Jack Cleutjens

Associate professor

Dr Jack Cleutjens has been working for Maastricht University since 1985. After finishing his thesis 'Basement membrane heterogeneity' in 1989, he started working in the cardiovascular field as a post-doc on the regulation of the wound healing after myocardial infarction. His main interest is in the area of extracellular matrix remodeling, mainly collagen synthesis and degradation.

His area of focus is education and cardiovascular research. He is a specialist in the field of morphometry and (digital) microscopy. Jack Cleutjens is a member of the Dutch Society of Pathology, Experimental Pathology section and of the Dutch Society for Matrix Biology.

Focus areas:
• Cardiovascular examination
• Extracellular matrix turnover
• Myocardial infarction / atherosclerosis
• (Digital) microscopy
• Morphometry


Department of Pathology
Verheylaan 10, 6229 HX Maastricht
Room number: VH10 5.M1-002
T: +31(0)43 387 66 31

  • 2023
    • Keijbeck, A., Raaijmaakers, A., Hillen, L., Gelens, M., van Kuijk, S., Cleutjens, J. P., Peutz-Kootstra, C., & Christiaans, M. (2023). Visual interstitial fibrosis assessment as continuous variable in protocol renal transplant biopsies. Histopathology, 82(5), 713-721. https://doi.org/10.1111/his.14857
  • 2022
    • Moshi, J. M., Ummelen, M., Broers, J. L. V., Smedts, F., Van de Vijver, K. K., Cleutjens, J. P. M., Litjens, R. J. N. T. M., Ramaekers, F. C. S., & Hopman, A. H. N. (2022). SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN. Histochemistry and Cell Biology, 158(6), 545-559. https://doi.org/10.1007/s00418-022-02145-6
  • 2021
    • Widowski, H., Ophelders, D. R. M. G., van Leeuwen, A. J. C. N., Nikkels, P. G. J., Severens-Rijvers, C. A. H., LaPointe, V. L. S., Cleutjens, J. P. M., Hütten, M. C., Kemp, M. W., Payne, M. S., Saito, M., Usuda, H., Newnham, J. P., Jobe, A. H., Kramer, B. W., Delhaas, T., Wolfs, T. G. A. M., & Reynaert, N. L. (2021). Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero. Pediatric Research, 90(3), 549-558. https://doi.org/10.1038/s41390-020-01204-9
    • Widowski, H., Reynaert, N. L., Ophelders, D. R. M. G., Hütten, M. C., Nikkels, P. G. J., Severens-Rijvers, C. A. H., Cleutjens, J. P. M., Kemp, M. W., Newnham, J. P., Saito, M., Usuda, H., Payne, M. S., Jobe, A. H., Kramer, B. W., Delhaas, T., & Wolfs, T. G. A. M. (2021). Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells. Frontiers in medicine, 8, [614239]. https://doi.org/10.3389/fmed.2021.614239
    • van Gorp, C., de Lange, I. H., Massy, K. R. I., Kessels, L., Jobe, A. H., Cleutjens, J. P. M., Kemp, M. W., Saito, M., Usada, H., Newnham, J., Hütten, M., Kramer, B. W., Zimmermann, L. J., & Wolfs, T. G. A. M. (2021). Intestinal Goblet Cell Loss during Chorioamnionitis in Fetal Lambs: Mechanistic Insights and Postnatal Implications. International journal of molecular sciences, 22(4), [1946]. https://doi.org/10.3390/ijms22041946
    • Heij, L. R., Tan, X., Kather, J. N., Niehues, J. M., Sivakumar, S., Heussen, N., van der Kroft, G., Damink, S. W. M. O., Lang, S., Aberle, M. R., Luedde, T., Gaisa, N. T., Bednarsch, J., Liu, D. H. W., Cleutjens, J. P. M., Modest, D. P., Neumann, U. P., & Wiltberger, G. J. (2021). Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer. Journal of Clinical Medicine, 10(3), [490]. https://doi.org/10.3390/jcm10030490
  • 2018
    • Bijnen, M., Beelen, N., Wetzels, S., van De Gaar, J., Vroomen, M., Wijnands, E., Scheijen, J. L., van de Waarenburg, M. P. H., Gijbels, M. J., Cleutjens, J. P., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2018). RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr(-/-) mice. Scientific Reports, 8, [15256]. https://doi.org/10.1038/s41598-018-33661-y
    • van den Hil, L. C. L., Vogels, R. R. M., van Barneveld, K. W. Y., Gijbels, M. J. J., Peutz-Kootstra, C. J., Cleutjens, J. P. M., Schreinemacher, M. H. F., & Bouvy, N. D. (2018). Comparability of histological outcomes in rats and humans in a hernia model. Journal of Surgical Research, 229, 271-276. https://doi.org/10.1016/j.jss.2018.03.019
    • Barkhuizen, M., van Dijck, F. J. P., Jellema, R. K., Gussenhoven, R., Engelbertink, I., van Mechele, R., Cleutjens, J. P. M., Seehase, M., Steinbusch, H. W. M., Zimmerman, L. J., Gavilanes, A. W. D., & Kramer, B. W. (2018). The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric Research, 83(6), 1190-1199. https://doi.org/10.1038/pr.2018.42
    • Henatsch, D., Alsulami, S., Duijvestijn, A. M., Cleutjens, J. P., Peutz-Kootstra, C. J., & Stokroos, R. J. (2018). Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities Secondary Analysis of a Randomized Clinical Trial. JAMA Otolaryngology - Head and Neck Surgery, 144(3), 211-217. https://doi.org/10.1001/jamaoto.2017.2801