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Uyên Châu Nguyên wins UM Dissertation Prize 2025

Uyên Châu Nguyên wins UM Dissertation Prize 2025

29 January 2026

During the Dies Natalis of Maastricht University, Uyên Châu Nguyên received the UM Dissertation Prize 2025.

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Global research network launched to study menopause and heart health

Global research network launched to study menopause and heart health

20 January 2026

Ten international health research funders, including the Dutch Heart Foundation, are investing $10 million in a new global research network to improve early prevention of cardiovascular disease in women. The initiative focuses on understanding how menopause affects heart health and how early intervention can reduce risk.

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Carim Maastricht
Carim Maastricht

Erik Biessen

Professor

Prof. Erik Biessen graduated with specialisations in Physical and Bio-Chemistry at Wageningen University. After a series of post-doctoral fellowships at Leiden University, in the labs of Prof. Van Boom (Organic Chemistry; glycolipid synthesis) and Prof. Van Berkel (Biopharmaceutics; drug/gene targeting), he was in 1994, selected as one of 6 post-docs the Molecular Cardiology programme (a competitive 12 year career development track of the Netherlands Heart Foundation. In 2001, he received the NWO innovative research premium incentive (Vidi) and in 2003 the NHS Established Investigator award, to be appointed Professor of Therapeutic Gene Modulation in 2005. In 2007, he moved to Maastricht University to lead the Experimental Vascular Pathology group. Prof Biessen has a part time appointment at the Institute for Molecular Cardiovascular Research, RWTH Aachen.

Erik Biessen’s current passion is to deploy systems medicine approaches, to understand and define critical innate immune pathways in human atherosclerosis and cardiometabolic comorbidities and to validate the relevance of these processes for disease progression by intervention studies in in vitro and in vivo models. Hereto, the group has developed a new high content microscopy based functionomics platform to measure macrophage functional profile at unprecedented resolution and speed and a technology pipeline for spatial mapping of macrophage phenotype and molecular context. Keywords of his research: systems medicine, bioinformatics, multispectral analysis, macrophage biology. Dr Biessen is partner of several H2020-ITN (EvolUtion, INTRICARE, CareSyan), and two Interreg programmes and is coordinator of H2020/ERA-CVD project (AtheroMacHete).

Erik-biessen

Department of Pathology
Verheylaan 10, 6229 HX Maastricht
Room number: 5M01.032
T: +31(0)43 387 46 35

  • 2021
    • Merlin, J., Ivanov, S., Dumont, A., Sergushichev, A., Gall, J., Stunault, M., Ayrault, M., Vaillant, N., Castiglione, A., Swain, A., Orange, F., Gallerand, A., Berton, T., Martin, J.-C., Carobbio, S., Masson, J., Gaisler-Salomon, I., Maechler, P., Rayport, S., ... Yvan-Charvet, L. (2021). Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation. Nature Metabolism, 3(10), 1313-1326. https://doi.org/10.1038/s42255-021-00471-y
    • Saar-Kovrov, V., Zidek, W., Orth-Alampour, S., Fliser, D., Jankowski, V., Biessen, E. A. L., & Jankowski, J. (2021). Reduction of protein-bound uraemic toxins in plasma of chronic renal failure patients: A systematic review. Journal of Internal Medicine, 290(3), 499-526. https://doi.org/10.1111/joim.13248
    • Jaminon, A. M. G., Akbulut, A. C., Rapp, N., Kramann, R., Biessen, E. A. L., Temmerman, L., Mees, B., Brandenburg, V., Dzhanaev, R., Jahnen-Dechent, W., Floege, J., Uitto, J., Reutelingsperger, C. P., & Schurgers, L. J. (2021). Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity. Cells, 10(8), Article 2097. https://doi.org/10.3390/cells10082097
    • Tillie, R. J. H. A., Theelen, T. L., van Kuijk, K., Temmerman, L., de Bruijn, J., Gijbels, M., Betsholtz, C., Biessen, E. A. L., & Sluimer, J. C. (2021). A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis. Cells, 10(7), Article 1746. https://doi.org/10.3390/cells10071746
    • Jin, H., Goossens, P., Juhasz, P., Eijgelaar, W.-J., Manca, M., Karel, J., Smirnov, E., Sikkink, C. J. J. M., Mees, B., Waring, O., van Kuijk, K., Fazzi, G., Gijbels, M., Kutmon, M., Evelo, C., Hedin, U., Daemen, M. J., Sluimer, J., Matic, L. P., & Biessen, E. (2021). Integrative multiomics analysis of human atherosclerosis reveals a serum response factor-driven network associated with intraplaque hemorrhage. Clinical and Translational Medicine, 11(6), Article e458. https://doi.org/10.1002/ctm2.458
    • Sluimer, J. C., & Biessen, E. A. L. (2021). Arterial lymphangiogenesis ReSPONDINg 2 a new cue: the R-spondin2/LRG4 axis limits VEGFR3-mediated lymphangiogenesis and reverse cholesterol transport. Cardiovascular Research, 117(6), 1417-1419. https://doi.org/10.1093/cvr/cvab050
    • Seime, T., Akbulut, A. C., Liljeqvist, M. L., Siika, A., Jin, H., Winski, G., van Gorp, R. H., Karlöf, E., Lengquist, M., Buckler, A. J., Kronqvist, M., Waring, O. J., Lindeman, J. H. N., Biessen, E. A. L., Maegdefessel, L., Razuvaev, A., Schurgers, L. J., Hedin, U., & Matic, L. (2021). Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification. Cells, 10(6), Article 1276. https://doi.org/10.3390/cells10061276
    • Sundararaman, S. S., Peters, L. J. F., Jansen, Y., Gencer, S., Yan, Y., Nazir, S., Marquez, A. B., Kahles, F., Lehrke, M., Biessen, E. A. L., Jankowski, J., Weber, C., Doering, Y., & van der Vorst, E. P. C. (2021). Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice. Scientific Reports, 11(1), Article 10409. https://doi.org/10.1038/s41598-021-89893-y
    • Demandt, J. A. F., van Kuijk, K., Theelen, T. L., Marsch, E., Heffron, S. P., Fisher, E. A., Carmeliet, P., Biessen, E. A. L., & Sluimer, J. C. (2021). Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice. Frontiers in Cell and Developmental Biology, 9, Article 664258. https://doi.org/10.3389/fcell.2021.664258
    • Quiles-Jimenez, A., Gregersen, I., Segers, F. M., Skarpengland, T., Kroustallaki, P., Yang, K., Kong, X. Y., Lauritzen, K. H., Olsen, M. B., Karlsen, T. R., Nyman, T. A., Sagen, E. L., Bjerkeli, V., Suganthan, R., Nygard, S., Scheffler, K., Prins, J., Van der Veer, E., Ogaard, J. D. S., ... Halvorsen, B. (2021). DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis, 324, 123-132. https://doi.org/10.1016/j.atherosclerosis.2021.02.023
    • Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J., ... LifeTime Community Working Groups (2021). Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine. Nature, 592(7852), E8-E8. https://doi.org/10.1038/s41586-021-03287-8
    • Demandt, J. A. F., Dubois, L. J., van Kuijk, K., Zat'ovicova, M., Jin, H., Parkkila, S., van der Laan, S. W., Jelenska, L., Mees, B. M. E., Reutelingsperger, C. P. M., Cleutjens, K. B. J. M., van der Kallen, C. J. H., Schalkwijk, C. G., van Greevenbroek, M. M. J., Biessen, E. A. L., Pasterkamp, G., Pastorekova, S., Stehouwer, C. D. A., & Sluimer, J. C. (2021). The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease. Scientific Reports, 11(1), Article 425. https://doi.org/10.1038/s41598-020-79978-5
  • 2020
    • van Geffen, J. P., Swieringa, F., van Kuijk, K., Tullemans, B. M. E., Solari, F. A., Peng, B., Clemetson, K. J., Farndale, R. W., Dubois, L. J., Sickmann, A., Zahedi, R. P., Ahrends, R., Biessen, E. A. L., Sluimer, J. C., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2020). Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome. Scientific Reports, 10(1), Article 21407. https://doi.org/10.1038/s41598-020-78522-9
    • Chteinberg, E., Wetzels, S., Gerritsen, W., Temmerman, L., van den Oord, J., Biessen, E., Kurz, A. K., Winnepenninckx, V., Zenke, M., Speel, E.-J., & Hausen, A. Z. (2020). Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro. Therapeutic Advances in Medical Oncology, 12, Article 1758835920975621. https://doi.org/10.1177/1758835920975621
    • Furmanik, M., Chatrou, M., van Gorp, R., Akbulut, A., Willems, B., Schmidt, H., van Eys, G., Bochaton-Piallat, M.-L., Proudfoot, D., Biessen, E., Hedin, U., Perisic, L., Mees, B., Shanahan, C., Reutelingsperger, C., & Schurgers, L. (2020). Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification. Circulation Research, 127(7), 911-927. https://doi.org/10.1161/CIRCRESAHA.119.316159
    • Cao, J., Goossens, P., Martin-Lorenzo, M., Dewez, F., Claes, B. S. R., Biessen, E. A. L., Heeren, R. M. A., & Balluff, B. (2020). Atheroma-Specific Lipids in ldlr(-/-) and apoe(-/-) Mice Using 2D and 3D Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Journal of the American Society for Mass Spectrometry, 31(9), 1825-1832. https://doi.org/10.1021/jasms.0c00070
    • Peters, L. J. F., Floege, J., Biessen, E. A. L., Jankowski, J., & van der Vorst, E. P. C. (2020). MicroRNAs in Chronic Kidney Disease: Four Candidates for Clinical Application. International journal of molecular sciences, 21(18), Article 6547. https://doi.org/10.3390/ijms21186547
    • Zhang, H., Bredewold, E. O. W., Vreeken, D., Duijs, J. M. G. J., de Boer, H. C., Kraaijeveld, A. O., Jukema, J. W., Pijls, N. H., Waltenberger, J., Biessen, E. A. L., van der Veer, E. P., van Zonneveld, A. J., & van Gils, J. M. (2020). Prediction Power on Cardiovascular Disease of Neuroimmune Guidance Cues Expression by Peripheral Blood Monocytes Determined by Machine-Learning Methods. International journal of molecular sciences, 21(17), Article 6364. https://doi.org/10.3390/ijms21176364
    • Kerkhofs, D., van Hagen, B. T., Milanova, I. V., Schell, K. J., van Essen, H., Wijnands, E., Goossens, P., Blankesteijn, W. M., Unger, T., Prickaerts, J., Biessen, E. A., van Oostenbrugge, R. J., & Foulquier, S. (2020). Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension. Theranostics, 10(21), 9512-9527. https://doi.org/10.7150/thno.44394
    • Peters, L. J. F., Biessen, E. A. L., Hohl, M., Weber, C., van der Vorst, E. P. C., & Santovito, D. (2020). Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease. Frontiers in physiology, 11, Article 793. https://doi.org/10.3389/fphys.2020.00793
    • Legein, B., Janssen, E. M., Theelen, T., Gijbels, M., Walraven, J., Klarquist, J. S., Hennies, C. M., Wouters, K., Seijkens, T., Wijnands, E., Sluimer, J., Lutgens, E., Zenke, M., Hildner, K., Biessen, E., & Temmerman, L. (2020). Author Correction: Ablation of CD8α+ dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Scientific Reports, 10(1), Article 8747. https://doi.org/10.1038/s41598-020-65653-2
    • Hung, J., Scanlon, J. P., Mahmoud, A. D., Rodor, J., Ballantyne, M., Fontaine, M. A. C., Temmerman, L., Kaczynski, J., Connor, K. L., Bhushan, R., Biessen, E. A. L., Newby, D. E., Sluimer, J. C., & Baker, A. H. (2020). Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON). Arteriosclerosis Thrombosis and Vascular Biology, 40(3), 697-713. https://doi.org/10.1161/ATVBAHA.119.313430
    • van der Vorst, E. P. C., Daissormont, I., Aslani, M., Seijkens, T., Wijnands, E., Lutgens, E., Duchene, J., Santovito, D., Doering, Y., Halvorsen, B., Aukrust, P., Weber, C., Hoepken, U. E., & Biessen, E. A. L. (2020). Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development. Thrombosis and Haemostasis, 120(2), 344-347. https://doi.org/10.1055/s-0039-3400746
    • van der Vorst, E. P. C., Biessen, E. A. L., & Donners, M. M. P. C. (2020). Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arteriosclerosis Thrombosis and Vascular Biology, 40(2), E31-E32. https://doi.org/10.1161/atvbaha.119.313725
    • Giamouridis, D., Gao, M. H., Lai, N. C., Guo, T., Miyanohara, A., Blankesteijn, W. M., Biessen, E. A. L., & Hammond, H. K. (2020). Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice. Molecular Therapy, 28(1), 180-188. https://doi.org/10.1016/j.ymthe.2019.10.003
    • Wetzels - van Hooijdonk, S., Bijnen, M., Wijnands, E., van de Gaar, M. J., Tan, A., Coort, S., Biessen, E., Schalkwijk, C., & Wouters, K. (2020). CD11c−MHC2low Macrophages Are a New Inflammatory and Dynamic Subset in Murine Adipose Tissue. Immunometabolism, 2(2), Article e200015. https://doi.org/10.20900/immunometab20200015
  • 2019
    • Donners, M. M. P. C., & Biessen, E. A. L. (2019). SCRIBbling the role of endothelial polarity in atherosclerosis. Cardiovascular Research, 115(14), 1937-1939. https://doi.org/10.1093/cvr/cvz171
    • Fontaine, M. A. C., Westra, M. M., Bot, I., Jin, H., Franssen, A. J. P. M., Bot, M., de Jager, S. C. A., Dzhagalov, I., He, Y.-W., van Vlijmen, B. J. M., Gijbels, M. J. J., Reutelingsperger, C. P., van Berkel, T. J. C., Sluimer, J. C., Temmerman, L., & Biessen, E. A. L. (2019). Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells. Scientific Reports, 9(1), Article 14547. https://doi.org/10.1038/s41598-019-51020-3
    • Montserrat-de la Paz, S., Naranjo, M. C., Millan-Linares, M. C., Lopez, S., Abia, R., Biessen, E. A. L., Muriana, F. J. G., & Bermudez, B. (2019). Monounsaturated Fatty Acids in a High-Fat Diet and Niacin Protect from White Fat Dysfunction in the Metabolic Syndrome. Molecular Nutrition & Food Research, 63(19), Article 1900425. https://doi.org/10.1002/mnfr.201900425
    • Korporaal, S. J. A., Molenaar, T. J. M., Lutters, B. C. H., Meurs, I., Drost-Verhoef, S., Kuiper, J., van Berkel, T. J. C., & Biessen, E. A. L. (2019). Peptide Antagonists for P-selectin Discriminate between Sulfatide-Dependent Platelet Aggregation and PSGL-1-Mediated Cell Adhesion. Journal of Clinical Medicine, 8(8), Article 1266. https://doi.org/10.3390/jcm8081266
    • Jin, H., Goossens, P., Karel, J., Daemen, M., Sluimer, J., & Biessen, E. (2019). Integrative Multi-Omics Analysis Of Human Atherosclerosis Reveals An Intraplaque Bleeding Associated Network, Which Offers Better Prediction Of Disease Stage. Atherosclerosis, 287, e63-e63. Article EAS19-0625. https://doi.org/10.1016/j.atherosclerosis.2019.06.180
    • Van Kuijk, K., Theelen, T., Demandt, J., Marsch, E., Gijbels, M., Jin, H., Reutelingsperger, C., Cosemans, J., Schurgers, L., Carmeliet, P., Biessen, E., Daemen, M., & Sluimer, J. (2019). MYELOID PHD2 KNOCKDOWN DRIVES MACROPHAGE APOPTOSIS AND PARACRINE FIBROBLAST/SMOOTH MUSCLE CELL COLLAGEN SECRETION LEADING TO ATHEROSCLEROTIC PLAQUE FIBROSIS. Atherosclerosis, 287, E10-E10. https://doi.org/10.1016/j.atherosclerosis.2019.06.027
    • Giamouridis, D., Gao, M. H., Lai, N. C., Tan, Z., Kim, Y. C., Guo, T., Miyanohara, A., Blankesteijn, M. W., Biessen, E. A. L., & Hammond, H. K. (2019). Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart. Human Gene Therapy, 30(1), 10-20. https://doi.org/10.1089/hum.2018.103
  • 2018
    • Bijnen, M., Beelen, N., Wetzels, S., van De Gaar, J., Vroomen, M., Wijnands, E., Scheijen, J. L., van de Waarenburg, M. P. H., Gijbels, M. J., Cleutjens, J. P., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2018). RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr(-/-) mice. Scientific Reports, 8(1), Article 15256. https://doi.org/10.1038/s41598-018-33661-y
    • Bijnen, M., Josefs, T., Cuijpers, I., Maalsen, C. J., van de Gaar, J., Vroomen, M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2018). Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice. Gut, 67(7), 1317-1327. https://doi.org/10.1136/gutjnl-2016-313654
    • Wetzels, S., Bijnen, M., Wijnands, E., Biessen, E. A. L., Schalkwijk, C. G., & Wouters, K. (2018). Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry. Journal of visualized experiment, (133), Article e57319 . https://doi.org/10.3791/57319
    • Maracle, C. X., Agca, R., Helder, B., Meeuwsen, J. A. L., Niessen, H. W. M., Biessen, E. A. L., de Winther, M. P. J., de Jager, S. C. A., Nurmohamed, M. T., & Tas, S. W. (2018). Noncanonical NF-kappa B signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction. Atherosclerosis, 270, 33-41. https://doi.org/10.1016/j.atherosclerosis.2018.01.032
    • Giamouridis, D., Gao, M., Lai, N. C., Tan, Z., Kim, B. C., Guo, T., Miyanohara, A., Blankesteijn, M., Biessen, E., & Hammond, H. K. (2018). Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC: Basic to Translational Science, 3(2), 249-264. https://doi.org/10.1016/j.jacbts.2017.12.004
  • 2017
    • Nagenborg, J., Goossens, P., Biessen, E. A. L., & Donners, M. M. P. C. (2017). Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment. European Journal of Pharmacology, 816, 14-24. https://doi.org/10.1016/j.ejphar.2017.10.005
    • Kusters, P., Seijkens, T., Buerger, C., Legein, B., Winkels, H., Gijbels, M., Barthels, C., Bennett, R., Beckers, L., Atzler, D., Biessen, E., Brocker, T., Weber, C., Gerdes, N., & Lutgenst, E. (2017). Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. American Journal of Pathology, 187(12), 2912-2919. https://doi.org/10.1016/j.ajpath.2017.08.016
    • Biessen, E. A. L., & Wouters, K. (2017). Macrophage complexity in human atherosclerosis: opportunities for treatment?Current Opinion in Lipidology, 28(5), 419-426. https://doi.org/10.1097/MOL.0000000000000447
    • Theodorou, K., van der Vorst, E. P. C., Gijbels, M. J., Wolfs, I. M. J., Jeurissen, M., Theelen, T. L., Sluimer, J. C., Wijnands, E., Cleutjens, J. P., Li, Y., Jansen, Y., Weber, C., Ludwig, A., Bentzon, J. F., Bartsch, J. W., Biessen, E. A. L., & Donners, M. M. P. C. (2017). Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Scientific Reports, 7(1), Article 11670. https://doi.org/10.1038/s41598-017-10549-x
    • Gajjala, P. R., Jankowski, V., Heinze, G., Bilo, G., Zanchetti, A., Noels, H., Liehn, E., Perco, P., Schulz, A., Delles, C., Kork, F., Biessen, E., Narkiewicz, K., Kawecka-Jaszcz, K., Floege, J., Soranna, D., Zidek, W., & Jankowski, J. (2017). Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma. Hypertension, 70(2), 412-419. https://doi.org/10.1161/HYPERTENSIONAHA.116.08906
    • van der Vorst, E. P. C., Theodorou, K., Biessen, E. A. L., & Donners, M. M. P. C. (2017). Disease- or Storage-Associated Structural Modifications Are Unlikely to Explain HDL Pro-inflammatory Effects on Macrophages. Cell Metabolism, 26(1), 4-5. https://doi.org/10.1016/j.cmet.2017.05.017
    • Bucerius, J., Barthel, H., Tiepolt, S., Werner, P., Sluimer, J. C., Wildberger, J. E., Patt, M., Hesse, S., Gertz, H.-J., Biessen, E. A. L., Mottaghy, F. M., & Sabri, O. (2017). Feasibility of in vivo (18)F-florbetaben PET/MR imaging of human carotid amyloid-beta. European Journal of Nuclear Medicine and Molecular Imaging, 44(7), 1119-1128. https://doi.org/10.1007/s00259-017-3651-2
    • Temmerman, L., Westra, M. M., Bot, I., van Vlijmen, B. J. M., Van Bree, N., Bot, M., Habets, K. L. L., Keulers, T. G. H., van der Vlag, J., Cotter, T. G., van Berkel, T. J. C., & Biessen, E. A. L. (2017). Leukocyte Bim deficiency does not impact atherogenesis in ldlr(-/-) mice, despite a pronounced induction of autoimmune inflammation. Scientific Reports, 7(1), Article 3086. https://doi.org/10.1038/s41598-017-02771-4
    • Bermudez, B., Dahl, T. B., Medina, I., Groeneweg, M., Holm, S., Montserrat-de la Paz, S., Rousch, M., Otten, J., Herias, V., Varela, L. M., Ranheim, T., Yndestad, A., Ortega-Gomez, A., Abia, R., Nagy, L., Aukrust, P., Muriana, F. J. G., Halvorsen, B., & Leonardus Biessen, E. A. (2017). Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPAR gamma-Dependent Monocyte Differentiation and Function. Arteriosclerosis Thrombosis and Vascular Biology, 37(6), 1157-1167. https://doi.org/10.1161/ATVBAHA.116.308187
    • Haitjema, S., Meddens, C. A., van der Laan, S. W., Kofink, D., Harakalova, M., Tragante, V., Asl, H. F., van Setten, J., Brandt, M. M., Bis, J. C., O'Donnell, C., Cheng, C., Hoefer, I. E., Waltenberger, J., Biessen, E., Jukema, J. W., Doevendans, P. A. F. M., Nieuwenhuis, E. E. S., Erdmann, J., ... METASTROKE Grp Int Stroke Genetics (2017). Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization. Circulation : Cardiovascular Genetics, 10(2), Article 001664. https://doi.org/10.1161/CIRCGENETICS.116.001664
    • Rademakers, T., van der Vorst, E. P. C., Daissormont, I. T. M. N., Otten, J. J. T., Theodorou, K., Theelen, T. L., Gijbels, M., Anisimov, A., Nurmi, H., Lindeman, J. H. N., Schober, A., Heeneman, S., Alitalo, K., & Biessen, E. A. L. (2017). Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Scientific Reports, 7, Article 45263. https://doi.org/10.1038/srep45263
    • Wouters, K., Gaens, K., Bijnen, M., Verboven, K., Jocken, J., Wetzels, S., Wijnands, E., Hansen, D., van Greevenbroek, M., Duijvestijn, A. M., Biessen, E. A. L., Blaak, E. E., Stehouwer, C. D. A., & Schalkwijk, C. G. (2017). Circulating classical monocytes are associated with CD11c(+) macrophages in human visceral adipose tissue. Scientific Reports, 7, Article 42665. https://doi.org/10.1038/srep42665
Overview