Julie Staals

Associate professor

Dr Julie Staals is working as a clinical neurologist at Maastricht UMC+. Her specialisation is neurovascular diseases. She has obtained her medical degree at Maastricht University. Afterwards, she did a parallel tract in neurology training and PhD research project, both were finished in 2009. In 2013 she did a short research fellowship at the Brain Research Imaging Center in Edinburgh, UK. Her research focus is on clinical studies in cerebral small vessel disease, mainly the effects of hypertension, the rol of endothelial function, blood-brain barrier and the neurovascular unit, advanced imaging, and the cognitive consequences of this disease. She developed the ‘total SVD score’, a highly cited score for MRI severity of cerebral small vessel disease. Other clinical research topics are intracerebral haemorrhage and acute stroke treatments.

She is currently involved in:
SVDs@target, a EU Horizon2020 multicenter project on mechanisms in cerebral small vessel disease (www.svds-at-target.eu)

CRUCIAL, a EU Horizon2020 multicenter project on microvascular rarefaction in vascular cognitive impairment and heart failure (www.crucial-project.eu)

MRCLEAN trials, acute clinical stroke trials aiming at improving outcome in endovascular treatment (www.contrast-consortium.nl)

 

Department of Neurology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2024
    • Prats-Sanchez, L., Camps-Renom, P., Nash, P. S., Wilson, D., Ambler, G., Best, J. G., Guasch-Jiménez, M., Ramos-Pachón, A., Martinez-Domeño, A., Lambea-Gil, Á., Díaz, G. E., Guisado-Alonso, D., Du, H., Al-Shahi Salman, R., Jäger, H. R., Lip, G. Y., Ay, H., Jung, S., Bornstein, N. M., ... Microbleeds International Collaborative Network (MICON) (2024). Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds. Neurology, 102(7), Article 209173. https://doi.org/10.1212/WNL.0000000000209173
    • Voorter, P. H. M., van Dinther, M., Jansen, W. J., Postma, A. A., Staals, J., Jansen, J. F. A., van Oostenbrugge, R. J., van der Thiel, M. M., & Backes, W. H. (2024). Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights. Journal of Magnetic Resonance Imaging, 59(2), 397-411. Article jmri28989. https://doi.org/10.1002/jmri.28989
    • Knapen, R. R. M. M., Pirson, F. A. V., Langezaal, L. C. M., Brouwer, J., Majoie, C. B. L. M., Emmer, B. J., Vos, J.-A., van Doormaal, P.-J., Yoo, A. J., Bruggeman, A. A. E., Lycklama À Nijeholt, G. J., van der Leij, C., van Oostenbrugge, R. J., van Zwam, W. H., Schonewille, W. J., MR CLEAN Registry Investigators, Goldhoorn, R.-J., Hinsenveld, W., Staals, J., ... Pirson, A.-F. (2024). Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study. Stroke, 55(2), 403-412. https://doi.org/10.1161/STROKEAHA.123.043777
    • Best, J. G., Ambler, G., Wilson, D., Du, H., Lee, K.-J., Lim, J.-S., Teo, K. C., Mak, H., Kim, Y. D., Song, T.-J., Selcuk Demirelli, D., Nishihara, M., Yoshikawa, M., Kubacka, M., Zietz, A., Al-Shahi Salman, R., Jäger, H. R., Lip, G. Y. H., Panos, L., ... Werring, D. J. (2024). Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA: A Pooled Analysis. Neurology, 102(1), Article e207795. https://doi.org/10.1212/WNL.0000000000207795
    • van Dinther, M. M., Hooghiemstra, A. E., Bron, E., Versteeg, A. E., Leeuwis, A., Kalay, T. E., Moonen, J., Kuipers, S. H., Backes, W., Jansen, J. F. A., van Osch, M. J. P., Biessels, G.-J., Staals, J. J., van Oostenbrugge, R., & Heart-Brain Connection Consortium (2024). Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment. Alzheimer's & Dementia, 20(1), 136-144. https://doi.org/10.1002/alz.13408
  • 2023
    • Oestreich, L. K., Lo, J. W., Di Biase, M. A., Sachdev, P. S., Mok, A. H., Wright, P., Crawford, J. D., Lam, B., Traykov, L., Köhler, S., Staals, J. E., van Oostenbrugge, R., Chen, C., Desmond, D. W., Yu, K.-H., Lee, M., Klimkowicz-Mrowiec, A., Bordet, R., O'Sullivan, M. J., & Zalesky, A. (2023). Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets. Psychiatry and Clinical Neurosciences. Advance online publication. https://doi.org/10.1111/pcn.13633
    • Robbe, M. M. Q., Pinckaers, F. M. E., Olthuis, S. G. H., Bos, M. J., van Oostenbrugge, R. J., van Zwam, W. H., Staals, J., & Postma, A. A. (2023). Procedural Blood Pressure and Intracranial Hemorrhage on Dual-Energy Computed Tomography After Endovascular Stroke Treatment. Cardiovascular and Interventional Radiology. Advance online publication. https://doi.org/10.1007/s00270-023-03619-3
    • Van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H., Marquering, H. A., De Jong, H. W. A. M., Berkhemer, O. A., Van Zwam, W. H., Van Walderveen, M. A. A., Van Den Wijngaard, I. R., Dippel, D. W. J., Yoo, A. J., Campbell, B., Kunz, W. G., Majoie, C. B., Emmer, B. J., ... MR CLEAN Registry Investigators (2023). Costs and health effects of CT perfusion-based selection for endovascular thrombectomy within 6 hours of stroke onset: a model-based health economic evaluation. Journal of Neurology Neurosurgery and Psychiatry. Advance online publication. https://doi.org/10.1136/jnnp-2023-331862
    • de Kort, F. A. S., Coenen, M., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Bordet, R., Cammà, G., Chen, C. P. L. H., Dewenter, A., Duering, M., Fang, R., van der Giessen, R. S., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kan, C. N., Kim, J., Kim, B. J., ... Biessels, G. J. (2023). White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies. Stroke, 54(12), 3021–3029. https://doi.org/10.1161/STROKEAHA.123.044297
    • Bakker, L., Ramakers, I. H. G. B., J P M Eussen, S., Choe, K., van den Hove, D. L. A., Kenis, G., Rutten, B. P. F., van Oostenbrugge, R. J., Staals, J., Ulvik, A., Ueland, P. M., Verhey, F. R. J., & Köhler, S. (2023). The role of the kynurenine pathway in cognitive functioning after stroke: A prospective clinical study. Journal of the neurological sciences, 454(1), Article 120819. https://doi.org/10.1016/j.jns.2023.120819
    • Kopczak, A., Stringer, M. S., van den Brink, H., Kerkhofs, D., Blair, G. W., van Dinther, M., Reyes, C. A., Garcia, D. J., Onkenhout, L., Wartolowska, K. A., Thrippleton, M. J., Kampaite, A., Duering, M., Staals, J., Lesnik-Oberstein, S., Muir, K. W., Middeke, M., Norrving, B., Bousser, M. G., ... TREAT-SVDs collaborators (2023). Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial. Lancet Neurology, 22(11), 991-1004. https://doi.org/10.1016/S1474-4422(23)00293-4
    • Elschot, E. P., Backes, W. H., de Jong, J. J. A., Drenthen, G. S., Wong, S. M., Staals, J., Postma, A. A., Rouhl, R. P. W., van Oostenbrugge, R. J., & Jansen, J. F. A. (2023). Assessment of the clinical feasibility of detecting subtle blood-brain barrier leakage in cerebral small vessel disease using dynamic susceptibility contrast MRI. Magnetic Resonance Imaging, 102(1), 55-61. https://doi.org/10.1016/j.mri.2023.04.004
    • van Lanen, R. H. G. J., Haeren, R. H. L., Staals, J., Dings, J. T. A., Schijns, O. E. M. G., Hoogland, G., van Kuijk, S. M. J., Kapsokalyvas, D., van Zandvoort, M. A. M. J., Vink, H., Rijkers, K., & ACE Epilepsy Surgery Group (2023). Cerebrovascular glycocalyx damage and microcirculation impairment in patients with temporal lobe epilepsy. Journal of Cerebral Blood Flow and Metabolism, 43(10), 1737-1751. https://doi.org/10.1177/0271678X231179413
    • Voorter, P. H. M., Backes, W. H., Gurney-Champion, O. J., Wong, S.-M., Staals, J., van Oostenbrugge, R. J., van Der Thiel, M. M., Jansen, J. F. A., & Drenthen, G. S. (2023). Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease. Magnetic Resonance in Medicine, 90(4), 1657 - 1671. https://doi.org/10.1002/mrm.29753
    • van Voorst, H., Hoving, J. W., Koopman, M. S., Daems, J. D., Peerlings, D., Buskens, E., Lingsma, H. F., Beenen, L. F. M., de Jong, H. W. A. M., Berkhemer, O. A., van Zwam, W. H., Roos, Y. B. W. E. M., van Walderveen, M. A. A., van den Wijngaard, I., Dippel, D. W. J., Yoo, A. J., Campbell, B. C. V., Kunz, W. G., Emmer, B. J., ... MR CLEAN Registry Investigators (2023). Cost-effectiveness of CT perfusion for the detection of large vessel occlusion acute ischemic stroke followed by endovascular treatment: a model-based health economic evaluation study. European Radiology. Advance online publication. https://doi.org/10.1007/s00330-023-10119-y
    • Rudilosso, S., Stringer, M. S., Thrippleton, M., Chappell, F., Blair, G. W., Garcia, D. J., Doubal, F., Hamilton, I., Janssen, E., Kopczak, A., Ingrisch, M., Kerkhofs, D., Backes, W. H., Staals, J., Duering, M., Dichgans, M., Wardlaw, J. M., & SVDs@Target Investigators (2023). Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease. Journal of Cerebral Blood Flow and Metabolism, 43(9), 1490-1502. https://doi.org/10.1177/0271678X231173444
    • Schaper, F. L. W. V. J., Nordberg, J., Cohen, A. L., Lin, C., Hsu, J., Horn, A., Ferguson, M. A., Siddiqi, S. H., Drew, W., Soussand, L., Winkler, A. M., Simo, M., Bruna, J., Rheims, S., Guenot, M., Bucci, M., Nummenmaa, L., Staals, J., Colon, A. J., ... Fox, M. D. (2023). Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology, 80(9), 891-902. https://doi.org/10.1001/jamaneurol.2023.1988
    • Exalto, L. G., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Best, J. G., Bordet, R., Chen, C. P. L. H., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kim, J., Kappelle, L. J., Kim, B. J., Köhler, S., de Kort, P. L. M., ... Biessels, G. J. (2023). Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke. Stroke, 54(9), 2296-2303. https://doi.org/10.1161/STROKEAHA.123.042507
    • Manukjan, N., Majcher, D., Leenders, P., Caiment, F., van Herwijnen, M., Smeets, H. J. J., Suidgeest, E., van der Weerd, L., Vanmierlo, T., Jansen, J. F. A., Backes, W. H. H., van Oostenbrugge, R. J. J., Staals, J., Fulton, D., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2023). Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood-brain barrier impairment. Acta neuropathologica communications, 11(1), Article 128. https://doi.org/10.1186/s40478-023-01627-5
    • Kerkhofs, D., Helgers, R., Hermes, D., Steinbusch, H. P. J., Van Essen, H., Leenders, P., Prickaerts, J., Staals, J., Biessen, E. A., Van Oostenbrugge, R. J., & Foulquier, S. (2023). Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. Journal of Hypertension, 41(7), 1159-1167. https://doi.org/10.1097/HJH.0000000000003445
    • Soo, Y., Zietz, A., Yiu, B., Mok, V. C. T., Polymeris, A. A., Seiffge, D., Ambler, G., Wilson, D., Leung, T. W. H., Tsang, S. F., Chu, W., Abrigo, J., Cheng, C., Lee, K.-J., Lim, J.-S., Shiozawa, M., Koga, M., Chabriat, H., Hennerici, M., ... Peters, N. (2023). Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation. Annals of Neurology, 94(1), 61-74. https://doi.org/10.1002/ana.26642
    • Duering, M., Biessels, G. J., Brodtmann, A., Chen, C., Cordonnier, C., de Leeuw, F.-E., Debette, S., Frayne, R., Jouvent, E., Rost, N. S., ter Telgte, A., Salman, R. A.-S., Backes, W. H., Bae, H.-J., Brown, R., Chabriat, H., De Luca, A., deCarli, C., Dewenter, A., ... Et al. (2023). Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurology, 22(7), 602-618. https://doi.org/10.1016/S1474-4422(23)00131-X
    • Lo, J. W., Crawford, J. D., Desmond, D. W., Bae, H. J., Lim, J. S., Godefroy, O., Roussel, M., Köhler, S., Staals, J., Verhey, F., Chen, C., Xu, X., Chong, E. J., Kandiah, N., Bordet, R., Dondaine, T., Mendyk, A. M., Brodaty, H., Traykov, L., ... Sachdev, P. S. (2023). Short-term Trajectories of Poststroke Cognitive Function: A STROKOG Collaboration Study. Neurology, 100(23), E2331-E2341. https://doi.org/10.1212/WNL.0000000000207281
    • Starmans, N. L., Wolters, F. J., Leeuwis, A. E., Bron, E. E., La Rocca, H. P. B., Staals, J., Biessels, G. J., & Kappelle, L. J. (2023). Twenty-four hour blood pressure variability and the prevalence and the progression of cerebral white matter hyperintensities. Journal of Cerebral Blood Flow and Metabolism, 43(5), 801-811. https://doi.org/10.1177/0271678X221149937
    • Olthuis, S. G. H., Pirson, F. A. V., Pinckaers, F. M. E., Hinsenveld, W. H., Nieboer, D., Ceulemans, A., Knapen, R. R. M. M., Robbe, M. M. Q., Berkhemer, O. A., van Walderveen, M. A. A., Lycklama À Nijeholt, G. J., Uyttenboogaart, M., Schonewille, W. J., van der Sluijs, P. M., Wolff, L., van Voorst, H., Postma, A. A., Roosendaal, S. D., van der Hoorn, A., ... MR CLEAN-LATE Investigators (2023). Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial. Lancet, 401(10385), 1371-1380. https://doi.org/10.1016/S0140-6736(23)00575-5
    • Olthuis, S. G. H., Hinsenveld, W. H., Pinckaers, F. M. E., Amini, M., Lingsma, H. F., Staals, J., Schreuder, T. H. C. M. L., Schonewille, W. J., Yo, L. S. F., Roos, Y. B. W. E. M., Postma, A. A., Dippel, D. W. J., van Zwam, W. H., van Oostenbrugge, R. J., de Ridder, I. R., & MR CLEAN Registry Investigators (2023). Association between type of intervention center and outcomes after endovascular treatment for acute ischemic stroke: Results from the MR CLEAN Registry. European Stroke Journal, 8(1), 224-230. https://doi.org/10.1177/23969873221145771
    • Kopczak, A., Stringer, M. S., van den Brink, H., Kerkhofs, D., Blair, G. W., van Dinther, M., Onkenhout, L., Wartolowska, K. A., Thrippleton, M. J., Duering, M., Staals, J., Middeke, M., Andre, E., Norrving, B., Bousser, M. G., Mansmann, U., Rothwell, P. M., Doubal, F. N., van Oostenbrugge, R., ... SVDs@Target Investigators (2023). The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial. European Stroke Journal, 8(1), 387-397. https://doi.org/10.1177/23969873221143570
    • Olthuis, S. G. H., den Hartog, S. J., van Kuijk, S. M. J., Staals, J., Benali, F., van der Leij, C., Beumer, D., Nijeholt, G. J. L. A., Uyttenboogaart, M., Martens, J. M., Van Doormaal, P. J., Vos, J. A., Emmer, B. J., Dippel, D. W. J., van Zwam, W. H., van Oostenbrugge, R. J., de Ridder, I. R., & MR CLEAN Registry Investigators (2023). Influence of the interventionist's experience on outcomes of endovascular thrombectomy in acute ischemic stroke: results from the MR CLEAN Registry. Journal of Neurointerventional Surgery, 15(2), 113-119. https://doi.org/10.1136/neurintsurg-2021-018295
    • van Dinther, M., Bennett, J., Thornton, G. D., Voorter, P. H. M., Casajus, A. E., Hughes, A., Captur, G., Holtackers, R. J., Staals, J., Backes, W. H., Bastarika, G., Jones, E. A. V., Gonzalez, A., van Oostenbrugge, R., Treibel, T. A., & CRUCIAL Consortium (2023). Evaluation of miCRovascular rarefaction in vascUlar Cognitive Impairment and heArt faiLure (CRUCIAL): Study protocol for an observational study. Cerebrovascular Diseases Extra, 13(1), 18-32. https://doi.org/10.1159/000529067
  • 2022
    • van der Steen, W., van der Sluijs, P. M., van de Graaf, R. A., Su, R., Wolff, L., van Voorst, H., den Hertog, H. M., van Doormaal, P. J., van Es, A. C. G. M., Staals, J., van Zwam, W., Lingsma, H. F., van den Berg, R., Majoie, C. B. L. M., van der Lugt, A., Dippel, D. W. J., Roozenbeek, B., & MR CLEAN-MED investigators (2022). Safety and efficacy of periprocedural antithrombotics in patients with successful reperfusion after endovascular stroke treatment. Journal of Stroke & Cerebrovascular Diseases, 31(10), Article 106726. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106726
    • van Dinther, M., Voorter, P. H. M., Schram, M. T., Berendschot, T. T. J. M., Houben, A. J. H. M., Webers, C. A. B., van Oostenbrugge, R. J., Backes, W. H., Staals, J., & Jansen, J. F. A. (2022). Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI. Journal of the Neurological Sciences, 440, Article 120359. https://doi.org/10.1016/j.jns.2022.120359
    • Rudilosso, S., Chui, E., Stringer, M. S., Thrippleton, M., Chappell, F., Blair, G., GarcÃa, D. J., Doubal, F., Hamilton, I., Kopczak, A., Ingrish, M., Kerkhofs, D., Backes, W. H., Staals, J., van Oostenbrugge, R., Duering, M., Dichgans, M., Wardlaw, J. M., & SVDs@Target Investigators (2022). Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel Disease. Neurology, 99(5), E440-E452. https://doi.org/10.1212/WNL.0000000000200614
    • Pirson, F. A. V. A., Boodt, N., Brouwer, J., Bruggeman, A. A. E., Hinsenveld, W. H., Staals, J., van Zwam, W. H., van der Leij, C., Brans, R. J. B., Majoie, C. B. L. M., Dippel, D. W. J., van der Lugt, A., Schonewille, W. J., van Oostenbrugge, R. J., & MR CLEAN Registry Investigators (2022). Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry. Stroke, 53(8), 2468-2477. https://doi.org/10.1161/strokeaha.121.038054
    • Karel, M. F. A., Roosen, M. G. C. H., Tullemans, B. M. E., Zhang, C. E., Staals, J., Cosemans, J. M. E. M., & Koenen, R. R. (2022). Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence. Journal of Neuroimmunology, 367, Article 577863. https://doi.org/10.1016/j.jneuroim.2022.577863
    • Verberne, D. P. J., Kroese, M. E. A. L., Staals, J., Ponds, R. W. H. M., & van Heugten, C. M. (2022). Nurse-led stroke aftercare addressing long-term psychosocial outcome: a comparison to care-as-usual. Disability and Rehabilitation, 44(12), 2849-2857. https://doi.org/10.1080/09638288.2020.1849417
    • van Dinther, M., Voorter, P. H. M., Jansen, J. F. A., Jones, E. A. V., van Oostenbrugge, R. J., Staals, J., & Backes, W. H. (2022). Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, 42(5), 718-737. Article 0271678X221076557. https://doi.org/10.1177/0271678X221076557
    • Lo, J. W., Crawford, J. D., Desmond, D. W., Bae, H.-J., Lim, J.-S., Godefroy, O., Roussel, M., Kang, Y., Jahng, S., Köhler, S., Staals, J., Verhey, F., Chen, C., Xu, X., Chong, E. J., Kandiah, N., Yatawara, C., Bordet, R., Dondaine, T., ... Stroke and Cognition (STROKOG) Collaboration (2022). Long-Term Cognitive Decline After Stroke: An Individual Participant Data Meta-Analysis. Stroke, 53(4), 1318-1327. https://doi.org/10.1161/strokeaha.121.035796
    • Schwarz, G., Banerjee, G., Hostettler, I. C., Ambler, G., Seiffge, D. J., Brookes, T. S., Wilson, D., Cohen, H., Yousry, T., Salman, R. A.-S., Lip, G. Y. H., Brown, M. M., Muir, K. W., Houlden, H., Jäger, R., Werring, D. J., Staals, J., & CROMIS-2 investigators (2022). Magnetic resonance imaging-based scores of small vessel diseases: Associations with intracerebral haemorrhage location. Journal of the Neurological Sciences, 434, Article 120165. https://doi.org/10.1016/j.jns.2022.120165
    • van der Steen, W., van de Graaf, R. A., Chalos, V., Lingsma, H. F., van Doormaal, P. J., Coutinho, J. M., Emmer, B. J., de Ridder, I., van Zwam, W., van der Worp, H. B., van der Schaaf, I., Gons, R. A. R., Yo, L. S. F., Boiten, J., van den Wijngaard, I., Hofmeijer, J., Martens, J., Schonewille, W., Vos, J. A., ... MR CLEAN-MED investigators (2022). Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial. Lancet, 399(10329), 1059-1069. https://doi.org/10.1016/S0140-6736(22)00014-9
    • Peeters, M. T. J., Vroman, F., Schreuder, TAHCML., van Oostenbrugge, R. J., & Staals, J. (2022). Decrease in incidence of oral anticoagulant-related intracerebral hemorrhage over the past decade in the Netherlands. European Stroke Journal, 7(1), 20-27. Article 23969873211062011. https://doi.org/10.1177/23969873211062011
    • Pirson, F. A. V., Boodt, N., Brouwer, J., Bruggeman, A. A. E., den Hartog, S. J., Goldhoorn, R.-J. B., Langezaal, L. C. M., Staals, J., van Zwam, W. H., van der Leij, C., Brans, R. J. B., Majoie, C. B. L. M., Coutinho, J. M., Emmer, B. J., Dippel, D. W. J., van der Lugt, A., Vos, J.-A., van Oostenbrugge, R. J., Schonewille, W. J., & MR CLEAN Registry Investigators (2022). Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice: Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry. Stroke, 53(3), 758-768. Article STROKEAHA121034786. https://doi.org/10.1161/strokeaha.121.034786
    • Kremers, F., Venema, E., Duvekot, M., Yo, L., Bokkers, R., Nijeholt, G. L. A., van Es, A., van der Lugt, A., Majoie, C., Burke, J., Roozenbeek, B., Lingsma, H., Dippel, D., MR CLEAN Registry Investigators, van Oostenbrugge, R. J., van Zwam, W., Goldhoorn, R.-J., Hinsenveld, W., & Staals, J. (2022). Outcome Prediction Models for Endovascular Treatment of Ischemic Stroke: Systematic Review and External Validation. Stroke, 53(3), 825-836. https://doi.org/10.1161/STROKEAHA.120.033445
    • van Dinther, M., Schram, M. T., Jansen, J. F. A., Backes, W. H., Houben, A. J. H. M., Berendschot, T. T. J. M., Schalkwijk, C. G., Stehouwer, C. D. A., van Oostenbrugge, R. J., & Staals, J. (2022). Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study. Geroscience, 44(1), 147-157. https://doi.org/10.1007/s11357-021-00493-0
    • Biesbroek, J. M., Weaver, N. A., Aben, H. P., Kuijf, H. J., Abrigo, J., Bae, H.-J., Barbay, M., Best, J. G., Bordet, R., Chappell, F. M., Chen, C. P. L. H., Dondaine, T., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kang, Y., ... Biessels, G. J. (2022). Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke. NeuroImage: Clinical, 34, Article 103018. https://doi.org/10.1016/j.nicl.2022.103018
  • 2021
    • van Meenen, L. C. C., den Hartog, S. J., Groot, A. E., Emmer, B. J., Smeekes, M. D., Siegers, A., Kommer, G. J., Majoie, C. B. L. M., Roos, Y. B. W. E. M., van Es, A. C. G. M., Dippel, D. W., van der Worp, H. B., Lingsma, H. F., Roozenbeek, B., Coutinho, J. M., MR CLEAN Registry Investigators, van Oostenbrugge, R. J., van Zwam, W., Hinsenveld, W., ... Postma - Jacobi, L. (2021). Relationship between primary stroke center volume and time to endovascular thrombectomy in acute ischemic stroke. European Journal of Neurology, 28(12), 4031-4038. https://doi.org/10.1111/ene.15107
    • Schreuder, F. H. B. M., van Nieuwenhuizen, K. M., Hofmeijer, J., Vermeer, S. E., Kerkhoff, H., Zock, E., Luijckx, G. J., Messchendorp, G. P., van Tuijl, J., Bienfait, H. P., Booij, S. J., van den Wijngaard, I. R., Remmers, M. J. M., Schreuder, A. H. C. M. L., Dippel, D. W., Staals, J., Brouwers, P. J. A. M., Wermer, M. J. H., Coutinho, J. M., ... APACHE-AF Trial Investigators (2021). Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF): a randomised, open-label, phase 2 trial. Lancet Neurology, 20(11), 907-916. https://doi.org/10.1016/S1474-4422(21)00298-2
    • Samuels, N., van de Graaf, R. A., van den Berg, C. A. L., Venema, S. M. U., Bala, K., van Doormaal, P. J., van der Steen, W., Witvoet, E., Boiten, J., den Hertog, H., Schonewille, W. J., Hofmeijer, J., Schreuder, F., Schreuder, T. A. H. C. M. L., van der Worp, H. B., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Burke, J. F., van Es, A. C. G. M., ... Postma - Jacobi, L. (2021). Blood Pressure in the First 6 Hours Following Endovascular Treatment for Ischemic Stroke Is Associated With Outcome. Stroke, 52(11), 3514-3522. https://doi.org/10.1161/STROKEAHA.120.033657
    • Verberne, D. P. J., Ponds, R. W. H. M., Kroese, M. E. A. L., Wijenberg, M. L. M., Barten, D. G., Pasmans, R., Staals, J., & van Heugten, C. M. (2021). Correction to: Long-term psychosocial outcome following mild traumatic brain injury and minor stroke: a direct longitudinal comparison. Journal of Neurology, 268(11), 4404-4405. https://doi.org/10.1007/s00415-021-10741-0
    • Benali, F., van der Leij, C., Staals, J., & van Zwam, W. H. (2021). Use of heparinized saline flush during endovascular thrombectomy for acute ischemic stroke; a survey of clinical practice in the Netherlands. CVIR Endovascular, 4(1), Article 76. https://doi.org/10.1186/s42155-021-00264-0
    • Kerkhofs, D., Wong, S. M., Zhang, E., Uiterwijk, R., Hoff, E. I., Jansen, J. F. A., Staals, J., Backes, W. H., & van Oostenbrugge, R. J. (2021). Blood-brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study. Geroscience, 43(4), 1643-1652. https://doi.org/10.1007/s11357-021-00399-x