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Professorship Julie Staals

Professorship Julie Staals

22 April 2024

Dr Julie Staals (Dept. of Neurology) has been appointed as professor 'Neurovascular disease' as of 1 April 2024.

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ERC Advanced Grant awarded to Prof. Andy Baker

ERC Advanced Grant awarded to Prof. Andy Baker

15 April 2024

Prof. Andy Baker (Dept of Pathology) has been awarded a European Research Council (ERC) Advanced Grant of €2,5M for his research project PolymiRize: Poly-miRNA targeting to prevent and reverse complex tissue remodelling after acute cardiovascular events'.

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Carim Maastricht
Carim Maastricht

Julie Staals

Professor

Prof.  Julie Staals is working as a clinical neurologist at Maastricht UMC+. Her specialisation is neurovascular diseases. She has obtained her medical degree at Maastricht University. Afterwards, she did a parallel tract in neurology training and PhD research project, both were finished in 2009. In 2013 she did a short research fellowship at the Brain Research Imaging Center in Edinburgh, UK. Her research focus is on clinical studies in cerebral small vessel disease, mainly the effects of hypertension, the rol of endothelial function, blood-brain barrier and the neurovascular unit, advanced imaging, and the cognitive consequences of this disease. She developed the ‘total SVD score’, a highly cited score for MRI severity of cerebral small vessel disease. Other clinical research topics are intracerebral haemorrhage and acute stroke treatments.

Julie Staals  has been appointed as professor 'Neurovascular disease' as of 1 April 2024. Julie is neurologist at Maastricht UMC+ and leader of the stroke clinic. Her research aims at unravelling the pathophysiology of cerebral small vessel disease, a common ageing-related disease leading to stroke and dementia, which falls within the research programs of both CARIM and MHeNS. Furthermore she is involved in clinical studies on the very successfull acute endovascular stroke treatment. The inaugural lecture will follow later.

She is currently involved in:
SVDs@target, a EU Horizon2020 multicenter project on mechanisms in cerebral small vessel disease (www.svds-at-target.eu)

CRUCIAL, a EU Horizon2020 multicenter project on microvascular rarefaction in vascular cognitive impairment and heart failure (www.crucial-project.eu)

MRCLEAN trials, acute clinical stroke trials aiming at improving outcome in endovascular treatment (www.contrast-consortium.nl)

 

Julie-staals

Department of Neurology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2018
    • Tsivgoulis, G., Wilson, D., Katsanos, A. H., Sargento-Freitas, J., Marques-Matos, C., Azevedo, E., Adachi, T., Brelie, C., Aizawa, Y., Abe, H., Tomita, H., Okumura, K., Hagii, J., Seiffge, D. J., Lioutas, V.-A., Traenka, C., Varelas, P., Basir, G., Krogias, C., ... Werring, D. J. (2018). Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage. Annals of Neurology, 84(5), 694-704. https://doi.org/10.1002/ana.25342
    • Dickie, D. A., Hernandez, M. D. C. V., Makin, S. D., Staals, J., Wiseman, S. J., Bastin, M. E., & Wardlaw, J. M. (2018). The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury. International journal of stroke, 13(8), 849-856. https://doi.org/10.1177/1747493018770222
    • Uiterwijk, R., Staals, J., Huijts, M., van Kuijk, S. M. J., de Leeuw, P. W., Kroon, A. A., & van Oostenbrugge, R. J. (2018). Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension. Journal of Clinical Hypertension, 20(10), 1458-1463. https://doi.org/10.1111/jch.13372
    • Douven, E., Aalten, P., Staals, J., Schievink, S. H. J., van Oostenbrugge, R. J., Verhey, F. R. J., & Kohler, S. (2018). Co-occurrence of depressive symptoms and executive dysfunction after stroke: associations with brain pathology and prognosis. Journal of Neurology Neurosurgery and Psychiatry, 89(8), 859-865. https://doi.org/10.1136/jnnp-2017-317548
    • Douven, E., Staals, J., Schievink, S. H. J., van Oostenbrugge, R. J., Verhey, F. R. J., Wetzels-Meertens, S., Kohler, S., & Aalten, P. (2018). Personality traits and course of symptoms of depression and apathy after stroke: Results of the CASPER study. Journal of Psychosomatic Research, 111, 69-75. https://doi.org/10.1016/j.jpsychores.2018.05.010
    • Autar, A. S. A., Hund, H. M., Ramlal, S. A., Hansen, D., Nijeholt, G. J. L. A., Emmer, B. J., de Maat, M. P. M., Dippel, D. W. J., van der Lugt, A., van Es, A. C. G. M., van Beusekom, H. M. M., MR CLEAN Registry Investigators, Goldhoorn, R.-J., Staals, J., Postma - Jacobi, L., van Oostenbrugge, R. J., & van Zwam, W. (2018). High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke. Journal of the American Heart Association, 7(13), Article 008563. https://doi.org/10.1161/JAHA.118.008563
    • Loos, C. M. J., Staals, J., & Wardlaw, J. M. (2018). Response by Loos et al to Letter Regarding Article, "Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging". Stroke, 49(7), E269-E269. https://doi.org/10.1161/STROKEAHA.118.021876
    • Loos, C. M. J., McHutchison, C., Cvoro, V., Makin, S. D. J., Staals, J., Chappell, F., Dennis, M. S., van Oostenbrugge, R. J., & Wardlaw, J. M. (2018). The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke. International journal of stroke, 13(5), 518-524. https://doi.org/10.1177/1747493017730780
    • Makin, S. D. J., Doubal, F. N., Shuler, K., Chappell, F. M., Staals, J., Dennis, M. S., & Wardlaw, J. M. (2018). The impact of early-life intelligence quotient on post stroke cognitive impairment. European Stroke Journal, 3(2), 145-156. https://doi.org/10.1177/2396987317750517
    • Loos, C. M. J., Makin, S. D. J., Staals, J., Dennis, M. S., van Oostenbrugge, R. J., & Wardlaw, J. M. (2018). Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging. Stroke, 49(5), 1183–1188. https://doi.org/10.1161/STROKEAHA.117.020495
    • Jansen, I. G. H., Mulder, M. J. H. L., Goldhoorn, R.-J. B., Emmer, B. J., van Es, A. C. G. M., Roozenbeek, B., Schonewille, W. J., van den Berg, R., Coutinho, J. M., Staals, J., Postma, A. A., Lycklama, G. J., Hofmeijer, J., Martens, J. M., den Hertog, H. M., Sturm, F. J. C., van der Worp, H. B., Lo, R. H., Heijboer, R. J. J., ... MR CLEAN Registry Investigators (2018). Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry). BMJ, 360, Article 949. https://doi.org/10.1136/bmj.k949
    • Douven, E., Kohler, S., Schievink, S. H. J., van Oostenbrugge, R. J., Staals, J., Verhey, F. R. J., & Aalten, P. (2018). Baseline Vascular Cognitive Impairment Predicts the Course of Apathetic Symptoms After Stroke: The CASPER Study. American Journal of Geriatric Psychiatry, 26(3), 291-300. https://doi.org/10.1016/j.jagp.2017.09.022
    • Houben, R., Schreuder, F. H. B. M., Bekelaar, K. J., Claessens, D., van Oostenbrugge, R. J., & Staals, J. (2018). Predicting Prognosis of Intracerebral Hemorrhage (ICH): Performance of ICH Score Is Not Improved by Adding Oral Anticoagulant Use. Frontiers in Neurology, 9, Article 100. https://doi.org/10.3389/fneur.2018.00100
    • Uiterwijk, R., Staals, J., Huijts, M., de Leeuw, P. W., Kroon, A. A., & van Oostenbrugge, R. J. (2018). Framingham Stroke Risk Profile is related to cerebral small vessel disease progression and lower cognitive performance in patients with hypertension. Journal of Clinical Hypertension, 20(2), 240-245. https://doi.org/10.1111/jch.13175
    • Wong, S. M., Backes, W. H., Zhang, C. E., Staals, J., van Oostenbrugge, R. J., Jeukens, C. R. L. P. N., & Jansen, J. F. A. (2018). On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease. American Journal of Neuroradiology, 39(2), 226-231. https://doi.org/10.3174/ajnr.A5474
  • 2017
    • Makin, S. D. J., Mubki, G. F., Doubal, F. N., Shuler, K., Staals, J., Dennis, M. S., & Wardlaw, J. M. (2017). Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review. Journal of Stroke & Cerebrovascular Diseases, 26(12), 3020-3028. https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.08.004
    • Di Napoli, M., Behrouz, R., Topel, C. H., Misra, V., Pomero, F., Giraudo, A., Pennati, P., Masotti, L., Schreuder, F. H. B. M., Staals, J., Klijn, C. J. M., Smith, C. J., Parry-Jones, A. R., Slevin, M. A., Silver, B., Willey, J. Z., Azarpazhooh, M. R., Vallejo, J. M., Nzwalo, H., ... MNEMONICH Investigators (2017). Hypoalbuminemia, systemic inflammatory response syndrome, and functional outcome in intracerebral hemorrhage. Journal of Critical Care, 41, 247-253. https://doi.org/10.1016/j.jcrc.2017.06.002
    • Wardlaw, J. M., Chappell, F. M., Hernandez, M. D. C. V., Makin, S. D. J., Staals, J., Shuler, K., Thrippleton, M. J., Armitage, P. A., Munoz-Maniega, S., Heye, A. K., Sakka, E., & Dennis, M. S. (2017). White matter hyperintensity reduction and outcomes after minor stroke. Neurology, 89(10), 1003-1010. https://doi.org/10.1212/WNL.0000000000004328
    • Douven, E., Kohler, S., Rodriguez, M. M. F., Staals, J., Verhey, F. R. J., & Aalten, P. (2017). Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis. Neuropsychology Review, 27(3), 202-219. https://doi.org/10.1007/s11065-017-9356-2
    • Claessens, D., Bekelaar, K., Schreuder, F. H. B. M., de Greef, B. T. A., Vlooswijk, M. C. G., Staals, J., van Oostenbrugge, R. J., & Rouhl, R. P. W. (2017). Mortality after primary intracerebral hemorrhage in relation to post-stroke seizures. Journal of Neurology, 264(9), 1885-1891. https://doi.org/10.1007/s00415-017-8573-1
    • Wong, S. M., Jansen, J. F. A., Zhang, C. E., Staals, J., Hofman, P. A. M., van Oostenbrugge, R. J., Jeukens, C. R. L. P. N., & Backes, W. H. (2017). Measuring subtle leakage of the blood-brain barrier in cerebrovascular disease with DCE-MRI: Test-retest reproducibility and its influencing factors. Journal of Magnetic Resonance Imaging, 46(1), 159-166. https://doi.org/10.1002/jmri.25540
    • Mulder, M. J. H. L., Berkhemer, O. A., Fransen, P. S. S., van den Berg, L. A., Lingsma, H. F., den Hertog, H. M., Staals, J., Jenniskens, S. F. M., van Oostenbrugge, R. J., van Zwam, W. H., Majoie, C. B. L. M., van der Lugt, A., Dippel, D. W. J., & MR CLEAN Investigators (2017). Does prior antiplatelet treatment improve functional outcome after intra-arterial treatment for acute ischemic stroke?International journal of stroke, 12(4), 368-376. https://doi.org/10.1177/1747493016677842
    • Uiterwijk, R., Staals, J., Huijts, M., de Leeuw, P. W., Kroon, A. A., & van Oostenbrugge, R. J. (2017). MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension. Journal of Hypertension, 35(6), 1263-1270. https://doi.org/10.1097/HJH.0000000000001294
    • Wilson, D., Seiffge, D. J., Traenka, C., Basir, G., Purrucker, J. C., Rizos, T., Sobowale, O. A., Sallinen, H., Yeh, S.-J., Wu, T. Y., Ferrigno, M., Houben, R., Schreuder, F. H. B. M., Perry, L. A., Tanaka, J., Boulanger, M., Salman, R. A.-S., Jaeger, H. R., Ambler, G., ... CROMIS-2 Collaborators (2017). Outcome of intracerebral hemorrhage associated with different oral anticoagulants. Neurology, 88(18), 1693-1700. https://doi.org/10.1212/WNL.0000000000003886
    • Cleutjens, F. A. H. M., Ponds, R. W. H. M., Spruit, M. A., Burgmans, S., Jacobs, H. I. L., Gronenschild, E. H. B. M., Staals, J., Franssen, F. M. E., Dijkstra, J. B., Vanfleteren, L. E. G. W., Hofman, P. A., Wouters, E. F. M., & Janssen, D. J. A. (2017). The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study. Frontiers in Aging Neuroscience, 9, Article 88. https://doi.org/10.3389/fnagi.2017.00088
    • Zhang, C. E., Wong, S. M., Uiterwijk, R., Staals, J., Backes, W. H., Hoff, E. I., Schreuder, T., Jeukens, C. R. L. P. N., Jansen, J. F. A., & van Oostenbrugge, R. J. (2017). Intravoxel Incoherent Motion Imaging in Small Vessel Disease Microstructural Integrity and Microvascular Perfusion Related to Cognition. Stroke, 48(3), 658-663. https://doi.org/10.1161/STROKEAHA.116.015084
    • Zhang, C. E., Wong, S. M., van de Haar, H. J., Staals, J., Jansen, J. F. A., Jeukens, C. R. L. P. N., Hofman, P. A. M., van Oostenbrugge, R. J., & Backes, W. H. (2017). Blood-brain barrier leakage is more widespread in patients with cerebral small vessel disease. Neurology, 88(5), 426-432. https://doi.org/10.1212/WNL.0000000000003556
    • Pinter, D., Ritchie, S. J., Doubal, F., Gattringer, T., Morris, Z., Bastin, M. E., Hernandez, M. D. C. V., Royle, N. A., Corley, J., Maniega, S. M., Pattie, A., Dickie, D. A., Staals, J., Gow, A. J., Starr, J. M., Deary, I. J., Enzinger, C., Fazekas, F., & Wardlaw, J. (2017). Impact of small vessel disease in the brain on gait and balance. Scientific Reports, 7, Article 41637. https://doi.org/10.1038/srep41637
    • Haeren, R. H. L., Vink, H., Staals, J., van Zandvoort, M. A. M. J., Dings, J., van Overbeeke, J. J., Hoogland, G., Rijkers, K., & Schijns, O. E. M. G. (2017). Protocol for intraoperative assessment of the human cerebrovascular glycocalyx. BMJ Open, 7(1), Article 013954. https://doi.org/10.1136/bmjopen-2016-013954
    • Wong, S. M., Zhang, C. E., van Bussel, F. C. G., Staals, J., Jeukens, C. R. L. P. N., Hofman, P. A. M., van Oostenbrugge, R. J., Backes, W. H., & Jansen, J. F. A. (2017). Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging. NeuroImage: Clinical, 14, 216-221. https://doi.org/10.1016/j.nicl.2017.01.017
    • Douven, E., Kohler, S., Schievink, S. H. J., van Oostenbrugge, R. J., Staals, J., Verhey, F. RJ., & Aalten, P. (2017). Temporal Associations between Fatigue, Depression, and Apathy after Stroke: Results of the Cognition and Affect after Stroke, a Prospective Evaluation of Risks Study. Cerebrovascular Diseases, 44(5-6), 330-337. https://doi.org/10.1159/000481577
  • 2016
    • Uiterwijk, R., van Oostenbrugge, R. J., Huijts, M., De Leeuw, P. W., Kroon, A. A., & Staals, J. (2016). Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension. Frontiers in Aging Neuroscience, 8, Article 301. https://doi.org/10.3389/fnagi.2016.00301
    • Field, T. S., Doubal, F. N., Johnson, W., Backhouse, E., McHutchison, C., Cox, S., Corley, J., Pattie, A., Gow, A. J., Shenkin, S., Cvoro, V., Morris, Z., Staals, J., Bastin, M., Deary, I. J., & Wardlaw, J. M. (2016). Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936. Aging, 8(9), 2039-2061. https://doi.org/10.18632/aging.101043
    • van Overbeek, E. C., Staals, J., & van Oostenbrugge, R. J. (2016). Decreased kidney function relates to progression of cerebral microbleeds in lacunar stroke patients. International journal of stroke, 11(6), 695-700. https://doi.org/10.1177/1747493016641966
    • Douven, E., Schievink, S. H. J., Verhey, F. R. J., van Oostenbrugge, R. J., Aalten, P., Staals, J., & Köhler, S. (2016). The Cognition and Affect after Stroke - a Prospective Evaluation of Risks (CASPER) study: rationale and design. BMC Neurology, 16, Article 65. https://doi.org/10.1186/s12883-016-0588-1
    • Frusch, K. J. M., Houben, R., Schreuder, F. H. B. M., Postma - Jacobi, L., & Staals, J. (2016). Association between eye position on brain scan and hospital mortality in acute intracerebral hemorrhage. European Journal of Neurology, 23(4), 831-835. https://doi.org/10.1111/ene.12951
    • Uiterwijk, R., Huijts, M., Staals, J., Rouhl, R. P. W., De Leeuw, P. W., Kroon, A. A., & Van Oostenbrugge, R. J. (2016). Endothelial Activation Is Associated With Cognitive Performance in Patients With Hypertension. American Journal of Hypertension, 29(4), 464-469. https://doi.org/10.1093/ajh/hpv122
    • van Overbeek, E. C., Staals, J., Knottnerus, I. L. H., ten Cate, H., & van Oostenbrugge, R. J. (2016). Plasma tPA-Activity and Progression of Cerebral White Matter Hyperintensities in Lacunar Stroke Patients. PLOS ONE, 11(3), Article e0150740. https://doi.org/10.1371/journal.pone.0150740
    • Fransen, P. S. S., Berkhemer, O. A., Lingsma, H. F., Beumer, D., van den Berg, L. A., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2016). Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke A Randomized Clinical Trial. JAMA Neurology, 73(2), 190-196. https://doi.org/10.1001/jamaneurol.2015.3886
  • 2015
    • Staals, J., Booth, T., Morris, Z., Bastin, M. E., Gow, A. J., Corley, J., Redmond, P., Starr, J. M., Deary, I. J., & Wardlaw, J. M. (2015). Total MRI load of cerebral small vessel disease and cognitive ability in older people. Neurobiology of Aging, 36(10), 2806-2811. https://doi.org/10.1016/j.neurobiolaging.2015.06.024
    • Loos, C. M. J., Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients. PLOS ONE, 10(9), Article e0137323. https://doi.org/10.1371/journal.pone.0137323
    • Parry-Jones, A. R., Di Napoli, M., Goldstein, J. N., Schreuder, F. H. B. M., Tetri, S., Tatlisumak, T., Yan, B., van Nieuwenhuizen, K. M., Dequatre-Ponchelle, N., Lee-Archer, M., Horstmann, S., Wilson, D., Pomero, F., Masotti, L., Lerpiniere, C., Godoy, D. A., Cohen, A. S., Houben, R., Al-Shahi Salman, R., ... Meretoja, A. (2015). Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage. Annals of Neurology, 78(1), 54-62. https://doi.org/10.1002/ana.24416
    • Klarenbeek, P., van Oostenbrugge, R. J., & Staals, J. (2015). Ambulatory Arterial Stiffness Index Is Not Associated With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Lacunar Stroke Patients. Journal of Clinical Hypertension, 17(5), 352-356. https://doi.org/10.1111/jch.12504
    • Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., van Walderveen, M. A. A., Staals, J., Hofmeijer, J., van Oostayen, J. A., Nijeholt, G. J. L. A., Boiten, J., Brouwer, P. A., Emmer, B. J., de Bruijn, S. F., ... Dippel, D. W. J. (2015). A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke. New England Journal of Medicine, 372(1), 11-20. https://doi.org/10.1056/NEJMoa1411587
  • 2014
    • Staals, J., Makin, S. D. J., Doubal, F. N., Dennis, M. S., & Wardlaw, J. M. (2014). Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology, 83(14), 1228-1234. https://doi.org/10.1212/WNL.0000000000000837
    • Uiterwijk, R., Huijts, M., Staals, J., Duits, A., Gronenschild, E., Kroon, A. A., de Leeuw, P. W., & van Oostenbrugge, R. J. (2014). Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds. Hypertension, 64(3), 653-657. https://doi.org/10.1161/HYPERTENSIONAHA.114.03621
    • van Dooren, M., Staals, J., de Leeuw, P. W., Kroon, A. A., Henskens, L. H., & van Oostenbrugge, R. J. (2014). Progression of Brain Microbleeds in Essential Hypertensive Patients: A 2-Year Follow-up Study. American Journal of Hypertension, 27(8), 1045-1051. https://doi.org/10.1093/ajh/hpu032
    • Schols, A. M. R., Schreuder, F. H. B. M., van Raak, E. P. M., Schreuder, T. H. C. M. L., Rooyer, F. A., van Oostenbrugge, R. J., & Staals, J. (2014). Incidence of Oral Anticoagulant-Associated Intracerebral Hemorrhage in the Netherlands. Stroke, 45(1), 268-270. https://doi.org/10.1161/STROKEAHA.113.003003
    • Huijts, M., Duits, A., Staals, J., Kroon, A. A., de Leeuw, P. W., & van Oostenbrugge, R. J. (2014). Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease. Current Neurovascular Research, 11(2), 136-141. https://doi.org/10.2174/1567202611666140310102248
  • 2013
    • Huijts, M., Duits, A., van Oostenbrugge, R. J., Kroon, A. A., de Leeuw, P. W., & Staals, J. (2013). Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study in first-ever lacunar stroke and hypertensive patients. Frontiers in Aging Neuroscience, 5, Article 72. https://doi.org/10.3389/fnagi.2013.00072
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