Miranda Nabben

Assistant Professor

Dr. Miranda Nabben obtained her MSc in Pharmaceutical Sciences (Utrecht University) and PhD in Human Biology (Maastricht University). She performed postdoctoral research at the University of Washington, Seattle, and at Eindhoven University of Technology, before returning to Maastricht University, where she was appointed Assistant Professor in 2019 and since 2025 holds a joint position in Cardiology and Clinical Genetics.

Her research team investigates cardiac substrate metabolism and metabolic remodeling in heart failure, with a particular focus on fuel flexibility, patterns of substrate utilization, and sex-specific mechanisms, aiming to uncover novel therapeutic targets to improve patient outcomes. She has received multiple grants and awards, including the Kootstra Talent Award, VENI fellowship, NWO Off Road Award, and the Dekker Senior Scientist Award from the Dutch Heart Foundation. Current projects focus on cellular regulation of cardiomyocyte metabolism, metabolic changes in cardiomyopathies, and identification of novel drivers of heart failure.

Dr. Nabben actively contributes to national and European research networks, including the DCVA Double Dose consortium and the ERA4Health Cardinnov project. She has been a board member of the International Society for Heart and Vascular Metabolism (SHVM), is board member of CARIM Division Heart, and serves on the editorial boards of Frontiers in Cardiovascular Medicine and the International Journal of Molecular Sciences. She is committed to mentoring young researchers and has supervised multiple PhD students, postdoctoral fellows, and technicians.

  • 2026
    • Glatz, J. F. C., Heather, L. C., Larsen, T. S., Nabben, M., & Luiken, J. J. F. P. (2026). The metabolic balancing act between fatty acid and glucose substrate use for optimal myocardial function: key role for membrane substrate transporters. American Journal of Physiology-heart and Circulatory Physiology, 330(4), H1195-H1207. https://doi.org/10.1152/ajpheart.00868.2025
    • Schianchi, F., Guns, J., Bouwman, F. G., Bogie, J. F. J., Nabben, M., Strzelecka, A., Van Leeuwen, R., Kapsokalyvas, D., Dennis, K. M. J. H., Heather, L. C., Wang, S., Glatz, J. F. C., Neumann, D., & Luiken, J. J. F. P. (2026). Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart. Cellular and Molecular Life Sciences, 83(1), Article 187. https://doi.org/10.1007/s00018-026-06179-0
    • Torfs, T., Veltrop, R. J. A., Lezzoche, G., Heymans, S. R. B., Verdonschot, J. A. J., & Nabben, M. (2026). Metabolic Dysregulation in Laminopathies: Implications for Heart Failure and Cardiac Health. Current Heart Failure Reports, 23(1), Article 6. https://doi.org/10.1007/s11897-025-00735-8
    • Willemars, M. M. A., Sun, A., Wang, S., Simsek Papur, O., Brouns-Strzelecka, A., Van Leeuwen, R., Vanherle, S. J. V., Kapsokalyvas, D., Glatz, J. F. C., Neumann, D., Nabben, M., & Luiken, J. J. F. P. (2026). Phosphatidylinositol 4-Kinase IIIβ: A Therapeutic Target for Contractile Dysfunction in Hypertrophic Cardiomyocytes. International Journal of Molecular Sciences, 27(2), Article 595. https://doi.org/10.3390/ijms27020595
  • 2025
    • Stroeks, S. L. V. M., Merlo, M., Mora-Ayestaran, N., Jason, M., Tayal, U., Wang, P., Cannatà, A., Sikking, M. A., Dal Ferro, M., Peiro, B., Willemars, M., Hellebrekers, D. M. E. I., van Leeuwen, R. E. W., Setti, M., Gonzalez-Lopez, E., Krapels, I. P. C., Pio Loco Detto Gava, C., van den Wijngaard, A., Henkens, M. T. H. M., ... Verdonschot, J. A. J. (2025). Sex Differences in Prognosis of Patients With Genetic Dilated Cardiomyopathy. Circulation-Heart Failure, 18(11), e012592. Article 012592. https://doi.org/10.1161/CIRCHEARTFAILURE.124.012592
    • Wong, L. Y., Torfs, T., Vanherle, S. J. V., Janssen, J., Claes, G. R. F., Stroeks, S. L. V. M., Willemars, M. M. A., Schianchi, F., Kapsokalyvas, D., Weltjens, E., Swinnen, A., Strzelecka, A., Krapels, I. P. C., Heymans, S. R. B., Glatz, J., van den Wijngaard, A., Brunner, H. G., Broers, J., Luiken, J. F. P., ... Nabben, M. (2025). Clinical and metabolic consequences of a historic pathogenic lamin A/C founder variant. Scientific Reports, 15(1), Article 23842. https://doi.org/10.1038/s41598-025-08495-0
    • Michel, L. Y. M., Esfahani, H., De Mulder, D., Verdoy, R., Ambroise, J., Roelants, V., Bouchard, B., Fabian, N., Savary, J., Dewulf, J. P., Doumont, T., Bouzin, C., Haufroid, V., Luiken, J. J. F. P., Nabben, M., Singleton, M. L., Bertrand, L., Ruiz, M., Des Rosiers, C., & Balligand, J.-L. (2025). An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress. Circulation, 151(18), 1312-1328. https://doi.org/10.1161/CIRCULATIONAHA.124.067876
  • 2024
    • Wang, F., Neumann, D., Kapsokalyvas, D., Hoes, M. F., Schianchi, F., Glatz, J. F. C., Nabben, M., & Luiken, J. J. F. P. (2024). Specific Compounds Derived from Traditional Chinese Medicine Ameliorate Lipid-Induced Contractile Dysfunction in Cardiomyocytes. International Journal of Molecular Sciences, 25(15), Article 8131. https://doi.org/10.3390/ijms25158131
    • Wang, S., Han, Y., Liu, R., Hou, M., Neumann, D., Zhang, J., Wang, F., Li, Y., Zhao, X., Schianchi, F., Dai, C., Liu, L., Nabben, M., Glatz, J. F. C., Wu, X., Lu, X., Li, X., & Luiken, J. J. F. P. (2024). Glycolysis-Mediated Activation of v-ATPase by Nicotinamide Mononucleotide Ameliorates Lipid-Induced Cardiomyopathy by Repressing the CD36-TLR4 Axis. Circulation Research, 134(5), 505-525. https://doi.org/10.1161/CIRCRESAHA.123.322910
    • Oberman, K., van Leeuwen, B. L., Nabben, M., Villafranca, J. E., & Schoemaker, R. G. (2024). J147 Affects Cognition And Anxiety After Surgery In Zucker Rats. Physiology & Behavior, 273, Article 114413. https://doi.org/10.1016/j.physbeh.2023.114413