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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Publications

Section Judith Sluimer Section Judith Cosemans Section Julie Staals Section Joachim Wildberger
  • 2015
    • Chaudhari, S. M., Sluimer, J. C., Koch, M., Theelen, T. L., Manthey, H. D., Busch, M., Caballero-Franco, C., Vogel, F., Cochain, C., Pelisek, J., Daemen, M. J., Lutz, M. B., Goerlach, A., Kissler, S., Hermanns, H. M., & Zernecke, A. (2015). Deficiency of HIF1 alpha in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arteriosclerosis Thrombosis and Vascular Biology, 35(11), 2316-2325. https://doi.org/10.1161/ATVBAHA.115.306171
    • Gajjala, P. R., Fliser, D., Speer, T., Jankowski, V., & Jankowski, J. (2015). Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease. Nephrology Dialysis Transplantation, 30(11), 1814-1824. https://doi.org/10.1093/ndt/gfv048
    • Halvorsen, B., Espeland, M. Z., Andersen, G. O., Yndestad, A., Sagen, E. L., Rashidi, A., Knudsen, E. C., Skjelland, M., Skagen, K. R., Krohg-Sorensen, K., Holm, S., Ritschel, V., Holven, K. B., Biessen, E. A. L., Aukrust, P., & Dahl, T. B. (2015). Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages. Atherosclerosis, 243(1), 204-210. https://doi.org/10.1016/j.atherosclerosis.2015.09.010
    • van der Valk, F. M., Sluimer, J. C., Voo, S. A., Verberne, H. J., Nederveen, A. J., Windhorst, A. D., Stroes, E. S. G., Lambin, P., & Daemen, M. J. A. P. (2015). In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans. JACC-Cardiovascular Imaging, 8(11), 1340-1341. https://doi.org/10.1016/j.jcmg.2014.12.015
    • Mulder, M. J. H. L., van Oostenbrugge, R. J., & Dippel, D. W. J. (2015). Letter by Mulder et al Regarding Article, "2015 AHA/ASA Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association". Stroke, 46(11), E235-E235. https://doi.org/10.1161/STROKEAHA.115.010913
    • Daeichin, V., Sluimer, J. C., van der Heiden, K., Skachkov, I., Kooiman, K., Janssen, A., Janssen, B., Bosch, J. G., de Jong, N., Daemen, M. J. A. P., & van der Steen, A. F. W. (2015). Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse. Ultrasound International Open, 1(2), E67-71. https://doi.org/10.1055/s-0035-1565092
    • Glorieux, G., Mullen, W., Duranton, F., Filip, S., Gayrard, N., Husi, H., Schepers, E., Neirynck, N., Schanstra, J. P., Jankowski, J., Mischak, H., Argiles, A., Vanholder, R., Vlahou, A., & Klein, J. (2015). New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis. Nephrology Dialysis Transplantation, 30(11), 1842-1852. https://doi.org/10.1093/ndt/gfv254
    • Legein, B., Janssen, E. M., Theelen, T. L., Gijbels, M. J., Walraven, J., Klarquist, J. S., Hennies, C. M., Wouters, K., Seijkens, T. T. P., Wijnands, E., Sluimer, J. C., Lutgens, E., Zenke, M., Hildner, K., Biessen, E. A. L., & Temmerman, L. (2015). Ablation of CD8 alpha(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Scientific Reports, 5, Article 15414. https://doi.org/10.1038/srep15414
    • Hansen, D. C., Seco, J., Sorensen, T. S., Petersen, J. B. B., Wildberger, J. E., Verhaegen, F., & Landry, G. (2015). A simulation study on proton computed tomography ( CT) stopping power accuracy using dual energy CT scans as benchmark. Acta Oncologica, 54(9), 1638-1642. https://doi.org/10.3109/0284186X.2015.1061212
    • Bouwman, R. W., van Engen, R. E., Young, K. C., den Heeten, G. J., Broeders, M. J. M., Schopphoven, S., Jeukens, C. R. L. P. N., Veldkamp, W. J. H., & Dance, D. R. (2015). Average glandular dose in digital mammography and digital breast tomosynthesis: comparison of phantom and patient data. Physics in Medicine and Biology, 60(20), 7893-7907. https://doi.org/10.1088/0031-9155/60/20/7893
    • Agbani, E. O., van den Bosch, M. T. J., Brown, E., Williams, C. M., Mattheij, N. J. A., Cosemans, J. M. E. M., Collins, P. W., Heemskerk, J. W. M., Hers, I., & Poole, A. W. (2015). Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets. Circulation, 132(15), 1414-1424. https://doi.org/10.1161/CIRCULATIONAHA.114.015036
    • Selle, J., Asare, Y., Kohncke, J., Alampour-Rajabi, S., Shagdarsuren, G., Klos, A., Weber, C., Jankowski, J., & Shagdarsuren, E. (2015). Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice. Thrombosis and Haemostasis, 114(4), 848-858. https://doi.org/10.1160/TH14-12-1075
    • Kosanovic, D., Luitel, H., Dahal, B. K., Cornitescu, T., Janssen, W., Danser, A. H. J., Garrelds, I. M., De Mey, J. G. R., Fazzi, G., Schiffers, P., Iglarz, M., Fischli, W., Ghofrani, H. A., Weissmann, N., Grimminger, F., Seeger, W., Reiss, I., & Schermuly, R. T. (2015). Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis. European Respiratory Journal, 46(4), 1084-1094. https://doi.org/10.1183/09031936.00018215
    • Lalji, U. C., Jeukens, C. R. L. P. N., Houben, I., Nelemans, P. J., van Engen, R. E., van Wylick, E., Beets-Tan, R. G. H., Wildberger, J. E., Paulis, L. E., & Lobbes, M. B. I. (2015). Evaluation of low-energy contrast-enhanced spectral mammography images by comparing them to full-field digital mammography using EUREF image quality criteria. European Radiology, 25(10), 2813-2820. https://doi.org/10.1007/s00330-015-3695-2
    • Pena, M. J., Jankowski, J., Heinze, G., Kohl, M., Heinzel, A., Bakker, S. J. L., Gansevoort, R. T., Rossing, P., de Zeeuw, D., Heerspink, H. J. L., & Jankowski, V. (2015). Plasma proteomics classifiers improve risk prediction for renal disease in patients with hypertension or type 2 diabetes. Journal of Hypertension, 33(10), 2123-2132. https://doi.org/10.1097/HJH.0000000000000685
    • Paulis, L. E., Lobbes, M. B. I., Lalji, U. C., Gelissen, N., Bouwman, R. W., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2015). Radiation Exposure of Digital Breast Tomosynthesis Using an Antiscatter Grid Compared With Full-Field Digital Mammography. Investigative Radiology, 50(10), 679-685. https://doi.org/10.1097/RLI.0000000000000168
    • Staals, J., Booth, T., Morris, Z., Bastin, M. E., Gow, A. J., Corley, J., Redmond, P., Starr, J. M., Deary, I. J., & Wardlaw, J. M. (2015). Total MRI load of cerebral small vessel disease and cognitive ability in older people. Neurobiology of Aging, 36(10), 2806-2811. https://doi.org/10.1016/j.neurobiolaging.2015.06.024
    • Berkhemer, O. A., van Zwam, W. H., & Dippel, D. W. J. (2015). Stent-Retriever Thrombectomy for Stroke. New England Journal of Medicine, 373(11), 1076-1076. https://doi.org/10.1056/NEJMc1508744
    • Loos, C. M. J., Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients. PLOS ONE, 10(9), Article e0137323. https://doi.org/10.1371/journal.pone.0137323
    • van der Vorst, E. P. C., Doring, Y., & Weber, C. (2015). Chemokines and their receptors in Atherosclerosis. Journal of Molecular Medicine, 93(9), 963-971. https://doi.org/10.1007/s00109-015-1317-8
    • Bentala, M., Heuts, S., Vos, R., Maessen, J., Scohy, T. V., Gerritse, B. M., & Sardari Nia, P. (2015). Comparing the endo-aortic balloon and the external aortic clamp in minimally invasive mitral valve surgery. Interactive Cardiovascular and Thoracic Surgery, 21(3), 359-365. https://doi.org/10.1093/icvts/ivv160
    • Lell, M. M., Wildberger, J. E., Alkadhi, H., Damilakis, J., & Kachelriess, M. (2015). Evolution in Computed Tomography The Battle for Speed and Dose. Investigative Radiology, 50(9), 629-644. https://doi.org/10.1097/RLI.0000000000000172
    • Rueth, M., Lemke, H. .-D., Preisinger, C., Krieter, D., Theelen, W., Gajjala, P., Devine, E., Zidek, W., Jankowski, J., & Jankowski, V. (2015). Guanidinylations of albumin decreased binding capacity of hydrophobic metabolites. Acta Physiologica, 215(1), 13-23. https://doi.org/10.1111/apha.12518
    • Kim, H., Park, C. M., Goo, J. M., Wildberger, J. E., & Kauczor, H.-U. (2015). Quantitative Computed Tomography Imaging Biomarkers in the Diagnosis and Management of Lung Cancer. Investigative Radiology, 50(9), 571-583. https://doi.org/10.1097/RLI.0000000000000152
    • Medina, I., Cougoule, C., Drechsler, M., Bermudez, B., Koenen, R. R., Sluimer, J., Wolfs, I., Doering, Y., Herias, V., Gijbels, M., Bot, I., de Jager, S. C. A., Weber, C., Cleutjens, J., van Berkel, T. J. C., Sikkink, K.-J., Mocsai, A., Maridonneau-Parini, I., Soehnlein, O., & Biessen, E. A. L. (2015). Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility. Circulation, 132(6), 490-501. https://doi.org/10.1161/CIRCULATIONAHA.114.012316
    • Theelen, T. L., Lappalainen, J. P., Sluimer, J. C., Gurzeler, E., Cleutjens, J. P., Gijbels, M. J., Biessen, E. A. L., Daemen, M. J. A. P., Alitalo, K., & Yla-Herttuala, S. (2015). Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. Atherosclerosis, 241(2), 297-304. https://doi.org/10.1016/j.atherosclerosis.2015.05.018
    • Luiken, J. J. F. P., Glatz, J. F. C., & Neumann, D. (2015). Cardiac contraction-induced GLUT4 translocation requires dual signaling input. Trends in Endocrinology and Metabolism, 26(8), 404-410. https://doi.org/10.1016/j.tem.2015.06.002
    • PROVIDI Study Grp, & Wildberger, J. (2015). Incidental findings on chest CT imaging are associated with increased COPD exacerbations and mortality. Thorax, 70(8), 725-731. https://doi.org/10.1136/thoraxjnl-2014-206160
    • Sailer, A. M., Schurink, G. W. H., Bol, M. E., de Haan, M. W., van Zwam, W. H., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2015). Occupational Radiation Exposure During Endovascular Aortic Repair. Cardiovascular and Interventional Radiology, 38(4), 827-832. https://doi.org/10.1007/s00270-014-1025-8
    • van Hoof, R. H. M., Hermeling, E., Truijman, M. T. B., van Oostenbrugge, R. J., Daemen, J. W. H., van der Geest, R. J., van Orshoven, N. P., Schreuder, A. H., Backes, W. H., Daemen, M. J. A. P., Wildberger, J. E., & Kooi, M. E. (2015). Phase-based vascular input function: Improved quantitative DCE-MRI of atherosclerotic plaques. Medical Physics, 42(8), 4619-4628. https://doi.org/10.1118/1.4924949
    • van der Vorst, E. P. C., Doering, Y., & Weber, C. (2015). MIF and CXCL12 in cardiovascular diseases: functional differences and similarities. Frontiers in Immunology, 6(JUL), Article 373. https://doi.org/10.3389/fimmu.2015.00373
    • Mihl, C., Kok, M., Wildberger, J. E., Turek, J., Muehlenbruch, G., & Das, M. (2015). Computed Tomography Angiography With High Flow Rates An In Vitro and In Vivo Feasibility Study. Investigative Radiology, 50(7), 464-469. https://doi.org/10.1097/RLI.0000000000000153
    • Jurencak, T., Turek, J., Kietselaer, B., Mihl, C., Kok, M., van Ommen, V. G. V. A., van Garsse, L. A. F. M., Nijssen, E. C., Wildberger, J. E., & Das, M. (2015). MDCT evaluation of aortic root and aortic valve prior to TAVI. What is the optimal imaging time point in the cardiac cycle?European Radiology, 25(7), 1975-1983. https://doi.org/10.1007/s00330-015-3607-5
    • Tonkin, J., Temmerman, L., Sampson, R. D., Gallego-Colon, E., Barberi, L., Bilbao, D., Schneider, M. D., Musaro, A., & Rosenthal, N. (2015). Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization. Molecular Therapy, 23(7), 1189-1200. https://doi.org/10.1038/mt.2015.66
    • Parry-Jones, A. R., Di Napoli, M., Goldstein, J. N., Schreuder, F. H. B. M., Tetri, S., Tatlisumak, T., Yan, B., van Nieuwenhuizen, K. M., Dequatre-Ponchelle, N., Lee-Archer, M., Horstmann, S., Wilson, D., Pomero, F., Masotti, L., Lerpiniere, C., Godoy, D. A., Cohen, A. S., Houben, R., Al-Shahi Salman, R., ... Meretoja, A. (2015). Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage. Annals of Neurology, 78(1), 54-62. https://doi.org/10.1002/ana.24416
    • Kok, M., Kietselaer, B. L. J. H., Mihl, C., Altintas, S., Nijssen, E. C., Wildberger, J. E., & Das, M. (2015). Contrast Enhancement of the Right Ventricle during Coronary CT Angiography - Is It Necessary?PLOS ONE, 10(6), Article e0128625. https://doi.org/10.1371/journal.pone.0128625
    • Temmerman, L., & Biessen, E. A. L. (2015). Deadly tricks to combat atherosclerosis. Cardiovascular Research, 106(3), 345-347. https://doi.org/10.1093/cvr/cvv133
    • Mastenbroek, T. G., Van Geffen, J. P., Heemskerk, J. W. M., & Cosemans, J. M. E. M. (2015). Acute and persistent platelet and coagulant activities in atherothrombosis. Journal of Thrombosis and Haemostasis, 13(S1), S272-S280. https://doi.org/10.1111/jth.12972
    • Providi Study Group, & Wildberger, J. (2015). Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value?European Radiology, 25(6), 1646-1654. https://doi.org/10.1007/s00330-014-3495-0
    • Curaj, A., Wu, Z., Fokong, S., Liehn, E. A., Weber, C., Burlacu, A., Lammers, T., van Zandvoort, M., & Kiessling, F. (2015). Noninvasive Molecular Ultrasound Monitoring of Vessel Healing After Intravascular Surgical Procedures in a Preclinical Setup. Arteriosclerosis Thrombosis and Vascular Biology, 35(6), 1366-1373. https://doi.org/10.1161/ATVBAHA.114.304857
    • Smulders, M. W., Bekkers, S. C. A. M., Kim, H. W., Van Assche, L. M. R., Parker, M. A., & Kim, R. J. (2015). Performance of CMR Methods for Differentiating Acute From Chronic MI. JACC-Cardiovascular Imaging, 8(6), 669-679. https://doi.org/10.1016/j.jcmg.2014.12.030
    • Kuijpers, M. J. E., Mattheij, N. J. A., Cipolla, L., van Geffen, J. P., Lawrence, T., Donners, M. M. P. C., Boon, L., Lievens, D., Torti, M., Noels, H., Gerdes, N., Cosemans, J. M. E. M., Lutgens, E., & Heemskerk, J. W. M. (2015). Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase beta, and Not Via CD40 and I kappa B Kinase alpha. Arteriosclerosis Thrombosis and Vascular Biology, 35(6), 1374-1381. https://doi.org/10.1161/ATVBAHA.114.305127
    • Daeichin, V., Akkus, Z., Skachkov, I., Kooiman, K., Needles, A., Sluimer, J., Janssen, B., Daemen, M. J. A. P., van der Steen, A. F. W., de Jong, N., & Bosch, J. G. (2015). Quantification of Bound Microbubbles in Ultrasound Molecular Imaging. Ieee Transactions on Ultrasonics Ferroelectrics and Frequency Control, 62(6), 1190-1200. https://doi.org/10.1109/TUFFC.2015.006264
    • Neumann, D., Luiken, J. J. F. P., Nabben, M., & Glatz, J. F. C. (2015). Letter by Neumann et al Regarding Article, "Myostatin Regulates Energy Homeostasis in the Heart and Prevents Heart Failure". Circulation Research, 116(10), E95-E96. https://doi.org/10.1161/CIRCRESAHA.115.306463
    • Van der Donckt, C., Van Herck, J. L., Schrijvers, D. M., Vanhoutte, G., Verhoye, M., Blockx, I., Van Der Linden, A., Bauters, D., Lijnen, H. R., Sluimer, J. C., Roth, L., Van Hove, C. E., Fransen, P., Knaapen, M. W., Hervent, A.-S., De Keulenaer, G. W., Bult, H., Martinet, W., Herman, A. G., & De Meyer, G. R. Y. (2015). Elastin fragmentation inatheroscleroticmice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death. European Heart Journal, 36(17), 1049-1058A. https://doi.org/10.1093/eurheartj/ehu041
    • Oligschlaeger, Y., Miglianico, M., Chanda, D., Scholz, R., Thali, R. F., Tuerk, R., Stapleton, D. I., Gooley, P. R., & Neumann, D. (2015). The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation. Journal of Biological Chemistry, 290(18), 11715-11728. https://doi.org/10.1074/jbc.M114.633271
    • Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Ambulatory Arterial Stiffness Index Is Not Associated With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Lacunar Stroke Patients. Journal of Clinical Hypertension, 17(5), 352-356. https://doi.org/10.1111/jch.12504
    • van Bussel, F. C., Backes, W. H., Hofman, P. A., van Oostenbrugge, R. J., Kessels, A. G., van Boxtel, M. P., Schram, M. T., Stehouwer, C. D., Wildberger, J. E., & Jansen, J. F. (2015). On the Interplay of Microvasculature, Parenchyma, and Memory in Type 2 Diabetes. Diabetes Care, 38(5), 876-882. https://doi.org/10.2337/dc14-2043
    • Heeneman, S., Pool, A. O., Schuwirth, L. W. T., van der Vleuten, C. P. M., & Driessen, E. W. (2015). The impact of programmatic assessment on student learning: theory versus practice. Medical Education, 49(5), 487-498. https://doi.org/10.1111/medu.12645
    • van den Berg, L. A., Koelman, D. L. H., Berkhemer, O. A., Rozeman, A. D., Fransen, P. S. S., Beumer, D., Dippel, D. W., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Brouwer, P. A., Jenniskens, S., Boiten, J., Nijeholt, G. A. L. A., Vos, J. A., Schonewille, W. J., Majoie, C. B. L. M., & Roos, Y. B. W. E. M. (2015). Type of Anesthesia and Differences in Clinical Outcome After Intra-Arterial Treatment for Ischemic Stroke. Stroke, 46(5), 1257-1262. https://doi.org/10.1161/STROKEAHA.115.008699