Marc van Zandvoort

Professor

Prof. Marc A.M.J. van Zandvoort achieved his PhD degree in Biophysics at Utrecht University (1994) and worked as a postdoc at Universitá di Bologna and LENS institute, Florence (Italy). He returned to Utrecht University as a postdoc in 1996. In 1998, he moved to Maastricht University first as postdoc, from 2000 as assistant professor Biophysics. In 2007, he became associate professor at the department of Biomedical Engineering. In 2012, he moved to the department of Molecular Cell Biology. Currently, he is interim head of that department. In 2017 he obtained the chair 'Advanced Optical Microscopy' in Maastricht.

In 2009, he became professor Biophysics of Microscopy (part-time) at the Universitätsklinikum Aachen (Germany) and scientific leader of the Two-photon core-facility in Aachen.

He is board member of the conference series Focus on Microscopy, board member of the Dutch Society of Microscopy, and board member of the NL-BioImaging-AM initiative. He also is leader of the EuroBioImaging Node Maastricht.

His research currently zooms on the application of advanced optical microscopy (multi-photon, high-resolution 3D-STED microscopy, spectral microscopy) to biomedical cardiovascular and oncological questions. As an example, his group recently developed a method to measure mouse carotid plaque microvessel functionality using in vivo multi-photon microscopy. He has also done a variety of studies on bimodal (e.g., optical-MRI, optical-US) imaging. In combination with the techniques used, a variety of systems can be studied, ranging from artificial systems, via cells in culture (e.g., lamin substructure, mitochondrial network and substructure), to whole tissues, organs, and animals.

He has tutored both scientists with background in physics and biomedical research. He is an experienced teacher for a wide range of students (medicine, biomedical engineering, science students) and in a variety of roles (mentor, tutor, internship). His research group currently encompasses technicians, PhD students and postdocs in Maastricht and Aachen. Finally, he has been organising the TripleM PhD/Postdoc course and conference series in Maastricht.

Department of Molecular Cell Biology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
T: +31 (0)43 388 13 61

2010
- Drechsler, M., Megens, R. T. A., van Zandvoort, M., Weber, C., & Soehnlein, O. (2010). Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis. Circulation, 122(18), 1837–1845. https://doi.org/10.1161/CIRCULATIONAHA.110.961714
- Subramanian, P., Karshovska, E., Reinhard, P., Megens, R. T. A., Zhou, Z., Akhtar, S., Schumann, U., Li, X., van Zandvoort, M., Ludin, C., Weber, C., & Schober, A. (2010). Lysophosphatidic Acid Receptors LPA1 and LPA3 Promote CXCL12-Mediated Smooth Muscle Progenitor Cell Recruitment in Neointima Formation. Circulation Research, 107(1), 96-U197. https://doi.org/10.1161/CIRCRESAHA.109.212647
- Langer, H. F., von der Ruhr, J. W., Daub, K., Schoenberger, T., Stellos, K., May, A. E., Schnell, H., Gauss, A., Hafner, R., Lang, P., Schumm, M., Buehring, H.-J., Klingel, K., Conrad, S., Schaller, M., van Zandvoort, M., Jung, G., Dimmeler, S., Skutella, T., & Gawaz, M. (2010). Capture of endothelial progenitor cells by a bispecific protein/monoclonal antibody molecule induces reendothelialization of vascular lesions. Journal of Molecular Medicine, 88(7), 687-699. https://doi.org/10.1007/s00109-010-0614-5
- Oostendorp, M., Douma, K., Hackeng, T. M., Post, M. J., van Zandvoort, M. A. M. J., & Backes, W. H. (2010). Gadolinium-Labeled Quantum Dots for Molecular Magnetic Resonance Imaging: R-1 Versus R-2 Mapping. Magnetic Resonance in Medicine, 64(1), 291-298. https://doi.org/10.1002/mrm.22342
- Meens, M. J. P. M. T., Compeer, M. G., Hackeng, T. M., van Zandvoort, M. A., Janssen, B. J. A., & De Mey, J. G. R. (2010). Stimuli of Sensory-Motor Nerves Terminate Arterial Contractile Effects of Endothelin-1 by CGRP and Dissociation of ET-1/ETA-Receptor Complexes. PLOS ONE, 5(6), 11. https://doi.org/10.1371/journal.pone.0010917
- Douma, K., Oostendorp, M., Slaaf, D. W., Post, M. J., Backes, W. H., & van Zandvoort, M. A. M. J. (2010). Evaluation of Magnetic Resonance Vessel Size Imaging by Two-Photon Laser Scanning Microscopy. Magnetic Resonance in Medicine, 63(4), 930-939. https://doi.org/10.1002/mrm.22248
- Oostendorp, M., Douma, K., Wagenaar, A., Slenter, J. M. G. M., Hackeng, T. M., van Zandvoort, M. A. M. J., Post, M. J., & Backes, W. H. (2010). Molecular Magnetic Resonance Imaging of Myocardial Angiogenesis After Acute Myocardial Infarction. Circulation, 121(6), 775-U85. https://doi.org/10.1161/CIRCULATIONAHA.109.889451
- van Triest, H. J. W., Megens, R. T. A., van Assen, H. C., Romeny, B. M. T. H., & van Zandvoort, M. A. M. J. (2010). Arterial radius estimation from microscopic data using a new algorithm for circle parameter estimation. Journal of Biomedical Optics, 15(2), 8. https://doi.org/10.1117/1.3368679
- Megens, R. T. A., Reitsma, S., Prinzen, L., Egbrink, M. G. A. O., Engels, W., Leenders, P. J. A., Brunenberg, E. J. L., Reesink, K. D., Janssen, B. J. A., Romeny, B. M. T. H., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2010). In vivo high-resolution structural imaging of large arteries in small rodents using two-photon laser scanning microscopy. Journal of Biomedical Optics, 15(1), 10. Article 011108. https://doi.org/10.1117/1.3281672
- Oostendorp, M., Douma, K., Hackeng, T. M., van Zandvoort, M. A. M. J., Post, M. J., & Backes, W. H. (2010). Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging. Contrast Media & Molecular Imaging, 5(1), 9-17. https://doi.org/10.1002/cmmi.361
2009
- Miserus, R. J., Herias, M. V., Prinzen, L., Lobbes, M. B., van Suylen, R. J., Dirksen, A., Hackeng, T. M., Heemskerk, J. W., van Engelshoven, J. M., Daemen, M. J. A. P., van Zandvoort, M. A. M. J., Heeneman, S., & Kooi, M. E. (2009). Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent. JACC-Cardiovascular Imaging, 2(8), 987-96. https://doi.org/10.1016/j.jcmg.2009.03.015
- Miserus, R., Dirksen, A., Suylen, D. P., Herias, V., Prinzen, L., van Zandvoort, M. A. M. J., Kooi, M. E., Dawson, P., Heeneman, S., Daemen, M. J., & Hackeng, T. M. (2009). Total Chemical Synthesis of Bimodal-Labeled Rantes as a Pet/Tplsm Probe for in Vivo Molecular Imaging of Atherosclerotic Plaque Instability. Biopolymers, 92(4), 376-376. http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ResearchSoft&SrcApp=EndNote&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000266753100412
- Kuijpers, M., Gilio, K., Reitsma, S., Unal - Nergiz, R., Prinzen, L., Heeneman, S., Lutgens, E., van Zandvoort, M., Nieswandt, B., Oude Egbrink, M., & Heemskerk, J. (2009). Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model. Journal of Thrombosis and Haemostasis, 7(1), 152-161. https://doi.org/10.1111/j.1538-7836.2008.03186.x
2008
- Oostendorp, M., Douma, K., Hackeng, T. M., Dirksen, A., Post, M. J., van Zandvoort, M. A. M., & Backes, W. H. (2008). Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cNGR-labeled paramagnetic quantum dots. Cancer Research, 68(18), 7676-7683. https://doi.org/10.1158/0008-5472.CAN-08-0689
2007
- Megens, R. T. A., Oude Egbrink, M. G. A., Cleutjens, J. P. M., Kuijpers, M. J. E., Schiffers, P. H. M., Merkx, M., Slaaf, D. W., & van Zandvoort, M. A. M. J. (2007). Imaging collagen in intact viable healthy and atherosclerotic arteries using fluorescently labeled CNA35 and two-photon laser scanning microscopy. Molecular Imaging, 6(4), 247-60. https://doi.org/10.2310/7290.2007.00021
- Prinzen, L., Miserus, R.-J. J. H. M., Dirksen, A., Hackeng, T. M., Deckers, N., Bitsch, N. J., Megens, R. T. A., Douma, K., Heemskerk, J. W., Kooi, M. E., Frederik, P. M., Slaaf, D. W., van Zandvoort, M. A. M. J., & Reutelingsperger, C. P. M. (2007). Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano Letters, 7(1), 93-100. https://doi.org/10.1021/nl062226r
- van Gestel, M. A., Reitsma, S., Slaaf, D., Heijnen, V., Feijge, M., Lindhout, T., van Zandvoort, M., Elg, M., Reneman, R., Heemskerk, J., & Oude Egbrink, M. (2007). Both ADP and thrombin regulate arteriolar thrombus stabilization and embolization, but are not involved in initial hemostasis as induced by micropuncture. Microcirculation, 14(3), 193-205. https://doi.org/10.1080/10739680601139294
- Reitsma, S., Slaaf, D., Vink, H., van Zandvoort, M., & Oude Egbrink, M. (2007). The endothelial glycocalyx: composition, functions and visualization. Pflugers Archiv-European Journal of Physiology, 454(3), 345-359. https://doi.org/10.1007/s00424-007-0212-8
- Megens, R., Reitsma, S., Schiffers, P., Hilgers, R., de Mey, J., Slaaf, D., Oude Egbrink, M., & van Zandvoort, M. (2007). Two-photon microscopy of vital murine elastic and muscular arteries. Combined structural and functional imaging with subcellular resolution. Journal of Vascular Research, 44(2), 87-98. https://doi.org/10.1159/000098259
2006
- Buehler, A., van Zandvoort, M. A. M. J., Stelt, B. J., Hackeng, T. M., Schrans-Stassen, B. H. G. J., Bennaghmouch, A., Hofstra, L., Cleutjens, J. P. M., Duijvestijn, A., Smeets, M. B., de Kleijn, D. P. V., Post, M. J., & de Muinck, E. D. (2006). cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo. Arteriosclerosis Thrombosis and Vascular Biology, 26(12), 2681-7. https://doi.org/10.1161/01.ATV.0000245807.65714.0b
2004
- van Zandvoort, M., Engels, W., Douma, K., Beckers, L., Oude Egbrink, M., Daemen, M., & Slaaf, D. (2004). Two-photon microscopy for imaging of the (atherosclerotic) vascular wall: a proof of concept study. Journal of Vascular Research, 41(1), 54-63. https://doi.org/10.1159/000076246
2002
- van Zandvoort, M. A. M. J., de Grauw, C. J. ., Gerritsen, H. C., Broers, J. L. V., Oude Egbrink, M. G. A., Ramaekers, F. C. S., & Slaaf, D. W. (2002). Discrimination of DNA and RNA in cells by a vital fluorescent probe: Lifetime imaging of SYTO13 in healthy and apoptotic cells.Cytometry, 47, 226-235. https://doi.org/10.1002/cyto.10076

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Marc van Zandvoort

Professor