Arina ten Cate-Hoek

Associate professor

Dr Arina ten Cate-Hoek graduated as a medical doctor at the University of Amsterdam and as a Clinical Epidemiologist at the University of Maastricht. Her PhD thesis was on new developments in diagnosis and treatment of deep venous thrombosis. She currently holds a clinical position at the Heart+Vascular Center of Maastricht UMC+ and her specialty is in the prevention and treatment of venous thrombotic disease, especially the Post Thrombotic Syndrome. She is the medical director of the Anticoagulation Clinic as well as the medical coordinator of the Thrombosis Expertise Centre Maastricht. She gained some laboratory experience in the laboratory of the Harvard University Beth Israel Deaconess Medical Center in Boston and the Laboratory of the Netherlands Red Cross Blood Transfusion Service (CLB)in Amsterdam.

Since 2003, she has been working at the Maastricht UMC+ where she combines clinical work with clinical and translational research. The main topic of het research is prevention and treatment of the Post Thrombotic Syndrome. She received research grants mainly from ZonMw Efficiency research.

Department of Internal Medicine
P. Debyelaan 25, 6229 HX Maastricht
PO Box 612, 6200 MD Maastricht

  • 2024
    • Iding, A. F. J., Limpens, T. M. P., Ten Cate, H., & Ten Cate-Hoek, A. J. (2024). Chronic inflammatory diseases increase the risk of post-thrombotic syndrome: A prospective cohort study. European journal of internal medicine, 120, 85-91. https://doi.org/10.1016/j.ejim.2023.10.014
    • Ten Cate-Hoek, A., & Ten Cate, H. (2024). Stressful experiences and venous thromboembolism. European journal of internal medicine. Advance online publication. https://doi.org/10.1016/j.ejim.2024.01.014
  • 2023
    • Baidildinova, G., Pallares Robles, A., ten Cate, V., Kremers, B. M. M., Heitmeier, S., ten Cate, H., Mees, B. M. E., Spronk, H. M. H., Wild, P. S., ten Cate-Hoek, A. J., & Jurk, K. (2023). Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease. Thrombosis Research, 230(1), 105-118. https://doi.org/10.1016/j.thromres.2023.08.017
    • Iding, A. F. J., Kremers, B. M. M., Pallares Robles, A., ten Cate, H., & ten Cate-Hoek, A. J. (2023). Residual Venous Obstruction as an Indicator of Clinical Outcomes following Deep Vein Thrombosis: A Management Study. Thrombosis and Haemostasis, 123(08), 763-772. https://doi.org/10.1055/a-2059-4737
    • Robles, A. P., ten Cate, V., Lenz, M., Schulz, A., Prochaska, J. H., Rapp, S., Koeck, T., Leineweber, K., Heitmeier, S., Opitz, C. F., Held, M., Espinola-Klein, C., Lackner, K. J., Muenzel, T., V. Konstantinides, S., ten Cate-Hoek, A., ten Cate, H., & Wild, P. S. (2023). Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification. Thrombosis Research, 227(1), 71-81. https://doi.org/10.1016/j.thromres.2023.04.023
    • Nagy, M., Robles, A. P., Visser, M., Koeck, T., ten Cate, V., ten Cate-Hoek, A. J., Schwers, S., Heitmeier, S., ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2023). Predictive value for increased activated factor XI activity in acute venous thromboembolism. Journal of Thrombosis and Haemostasis, 21(6), 1610-1622. https://doi.org/10.1016/j.jtha.2023.02.031
    • Akbalut, C., Arisz, R., Baaten, C., Baildildinova, G., Barakzie, A., Bauersachs, R., Ten Berg, J. M., van den Broek, W., de Boer, H. C., Broker, V., Buka, R., Ten Cate, H., Cate, A. T., De Luca, C., De Simone, I., Dignat-George, F., Freson, K., Gazzaniga, G., van Gorp, E., ... van Zonneveld, A.-J. (2023). Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 123(8), 808-839. https://doi.org/10.1055/a-2052-9175
    • Schreurs, R. H. P., ten Cate-Hoek, A. J., ten Cate, H., & Joore, M. A. (2023). Budget Impact of Three Improvement Targets for Compression Therapy for Patients with Deep Venous Thrombosis in The Netherlands. PharmacoEconomics - open, 7(3), 479-491. https://doi.org/10.1007/s41669-023-00403-4
    • Iding, A. F. J., Robles, A. P., Ten Cate, V., Ten Cate, H., Wild, P. S., & Ten Cate-Hoek, A. J. (2023). Exploring phenotypes of deep vein thrombosis in relation to clinical outcomes beyond recurrence. Journal of Thrombosis and Haemostasis, 21(5), 1238-1247. https://doi.org/10.1016/j.jtha.2023.01.025
    • de Jong, C. M. M., Visser, C., Bemelmans, R. H. H., Boersma, W. G., van den Borst, B., Burggraaf, J. L. I., Cannegieter, S. C., ten Cate-Hoek, A. J., Croles, F. N., Faber, H. J., Faber, L. M., Hellemons, M. E., Hessels, L. M., Huisman, M., Kamphuisen, P. W., Koster, S. C. E., Kroft, L. J. M., van der Lee, I., Leentjens, J., ... Dutch COVID & Thrombosis Coalition (2023). Chronic thromboembolic pulmonary hypertension and clot resolution after COVID-19-associated pulmonary embolism. European Respiratory Journal, 61(4), Article 2300171. https://doi.org/10.1183/13993003.00171-2023
    • Kremers, B. M. M., Daemen, J. H. C., ten Cate, H., Spronk, H. M. H., Mees, B. M. E., & Cate-Hoek, A. J. T. (2023). Inadequate response to antiplatelet therapy in patients with peripheral artery disease: a prospective cohort study. Thrombosis Journal, 21(1), Article 5. https://doi.org/10.1186/s12959-022-00445-4
    • Schropp, L., de Kleijn, R. J. C. M. F., Westerink, J., Nijkeuter, M., Vonken, E. J., van der Schaaf, I. C., Goedee, H. S., Vrancken, A. F. J. E., van Hattum, E. S., Petri, B. J., de Borst, G. J., Ünlü, Ç., Bemelmans, R. H. H., Westerweel, P. E., Lijkwan, M., Esselink, A. C., Bode, A. S., Msc, H. N., ten Cate, A., ... TROTS registry collaborators (2023). Thoracic outlet syndrome (TROTS) registry: A study protocol for the primary upper extremity deep venous thrombosis section. PLOS ONE, 18(1), Article e0279708. https://doi.org/10.1371/journal.pone.0279708
    • Iding, A. F. J., Kremers, B. M. M., Nagy, M., Robles, A. P., Ten Cate, H., Spronk, H. M. H., & Ten Cate-Hoek, A. J. (2023). Translational insights into mechanisms underlying residual venous obstruction and the role of factor XI, P-selectin and GPVI in recurrent venous thromboembolism. Thrombosis Research, 221(1), 58-64. https://doi.org/10.1016/j.thromres.2022.11.023
    • Iding, A., Cate-Hoek, A. T., & Cate, H. T. (2023). Determining 'thrombogenicity' in patients with coronary artery disease; what's next?European Heart Journal, 44(19), 1729–1731. https://doi.org/10.1093/eurheartj/ehad106
  • 2022
    • Ten Cate-Hoek, A. J. (2022). Lower strength stockings: is less better?The Lancet Haematology, 9(12), e865-e866. https://doi.org/10.1016/S2352-3026(22)00266-6
    • Kremers, B. M. M., Posma, J. N., Heitmeier, S., Glunz, J., Ten Cate, H., Pallares Robles, A., Daemen, J. H. C., Ten Cate-Hoek, A. J., Mees, B. M. E., & Spronk, H. M. H. (2022). Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease. Scientific Reports, 12(1), Article 18388. https://doi.org/10.1038/s41598-022-23260-3
    • Abdulrehman, J., Elbaz, C., Aziz, D., Parpia, S., Fazelzad, R., Eischer, L., Rodger, M. A., Cannegieter, S. C., ten Cate-Hoek, A., Nagler, M., Schulman, S., Rezende, S. M., Olie, V., Palareti, G., Marcucci, M., Douketis, J., Poli, D., Zabczyk, M., de Sousa, D. A., ... Skeith, L. (2022). Recurrence after stopping anticoagulants in women with combined oral contraceptive-associated venous thromboembolism: A systematic review and meta-analysis. British Journal of Haematology, 199(1), 130-142. https://doi.org/10.1111/bjh.18331
    • Gwozdz, A. M., de Jong, C. M. M., Fialho, L. S., Likitabhorn, T., Sossi, F., Jaber, P. B., Højen, A. A., Arcelus, J. I., Auger, W. R., Ay, C., Barco, S., Gazzana, M. B., Bayley, J., Bertoletti, L., Cate-Hoek, A. T., Cohen, A. T., Connors, J. M., Galanaud, J.-P., Labropoulos, N., ... Klok, F. A. (2022). Development of an international standard set of outcome measures for patients with venous thromboembolism: an International Consortium for Health Outcomes Measurement consensus recommendation. The Lancet Haematology, 9(9), e698-e706. https://doi.org/10.1016/S2352-3026(22)00215-0
    • Gulpen, A. J. W., Braeken, D. C. W., Schalla, S., Ten Cate, H., Crijns, H. J., & Ten Cate-Hoek, A. J. (2022). Long-Term Adherence to Direct Oral Anticoagulants in Patients with Atrial Fibrillation: A Comparative Cross-Sectional Study. Acta Haematologica, 145(5), 476-483. https://doi.org/10.1159/000524094
    • Iding, A. F. J., & Ten Cate-Hoek, A. J. (2022). How to optimize the prevention of post‑thrombotic syndrome: recent advances. Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine, 132(7-8), Article 16288. https://doi.org/10.20452/pamw.16288
    • Schreurs, R. H. P., Joore, M. A., De Bruijn-Geraets, D. P., Ten Cate, H., & Ten Cate-Hoek, A. J. (2022). A realist evaluation to identify targets to improve the organization of compression therapy for deep venous thrombosis- and chronic venous disease patients. PLOS ONE, 17(8), Article e0272566. https://doi.org/10.1371/journal.pone.0272566
    • Bistervels, I. M., Bavalia, R., Beyer-Westendorf, J., ten Cate-Hoek, A. J., Schellong, S. M., Kovacs, M. J., Falvo, N., Meijer, K., Stephan, D., Boersma, W. G., ten Wolde, M., Couturaud, F., Verhamme, P., Brisot, D., Kahn, S. R., Ghanima, W., Montaclair, K., Hugman, A., Carroll, P., ... Hokusai PTS Investigators (2022). Postthrombotic syndrome and quality of life after deep vein thrombosis in patients treated with edoxaban versus warfarin. Research and practice in thrombosis and haemostasis, 6(5), Article e12748. https://doi.org/10.1002/rth2.12748
    • Arnoldussen, C. W. K. P., Notten, P., Brans, R., Vroegindeweij, D., Tick, L. W., van de Poel, M. H. W., Wikkeling, O. R. M., Vleming, L. J., Koster, A., Jie, K. S. G., Jacobs, E. M. G., Planken, N., Wittens, C. H. A., ten Cate, H., Wildberger, J. E., & ten Cate-Hoek, A. J. (2022). Clinical impact of assessing thrombus age using magnetic resonance venography prior to catheter-directed thrombolysis. European Radiology, 32(7), 4555-4564. https://doi.org/10.1007/s00330-022-08599-5
    • Schreurs, R. H. P., Joore, M. A., Ten Cate, H., & Ten Cate-Hoek, A. J. (2022). Development of a Consensus-Based Cross-Domain Protocol for the Management of Elastic Compression Stocking Therapy in Patients With Deep Venous Thrombosis and Chronic Venous Disease: A Modified Delphi Study. Frontiers in Cardiovascular Medicine, 9, Article 891364. https://doi.org/10.3389/fcvm.2022.891364
  • 2021
    • Bruggemann, R. A. G., Alnima, T., Brouns, S. H. A., Hanssen, N. M. J., Schols, J. M. G. A., ten Cate, H., Spaetgens, B., & ten Cate-Hoek, A. J. (2021). A known unknown? Pharmacological prevention of venous thromboembolism in nursing home residents. Journal of the American Geriatrics Society, 69(11), 3338-3343. https://doi.org/10.1111/jgs.17422
    • Prochaska, J. H., Arnold, N., Falcke, A., Kopp, S., Schulz, A., Buch, G., Moll, S., Panova-Noeva, M., Junger, C., Eggebrecht, L., Pfeiffer, N., Beutel, M., Binder, H., Grabbe, S., Lackner, K. J., Ten Cate-Hoek, A., Espinola-Klein, C., Munzel, T., & Wild, P. S. (2021). Chronic venous insufficiency, cardiovascular disease, and mortality: a population study. European Heart Journal, 42(40), 4157-4165. https://doi.org/10.1093/eurheartj/ehab495
    • Schreurs, R. H. P., Joore, M. A., ten Cate, H., & ten Cate-Hoek, A. J. (2021). Using the Functional Resonance Analysis Method to explore how elastic compression therapy is organised and could be improved from a multistakeholder perspective. BMJ Open, 11(10), Article e048331. https://doi.org/10.1136/bmjopen-2020-048331
    • Petersohn, S., Grimm, S. E., Ramaekers, B. L. T., ten Cate-Hoek, A. J., & Joore, M. A. (2021). Exploring the Feasibility of Comprehensive Uncertainty Assessment in Health Economic Modeling: A Case Study. Value in Health, 24(7), 983-994. https://doi.org/10.1016/j.jval.2021.01.004
    • Notten, P., de Smet, A. A. E. A., Tick, L. W., van de Poel, M. H. W., Wikkeling, O. R. M., Vleming, L.-J., Koster, A., Jie, K.-S. G., Jacobs, E. M. G., Ebben, H. P., Coppens, M., ten Cate, H., Wittens, C. H. A., & ten Cate-Hoek, A. J. (2021). CAVA (Ultrasound-Accelerated Catheter-Directed Thrombolysis on Preventing Post-Thrombotic Syndrome) Trial: Long-Term Follow-Up Results. Journal of the American Heart Association, 10(11), Article 018973. https://doi.org/10.1161/JAHA.120.018973
    • Iding, A. F. J., Witten, A., Isaacs, A., Castoldi, E., ten Cate, H., Stoll, M., & ten Cate-Hoek, A. J. (2021). Leukocyte gene expression in post-thrombotic syndrome. Thrombosis Research, 202, 40-42. https://doi.org/10.1016/j.thromres.2021.03.007
    • Nagler, M., Van Kuijk, S. M. J., Ten Cate, H., Prins, M. H., & Ten Cate-Hoek, A. J. (2021). Predicting Recurrent Venous Thromboembolism in Patients With Deep-Vein Thrombosis: Development and Internal Validation of a Potential New Prediction Model (Continu-8). Frontiers in Cardiovascular Medicine, 8, Article 655226. https://doi.org/10.3389/fcvm.2021.655226
    • Notten, P., ten Cate, H., & ten Cate-Hoek, A. J. (2021). Postinterventional antithrombotic management after venous stenting of the iliofemoral tract in acute and chronic thrombosis: A systematic review. Journal of Thrombosis and Haemostasis, 19(3), 753-796. https://doi.org/10.1111/jth.15197
    • Kakkos, S. K., Gohel, M., Baekgaard, N., Bauersachs, R., Bellmunt-Montoya, S., Black, S. A., ten Cate-Hoek, A. J., Elalamy, I., Enzmann, F. K., Geroulakos, G., Gottsater, A., Hunt, B. J., Mansilha, A., Nicolaides, A. N., Sandset, P. M., Stansby, G., de Borst, G. J., Goncalves, F. B., Chakfe, N., ... ESVS Guidelines Committee (2021). Editor's Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis. European Journal of Vascular and Endovascular Surgery, 61(1), 9-82. https://doi.org/10.1016/j.ejvs.2020.09.023
  • 2020
    • Notten, P., Strijkers, R. H. W., Toonder, I., ten Cate, H., & ten Cate-Hoek, A. J. (2020). Prevalence of venous obstructions in (recurrent) venous thromboembolism: a case-control study. Thrombosis Journal, 18(1), Article 23. https://doi.org/10.1186/s12959-020-00238-7
    • Takada, T., van Doorn, S., Parpia, S., de Wit, K., Anderson, D. R., Stevens, S. M., Woller, S. C., ten Cate-Hoek, A. J., Elf, J. L., Kraaijenhagen, R. A., Schutgens, R. E. G., Wells, P. S., Kearon, C., Moons, K. G. M., & Geersing, G. J. (2020). Diagnosing deep vein thrombosis in cancer patients with suspected symptoms: An individual participant data meta-analysis. Journal of Thrombosis and Haemostasis, 18(9), 2245-2252. https://doi.org/10.1111/jth.14900
    • Gulpen, A. J. W., van Dijk, J. K., Damen, N. L., ten Cate, H., Schalla, S., & Ten Cate-Hoek, A. J. (2020). Organisation of care for patients using direct oral anticoagulants. Netherlands Heart Journal, 28(9), 452-456. https://doi.org/10.1007/s12471-020-01436-8
    • Kremers, B., Wubbeke, L., Mees, B., ten Cate, H., Spronk, H., & ten Cate-Hoek, A. (2020). Plasma Biomarkers to Predict Cardiovascular Outcome in Patients With Peripheral Artery Disease A Systematic Review and Meta-Analysis. Arteriosclerosis Thrombosis and Vascular Biology, 40(9), 2018-2032. https://doi.org/10.1161/ATVBAHA.120.314774
    • Petersohn, S., Pouwels, X., Ramaekers, B., ten Cate-Hoek, A., & Joore, M. (2020). Rivaroxaban plus aspirin for the prevention of ischaemic events in patients with cardiovascular disease: a cost-effectiveness study. European Journal of Preventive Cardiology, 27(13), 1354-1365. https://doi.org/10.1177/2047487320913380
    • Notten, P., Arnoldussen, C. W. K. P., Brans, R., de Smet, A. A. E. A., Tick, L. W., van de Poel, M. H. W., Wikkeling, O. R. M., Vleming, L.-J., Koster, A., Jie, K.-S. G., Jacobs, E. M. G., Ebben, H. P., Planken, N., ten Cate, H., Wittens, C. H. A., & ten Cate-Hoek, A. J. (2020). Association of Successful Ultrasound-Accelerated Catheter-Directed Thrombolysis with Postthrombotic Syndrome: A Post Hoc Analysis of the CAVA Trial. Thrombosis and Haemostasis, 120(08), 1188-1199. https://doi.org/10.1055/s-0040-1713171
    • Brouns, S. H., Bruggemann, R., Linkens, A. E. M. J. H., Magdelijns, F. J., Joosten, H., Heijnen, R., ten Cate-Hoek, A. J., Schols, J. M. G. A., ten Cate, H., & Spaetgens, B. (2020). Mortality and the Use of Antithrombotic Therapies Among Nursing Home Residents withCOVID-19. Journal of the American Geriatrics Society, 68(8), 1647-1652. https://doi.org/10.1111/jgs.16664
    • van Miert, J. H. A., Veeger, N. J. G. M., ten Cate-Hoek, A. J., Piersma-Wichers, M., & Meijer, K. (2020). Effect of switching from acenocoumarol to phenprocoumon on time in therapeutic range and INR variability: A cohort study. PLOS ONE, 15(7), Article 0235639. https://doi.org/10.1371/journal.pone.0235639
    • Leader, A., ten Cate, V., ten Cate-Hoek, A. J., Beckers, E. A. M., Spectre, G., Giaccherini, C., Gurevich-Shapiro, A., Krashin, E., Raanani, P., Schouten, H. C., Falanga, A., & ten Cate, H. (2020). Anticoagulation in thrombocytopenic patients with hematological malignancy: A multinational clinical vignette-based experiment. European journal of internal medicine, 77, 86-96. https://doi.org/10.1016/j.ejim.2020.03.005
    • Ordieres-Ortega, L., Demelo-Rodriguez, P., Galeano-Valle, F., Kremers, B. M. M., ten Cate-Hoek, A. J., & ten Cate, H. (2020). Predictive value of D-dimer testing for the diagnosis of venous thrombosis in unusual locations: A systematic review. Thrombosis Research, 189, 5-12. https://doi.org/10.1016/j.thromres.2020.02.009
    • Notten, P., van Laanen, J. H. H., Eijgenraam, P., de Wolf, M. A. F., Kurstjens, R. L. M., ten Cate, H., & ten Cate-Hoek, A. J. (2020). Quality of anticoagulant therapy and the incidence of in-stent thrombosis after venous stenting. Research and practice in thrombosis and haemostasis, 4(4), 594-603. https://doi.org/10.1002/rth2.12330
    • d'Alessandro, E., Becker, C., Bergmeier, W., Bode, C., Bourne, J. H., Brown, H., Buller, H. R., ten Cate-Hoek, A. J., ten Cate, V., van Cauteren, Y. J. M., Cheung, Y. F. H., Cleuren, A., Coenen, D., Crijns, H. J. G. M., de Simone, I., Dolleman, S. C., Klein, C. E., Fernandez, D. I., Granneman, L., ... Scientific Reviewer Committee (2020). Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 120(4), 538-564. https://doi.org/10.1055/s-0040-1708035
    • Notten, P., & ten Cate-Hoek, A. J. (2020). Catheter interventions: an unresolved clinical controversy: Authors' reply. The Lancet Haematology, 7(3), e190. https://doi.org/10.1016/s2352-3026(20)30032-6
    • Notten, P., ten Cate-Hoek, A. J., Arnoldussen, C. W. K. P., Strijkers, R. H. W., de Smet, A. A. E. A., Tick, L. W., van de Poel, M. H. W., Wikkeling, O. R. M., Vleming, L.-J., Koster, A., Jie, K.-S. G., Jacobs, E. M. G., Ebben, H. P., Coppens, M., Toonder, I., ten Cate, H., & Wittens, C. H. A. (2020). Ultrasound-accelerated catheter-directed thrombolysis versus anticoagulation for the prevention of post-thrombotic syndrome (CAVA): a single-blind, multicentre, randomised trial. The Lancet Haematology, 7(1), E40-E49. https://doi.org/10.1016/S2352-3026(19)30209-1
  • 2019
    • Petersohn, S., Ramaekers, B. L. T., Olie, R. H., ten Cate-Hoek, A. J., Daemen, J.-W. H. C., ten Cate, H., & Joore, M. A. (2019). Comparison of three generic quality-of-life metrics in peripheral arterial disease patients undergoing conservative and invasive treatments. Quality of Life Research, 28(8), 2257-2279. https://doi.org/10.1007/s11136-019-02166-0
    • Stolk, L. M., de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., Hoek - ten Cate, A., & Burden, A. (2019). Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants (vol 83, pg 1835, 2017). British Journal of Clinical Pharmacology, 85(8), 1864-1864. https://doi.org/10.1111/bcp.14001
    • Gulpen, A. J. W., ten Cate, H., Henskens, Y. M. C., van Oerle, R., Wetzels, R., Schalla, S., Crijns, H. J., & ten Cate-Hoek, A. J. (2019). The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study. PLOS ONE, 14(6), Article 0217302. https://doi.org/10.1371/journal.pone.0217302