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Social and economic background influences survival in intensive care: Research with societal impact

Social and economic background influences survival in intensive care: Research with societal impact

18 August 2026

A large-scale study by researchers from Maastricht UMC+ and Amsterdam UMC demonstrates that lower socioeconomic status (SES) of patients admitted to Dutch intensive care units contributes to worse survival.

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Fatma Karapinar appointed as Professor in Medication Safety

Fatma Karapinar appointed as Professor in Medication Safety

12 August 2026

As of 1 June 2026, Dr Fatma Karapinar has been appointed Professor of Medication Safety at Maastricht University.

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Carim Maastricht
Carim Maastricht

Martijn Brouwers

Professor

Dr Martijn Brouwers obtained his MD degree (with honours) in 2002, after which he started his PhD project that focused on hepatic steatosis in familial combined hyperlipidemia. In 2006, he worked as a trainee at the Department of Internal Medicine and Endocrinology. Since 2012, he has been a staff member (internist-endocrinologist) at Maastricht UMC+ and in 2019 he was appointed as the head of the division of Endocrinology and Metabolic Disease and in 2025 as leader of the Division Vessels within CARIM. He is the scientific director of The Maastricht Study.  

His research focusses on the cardiometabolic consequences of metabolic dysfunction-associated steatotic liver disease (MASLD), and the role of fructose herein. MASLD consists of a histological spectrum comprising simple steatosis, steatohepatitis, fibrosis and cirrhosis. Evidence is accumulating that MASLD is not only a liver disease per se, it is also a risk factor for type 2 diabetes, chronic kidney disease, poly-endocrine metabolic ovarian syndrome (PMOS, formerly known as PCOS) and cardiovascular disease. This research line aims to elucidate the exact mechanistic link between MASLD and these systemic diseases, and how different sources of dietary fructose affect MASLD and its sequaelae. For this, a diverse set of studies is used, ranging from (genetic) epidemiology, to ‘human knockout’ models, to randomised controlled trials and experimental animal work. This research is in part funded by the Dutch Heart Foundation, the Dutch Diabetes Foundation and the European Foundation for the Study of Diabetes.

Brouwers pasfoto

Department ofInternal Medicine
P. Debeyelaan 25, 6229 HX Maastricht 
PO Box 5800, 6202 AZ Maastricht
T: +31(0)43 388 70 19

  • 2026
    • Buziau, A. M., Simons, N., Tolan, D. R., Caiment, F., Scheijen, J. L. J. M., van de Waarenburg, M. P., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2026). Endogenous fructose production in patients and mice with aldolase B deficiency. Molecular Genetics and Metabolism, 149(1-2), Article 110219. https://doi.org/10.1016/j.ymgme.2026.110219
    • Panis, B., van Golde, R. J. T., Brouwers, M. C. G. J., Körver-Keularts, I. M. L. W., Noga, M. J., & Rubio-Gozalbo, M. E. (2026). Reproductive potential in classical galactosemia: A case series based perspective. European Journal of Obstetrics and Gynecology and Reproductive Biology: X, 31, Article 100470. https://doi.org/10.1016/j.eurox.2026.100470
    • Buziau, A. M., Wesselius, A., Yu, E. Y.-W., Korver-Keularts, I. M. L. W., Visser, D., Steinbusch, L. K. M., Simons, P. I. H. G., van Greevenbroek, M. M. J., Dagnelie, P. C., Kooi, M. E., Eussen, S. J. P. M., Arts, I. C. W., van der Kallen, C. J. H., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2026). Metabolite Erythritol in 24-Hour Urine Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study. Diabetes, 75(5), 762-771. https://doi.org/10.2337/db25-0881
    • Visker, V. P., Kvist, A. V., Vestergaard, P., van den Bergh, J. P., Brouwers, M. C. J. G., Wyers, C. E., & Driessen, J. H. M. (2026). Fracture trends in Denmark from 1997 to 2021. Osteoporosis International, 37(2), 417-424. https://doi.org/10.1007/s00198-025-07746-0
    • Dimitropoulou, N. M., Beran, M., Eussen, S. J. P. M., Dingena, C. F., Dagnelie, P. C., Van Der Kallen, C. J. H., Koster, A., Van Greevenbroek, M. M. J., Brouwers, M. C. G. J., Schram, M. T., & de Galan, B. E. (2026). Liver fat content is not elevated in people with type 1 diabetes: the Maastricht Study. Diabetologia, 69(2), 364-373. https://doi.org/10.1007/s00125-025-06597-y
  • 2025
    • van Oeteren, M. A. J., De Groot, D. M., Buziau, A. M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Kroon, A. A., Eussen, S. J. P. M., Dagnelie, P. C., Van Greevenbroek, M. M. J., Houben, A. J. H. M., Meex, S. J. R., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2025). The effects of dietary fructose on blood pressure are modified by the food matrix. Clinical Nutrition, 55, 134-140. https://doi.org/10.1016/j.clnu.2025.10.017
    • Brouwers, M. C. G. J., Klop, B., Ribalta, J., & Cabezas, M. C. (2025). Familial Combined Hyperlipidemia: Myth or Reality?Current Atherosclerosis Reports, 27(1), Article 45. https://doi.org/10.1007/s11883-025-01289-9
    • Chen, H., Simons, P. I. H. G., Simons, N., van de Waarenburg, M. P. H., Bons, J. A. P., van der Ploeg, E. M. C. L., Feskens, E. J. M., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2025). Effects of glucose and fructose supplementation on serum sex hormone-binding globulin and testosterone levels: post-hoc analysis of a double-blind randomized controlled trial. Clinical Nutrition ESPEN, 69, 384-388. https://doi.org/10.1016/j.clnesp.2025.07.1123
    • Ren, Z., Wesselius, A., Kooi, M. E., van Greevenbroek, M., Dagnelie, P., Berendschot, T. T. J. M., Kroon, A. A., Houben, A. J. H. M., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2025). Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study. Diabetologia, 68(10), 2217-2226. https://doi.org/10.1007/s00125-025-06479-3
    • Tichler, A., Hertroijs, D. F. L., van Mastrigt, G. A. P. G., Brouwers, M. C. G. J., Ruwaard, D., & Elissen, A. M. J. (2025). Evaluating the feasibility of study methods for a future trial-based economic evaluation of a multistage shared decision-making program for type 2 diabetes mellitus: Protocol for a cluster-randomized controlled pilot study. PLOS ONE, 20(8), Article e0300944. https://doi.org/10.1371/journal.pone.0300944
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