Eline Kooi

Professor

Prof. Eline Kooi obtained a Master degree in Physics (University of Amsterdam, 1995) and a PhD degree in Molecular Physics at the same university (1999). She was trained in Medical Physics, specialisation Radiology, at Maastricht UMC from 1999-2004. Since 2004 she is a registered Medical Physicist at Maastricht UMC+. Presently, she is a Professor of Medical Physics, especially vascular imaging, at the Department of Radiology and Nuclear Medicine within CARIM.

Her research is focussed on sophisticated multi-modality cardiovascular imaging. Her group is at the international forefront of developing and evaluating imaging techniques to study plaque vulnerability. She has focussed on cutting edge imaging of the hallmarks of high-risk plaques in animals and patients. She was the first to demonstrate that plaque inflammation can be visualised in humans. Her group has the unique position of multi-modality imaging of the vessel wall (PET/MRI, ultrasound, CT) in different vascular beds (carotid and coronary arteries, aorta). She has performed numerous MR Spectroscopy studies on lipid metabolism, also in the heart. Recently, she has expanded her research towards cardiac MRI (perfusion MRI, T1 mapping).

She is a leading member of the steering committee of a multi-centre trial to determine the clinical value of plaque imaging (PARISK) and she coordinates plaque imaging within the European Carotid Surgery Trial-2 (ECST-2). She has published >100 scientific publications in international peer-reviewed journals. She has successfully completed supervision of 12 PhD students. Currently, she is supervising 6 PhD students and one post-doc student. She is frequently invited as invited speaker and/or moderator at the leading international conferences in her field. She has received numerous research grants.

Department of Radiology and Nuclear Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H1.328
T: +31(0)43 387 49 11

 

  • 2017
    • van Hoof, R. H. M., Schreuder, F. H. B. M., Nelemans, P., Truijman, M. T. B., van Orshoven, N. P., Schreuder, T. H., Mess, W. H., Heeneman, S., van Oostenbrugge, R. J., Wildberger, J. E., & Kooi, M. E. (2017). Ischemic Stroke Patients Demonstrate Increased Carotid Plaque Microvasculature Compared to (Ocular) Transient Ischemic Attack Patients. Cerebrovascular Diseases, 44(5-6), 297-303. https://doi.org/10.1159/000481146
  • 2016
    • Daemen, M. J. A. P., Ferguson, M. S., Gijsen, F. J. H., Hippe, D. S., Kooi, M. E., Demarco, K., van der Wal, A. C., Yuan, C., & Hatsukami, T. S. (2016). Carotid plaque fissure: An underestimated source of intraplaque hemorrhage. Atherosclerosis, 254, 102-108. https://doi.org/10.1016/j.atherosclerosis.2016.09.069
    • Holtackers, R. J., Spronck, B., Heusinkveld, M. H. G., Crombag, G., op het Roodt, J., Delhaas, T., Kooi, E., Reesink, K. D., & Hermeling, E. (2016). Head orientation should be considered in ultrasound studies on carotid artery distensibility. Journal of Hypertension, 34(8), 1551-1555. https://doi.org/10.1097/HJH.0000000000000985
    • van Hoof, R. H. M., Heeneman, S., Wildberger, J. E., & Kooi, E. (2016). Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature. Current Atherosclerosis Reports, 18(6), Article 33. https://doi.org/10.1007/s11883-016-0583-4
    • Vöö, S., Kwee, R. M., Sluimer, J. C., Schreuder, F. H. B. M., Wierts, R., Bauwens, M., Heeneman, S., Cleutjens, J. P. M., van Oostenbrugge, R. J., Daemen, J.-W. H., Daemen, M. J. A. P., Mottaghy, F. M., & Kooi, E. (2016). Imaging Intraplaque Inflammation in Carotid Atherosclerosis With F-18-Fluorocholine Positron Emission Tomography-Computed Tomography Prospective Study on Vulnerable Atheroma With Immunohistochemical Validation. Circulation-Cardiovascular Imaging, 9(5), Article e004467. https://doi.org/10.1161/CIRCIMAGING.115.004467
    • Schrauwen-Hinderling, V. B., Kooi, E., & Schrauwen, P. (2016). Mitochondrial Function and Diabetes: Consequences for Skeletal and Cardiac Muscle Metabolism. Antioxidants & Redox Signaling, 24(1), 39-51. https://doi.org/10.1089/ars.2015.6291
  • 2015
    • van Haare, J., Kooi, M. E., Vink, H., Post, M. J., van Teeffelen, J. W. G. E., Slenter, J., Munts, C., Cobelens, H., Strijkers, G. J., Koehn, D., & van Bilsen, M. (2015). Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet. Cardiovascular Diabetology, 14(1), Article 150. https://doi.org/10.1186/s12933-015-0312-2
    • van Hoof, R. H. M., Hermeling, E., Truijman, M. T. B., van Oostenbrugge, R. J., Daemen, J. W. H., van der Geest, R. J., van Orshoven, N. P., Schreuder, A. H., Backes, W. H., Daemen, M. J. A. P., Wildberger, J. E., & Kooi, M. E. (2015). Phase-based vascular input function: Improved quantitative DCE-MRI of atherosclerotic plaques. Medical Physics, 42(8), 4619-4628. https://doi.org/10.1118/1.4924949
  • 2007
    • Prinzen, L., Miserus, R.-J. J. H. M., Dirksen, A., Hackeng, T. M., Deckers, N., Bitsch, N. J., Megens, R. T. A., Douma, K., Heemskerk, J. W., Kooi, M. E., Frederik, P. M., Slaaf, D. W., van Zandvoort, M. A. M. J., & Reutelingsperger, C. P. M. (2007). Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano Letters, 7(1), 93-100. https://doi.org/10.1021/nl062226r