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Catheter treatment is not only effective, but also cost-effective for ischemic stroke

Catheter treatment is not only effective, but also cost-effective for ischemic stroke

29 September 2026

With ischemic stroke, every minute counts. However, many patients do not seek hospital care until it is too late, for example, because symptoms are not immediately recognized or because people wake up with signs of neurological deficits. As a result, a group of patients is no longer eligible for catheter treatment. 

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Platelets: more than a band-aid

Platelets: more than a band-aid

23 September 2026

Some processes in our body might seem obvious to us. If you cut your finger, the bleeding will stop shortly and form a scab. Behind that seemingly simple process hides a sophisticated system of platelets and clotting factors. By now, we know that platelets do much more than halt bleeding: they function as information carriers and regulators of disease processes. 

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Carim Maastricht
Carim Maastricht

Sabine Daemen

Post doc

Dr Sabine Daemen obtained her Bachelor and Master degree Biomedical Sciences at Maastricht University. In 2014 she was awarded a NWO NUTRIM graduate grant to studymuscle lipotoxicity in type 2 diabetes as a PhD student in the Department of Nutrition and Movement Sciences under supervision of Prof. Matthijs Hesselink. Using advanced microscopic techniques, her research obtained important insights in how muscle fat contributes to insulin resistance.

After obtaining her PhD in 2019, she moved to the USA to start as a postdoctoral researcher in the lab of Joel Schilling at Washington University in St. Louis. During her postdoctoral research she examined the role of macrophages in metabolic dysfunction-associated steatohepatitis (MASH (formerly NASH)) and was among the first to demonstrate distinct subpopulations of macrophages in murine and human MASH.

In 2022, Sabine was awarded a Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship to return to Maastricht University and continue her research on macrophage subpopulations in MASH in the laboratory of Dr. Kristiaan Wouters. Her research focuses on how adipose tissue inflammation shapes hepatic macrophage differentiation and function, and how these changes contribute to the development and progression of MASH-associated liver fibrosis. To enable in-depth immunophenotyping of immune cells in liver, adipose tissue, and blood, Sabine established a spectral flow cytometry platform within the laboratory.

In 2024 and 2025, she received a Career Development Grant from the Dutch Digestive Foundation (MDL Fonds) and a Veni grant from the Dutch Research Council (NWO), respectively. These projects investigate the reparative and antifibrotic functions of macrophages in MASH-associated liver fibrosis using complementary cell models, mouse models, and human liver biopsies, combined with state-of-the-art technologies including spatial transcriptomics and spectral flow cytometry.

 

 

Sabine daemen 6ab37f28d2370

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H5.326
T: +31(0)43 388 78 18

  • 2026
    • Daemen, S., Adelaar, T. I., Barlampas, P., Zhang, X., Schalkwijk, C. G., & Wouters, K. (2026). Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver. European Journal of Immunology, 56(6), Article e70217. https://doi.org/10.1002/eji.70217
  • 2025
    • Chan, M. M., Daemen, S., Beatty, W., Byrnes, K., Cho, K., Ferguson, D., Feldstein, N., Park, C., Guo, Z., Park, A. C., Fu, C. F., Florczak, K. L., He, L., Yang, B. Q., Javaheri, A., Patti, G. J., Finck, B. N., Razani, B., & Schilling, J. D. (2025). Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation in MASLD. Hepatology communications, 9(12), Article e0853. https://doi.org/10.1097/HC9.0000000000000853
    • Faber, J. G., van Herwijnen, M., Hauser, D., Daemen, S., Caiment, F., & van den Beucken, T. (2025). FOXO3 mediated gene expression modulates doxorubicin sensitivity in human cardiomyocytes. Toxicology, 518, Article 154267. https://doi.org/10.1016/j.tox.2025.154267
  • 2024
    • Chan, M. M., He, L., Finck, B. N., Schilling, J. D., & Daemen, S. (2024). Cutting Edge: Hepatic Stellate Cells Drive the Phenotype of Monocyte-derived Macrophages to Regulate Liver Fibrosis in Metabolic Dysfunction-associated. Journal of Immunology, 213(3), 251-256. https://doi.org/10.4049/jimmunol.2300847
  • 2023
    • Chan, M. M., Daemen, S., Beals, J. W., Terekhova, M., Yang, B. Q., Fu, C. F., He, L., Park, A. C., Smith, G. I., Razani, B., Byrnes, K., Beatty, W. L., Eckhouse, S. R., Eagon, J. C., Ferguson, D., Finck, B. N., Klein, S., Artyomov, M. N., & Schilling, J. D. (2023). Steatosis drives monocyte-derived macrophage accumulation in human metabolic dysfunction-associated fatty liver disease. JHEP Reports, 5(11), Article 100877. https://doi.org/10.1016/j.jhepr.2023.100877
    • Gemmink, A., Daemen, S., Wefers, J., Hansen, J., van Moorsel, D., Astuti, P., Jorgensen, J. A., Kornips, E., Schaart, G., Hoeks, J., Schrauwen, P., & Hesselink, M. K. C. (2023). Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity. Molecular Metabolism, 72(1), Article 101727. https://doi.org/10.1016/j.molmet.2023.101727
  • 2021
    • Daemen, S., van Polanen, N., Bilet, L., Phielix, E., Moonen-Kornips, E., Schrauwen-Hinderling, V. B., Schrauwen, P., & Hesselink, M. K. C. (2021). Postexercise changes in myocellular lipid droplet characteristics of young lean individuals are affected by circulatory nonesterified fatty acids. American Journal of Physiology : Endocrinology and Metabolism, 321(4), E453-E463. https://doi.org/10.1152/ajpendo.00654.2020
    • Gemmink, A., Daemen, S., Brouwers, B., Hoeks, J., Schaart, G., Knoops, K., Schrauwen, P., & Hesselink, M. K. C. (2021). Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1866(2), Article 158852. https://doi.org/10.1016/j.bbalip.2020.158852
    • Houzelle, A., Jorgensen, J. A., Schaart, G., Daemen, S., van Polanen, N., Fealy, C. E., Hesselink, M. K. C., Schrauwen, P., & Hoeks, J. (2021). Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity. Diabetologia, 64(2), 424-436. https://doi.org/10.1007/s00125-020-05335-w
  • 2020
    • Daemen, S., Gemmink, A., Paul, A., Billecke, N., Rieger, K., Parekh, S. H., & Hesselink, M. K. C. (2020). Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes. Diabetologia, 63(12), 2654-2664. https://doi.org/10.1007/s00125-020-05266-6
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