Judith Cosemans

Associate professor

Dr Judith Cosemans holds a master’s degree in Biological Health Sciences with specialisation in molecular biology from Maastricht University. She became fascinated to unravel the role of platelets in arterial thrombosis during her PhD research, which focussed on the dynamic regulation of thrombus stability. After finishing her PhD in 2009, she executed an award-winning postdoc project to develop flow chamber technology as a compatible alternative for experimental animal models of arterial thrombosis.

Dr Cosemans subsequently obtained two personal grants from the Dutch Heart Foundation (2011, 2015) and a Vidi grant from the Netherlands Organisation for Scientific Research (NWO, 2016). These grants facilitate her current research line, which lies on the interface of platelet signalling and vascular biology.

Her team aims to:
• provide novel mechanistic insight into the pathophysiology of thrombosis in the heart and in the brain
• develop better diagnostic tools and novel druggable targets to prevent recurrentthrombotic events

Department of Biochemistry
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht

  • 2020
    • Mastenbroek, T. G., Karel, M. F. A., Nagy, M., Chayoua, W., Korsten, E. I. J., Coenen, D. M., Debets, J., Konings, J., Brouns, A. E., Leenders, P. J. A., van Essen, H., van Oerle, R., Heitmeier, S., Spronk, H. M., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2020). Vascular protective effect of aspirin and rivaroxaban upon endothelial denudation of the mouse carotid artery. Scientific Reports, 10(1), [19360]. https://doi.org/10.1038/s41598-020-76377-8
    • Heinzmann, A. C. A., Karel, M. F. A., Coenen, D. M., Vajen, T., Meulendijks, N. M. M., Nagy, M., Suylen, D. P. L., Cosemans, J. M. E. M., Heemskerk, J. W. M., Hackeng, T. M., & Koenen, R. R. (2020). Complementary roles of platelet alpha(IIb)beta(3) integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles. Atherosclerosis, 310, 17-25. https://doi.org/10.1016/j.atherosclerosis.2020.07.015
    • Tilburg, J., Coenen, D. M., Zirka, G., Dolleman, S., van Oeveren-Rietdijk, A. M., Karel, M. F. A., de Boer, H. C., Cosemans, J. M. E. M., Versteeg, H. H., Morange, P. E., van Vlijmen, B. J. M., Maracle, C. X., & Thomas, G. M. (2020). SLC44A2 deficient mice have a reduced response in stenosis but not in hypercoagulability driven venous thrombosis. Journal of Thrombosis and Haemostasis, 18(7), 1714-1727. https://doi.org/10.1111/jth.14835
    • Sternkopf, M., Nagy, M., Baaten, C. C. F. M. J., Kuijpers, M. J. E., Tullemans, B. M. E., Wirth, J., Theelen, W., Mastenbroek, T. G., Lehrke, M., Winnerling, B., Baerts, L., Marx, N., De Meester, I., Doring, Y., Cosemans, J. M. E. M., Daiber, A., Steven, S., Jankowski, J., Heemskerk, J. W. M., & Noels, H. (2020). Native, Intact Glucagon-Like Peptide 1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions. Arteriosclerosis Thrombosis and Vascular Biology, 40(3), E65-E77. https://doi.org/10.1161/ATVBAHA.119.313645
    • Karel, M. F. A., Hechler, B., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2020). Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations. Platelets, 31(4), 439-446. https://doi.org/10.1080/09537104.2019.1708884
  • 2019
    • Van Kuijk, K., Theelen, T., Demandt, J., Marsch, E., Gijbels, M., Jin, H., Reutelingsperger, C., Cosemans, J., Schurgers, L., Carmeliet, P., Biessen, E., Daemen, M., & Sluimer, J. (2019). MYELOID PHD2 KNOCKDOWN DRIVES MACROPHAGE APOPTOSIS AND PARACRINE FIBROBLAST/SMOOTH MUSCLE CELL COLLAGEN SECRETION LEADING TO ATHEROSCLEROTIC PLAQUE FIBROSIS. Atherosclerosis, 287, E10-E10. https://doi.org/10.1016/j.atherosclerosis.2019.06.027
    • Govers-Riemslag, J. W. P., Konings, J., Cosemans, J. M. E. M., van Geffen, J. P., de Laat, B., Heemskerk, J. W. M., Dargaud, Y., & Ten Cate, H. (2019). Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis. TH open : companion journal to thrombosis and haemostasis, 3(3), e273-e285. https://doi.org/10.1055/s-0039-1693485
  • 2018
    • Baaten, C. C. F. M. J., Meacham, S., de Witt, S. M., Feijge, M. A. H., Adams, D. J., Akkerman, J-W. N., Cosemans, J. M. E. M., Grassi, L., Jupe, S., Kostadima, M., Mattheij, N. J. A., Prins, M. H., Ramirez-Solis, R., Soehnlein, O., Swieringa, F., Weber, C., White, J. K., Ouwehand, W. H., & Heemskerk, J. W. M. (2018). A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding. Blood, 132(24), E35-E46. https://doi.org/10.1182/blood-2018-02-831982
    • Thomassen, S., Mastenbroek, T. G., Swieringa, F., Winckers, K., Feijge, M. A. H., Schrijver, R., Cosemans, J. M. E. M., Maroney, S. A., Mast, A. E., Hackeng, T. M., & Heemskerk, J. W. M. (2018). Suppressive Role of Tissue Factor Pathway Inhibitor-alpha in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength. Thrombosis and Haemostasis, 118(3), 502-513. https://doi.org/10.1055/s-0038-1627453
    • Nagy, M., Mastenbroek, T. G., Mattheij, N. J. A., de Witt, S., Clemetson, K. J., Kirschner, J., Schulz, A. S., Vraetz, T., Speckmann, C., Braun, A., Cosemans, J. M. E. M., Zieger, B., & Heemskerk, J. W. M. (2018). Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies. Haematologica-the Hematology Journal, 103(3), 540-549. https://doi.org/10.3324/haematol.2017.176974