Leon Schurgers

Professor

Initially trained in clinical chemistry and hematology at the University of Applied Science, Prof. Leon Schurgers obtained his PhD at the Department of Biochemistry within CARIM on the role of vitamin K1 and K2 on bone metabolism and cardiovascular disease. He worked as post-doc on a Dutch Heart Foundation grant on the role of matrix Gla-protein synthesized by vascular smooth muscle cell and calcification in collaboration with the group of Prof. Catherine Shanahan (Cambridge, UK).

In 2009, he was appointed on a tenured position at the Department of Biochemistry. After entering the Toptalent programme (Maastricht UMC+) in 2016, he was appointed as Professor of Biochemistry of Vascular Calcification in 2017. He is vice-chair of the department of Biochemistry. Since 2021, he chairs the stem cell research facility of the University of Maastricht (SCRUM).

The focus of his current work is elucidating the molecular mechanisms by which vascular remodelling is initiated and propagated. Key cellular events include phenotypic switching of vascular smooth muscle cells (SMCs) and the role of oxidative stress, extracellular vesicles and calcification. In this, he collaborates closely with the Cardiothoracic Surgery and Vascular Surgery departments of the Heart and Vessel Center (HVC) of the Maastricht University Medical Center. Patient derived primary SMCs are isolated from vascular tissue and induced pluripotent stem cells (iPSC) are generated from patient derived peripheral blood mononuclear cells (PBMCs). These iPSCs are used to differentiate into patient specific cardiovascular cells (i.e., cardiomyocytes, smooth muscle cells, endothelial cells and fibroblasts) to study cardiovascular disease.

The underlying causes of SMC phenotypic switching are insufficient to understand the pathogenesis of vascular ageing and calcification at a level that allows development of novel diagnostic tools and therapeutic strategies. In his project line, the Schurgers’ group aim to elucidate the molecular mechanisms of vitamin K-metabolism in health and vascular disease. Importantly, this work will help to understand the paradoxal observation that patients with low vitamin K-status during oral anticoagulant treatment develop enhanced vascular calcification and our results might provide new insights in prognostic and preventive measures to combat vascular ageing.

Professor Schurgers is Chairman of the steering scientific board on the world-wide quality assurance scheme for vitamin K detection and member of the scientific advisory boards of the Dutch Thrombosis Society.

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.314
T: +31(0)43 388 16 80

  • 2022
    • Kuppe, C., Ramirez Flores, R. O., Li, Z., Hayat, S., Levinson, R. T., Liao, X., Hannani, M. T., Tanevski, J., Wünnemann, F., Nagai, J. S., Halder, M., Schumacher, D., Menzel, S., Schäfer, G., Hoeft, K., Cheng, M., Ziegler, S., Zhang, X., Peisker, F., ... Kramann, R. (2022). Spatial multi-omic map of human myocardial infarction. Nature, 608(7924), 766-777. https://doi.org/10.1038/s41586-022-05060-x
    • Roumeliotis, S., Roumeliotis, A., Georgianos, P. I., Thodis, E., Schurgers, L. J., Maresz, K., Eleftheriadis, T., Dounousi, E., Tripepi, G., Mallamaci, F., & Liakopoulos, V. (2022). VItamin K In PEritonial DIAlysis (VIKIPEDIA): Rationale and study protocol for a randomized controlled trial. PLOS ONE, 17(8), [e0273102]. https://doi.org/10.1371/journal.pone.0273102
    • Pavlic, A., Bahram Sangani, N., Kerins, J., Nicolaes, G., Schurgers, L., & Reutelingsperger, C. (2022). Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification. International journal of molecular sciences, 23(16), [9178]. https://doi.org/10.3390/ijms23169178
    • Ebert, T., Tran, N., Schurgers, L., Stenvinkel, P., & Shiels, P. G. (2022). Ageing - Oxidative stress, PTMs and disease. Molecular Aspects of Medicine, 86, [101099]. https://doi.org/10.1016/j.mam.2022.101099
    • Oggero, S., Godec, T., van Gorp, R., Pinto, L. A., Schurgers, J. L., Reutelingsperger, C., Sever, P., Norling, L. V., Perretti, M., & Gupta, A. (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Journal of Hypertension, 40(8), 1522-1529. https://doi.org/10.1097/HJH.0000000000003178
    • Klein, L., Ophelders, D. R. M. G., van den Hove, D., Damoiseaux, M., Rutten, B. P. F., Reutelingsperger, C. P. M., Schurgers, L. J., & Wolfs, T. G. A. M. (2022). Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis. Brain, Behavior, & Immunity - Health, 23, [100458]. https://doi.org/10.1016/j.bbih.2022.100458
    • Petsophonsakul, P., Burgmaier, M., Willems, B., Heeneman, S., Stadler, N., Gremse, F., Reith, S., Burgmaier, K., Kahles, F., Marx, N., Natour, E., Bidar, E., Jacobs, M., Mees, B., Reutelingsperger, C., Furmanik, M., & Schurgers, L. (2022). Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress and extracellular vesicle release in vascular smooth muscle cells. Cardiovascular Research, 118(9), 2196-2210. https://doi.org/10.1093/cvr/cvab244
    • Jaminon, A. M. G., Rapp, N., Akbulut, A. C., Dzhanaev, R., Reutelingsperger, C. P., Jahnen-Dechent, W., & Schurgers, L. J. (2022). A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro. Journal of visualized experiment, (184), [e64029]. https://doi.org/10.3791/64029
    • Kremer, D., Groothof, D., Keyzer, C. A., Eelderink, C., Knobbe, T. J., Post, A., van Londen, M., Eisenga, M. F., Schurgers, L. J., Berger, S. P., de Borst, M. H., Bakker, S. J. L., & TransplantLines Investigators (2022). Reply to Janssen et al. Comment on "Kremer et al. Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies. Nutrients 2021, 13, 3069". Nutrients, 14(12), [2440]. https://doi.org/10.3390/nu14122440
    • Bhargava, S., de la Puente-Secades, S., Schurgers, L., & Jankowski, J. (2022). Lipids and lipoproteins in cardiovascular diseases: a classification. Trends in Endocrinology and Metabolism, 33(6), 409-423. https://doi.org/10.1016/j.tem.2022.02.001