Kanin Wichapong

Post doc

Dr Kanin Wichapong received his PhD degree in chemistry from Chulalongkorn University, Bangkok, Thailand. After completion of his PhD, he went back and worked as a postdoctoral researcher at Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany where he also carried out parts of his PhD. During his PhD and post-doc period, he worked on computational and physical chemistry subjects by applying in silico drug discovery and design technologies (e.g. virtual screening and molecular docking) to identify and develop novel inhibitors against different target proteins.

To broaden his research horizons with respect to new research fields in a new science environment, in December 2012 he moved to work at the Department of Biochemistry, Maastricht University. His main research focusses on applications of in silico approaches (such as molecular docking, molecular dynamics simulations, and binding free energy calculation) to study and investigate protein-protein interactions as well as to identify and design novel compounds (small compounds or peptides) to modulate protein-protein interactions. The identified bioactive compounds can be further developed as drugs to treat for several related diseases (e.g. cardiovascular diseases and cancer).

 

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.301

  • 2022
    • Nitz, K., Lacy, M., Bianchini, M., Wichapong, K., Kücükgöze, I. A., Bonfiglio, C. A., Migheli, R., Wu, Y., Burger, C., Li, Y., Forné, I., Ammar, C., Janjic, A., Mohanta, S., Duchene, J., Heemskerk, J. W. M., Megens, R. T. A., Schwedhelm, E., Huveneers, S., ... Atzler, D. (2022). The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Circulation Research, 131(8), 701-712. https://doi.org/10.1161/CIRCRESAHA.122.321094
    • van den Kerkhof, D. L., Nagy, M., Wichapong, K., Brouns, S. L. N., Suylen, D. P. L., Hackeng, T. M., & Dijkgraaf, I. (2022). Unraveling the role of the homoarginine residue in antiplatelet drug eptifibatide in binding to the αIIbβ3 integrin receptor. Thrombosis Research, 217, 96-103. https://doi.org/10.1016/j.thromres.2022.07.011
    • Huang, J., Jooss, N. J., Fernández, D. I., Sickmann, A., García, Á., Wichapong, K., Dijkgraaf, I., & Heemskerk, J. W. M. (2022). Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear. International journal of molecular sciences, 23(15), [8688]. https://doi.org/10.3390/ijms23158688
    • Hrdinova, J., Fernández, D. I., Ercig, B., Tullemans, B. M. E., Suylen, D. P. L., Agten, S. M., Jurk, K., Hackeng, T. M., Vanhoorelbeke, K., Voorberg, J., Reutelingsperger, C. P. M., Wichapong, K., Heemskerk, J. W. M., & Nicolaes, G. A. F. (2022). Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear. International journal of molecular sciences, 23(4), [2046]. https://doi.org/10.3390/ijms23042046
    • Uengwetwanit, T., Chutiwitoonchai, N., Wichapong, K., & Karoonuthaisiri, N. (2022). Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity. Computational and Structural Biotechnology Journal, 20, 882-890. https://doi.org/10.1016/j.csbj.2022.02.001
  • 2021
    • von Hundelshausen, P., Wichapong, K., Gabius, H. J., & Mayo, K. H. (2021). The marriage of chemokines and galectins as functional heterodimers. Cellular and Molecular Life Sciences, 78(24), 8073-8095. https://doi.org/10.1007/s00018-021-04010-6
    • van der Beelen, S. H. E., Agten, S. M., Suylen, D. P. L., Wichapong, K., Hrdinova, J., Mees, B. M. E., Spronk, H. M. H., & Hackeng, T. M. (2021). Letter: In response to a recent letter by Prior et al.Thrombosis Research, 207, 66-66. https://doi.org/10.1016/j.thromres.2021.06.017
    • Ercig, B., Arfman, T., Hrdinova, J., Wichapong, K., Reutelingsperger, C. P. M., Vanhoorelbeke, K., Nicolaes, G. A. F., & Voorberg, J. (2021). Conformational plasticity of ADAMTS13 in hemostasis and autoimmunity. Journal of Biological Chemistry, 297(4), [101132]. https://doi.org/10.1016/j.jbc.2021.101132
    • Huckriede, J., de Vries, F., Hultstroem, M., Wichapong, K., Reutelingsperger, C., Lipcsey, M., de Frutos, P. G., Frithiof, R., & Nicolaes, G. A. F. (2021). Histone H3 Cleavage in Severe COVID-19 ICU Patients. Frontiers in Cellular and Infection Microbiology, 11, [694186]. https://doi.org/10.3389/fcimb.2021.694186
    • Huckriede, J., Anderberg, S. B., Morales, A., de Vries, F., Hultstrom, M., Bergqvist, A., Ortiz-Perez, J. T., Sels, J. W., Wichapong, K., Lipcsey, M., van de Poll, M., Larsson, A., Luther, T., Reutelingsperger, C., Garcia de Frutos, P., Frithiof, R., & Nicolaes, G. A. F. (2021). Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients. Scientific Reports, 11(1), [15701]. https://doi.org/10.1038/s41598-021-95209-x