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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Sébastien Foulquier

Assistant Professor

Sébastien Foulquier is Assistant Professor at the Department of Pharmacology & Toxicology of Maastricht University, with a joint affiliation to the cardiovascular (CARIM) and neuroscience (MHeNs) research institutes. He trained as a pharmacist in Nancy, France, and obtained his Master and PhD in cardiovascular pharmacology before joining Maastricht University in 2012.

After eight years as a postdoctoral researcher, he was tenured as Assistant Professor in 2020 and started his own research group. His team studies neurodegeneration of vascular origin, and in particular vascular dementia caused by cerebral small vessel disease. He investigates how cardiometabolic stressors (hypertension, diabetes, obesity and heart failure) compromise the neuro-glio-vascular unit, leading to blood-brain barrier dysfunction, neuroinflammation, white matter injury and cognitive decline. Beyond understanding cSVD pathobiology, the group aims to identify the molecular and cellular targets that could prevent or delay its progression.

His research has been supported by national and European funding, including the Dutch Heart Foundation, the EFSD, and several H2020 and MSCA-ITN consortia, and is conducted in close collaboration with vascular neurology at Maastricht UMC+ and academic partners across Europe.

Sebastien-foulquier

Department of Pharmacology & Toxicology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: G4.222
T: +31(0)43 388 14 09

  • 2026
    • Gijs, M., Liang, L., Goezinne, F., Wang, Y., Foulquier, S., & Nuijts, R. M. M. A. (2026). Introducing the blood-tear barrier: Structure, function, and disruption in ocular surface homeostasis. Progress in Retinal and Eye Research, 114, Article 101492. https://doi.org/10.1016/j.preteyeres.2026.101492
    • van der Taelen, L., Lambrichts, S. M. P., Temmerman, L., El Ajjouri, R., Gijbels, M. J., Bitsch, N., Scheijen, J., van de Waarenburg, M., Kutmon, M., Unger, T., Staals, J., Schalkwijk, C. G., Briones, A. M., van Oostenbrugge, R. J., & Foulquier, S. (2026). Longitudinal Profiling Reveals Divergent Kidney and Brain Immune Responses during Metabolic Syndrome. Aging and Disease. Advance online publication. https://doi.org/10.14336/AD.2026.0557
    • Lambrichts, S. M. P., van der Taelen, L., Pastor, I., Leenders, P., Bitsch, N., Majcher, D., Hermes, D., Simmonds, S. J., van Herwijnen, M., Kamps, R., Weltjens, E., Jessen, P. J. J., Steinbusch, H. P., Arentz, F., Wiesmann, M., Kiliaan, A. J., Caiment, F., Kutmon, M., Jones, E. A., ... Foulquier, S. (2026). Downregulation of Trpv4 and Klf2 in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction. Journal of Cerebral Blood Flow and Metabolism. Advance online publication. https://doi.org/10.1177/0271678X261462714
    • Grzymala, B., Halldorsdottir, D. T., Thorsteinsso, H., Thorfinnsdottir, K., Sveinsdottir, H. S., Parker, M. O., Foulquier, S., & Karlsson, K. AE. (2026). Reinventing amlodipine. Journal of Pharmacology and Experimental Therapeutics, 393(6), Article 104900. https://doi.org/10.1016/j.jpet.2026.104900
    • Berends, E., Eussen, S. J. P. M., Backes, W. H., Dagnelie, P. C., Jansen, J. F. A., Galan, B. E. D., Greevenbroek, M. M. J. V., Kohler, S., Schram, M. T., Wesselius, A., Oostenbrugge, R. J., Foulquier, S., & Schalkwijk, C. G. (2026). Associations between methylglyoxal and cerebral small vessel disease and cognitive function-The Maastricht Study. Journal of Stroke & Cerebrovascular Diseases, 35(3), Article 108578. https://doi.org/10.1016/j.jstrokecerebrovasdis.2026.108578
  • 2025
    • Pencheva, M. G., Berends, E., van der Laan, K. W. F., Giudici, A., Niessen, P., Scheijen, J. L. J. M., Vangrieken, P., Leenders, P., Delhaas, T., Caiment, F., Kutmon, M., Trujillo, F. M., Wouters, K., Foulquier, S., Spronck, B., Reesink, K. D., & Schalkwijk, C. G. (2025). Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice. Cardiovascular Diabetology, 24(1), Article 283. https://doi.org/10.1186/s12933-025-02823-4
    • Van der Taelen, L., Briones, A. M., Unger, T., Staals, J., van Oostenbrugge, R. J., & Foulquier, S. (2025). Circulating immune cells in cerebral small vessel disease: a systematic review. Biogerontology, 26(3), Article 101. https://doi.org/10.1007/s10522-025-10250-x
    • Lambrichts, S. M. P., van Oostenbrugge, R. J., & Foulquier, S. (2025). TRPV4 in Cerebral Small Vessel Disease: A key interacting partner. Vascular Pharmacology, 159, Article 107492. https://doi.org/10.1016/j.vph.2025.107492
    • Berends, E., Vangrieken, P., Amiri, N., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Hermes, D. J. H. P., Wouters, K., van Oostenbrugge, R. J., Schalkwijk, C. G., & Foulquier, S. (2025). Increased Levels of Circulating Methylglyoxal Have No Consequence for Cerebral Microvascular Integrity and Cognitive Function in Young Healthy Mice. Molecular Neurobiology, 62(4), 4190-4202. Article 101148. https://doi.org/10.1007/s12035-024-04552-3
    • Vangrieken, P., Scheijen, J. L. J. M., Schiffers, P. M. H., van de Waarenburg, M. P. H., Foulquier, S., & Schalkwijk, C. C. G. (2025). Modelling the effects of elevated methylglyoxal levels on vascular and metabolic complications. Scientific Reports, 15(1), Article 6025. https://doi.org/10.1038/s41598-025-90661-5
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