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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Yannick Nielen

Assistant Professor

Yannick Nielen studied Pharmacy at the University of Groningen and obtained his degree in 2013, following a research internship at the University of Sydney. He subsequently earned his PhD at Maastricht University, conducting research on the relationship between osteoarthritis and diabetes mellitus.

After completing his PhD, he trained as a hospital pharmacist and clinical pharmacologist at Maastricht UMC+ and VieCuri Medical Center. In addition, he completed his epidemiology training in 2025.

Since 2022, Yannick has been working as a hospital pharmacist at Maastricht UMC+, where he combines his clinical responsibilities with scientific research and teaching.

His current research focuses on medication safety, pharmacoepidemiology and data-driven approaches to improving medication use. The focus of his research is the recognition, prevention and management of prescribing cascades. These are situations in which adverse drug reactions are mistaken for new medical conditions and subsequently treated with additional medication. He contributes to projects investigating the real-world occurrence and complexity of prescribing cascades, patient perspectives, and the development and evaluation of tools to support healthcare professionals in identifying and managing these events.In 2026, he obtained ZonMw funding for “Early Detection and Management of Adverse Drug Reactions in Primary Care”, focusing on earlier recognition and reporting of medication-related problems.

An important emerging research line is the use of artificial intelligence and advanced data-driven methods to detect medication-related problems in real-world healthcare data. This includes algorithmic detection of prescribing cascades and the development of approaches for earlier identification of adverse drug reactions and other medication-related problems.

Department of Clinical Pharmacy


  • 2026
    • Spronk, S. H., Nielen, J. T. H., Heier, L., Jessurun, N., Kant, A., & Karapinar-Carkit, F. (2026). Secondary data analysis of Adverse Drug Reactions reported by healthcare professionals and patients: interventions to manage ADRs of ACE inhibitors and ARBs. European Journal of Clinical Pharmacology, 82(6), Article 162. https://doi.org/10.1007/s00228-026-04088-6
    • van der Walle, K., Denig, P., Boerman, T., Magdelijns, F. J. H., Nielen, J. T. H., & Karapinar-Carkit, F. (2026). Creating Awareness of preScribing Cascades and Managing Adverse Drug Effects (CASC-ADE) Tool: Appraisal by Future End Users. Drugs & Aging. Advance online publication. https://doi.org/10.1007/s40266-026-01334-5
  • 2025
    • Werkman, N. C. C., Nielen, J. T. H., Tapia-Galisteo, J., Somolinos-Simon, F. J., Hernando, M. E., Wang, J., Jiu, L., Goettsch, W. G., Bosma, H., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Stehouwer, C. D. A., Driessen, J. H. M., & Garcia-Saez, G. (2025). Prediction of glycaemic control and quality of life in people with type 2 diabetes using glucose-lowering drugs with machine learning-The Maastricht study. Diabetes Obesity & Metabolism, 27(10), 5524-5537. https://doi.org/10.1111/dom.16598
    • Nielen, J. T. H., van der Walle, K., Spronk, S., Magdelijns, F., Denig, P., & Karapinar, F. (2025). Real-World Complexity of Prescribing Cascades. Basic & Clinical Pharmacology & Toxicology, 137(1), Article e70063. https://doi.org/10.1111/bcpt.70063
  • 2024
    • Werkman, N. C. C., Driessen, J. H. M., Klungel, O. H., Schaper, N. S., Souverein, P. C., Stehouwer, C. D. A., & Nielen, J. T. H. (2024). Incretin-based therapy and the risk of diabetic foot ulcers and related events. Diabetes Obesity & Metabolism, 26(9), 3764-3780. https://doi.org/10.1111/dom.15721
    • Werkman, N. C. C., García-Sáez, G., Nielen, J. T. H., Tapia-Galisteo, J., Somolinos-Simón, F. J., Hernando, M. E., Wang, J., Jiu, L., Goettsch, W. G., van der Kallen, C. J. H., Koster, A., Schalkwijk, C. G., de Vries, H., de Vries, N. K., Eussen, S. J. P. M., Driessen, J. H. M., & Stehouwer, C. D. A. (2024). Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study. Diabetologia, 67(4), 690-702. https://doi.org/10.1007/s00125-023-06082-4
  • 2023
    • Werkman, N. C. C., Driessen, J. H. M., Stehouwer, C. D. A., Vestergaard, P., Schaper, N. C., van den Bergh, J. P., & Nielen, J. T. H. (2023). The use of sodium-glucose co-transporter-2 inhibitors or glucagon-like peptide-1 receptor agonists versus sulfonylureas and the risk of lower limb amputations: a nation-wide cohort study. Cardiovascular Diabetology, 22(1), Article 160. https://doi.org/10.1186/s12933-023-01897-2
  • 2022
    • Clemmensen, K. K. B., Koster, A., Nielen, J. T. H., Dagnelie, P. C., Stehouwer, C. D. A., Bosma, H., Wesselius, A., Færch, K., & Eussen, S. J. P. M. (2022). Role of weekday variation on glucose, insulin, and triglyceride: A cross-sectional analysis from The Maastricht Study. Journal of Clinical Endocrinology & Metabolism, 107(8), E3145-E3151. https://doi.org/10.1210/clinem/dgac286
    • Røikjer, J., Werkman, N. C. C., Ejskjaer, N., van den Bergh, J. P. W., Vestergaard, P., Schaper, N. C., Jensen, M. H., Klungel, O., de Vries, F., Nielen, J. T. H., & Driessen, J. H. M. (2022). Incidence, hospitalization and mortality and their changes over time in people with a first ever diabetic foot ulcer. Diabetic Medicine, 39(4), Article e14725. https://doi.org/10.1111/dme.14725
  • 2021
    • van Veelen, A., Nielen, J. T. H., van Geel, R., & Croes, S. (2021). Comment on “Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case–control study from Denmark”. Journal of the American Academy of Dermatology, 85(6), E357-E357. https://doi.org/10.1016/j.jaad.2019.01.087
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