Sébastien Foulquier

Post doc

Dr Sébastien Foulquier studied pharmaceutical sciences at the Faculty of Pharmacy of Nancy, France from 2002 until 2008, where he specialised in R&D. He joined the Cardiovascular division of the Servier Research Institute in Suresnes for his senior internship before graduating with a Pharm.D. thesis awarded as 'Best experimental Pharm.D. thesis'. He pursued his studies with a Master in Cardiovascular physiopathology and pharmacology in Lyon, France and a PhD in Cardiovascular Pharmacology at Nancy University, France. During his PhD, he studied the impact of hypertension and the renin angiotensin system on the structure and function of the cerebral circulation in vivo. He completed his PhD in three years and got awarded with a prize for the best PhD thesis from the Faculty of Pharmacy. He joined Maastricht University in July 2012 as post-doctoral researcher.

Since 2012, he is leading research projects on cerebral small vessel disease, the most common form of Vascular Cognitive Impairment, with a focus on the contribution of vascular risk factors (especially Hypertension) to Blood Brain Barrier dysfunction, Microglial activation and Cognitive dysfunction. He obtained research grants from the European Society of Hypertension and Servier in 2015, from the Young Talent Programme of the Dutch Heart Foundation-CVON 'Heart-Brain Connection' in 2016, from the European Foundation for the Study of Diabetes EFSD-Boehringer Ingelheim in 2018, together with Prof. Casper Schalkwijk and Prof. Robert van Oostenbrugge. He is furthermore involved in two ongoing European projects: H2020-MSCA-ITN-EJD INTRICARE on the pharmacology of vascular calcification, and in H2020-PHC SVD@target on sporadic cerebral small vessel disease. Since July 2018, he is affiliated at both CARIM and MHeNS in Maastricht where he pursues his trans-disciplinary research on Vascular Cognitive Impairment.

Department of Pharmacology & Toxicology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G4.222

  • 2020
    • Reinhold, S., Blankesteijn, W. M., & Foulquier, S. (2020). The Interplay of WNT and PPAR gamma Signaling in Vascular Calcification. Cells, 9(12), [2658]. https://doi.org/10.3390/cells9122658
    • Kerkhofs, D., van Hagen, B. T., Milanova, I. V., Schell, K. J., van Essen, H., Wijnands, E., Goossens, P., Blankesteijn, W. M., Unger, T., Prickaerts, J., Biessen, E. A., van Oostenbrugge, R. J., & Foulquier, S. (2020). Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension. Theranostics, 10(21), 9512-9527. https://doi.org/10.7150/thno.44394
    • Manukjan, N., Ahmed, Z., Fulton, D., Blankesteijn, W. M., & Foulquier, S. (2020). A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions: Potential Relevance to Cerebral Small Vessel Disease. Cells, 9(6), [1545]. https://doi.org/10.3390/cells9061545
    • Foulquier, S. (2020). Brain perivascular macrophages: connecting inflammation to autonomic activity in hypertension. Hypertension Research, 43(2), 148-150. https://doi.org/10.1038/s41440-019-0359-7
  • 2019
    • Koizumi, T., Kerkhofs, D., Mizuno, T., Steinbusch, H. W. M., & Foulquier, S. (2019). Vessel-Associated Immune Cells in Cerebrovascular Diseases: From Perivascular Macrophages to Vessel-Associated Microglia. Frontiers in Neuroscience, 13, [1291]. https://doi.org/10.3389/fnins.2019.01291
    • Foulquier, S., Caolo, V., Swennen, G., Milanova, I., Reinhold, S., Recarti, C., Alenina, N., Bader, M., Steckelings, U. M., Vanmierlo, T., Post, M. J., Jones, E. A., van Oostenbrugge, R. J., & Unger, T. (2019). The role of receptor MAS in microglia-driven retinal vascular development. Angiogenesis, 22(4), 481-489. https://doi.org/10.1007/s10456-019-09671-3
    • Koizumi, T., Taguchi, K., Mizuta, I., Toba, H., Ohigashi, M., Onishi, O., Ikoma, K., Miyata, S., Nakata, T., Tanaka, M., Foulquier, S., Steinbusch, H. W. M., & Mizuno, T. (2019). Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model. Journal of Neuroinflammation, 16, [79]. https://doi.org/10.1186/s12974-019-1467-7
  • 2018
    • Meyer, M., Foulquier, S., Dupuis, F., Flament, S., Grimaud, L., Henrion, D., Lartaud, I., Monard, G., Grillier-Vuissoz, I., & Boisbrun, M. (2018). Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor. European Journal of Medicinal Chemistry, 158, 334-352. https://doi.org/10.1016/j.ejmech.2018.08.082
    • Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M. J., Blankesteijn, W. M., Rutten, B. P., Prickaerts, J., Van Oostenbrugge, R. J., & Unger, T. (2018). Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice. Hypertension Research, 41(10), 817-827. https://doi.org/10.1038/s41440-018-0090-9
    • Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2018). WNT Signaling in Cardiac and Vascular Disease. Pharmacological Reviews, 70(1), 68-141. https://doi.org/10.1124/pr.117.013896