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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Cécile Jeukens

Assistant Professor

Dr Cécile Jeukens completed her masters Physics degree cum laude in 1999 at the Radboud University Nijmegen after which she obtained her PhD on optical properties of nanostructures in 2005 at the same university. From 2004 to 2006, she was a postdoctoral researcher at the Radiotherapy department of UMC Utrecht on the topic of dynamic contrast enhanced MR and CT of prostate cancer. After her residency to become a medical physicist (Elkerliek hospital Helmond, 2006-2010), she worked as a medical physicist at the department of Radiology and Nuclear Medicine from 2010 until present.

As a medical physicist her focus is on x-ray equipment, supervisor of the medical physicist residents and  education. Also, she is the radiation protection expert of the hospital with specialty x-rays, manager of the radiation protection officers and head of the dosimetry center. As a researcher her focus is on in computed tomography (CT) and mammography and she collaborates with researchers locally as well as nationally and internationally.

The use of ionising radiation for medical imaging leads to the exposure of patients and staff members to potentially harmful radiation. Her research aims to prevent these adverse effects by optimising the benefit/risk-ratio of medical imaging, in particular in photon counting detector computed tomography (CT) and mammography. Opportunities for risk reduction arise from assessing the actual radiation exposure of patients and staff members, whereas innovation and optimisation of imaging techniques leads to increased benefits.

For CT, her approach is using big data analysis both in a local and international setting to gain insight how to improve CT-protocols with respect to the balance between image quality and radiation exposure. She has developed software to assess subjective image quality more reliably and to automatically assess the objective image quality of clinical CT-examinations. Next steps involve large scale image quality monitoring for optimisation studies and quality control purposes.

In mammography, she has great expertise on an innovative imaging technique called Contrast-Enhanced Mammography (CEM) implemented at the MUMC+ as early as 2013. It is important that the quality of CEM images in general is constant and reliable, for which she has developed a vendor neutral quality program using a new phantom developed by her, and additionally she is working on using AI for quality monitoring on clinical images.

2024 jeukens cecile 10023290 beeldvorming

Department of Radiology and Nuclear Medicine 
P.Debyelaan 25, 6229 HX Maastricht
Telephone work: 043 387 5893 / 4910

  • 2026
    • Jeukens, C. R. L. P. N., Martens, B., Vandewall, J., Jasper, S., Schrijnemaekers, G., Wildberger, J. E., & Flohr, T. G. (2026). A Practical Rule-of-Thumb to Adapt Contrast Media Dose in Photon-counting Detector CT. Investigative Radiology, 61(8), 527-536. https://doi.org/10.1097/RLI.0000000000001253
    • Croes, G. O., Nijholt, I. M., Boomsma, M. F., Bleeker, G., Greuter, M. J. W., Jeukens, C. R. L. P. N., van Pul, C., Siegersma, J. E., Streekstra, G. J., Vegter, A., Dam-Vervloet, A. J., & Dutch Association of Medical Specialists PiDRL task force (2026). Correction: Diagnostic reference level curves for paediatric fluoroscopic imaging in the Netherlands (sept, 10.1007/s00330-025-11643-9, 2025). European Radiology, 36(6), 5218. https://doi.org/10.1007/s00330-025-12216-6
    • Springer, S., Martens, B., Flohr, T., & Jeukens, C. (2026). Phantom-derived method for improving accurate material decomposition in photon-counting detector CT. European Radiology Experimental, 10(1), Article 39. https://doi.org/10.1186/s41747-026-00705-2
    • Nijssen, E. C., Martens, B., Hendriks, B. M., Gietema, H. A., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2026). Computed tomography pulmonary angiography in around-the-clock clinical care with individualised scan protocols: a 5-year observational study on incidence and causes of repeat scanning. European Radiology, 36(4), 3216-3226. https://doi.org/10.1007/s00330-025-12032-y
    • Stammen, L., Hoeijmakers, E. J. I., Flohr, T. G., Gietema, H. A., Vandewall, J., Wildberger, J. E., Jeukens, C. R. L. P. N., & Martens, B. (2026). Reducing contrast media dosage for pulmonary embolism CTPA in PCD-CT: a comparative study of EID-CT and PCD-CT in the era of individualized protocolling. European Radiology, 36(4), 3206-3215. https://doi.org/10.1007/s00330-025-12054-6
    • Lustermans, D., Fonseca, G. P., Vilches-Freixas, G., Rinaldi, I., Hoeijmakers, E., Jeukens, C. R., Parodi, K., Landry, G., Taasti, V. T., & Verhaegen, F. (2026). Evaluation of proton range differences in photon-counting and dual-energy computed tomography across imaging doses and anthropomorphic phantom sizes. Physics in Medicine and Biology, 71(6), Article 065008. https://doi.org/10.1088/1361-6560/ae50c8
    • Dutch Association of Medical Specialists PiDRL task force (2026). Diagnostic reference level curves for paediatric fluoroscopic imaging in the Netherlands. European Radiology, 36(3), 2074-2082. https://doi.org/10.1007/s00330-025-11643-9
    • van de Water, W., Jeukens, C. R. L. P. N., Antonello, M., Dubosq-Lebaz, M., Hamdi, S., Hazenberg, S. C. E. V. B., Lodema, S., Mani, K., Modarai, B., Secemsky, E. A., & D’Oria, M. G. G. (2026). Promising Radiation Reduction Techniques in Endovascular Aortic Interventions: A Multidisciplinary Consensus. European Journal of Vascular and Endovascular Surgery. Advance online publication. https://doi.org/10.1016/j.ejvs.2026.05.033
  • 2025
    • Bos, D., Wang, Y., Stewart, C., Chu, P. W., Luong, J., Haubold, J., Schroeer, B., Zensen, S., Duong, P.-A. T., Schindera, S., Jeukens, C. R. L. P. N., Das, M., Einstein, A. J., Cervantes, L., & Smith-Bindman, R. (2025). Diagnostic reference levels for indication-based CT categories in pediatric CT: data from an international registry. European Radiology, 35(12), 7985-7999. https://doi.org/10.1007/s00330-025-11724-9
    • Lustermans, D., Fonseca, G. P., Jeukens, C., Taasti, V. T., Parodi, K., Landry, G., & Verhaegen, F. (2025). Assessing quantitative material characteristics with low dose imaging in photon-counting and dual-energy computed tomography for radiotherapy. Physics in Medicine and Biology, 70(22), Article 225008. https://doi.org/10.1088/1361-6560/ae128c
    • Hoeijmakers, E. J. I., Martens, B., Wildberger, J. E., Flohr, T. G., & Jeukens, C. R. L. P. N. (2025). Objective assessment of diagnostic image quality in CT scans: what radiologists and researchers need to know. Insights into Imaging, 16(1), Article 154. https://doi.org/10.1186/s13244-025-02037-y
    • Lustermans, D., Fonseca, G. P., Jeukens, C. R., Taasti, V. T., Parodi, K., Landry, G., & Verhaegen, F. (2025). Evaluating photon-counting computed tomography for quantitative material characteristics and material differentiation in radiotherapy. Physics in Medicine and Biology, 70(10), Article 105013. https://doi.org/10.1088/1361-6560/add3ba
  • 2024
    • Di Maria, S., van Nijnatten, T. J. A., Jeukens, C. R. L. P. N., Vedantham, S., Dietzel, M., & Vaz, P. (2024). Understanding the risk of ionizing radiation in breast imaging: Concepts and quantities, clinical importance, and future directions. European Journal of Radiology, 181, Article 111784. https://doi.org/10.1016/j.ejrad.2024.111784
    • Hoeijmakers, E. J. I., Stammen, L., Wildberger, J. E., Eijsvoogel, N. G., Hersbach, J. M., Pernot, J. C. J. G., Flohr, T. G., Martens, B., & Jeukens, C. R. L. P. N. (2024). PCD-CT enables contrast media reduction in abdominal imaging compared to an individualized kV-adapted contrast media injection protocol on EID-CT. European Journal of Radiology, 179, Article 111680. https://doi.org/10.1016/j.ejrad.2024.111680
    • Hoeijmakers, E. J. I., Hoenen, K., Bauwens, M., Eekers, D. B. P., Jeukens, C. R. L. P. N., & Wierts, R. (2024). Dose rate conversion coefficients for ocular contamination in nuclear medicine: A Monte Carlo simulation with experimental validation. Medical Physics, 51(8), 5645-5653. https://doi.org/10.1002/mp.17073
    • Hoeijmakers, E. J. I., Martens, B., Hendriks, B. M. F., Mihl, C., Miclea, R. L., Backes, W. H., Wildberger, J. E., Zijta, F. M., Gietema, H. A., Nelemans, P. J., & Jeukens, C. R. L. P. N. (2024). How subjective CT image quality assessment becomes surprisingly reliable: pairwise comparisons instead of Likert scale. European Radiology, 34(7), 4494-4503. https://doi.org/10.1007/s00330-023-10493-7
    • Smith-Bindman, R., Kang, T., Chu, P. W., Wang, Y., Stewart, C., Das, M., Duong, P. A., Cervantes, L., Lamba, R., Lee, R. K., MacLeod, F., Kasraie, N., Neill, R., Pike, P., Roehm, J., Schindera, S., Chung, R., Delman, B. N., Jeukens, C. R. L. P. N., ... Szczykutowicz, T. P. (2024). Large variation in radiation dose for routine abdomen CT: reasons for excess and easy tips for reduction. European Radiology, 34(4), 2394-2404. https://doi.org/10.1007/s00330-023-10076-6
  • 2023
    • Jeukens, C. R. L. P. N., Brauer, M. T. H., Mihl, C., Laupman, E., Nijssen, E. C., Wildberger, J. E., Martens, B., & van Pul, C. (2023). A New Algorithm for Automatically Calculating Noise, Spatial Resolution, and Contrast Image Quality Metrics: Proof-of-Concept and Agreement With Subjective Scores in Phantom and Clinical Abdominal CT. Investigative Radiology, 58(9), 649-655. https://doi.org/10.1097/RLI.0000000000000954
  • 2022
    • Bos, D., Yu, S. I., Luong, J., Chu, P. L., Wang, Y. F., Einstein, A. J., Starkey, J., Delman, B. N., Duong, P. A. T., Das, M., Schindera, S., Goode, A. R., MacLeod, F., Wetter, A., Neill, R., Lee, R. K., Roehm, J., Seibert, J. A., Cervantes, L. F., ... Smith-Bindman, R. (2022). Diagnostic reference levels and median doses for common clinical indications of CT: findings from an international registry. European Radiology, 32(3), 1971-1982. https://doi.org/10.1007/s00330-021-08266-1
    • Martens, B., Wildberger, J. E., Van Kuijk, S. M. J., De Vos-Geelen, J., Jeukens, C. R. L. P. N., & Mihl, C. (2022). Influence of Contrast Material Temperature on Patient Comfort and Image Quality in Computed Tomography of the Abdomen: A Randomized Controlled Trial. Investigative Radiology, 57(2), 85-89. https://doi.org/10.1097/RLI.0000000000000807
    • Martens, B., Bosschee, J. G. A., Van Kuijk, S. M. J., Jeukens, C. R. L. P. N., Brauer, M. T. H., Wildberger, J. E., & Mihl, C. (2022). Finding the optimal tube current and iterative reconstruction strength in liver imaging; two needles in one haystack. PLOS ONE, 17(4), Article e0266194. https://doi.org/10.1371/journal.pone.0266194
  • 2021
    • Jeukens, C. R. L. P. N., Boere, H., Wagemans, B. A. J. M., Nelemans, P. J., Nijssen, E. C., Smith-Bindman, R., Wildberger, J. E., & Sailer, A. M. (2021). Probability of receiving a high cumulative radiation dose and primary clinical indication of CT examinations: a 5-year observational cohort study. BMJ Open, 11(1), Article e041883. https://doi.org/10.1136/bmjopen-2020-041883
  • 2020
    • Smith-Bindman, R., Chu, P., Wang, Y., Chung, R., Lopez-Solano, N., Einstein, A. J., Solberg, L., Cervantes, L. F., Yellen-Nelson, T., Boswell, W., Delman, B. N., Duong, P.-A., Goode, A. R., Kasraie, N., Lee, R. K., Neill, R., Pahwa, A., Pike, P., Roehm, J., ... Miglioretti, D. (2020). Comparison of the Effectiveness of Single-Component and Multicomponent Interventions for Reducing Radiation Doses in Patients Undergoing Computed Tomography A Randomized Clinical Trial. JAMA Internal Medicine, 180(5), 666-675. https://doi.org/10.1001/jamainternmed.2020.0064
    • Jeukens, C. R. L. P. N., Kutterer, G., Kicken, P. J., Frantzen, M. J., van Engelshoven, J. M. A., Wildberger, J. E., & Kemerink, G. J. (2020). Gonad shielding in pelvic radiography: modern optimised X-ray systems might allow its discontinuation. Insights into Imaging, 11(1), Article 15. https://doi.org/10.1186/s13244-019-0828-1
  • 2019
    • Lobbes, M. B., Hecker, J., Houben, I. P. L., Pluymakers, R., Jeukens, C., Laji, U. C., Gommers, S., Wildberger, J. E., & Nelemans, P. J. (2019). Evaluation of single-view contrast-enhanced mammography as novel reading strategy: a non-inferiority feasibility study. European Radiology, 29(11), 6211-6219. https://doi.org/10.1007/s00330-019-06215-7
    • Jeukens, C. R. L. P. N., van Dijk, T., Berben, C., Wildberger, J. E., & Lobbes, M. B. I. (2019). Evaluation of pressure-controlled mammography compression paddles with respect to force-controlled compression paddles in clinical practice. European Radiology, 29(5), 2545-2552. https://doi.org/10.1007/s00330-018-5953-6
    • Sailer, A. M., Paulis, L., Vergoossen, L., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2019). Optimizing Staff Dose in Fluoroscopy-Guided Interventions by Comparing Clinical Data with Phantom Experiments. Journal of Vascular and Interventional Radiology, 30(5), 701-708.e1. https://doi.org/10.1016/j.jvir.2018.11.019
    • Zhang, C. E., Wong, S. M., Uiterwijk, R., Backes, W. H., Jansen, J. F. A., Jeukens, C. R. L. P. N., van Oostenbrugge, R. J., & Staals, J. (2019). Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging. Brain Imaging and Behavior, 13(2), 389-395. https://doi.org/10.1007/s11682-018-9855-7
    • Hendriks, B. M. F., Schnerr, R. S., Milanese, G., Jeukens, C. R. L. P. N., Niesen, S., Eijsvoogel, N. G., Wildberger, J. E., & Das, M. (2019). Computed Tomography Pulmonary Angiography during Pregnancy: Radiation Dose of Commonly Used Protocols and the Effect of Scan Length Optimization. Korean Journal of Radiology, 20(2), 313-322. https://doi.org/10.3348/kjr.2017.0779
  • 2018
    • Lobbes, M. B., Mulder, H. K. P., Rousch, M., Backes, W. H., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2018). Quantification of enhancement in contrast-enhanced spectral mammography using a custom-made quantifier tool (I-STRIP): A proof-of-concept study. European Journal of Radiology, 106, 114-121. https://doi.org/10.1016/j.ejrad.2018.07.021
    • Boere, H., Eijsvoogel, N. G., Sailer, A. M., Wildberger, J. E., de Haan, M. W., Das, M., & Jeukens, C. R. L. P. N. (2018). Implementation of Size-Dependent Local Diagnostic Reference Levels for CT Angiography. American Journal of Roentgenology, 210(5), W226-W233. https://doi.org/10.2214/AJR.17.18566
    • Wong, S. M., Backes, W. H., Zhang, C. E., Staals, J., van Oostenbrugge, R. J., Jeukens, C. R. L. P. N., & Jansen, J. F. A. (2018). On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease. American Journal of Neuroradiology, 39(2), 226-231. https://doi.org/10.3174/ajnr.A5474
  • 2017
    • Minkels, T. J. M., Jeukens, C. R. L. P. N., Andriessen, P., van der Linden, A. N., Dam, A. J., van Straaten, H. L. M., Cottaar, E. J. E., & van Pul, C. (2017). DOSE EVALUATION FOR DIGITAL X-RAY IMAGING OF PREMATURE NEONATES. Radiation Protection Dosimetry, 177(4), 440-449. https://doi.org/10.1093/rpd/ncx062
    • Sailer, A. M., Vergoossen, L., Paulis, L., van Zwam, W. H., Das, M., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2017). Personalized Feedback on Staff Dose in Fluoroscopy-Guided Interventions: A New Era in Radiation Dose Monitoring. Cardiovascular and Interventional Radiology, 40(11), 1756-1762. https://doi.org/10.1007/s00270-017-1690-5
    • Houben, I. P. L., Van de Voorde, P., Jeukens, C. R. L. P. N., Wildberger, J. E., Kooreman, L. F., Smidt, M. L., & Lobbes, M. B. I. (2017). Contrast-enhanced spectral mammography as work-up tool in patients recalled from breast cancer screening has low risks and might hold clinical benefits. European Journal of Radiology, 94, 31-37. https://doi.org/10.1016/j.ejrad.2017.07.004
    • van de Haar, H. J., Jansen, J. F. A., Jeukens, C. R. L. P. N., Burgmans, S., van Buchem, M. A., Muller, M., Hofman, P. A. M., Verhey, F. R. J., van Osch, M. J. P., & Backes, W. H. (2017). Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI. Medical Physics, 44(8), 4112-4125. https://doi.org/10.1002/mp.12328
    • Wong, S. M., Jansen, J. F. A., Zhang, C. E., Staals, J., Hofman, P. A. M., van Oostenbrugge, R. J., Jeukens, C. R. L. P. N., & Backes, W. H. (2017). Measuring subtle leakage of the blood-brain barrier in cerebrovascular disease with DCE-MRI: Test-retest reproducibility and its influencing factors. Journal of Magnetic Resonance Imaging, 46(1), 159-166. https://doi.org/10.1002/jmri.25540
    • Zhang, C. E., Wong, S. M., Uiterwijk, R., Staals, J., Backes, W. H., Hoff, E. I., Schreuder, T., Jeukens, C. R. L. P. N., Jansen, J. F. A., & van Oostenbrugge, R. J. (2017). Intravoxel Incoherent Motion Imaging in Small Vessel Disease Microstructural Integrity and Microvascular Perfusion Related to Cognition. Stroke, 48(3), 658-663. https://doi.org/10.1161/STROKEAHA.116.015084
    • Schnerr, R. S., de Jong, A. N., Landry, G., Jeukens, C. R. L. P. N., & Wierts, R. (2017). Monte Carlo simulations of ceiling scatter in nuclear medicine: 99mTc, 131I and 18F. Medical Physics, 44(3), 1113-1119. https://doi.org/10.1002/mp.12113
    • Sailer, A. M., Paulis, L., Vergoossen, L., Kovac, A. O., Wijnhoven, G., Schurink, G. W. H., Mees, B., Das, M., Wildberger, J. E., de Haan, M. W., & Jeukens, C. R. L. P. N. (2017). Real-Time Patient and Staff Radiation Dose Monitoring in IR Practice. Cardiovascular and Interventional Radiology, 40(3), 421-429. https://doi.org/10.1007/s00270-016-1526-8
    • Zhang, C. E., Wong, S. M., van de Haar, H. J., Staals, J., Jansen, J. F. A., Jeukens, C. R. L. P. N., Hofman, P. A. M., van Oostenbrugge, R. J., & Backes, W. H. (2017). Blood-brain barrier leakage is more widespread in patients with cerebral small vessel disease. Neurology, 88(5), 426-432. https://doi.org/10.1212/WNL.0000000000003556
    • Wong, S. M., Zhang, C. E., van Bussel, F. C. G., Staals, J., Jeukens, C. R. L. P. N., Hofman, P. A. M., van Oostenbrugge, R. J., Backes, W. H., & Jansen, J. F. A. (2017). Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging. NeuroImage: Clinical, 14, 216-221. https://doi.org/10.1016/j.nicl.2017.01.017
  • 2016
    • Hemmes, B., Jeukens, C. R. L. P. N., Al-Haidari, A., Hofman, P. A. M., van der Linden, E., Brink, P. R. G., & Poeze - van Bokhoven, M. (2016). Effect of spineboard and headblocks on the image quality of head CT scans. Emergency Radiology, 23(3), 263-268. https://doi.org/10.1007/s10140-016-1396-z
    • Kluza, E., Kleijnen, J.-P. J. E., Martens, M. H., Rennspiess, D., Maas, M., Jeukens, C. R. L. P. N., Riedl, R. G., zur Hausen, A., Beets, G. L., & Beets-Tan, R. G. H. (2016). Non-invasive MR assessment of macroscopic and microscopic vascular abnormalities in the rectal tumour-surrounding mesorectum. European Radiology, 26(5), 1311-1319. https://doi.org/10.1007/s00330-015-3955-1
    • Hemmes, B., Jeukens, C., Kemerink, G. J., Brink, P., & Poeze - van Bokhoven, M. (2016). Effect of spinal immobilisation devices on radiation exposure in conventional radiography and computed tomography. Emergency Radiology, 23(2), 147-153. https://doi.org/10.1007/s10140-015-1371-0
  • 2015
    • Bouwman, R. W., van Engen, R. E., Young, K. C., den Heeten, G. J., Broeders, M. J. M., Schopphoven, S., Jeukens, C. R. L. P. N., Veldkamp, W. J. H., & Dance, D. R. (2015). Average glandular dose in digital mammography and digital breast tomosynthesis: comparison of phantom and patient data. Physics in Medicine and Biology, 60(20), 7893-7907. https://doi.org/10.1088/0031-9155/60/20/7893
    • Lalji, U. C., Jeukens, C. R. L. P. N., Houben, I., Nelemans, P. J., van Engen, R. E., van Wylick, E., Beets-Tan, R. G. H., Wildberger, J. E., Paulis, L. E., & Lobbes, M. B. I. (2015). Evaluation of low-energy contrast-enhanced spectral mammography images by comparing them to full-field digital mammography using EUREF image quality criteria. European Radiology, 25(10), 2813-2820. https://doi.org/10.1007/s00330-015-3695-2
    • Paulis, L. E., Lobbes, M. B. I., Lalji, U. C., Gelissen, N., Bouwman, R. W., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2015). Radiation Exposure of Digital Breast Tomosynthesis Using an Antiscatter Grid Compared With Full-Field Digital Mammography. Investigative Radiology, 50(10), 679-685. https://doi.org/10.1097/RLI.0000000000000168
    • Sailer, A. M., Schurink, G. W. H., Bol, M. E., de Haan, M. W., van Zwam, W. H., Wildberger, J. E., & Jeukens, C. R. L. P. N. (2015). Occupational Radiation Exposure During Endovascular Aortic Repair. Cardiovascular and Interventional Radiology, 38(4), 827-832. https://doi.org/10.1007/s00270-014-1025-8
    • Martens, M. H., Subhani, S., Heijnen, L. A., Lambregts, D. M. J., Buijsen, J., Maas, M., Riedl, R. G., Jeukens, C. R. L. P. N., Beets, G. L., Kluza, E., & Beets-Tan, R. G. H. (2015). Can perfusion MRI predict response to preoperative treatment in rectal cancer?Radiotherapy and Oncology, 114(2), 218-223. https://doi.org/10.1016/j.radonc.2014.11.044
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