernandez, D. I., Veninga, A., Baaten, C. C. F. M. J., Peters, L. J. F., Aarts, M. J. B., Eble, J. A., Campello, E., Spiezia, L., Simioni, P., van der Vorst, E. P. C., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2022). Tyrosine Kinase Inhibitor Sunitinib Delays Platelet-Induced Coagulation: Additive Effects of Aspirin. Thrombosis and Haemostasis, 122(01), 92-104. https://doi.org/10.1055/s-0041-1730312
    • Vignoli, A., Gamba, S., van der Meijden, P. E. J., Marchetti, M., Russo, L., Tessarolo, S., Giaccherini, C., Swieringa, F., Cate, H. T., Finazzi, G., Heemskerk, J. W. M., & Falanga, A. (2022). Increased platelet thrombus formation under flow conditions in whole blood from polycythaemia vera patients. Blood Transfusion, 20(2), 143-151. https://doi.org/10.2450/2021.0456-20
  • 2021
    • Hulshof, A.-M., Olie, R. H., Vries, M. J. A., Verhezen, P. W. M., van der Meijden, P. E. J., Ten Cate, H., & Henskens, Y. M. C. (2021). Rotational Thromboelastometry in High-Risk Patients on Dual Antithrombotic Therapy After Percutaneous Coronary Intervention. Frontiers in Cardiovascular Medicine, 8, Article 788137. https://doi.org/10.3389/fcvm.2021.788137
    • Tullemans, B. M. E., Veninga, A., Fernandez, D. I., Aarts, M. J. B., Eble, J. A., van der Meijden, P. E. J., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2021). Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment. International Journal of Molecular Sciences, 22(20), Article 11199. https://doi.org/10.3390/ijms222011199
    • Olie, R. H., van der Meijden, P. E. J., Vries, M. J. A., Veenstra, L., van't Hof, A. W. J., ten Berg, J. M., Henskens, Y. M. C., & ten Cate, H. (2021). Antithrombotic therapy in high-risk patients after percutaneous coronary intervention; study design, cohort profile and incidence of adverse events. Netherlands Heart Journal, 29(10), 525-535. https://doi.org/10.1007/s12471-021-01606-2
    • Olie, R. H., Hensgens, R. R. K., Wijnen, P. A. H. M., Veenstra, L. F., de Greef, B. T. A., Vries, M. J. A., van der Meijden, P. E. J., ten Berg, J. M., ten Cate, H., Bekers, O., & Henskens, Y. M. C. (2021). Differential Impact of Cytochrome 2C19 Allelic Variants on Three Different Platelet Function Tests in Clopidogrel-Treated Patients. Journal of Clinical Medicine, 10(17), Article 3992. https://doi.org/10.3390/jcm10173992
    • Baidildinova, G., Nagy, M., Jurk, K., Wild, P. S., ten Cate, H., & van der Meijden, P. E. J. (2021). Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease. Frontiers in Cardiovascular Medicine, 8, Article 684920. https://doi.org/10.3389/fcvm.2021.684920
    • de Breet, C. P. D. M., Zwaveling, S., Vries, M. J. A., van Oerle, R. G., Henskens, Y. M. C., Van't Hof, A. W. J., van der Meijden, P. E. J., Veenstra, L., ten Cate, H., & Olie, R. H. (2021). Thrombin Generation as a Method to Identify the Risk of Bleeding in High Clinical-Risk Patients Using Dual Antiplatelet Therapy. Frontiers in Cardiovascular Medicine, 8, Article 679934. https://doi.org/10.3389/fcvm.2021.679934
    • van den Kerkhof, D. L., van der Meijden, P. E. J., Hackeng, T. M., & Dijkgraaf, I. (2021). Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications. International journal of molecular sciences, 22(7), Article 3366. https://doi.org/10.3390/ijms22073366
    • Perrella, G., Huang, J., Provenzale, I., Swieringa, F., Heubel-Moenen, F. C. J., Farndale, R. W., Roest, M., van der Meijden, P. E. J., Thomas, M., Ariens, R. A. S., Jandrot-Perrus, M., Watson, S. P., & Heemskerk, J. W. M. (2021). Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation. Arteriosclerosis Thrombosis and Vascular Biology, 41(2), E97-E111. https://doi.org/10.1161/ATVBAHA.120.314641
  • 2020
    • Veninga, A., De Simone, I., Heemskerk, J. W. M., Ten Cate, H., & van der Meijden, P. E. J. (2020). Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding. Haematologica-the Hematology Journal, 105(8), 2020-2031. https://doi.org/10.3324/haematol.2019.235994
    • Brouns, S. L. N., van Geffen, J. P., Campello, E., Swieringa, F., Spiezia, L., van Oerle, R., Provenzale, I., Verdoold, R., Farndale, R. W., Clemetson, K. J., Spronk, H. M. H., van der Meijden, P. E. J., Cavill, R., Kuijpers, M. J. E., Castoldi, E., Simioni, P., & Heemskerk, J. W. M. (2020). Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation. Scientific Reports, 10(1), Article 11910. https://doi.org/10.1038/s41598-020-68438-9
    • Swieringa, F., Solari, F. A., Pagel, O., Beck, F., Huang, J., Feijge, M. A. H., Jurk, K., Koerver-Keularts, I. M. L. W., Mattheij, N. J. A., Faber, J., Pohlenz, J., Russo, A., Stumpel, C. T. R. M., Schrander, D. E., Zieger, B., van Der Meijden, P. E. J., Zahedi, R. P., Sickmann, A., & Heemskerk, J. W. M. (2020). Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS. Scientific Reports, 10(1), Article 11389. https://doi.org/10.1038/s41598-020-68379-3
    • d'Alessandro, E., Becker, C., Bergmeier, W., Bode, C., Bourne, J. H., Brown, H., Buller, H. R., ten Cate-Hoek, A. J., ten Cate, V., van Cauteren, Y. J. M., Cheung, Y. F. H., Cleuren, A., Coenen, D., Crijns, H. J. G. M., de Simone, I., Dolleman, S. C., Klein, C. E., Fernandez, D. I., Granneman, L., ... Scientific Reviewer Committee (2020). Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 120(4), 538-564. https://doi.org/10.1055/s-0040-1708035
    • Brouns, S. L. N., Provenzale, I., van Geffen, J. P., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2020). Localized endothelial-based control of platelet aggregation and coagulation under flow: A proof-of-principle vessel-on-a-chip study. Journal of Thrombosis and Haemostasis, 18(4), 931-941. https://doi.org/10.1111/jth.14719
    • Panova-Noeva, M., van der Meijden, P. E. J., & ten Cate, H. (2020). Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets. Journal of Clinical Medicine, 9(1), Article 92. https://doi.org/10.3390/jcm9010092
  • 2019
    • Provenzale, I., Brouns, S. L. N., van der Meijden, P. E. J., Swieringa, F., & Heemskerk, J. W. M. (2019). Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis. Micromachines, 10(11), Article 787. https://doi.org/10.3390/mi10110787
    • Olie, R. H., van der Meijden, P. E. J., Spronk, H. M. H., van Oerle, R., Barvik, S., Bonarjee, V. V. S., Ten Cate, H., & Nilsen, D. W. T. (2019). Effects of the PAR-1 Antagonist Vorapaxar on Platelet Activation and Coagulation Biomarkers in Patients with Stable Coronary Artery Disease. TH open : companion journal to thrombosis and haemostasis, 3(3), e259-e262. https://doi.org/10.1055/s-0039-1695710
    • Jooss, N. J., De Simone, I., Provenzale, I., Fernández, D. I., Brouns, S. L. N., Farndale, R. W., Henskens, Y. M. C., Kuijpers, M. J. E., Ten Cate, H., van der Meijden, P. E. J., Cavill, R., & Heemskerk, J. W. M. (2019). Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces. International journal of molecular sciences, 20(11), Article 2788. https://doi.org/10.3390/ijms20112788
    • van der Meijden, P. E. J., & Heemskerk, J. W. M. (2019). Platelet biology and functions: new concepts and clinical perspectives. Nature Reviews Cardiology, 16(3), 166-179. https://doi.org/10.1038/s41569-018-0110-0
  • 2018
    • Vries, M. J., van der Meijden, P. E., Kuiper, G. J., Nelemans, P. J., Wetzels, R. J., van Oerle, R. G., Lance, M. D., ten Cate, H., & Henskens, Y. M. (2018). Preoperative screening for bleeding disorders: A comprehensive laboratory assessment of clinical practice. Research and practice in thrombosis and haemostasis, 2(4), 767-777. https://doi.org/10.1002/rth2.12114
    • Baaten, C. C. F. M. J., Swieringa, F., Misztal, T., Mastenbroek, T. G., Feijge, M. A. H., Bock, P. E., Donners, M. M. P. C., Collins, P. W., Li, R., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2018). Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects. Blood advances, 2(18), 2320-2331. https://doi.org/10.1182/bloodadvances.2017011544
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R. J. H., van Oerle, R., Heijnen, H. F. G., ten Cate, H., Holloway, G. P., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica-the Hematology Journal, 103(9), 1557-1567. https://doi.org/10.3324/haematol.2017.185165
    • Swieringa, F., Spronk, H. M. H., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2018). Integrating platelet and coagulation activation in fibrin clot formation. Research and practice in thrombosis and haemostasis, 2(3), 450-460. https://doi.org/10.1002/rth2.12107
    • Olie, R. H., van der Meijden, P. E. J., & ten Cate, H. (2018). The coagulation system in atherothrombosis: Implications for new therapeutic strategies. Research and practice in thrombosis and haemostasis, 2(2), 188-198. https://doi.org/10.1002/rth2.12080
    • Spronk, H. M. H., Padro, T., Siland, J. E., Prochaska, J. H., Winters, J., van der Wal, A. C., Posthuma, J. J., Lowe, G., d'Alessandro, E., Wenzel, P., Coenen, D. M., Reitsma, P. H., Ruf, W., van Gorp, R. H., Koenen, R. R., Vajen, T., Alshaikh, N. A., Wolberg, A. S., Macrae, F. L., ... ten Cate, H. (2018). Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 118(2), 229-250. https://doi.org/10.1160/TH17-07-0492
  • 2017
    • Baaten, C. C. F. M. J., ten Cate, H., van der Meijden, P. E. J., & Heemskerk, J. W. M. (2017). Platelet populations and priming in hematological diseases. Blood Reviews, 31(6), 389-399. https://doi.org/10.1016/j.blre.2017.07.004
    • Vries, M. J. A., Bouman, H. J., Olie, R. H., Veenstra, L. F., Zwaveling, S., Verhezen, P. W. M., ten Cate-Hoek, A. J., ten Cate, H., Henskens, Y. M. C., & van der Meijden, P. E. J. (2017). Determinants of agreement between proposed therapeutic windows of platelet function tests in vulnerable patients. European Heart Journal-Cardiovascular Pharmacotherapy, 3(1), 11-17. https://doi.org/10.1093/ehjcvp/pvw026
  • 2016
    • Zentai, C., Solomon, C., van der Meijden, P. E. J., Spronk, H. M. H., Schnabel, J., Rossaint, R., & Grottke, O. (2016). Effects of Fibrinogen Concentrate on Thrombin Generation, Thromboelastometry Parameters, and Laboratory Coagulation Testing in a 24-Hour Porcine Trauma Model. Clinical and Applied Thrombosis-Hemostasis, 22(8), 749-759. https://doi.org/10.1177/1076029615584662
    • Zentai, C., van der Meijden, P. E. J., Braunschweig, T., Hueck, N., Honickel, M., Spronk, H. M. H., Rossaint, R., & Grottke, O. (2016). Hemostatic Therapy Using Tranexamic Acid and Coagulation Factor Concentrates in a Model of Traumatic Liver Injury. Anesthesia and Analgesia, 123(1), 38-48. https://doi.org/10.1213/ANE.0000000000001379
    • Mattheij, N. J. A., Swieringa, F., Mastenbroek, T. G., Berny-Lang, M. A., May, F., Baaten, C. C. F. M. J., van der Meijden, P. E. J., Henskens, Y. M. C., Beckers, E. A. M., Suylen, D. P. L., Nolte, M. W., Hackeng, T. M., McCarty, O. J. T., Heemskerk, J. W. M., & Cosemans, J. M. E. M. (2016). Coated platelets function in platelet-dependent fibrin formation via integrin alpha(IIb)beta(3) and transglutaminase factor XIII. Haematologica-the Hematology Journal, 101(4), 427-436. https://doi.org/10.3324/haematol.2015.131441
    • Baaten, C. C. F. M. J., Moenen, F. C. J. I., Henskens, Y. M. C., Swieringa, F., Wetzels, R., van Oerle, R., ten Cate, H., Beckers, E. A. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2016). Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy. Thrombosis Research, 140S1, S171-S171. https://doi.org/10.1016/s0049-3848(16)30125-6
    • Swieringa, F., Baaten, C. C. F. M. J., Verdoold, R., Mastenbroek, T. G., Rijnveld, N., van der Laan, K. O., Breel, E. J., Collins, P. W., Lance, M. D., Henskens, Y. M. C., Cosemans, J. M. E. M., Heemskerk, J. W. M., & van der Meijden, P. E. J. (2016). Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow. Arteriosclerosis Thrombosis and Vascular Biology, 36(4), 692-699. https://doi.org/10.1161/ATVBAHA.115.306537