Julie Staals

Associate professor

Dr Julie Staals is working as a clinical neurologist at Maastricht UMC+. Her specialisation is neurovascular diseases. She has obtained her medical degree at Maastricht University. Afterwards, she did a parallel tract in neurology training and PhD research project, both were finished in 2009. In 2013 she did a short research fellowship at the Brain Research Imaging Center in Edinburgh, UK. Her research focus is on clinical studies in cerebral small vessel disease, mainly the effects of hypertension, the rol of endothelial function, blood-brain barrier and the neurovascular unit, advanced imaging, and the cognitive consequences of this disease. She developed the ‘total SVD score’, a highly cited score for MRI severity of cerebral small vessel disease. Other clinical research topics are intracerebral haemorrhage and acute stroke treatments.

She is currently involved in:
SVDs@target, a EU Horizon2020 multicenter project on mechanisms in cerebral small vessel disease (www.svds-at-target.eu)

CRUCIAL, a EU Horizon2020 multicenter project on microvascular rarefaction in vascular cognitive impairment and heart failure (www.crucial-project.eu)

MRCLEAN trials, acute clinical stroke trials aiming at improving outcome in endovascular treatment (www.contrast-consortium.nl)


Department of Neurology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2022
    • Rudilosso, S., Chui, E., Stringer, M. S., Thrippleton, M., Chappell, F., Blair, G., GarcÃa, D. J., Doubal, F., Hamilton, I., Kopczak, A., Ingrish, M., Kerkhofs, D., Backes, W. H., Staals, J., van Oostenbrugge, R., Duering, M., Dichgans, M., Wardlaw, J. M., & SVDs@Target Investigators (2022). Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel Disease. Neurology, 99(5), E440-E452. https://doi.org/10.1212/WNL.0000000000200614
    • Pirson, F. A. V. A., Boodt, N., Brouwer, J., Bruggeman, A. A. E., Hinsenveld, W. H., Staals, J., van Zwam, W. H., van der Leij, C., Brans, R. J. B., Majoie, C. B. L. M., Dippel, D. W. J., van der Lugt, A., Schonewille, W. J., van Oostenbrugge, R. J., & MR CLEAN Registry Investigators (2022). Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry. Stroke, 53(8), 2468-2477. https://doi.org/10.1161/STROKEAHA.121.038054
    • Karel, M. F. A., Roosen, M. G. C. H., Tullemans, B. M. E., Zhang, C. E., Staals, J., Cosemans, J. M. E. M., & Koenen, R. R. (2022). Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence. Journal of Neuroimmunology, 367, [577863]. https://doi.org/10.1016/j.jneuroim.2022.577863
    • Verberne, D. P. J., Kroese, M. E. A. L., Staals, J., Ponds, R. W. H. M., & van Heugten, C. M. (2022). Nurse-led stroke aftercare addressing long-term psychosocial outcome: a comparison to care-as-usual. Disability and Rehabilitation, 44(12), 2849-2857. https://doi.org/10.1080/09638288.2020.1849417
    • van Dinther, M., Voorter, P. H. M., Jansen, J. F. A., Jones, E. A. V., van Oostenbrugge, R. J., Staals, J., & Backes, W. H. (2022). Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism, 42(5), 718-737. [0271678X221076557]. https://doi.org/10.1177/0271678X221076557
    • Lo, J. W., Crawford, J. D., Desmond, D. W., Bae, H-J., Lim, J-S., Godefroy, O., Roussel, M., Kang, Y., Jahng, S., Köhler, S., Staals, J., Verhey, F., Chen, C., Xu, X., Chong, E. J., Kandiah, N., Yatawara, C., Bordet, R., Dondaine, T., ... Stroke and Cognition (STROKOG) Collaboration (2022). Long-Term Cognitive Decline After Stroke: An Individual Participant Data Meta-Analysis. Stroke, 53(4), 1318-1327. https://doi.org/10.1161/strokeaha.121.035796
    • Schwarz, G., Banerjee, G., Hostettler, I. C., Ambler, G., Seiffge, D. J., Brookes, T. S., Wilson, D., Cohen, H., Yousry, T., Salman, R. A-S., Lip, G. Y. H., Brown, M. M., Muir, K. W., Houlden, H., Jäger, R., Werring, D. J., Staals, J., & CROMIS-2 investigators (2022). Magnetic resonance imaging-based scores of small vessel diseases: Associations with intracerebral haemorrhage location. Journal of the Neurological Sciences, 434, [120165]. https://doi.org/10.1016/j.jns.2022.120165
    • van der Steen, W., van de Graaf, R. A., Chalos, V., Lingsma, H. F., van Doormaal, P. J., Coutinho, J. M., Emmer, B. J., de Ridder, I., van Zwam, W., van der Worp, H. B., van der Schaaf, I., Gons, R. A. R., Yo, L. S. F., Boiten, J., van den Wijngaard, I., Hofmeijer, J., Martens, J., Schonewille, W., Vos, J. A., ... MR CLEAN-MED investigators (2022). Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial. Lancet, 399(10329), 1059-1069. https://doi.org/10.1016/S0140-6736(22)00014-9
    • Peeters, M. T. J., Vroman, F., Schreuder, TAHCML., van Oostenbrugge, R. J., & Staals, J. (2022). Decrease in incidence of oral anticoagulant-related intracerebral hemorrhage over the past decade in the Netherlands. European Stroke Journal, 7(1), 20-27. [23969873211062011]. https://doi.org/10.1177/23969873211062011
    • Pirson, F. A. V., Boodt, N., Brouwer, J., Bruggeman, A. A. E., den Hartog, S. J., Goldhoorn, R-J. B., Langezaal, L. C. M., Staals, J., van Zwam, W. H., van der Leij, C., Brans, R. J. B., Majoie, C. B. L. M., Coutinho, J. M., Emmer, B. J., Dippel, D. W. J., van der Lugt, A., Vos, J-A., van Oostenbrugge, R. J., Schonewille, W. J., & MR CLEAN Registry Investigators (2022). Endovascular Treatment for Posterior Circulation Stroke in Routine Clinical Practice: Results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry. Stroke, 53(3), 758-768. [STROKEAHA121034786]. https://doi.org/10.1161/strokeaha.121.034786