Marleen van Greevenbroek

Associate professor

Dr Marleen van Greevenbroek is Medical Biologist (University of Utrecht, 1992) and Epidemiologist (Maastricht University, 2012). She received her PhD degree in 1997 at the University of Utrecht, on a thesis concerning the effects of fatty acids on the production of intestinal triglyceride-rich lipoproteins. In September 1997, she was appointed at the University of Maastricht (Dept. of Internal Medicine), where she was involved in studies on the metabolic and genetic aspects of obesity and cardiometabolic diseases.

Her main area of research is the identification of early events in the development of insulin resistance, type 2 diabetes, and cardiovascular disease. In recent years, her research activities specifically focused on the role of the complement system herein. This research encompasses both cohort studies and experimental work.

Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

2026
- Dimitropoulou, N. M., Beran, M., Eussen, S. J. P. M., Dingena, C. F., Dagnelie, P. C., Van Der Kallen, C. J. H., Koster, A., Van Greevenbroek, M. M. J., Brouwers, M. C. G. J., Schram, M. T., & de Galan, B. E. (2026). Liver fat content is not elevated in people with type 1 diabetes: the Maastricht Study. Diabetologia, 69(2), 364-373. https://doi.org/10.1007/s00125-025-06597-y
2025
- van der Graaf, A., Warmerdam, R., Auwerx, C., Xie, M., Wood, A. R., Westra, H. J., Weiss, S., Völker, U., Visscher, P. M., Viñuela, A., Verlouw, J., Veldink, J., Tokolyi, A., Teumer, A., Souto, J. C., Soria, J. M., Slagboom, E., Singleton, A., Raitoharju, E., ... eQTLgen Consortium (2025). MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality. Nature Communications, 16(1), Article 6112. https://doi.org/10.1038/s41467-025-60868-1
- van Oeteren, M. A. J., De Groot, D. M., Buziau, A. M., Scheijen, J. L. J. M., van de Waarenburg, M. P. H., Kroon, A. A., Eussen, S. J. P. M., Dagnelie, P. C., Van Greevenbroek, M. M. J., Houben, A. J. H. M., Meex, S. J. R., Schalkwijk, C. G., & Brouwers, M. C. G. J. (2025). The effects of dietary fructose on blood pressure are modified by the food matrix. Clinical Nutrition, 55, 134-140. https://doi.org/10.1016/j.clnu.2025.10.017
- Meisters, R., Koster, A., Sezer, B., Albers, J., van Greevenbroek, M., de Galan, B., & Bosma, H. (2025). The importance of material deprivation in type 2 diabetes incidence: longitudinal analyses in the Maastricht study. BMC Public Health, 25(1), Article 3013. https://doi.org/10.1186/s12889-025-24263-1
- Jadhav, S. A., Benedikter, B. J., Mokhtar, S. B. A., van der Heide, F. C. T., Kumaramanickavel, G., van Greevenbroek, M. M. J., Webers, C. A. B., & Berendschot, T. T. J. M. (2025). Plasma Sphingomyelins as Biomarkers for Diabetic Retinal Neurodegeneration: The Maastricht Study. Ophthalmology Science, 5(6), Article 100870. https://doi.org/10.1016/j.xops.2025.100870
- den Brok, E. J., Hornborg-Svensson, C., Dimitropoulou, N. M., Broeng-Mikkelgaard, S., Olsen, M. T., Rahman, L. A., Papathanail, I., Wiede, A., Peters, J., Mertens, P. R., Zikou, E., Karamanakos, G., Athanasopoulos, S., Mitrakou, A., Makrilakis, K., van Kuijk, S. M. J., Mougiakakou, S., van Greevenbroek, M. M. J., Pedersen-Bjergaard, U., ... Melissa Consortium (2025). Study protocol for exploring diabetes numeracy and health literacy across Europe (EDUCATE): A multicentre cross-sectional study. Diabetic Medicine, 42(11), Article e70140. https://doi.org/10.1111/dme.70140
- van der Heide, F. C. T., Steens, I. L. M., Singh-Manoux, A., Sabia, S., Zhou, T. L., Kohler, S., Schram, M. T., van der Kallen, C. J. H., Berendschot, T. T. J. M., Webers, C. A. B., van Greevenbroek, M. M. J., Wesselius, A., Arts, I. C. W., Jansen, J. F. A., Backes, W. H., van Sloten, T. T., Blokland, G. A. M., & Stehouwer, C. D. A. (2025). Genetic variation in the glucagon-like peptide-1 receptor protein encoding region is associated with higher heart rate variability, but not with neurodegeneration of the brain, retina, and peripheral nerves: The Maastricht study. Cardiovascular Diabetology, 24(1), Article 397. https://doi.org/10.1186/s12933-025-02888-1
- Werkman, N. C. C., Nielen, J. T. H., Tapia-Galisteo, J., Somolinos-Simon, F. J., Hernando, M. E., Wang, J., Jiu, L., Goettsch, W. G., Bosma, H., Schram, M. T., van Greevenbroek, M. M. J., Wesselius, A., Stehouwer, C. D. A., Driessen, J. H. M., & Garcia-Saez, G. (2025). Prediction of glycaemic control and quality of life in people with type 2 diabetes using glucose-lowering drugs with machine learning-The Maastricht study. Diabetes Obesity & Metabolism, 27(10), 5524-5537. https://doi.org/10.1111/dom.16598
- Ren, Z., Wesselius, A., Kooi, M. E., van Greevenbroek, M., Dagnelie, P., Berendschot, T. T. J. M., Kroon, A. A., Houben, A. J. H. M., Stehouwer, C. D. A., & Brouwers, M. C. G. J. (2025). Steatotic liver disease interacts with a polygenic risk score for triglyceride clearance to impact the risk of hypertriglyceridaemia: The Maastricht Study. Diabetologia, 68(10), 2217-2226. https://doi.org/10.1007/s00125-025-06479-3
- van der Bruggen, M. M., van Greevenbroek, M. M. J., Spronck, B., Stehouwer, C. D. A., Delhaas, T., Reesink, K. D., & Schalkwijk, C. G. (2025). Plasma reactive dicarbonyls are not independently associated with arterial stiffness: The Maastricht Study. American Journal of Hypertension, 38(10), 777-787. https://doi.org/10.1093/ajh/hpaf068

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Marleen van Greevenbroek

Associate professor