Miranda Schram

Professor

Dr Miranda Schram holds a MSc in Biomedical Sciences (1999) and in Epidemiology (2002). She recieved her PhD entitled 'Patophysiology of diabetic complications, arterial stiffness, endothelial dysfunction and inflammation' at VU University Medical Center in Amsterdam in 2004, and is a registered Epidemiologist B. She has worked as post-doc epidemiologist at Erasmus MC in Rotterdam, at Leiden University Medical Center and as senior investigator at the National Institute for Public Health and the Environment in Bilthoven. From 2008 onwards, she has been working at Maastricht UMC+ as senior investigator at The Maastricht Study.

Miranda Schram is one of the founders of The Maastricht Study, a novel population-based cohort study on type 2 diabetes and its complications. Her scientific work focusses on the etiology and epidemiology of cognitive decline and depression in type 2 diabetes with a specific interest in the role of early vascular dysfunction. A second research line focusses on psychosocial aspects of diabetes, to understand how social networks, but also ethnicity and diabetes distress can affect diabetes treatment and the development of complications. Miranda is board member of The Maastricht Study, coordinator of the Dutch Diabetes Pearlstring Initiative, active member of the PSAD study group of the EASD and involved in the Netherlands Consortium of Demetia Cohorts.

Department of Internal Medicine
Randwycksingel 35, 6229 EG Maastricht
T: +31(0)6 122 64 289

2026
- Dimitropoulou, N. M., Beran, M., Eussen, S. J. P. M., Dingena, C. F., Dagnelie, P. C., Van Der Kallen, C. J. H., Koster, A., Van Greevenbroek, M. M. J., Brouwers, M. C. G. J., Schram, M. T., & de Galan, B. E. (2026). Liver fat content is not elevated in people with type 1 diabetes: the Maastricht Study. Diabetologia, 69(2), 364-373. https://doi.org/10.1007/s00125-025-06597-y
2025
- Soeterboek, J., Deckers, K., Backes, W. H., Jansen, J. F. A., Schram, M. T., Bosma, H., Lakerveld, J., & Kohler, S. (2025). A cross-sectional study on the association between environmental residential noise exposure with cognitive functioning and structural markers of brain damage-The Maastricht study. Environment International, 206, Article 109932. https://doi.org/10.1016/j.envint.2025.109932
- Okoro, C., Zhou, T. L., van der Kallen, C. J. H., Kohler, S., Schram, M. T., & Kroon, A. A. (2025). Lower heart rate variability is associated with worse memory function: The Maastricht Study. Journal of Alzheimer's Disease, 108(4), 1738-1748. https://doi.org/10.1177/13872877251389985
- Mateus, P., Garst, S., Yu, J., Cats, D., Harms, A. G. J., Birhanu, M., Beekman, M., Slagboom, P. E., Reinders, M., van der Grond, J., Dekker, A., Jansen, J. F. A., Beran, M., Schram, M. T., Visser, P. J., Moonen, J., Ghanbari, M., Roshchupkin, G., Vojinovic, D., ... Bron, E. E. (2025). Multi-Cohort Federated Learning Shows Synergy in Mortality Prediction for MRI-Based and Metabolomics-Based Age Scores. Journal of Healthcare Informatics Research, 9(4), 606-628. https://doi.org/10.1007/s41666-025-00208-6
- van der Heide, F. C. T., Steens, I. L. M., Singh-Manoux, A., Sabia, S., Zhou, T. L., Kohler, S., Schram, M. T., van der Kallen, C. J. H., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Arts, I. C. W., Jansen, J. F. A., Backes, W. H., van Sloten, T. T., Blokland, G. A. M., & Stehouwer, C. D. A. (2025). Genetic variation in the glucagon-like peptide-1 receptor protein encoding region is associated with higher heart rate variability, but not with neurodegeneration of the brain, retina, and peripheral nerves: The Maastricht study. Cardiovascular Diabetology, 24(1), Article 397. https://doi.org/10.1186/s12933-025-02888-1
- Werkman, N. C. C., Nielen, J. T. H., Tapia-Galisteo, J., Somolinos-Simon, F. J., Hernando, M. E., Wang, J., Jiu, L., Goettsch, W. G., Bosma, H., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Stehouwer, C. D. A., Driessen, J. H. M., & Garcia-Saez, G. (2025). Prediction of glycaemic control and quality of life in people with type 2 diabetes using glucose-lowering drugs with machine learning-The Maastricht study. Diabetes Obesity & Metabolism, 27(10), 5524-5537. https://doi.org/10.1111/dom.16598
- Sezer, B., Albers, J., Meisters, R., Schram, M., de Galan, B., Elbadawi, S. M. M., Koster, A., & Bosma, H. (2025). The associations of hair glucocorticoids with socioeconomic position and type 2 diabetes: Findings from the Maastricht study. Psychoneuroendocrinology, 181, Article 107589. https://doi.org/10.1016/j.psyneuen.2025.107589
- Steens, I. L. M., Schram, M. T., Houben, A. J. H. M., Berendschot, T. T. J. M., Koster, A., Bosma, H., Eussen, S. J. P. M., de Galan, B. E., & van Sloten, T. T. (2025). Type 2 diabetes and depression via microvascular dysfunction, neurodegeneration, inflammation, advanced glycation end products (AGEs), and arterial stiffness. Diabetes Obesity & Metabolism, 27(9), 4847-4858. Article 16527. https://doi.org/10.1111/dom.16527
- van Baal, T. L., Köhler, S., Koster, A., Meertens, R. M., Bosma, H., Schram, M. T., Jansen, J. F. A., Simons, S. O., de Galan, B. E., Eussen, S. J. P. M., Janssen, N., & Deckers, K. (2025). The association between sleep parameters, cognitive functioning, and markers of brain morphology: The Maastricht Study. Sleep, Article zsaf218. https://doi.org/10.1093/sleep/zsaf218
- Ahaouari, T., Berendsen, B., Schaper, N., Bosma, H., van Greevenbroek, M., de Galan, B., T. Schram, M., Savelberg, H., & Koster, A. (2025). Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device-Measured Physical Activity and Sedentary Behaviour-The Maastricht Study. Diabetes/Metabolism Research and Reviews, 41(5), Article e70069. https://doi.org/10.1002/dmrr.70069

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Miranda Schram

Professor