Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2024
    • Aydeniz, E., van Bussel, B. C. T., de Jongh, S., Schellens, J., Heines, S. J. H., van Kuijk, S. M. J., Tas, J., van Rosmalen, F., van der Horst, I. C. C., Bergmans, D. C. J. J., & MaastrICCht Collaborators (2024). Serial electrical impedance tomography course in different treatment groups; The MaastrICCht cohort. Journal of Critical Care, 80, Article 154506. https://doi.org/10.1016/j.jcrc.2023.154506
    • van der Knaap, N., Ariës, M. J. H., van der Horst, I. C. C., & Jansen, J. F. A. (2024). On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review. NeuroImage: Clinical, 42, Article 103589. https://doi.org/10.1016/j.nicl.2024.103589
    • van 't Hof, A. W. J., Delnoij, T. S. R., & van der Horst, I. C. C. (2024). Decision making in out-of-hospital cardiac arrest: what should come first?Netherlands Heart Journal, 32(3), 116-117. https://doi.org/10.1007/s12471-024-01856-w
    • Hesselink, G., Verhage, R., van der Horst, I. C. C., van der Hoeven, H., & Zegers, M. (2024). Consensus-based indicators for evaluating and improving the quality of regional collaborative networks of intensive care units: Results of a nationwide Delphi study. Journal of Critical Care, 79(1), Article 154440. https://doi.org/10.1016/j.jcrc.2023.154440
    • Heuts, S., van de Koolwijk, A. F., Gabrio, A., Ubben, J. F. H., van der Horst, I. C. C., Delnoij, T. S. R., Suverein, M. M., Maessen, J. G., Lorusso, R., & van de Poll, M. C. G. (2024). Extracorporeal life support in cardiac arrest: a post hoc Bayesian re-analysis of the INCEPTION trial. European Heart Journal: Acute Cardiovascular Care, 13(2), 191-200. Article zuad130. https://doi.org/10.1093/ehjacc/zuad130
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., ... van Royen, N. (2024). The Prognostic Value of Troponin-T in Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A COACT Substudy. Journal of the Society for Cardiovascular Angiography and Interventions, 3(2), Article 101191. https://doi.org/10.1016/j.jscai.2023.101191
    • de Kok, J. W. T. M., van Rosmalen, F., Koeze, J., Keus, F., van Kuijk, S. M. J., Castela Forte, J., Schnabel, R. M., Driessen, R. G. H., van Herpt, T. T. W., Sels, J.-W. E. M., Bergmans, D. C. J. J., Lexis, C. P. H., van Doorn, W. P. T. M., Meex, S. J. R., Xu, M., Borrat, X., Cavill, R., van der Horst, I. C. C., & van Bussel, B. C. T. (2024). Deep embedded clustering generalisability and adaptation for integrating mixed datatypes: two critical care cohorts. Scientific Reports, 14(1), Article 1045. https://doi.org/10.1038/s41598-024-51699-z
    • Domensino, A.-F., Tas, J., Donners, B., Kooyman, J., van der Horst, I., Haeren, R., Aries, M., & Heugten, C. (2024). Long-Term Follow-Up of Critically Ill Patients With Traumatic Brain Injury: from intensive care parameters to patient and caregiver-reported outcome. Journal of Neurotrauma, 41(1-2), 123-134. https://doi.org/10.1089/neu.2022.0474
    • Simons, J., Di Mauro, M., Mariani, S., Ravaux, J., van der Horst, I. C. C., Driessen, R. G. H., Sels, J. W., Delnoij, T., Brodie, D., Abrams, D., Mueller, T., Taccone, F. S., Belliato, M., Broman, M. L., Malfertheiner, M. V., Boeken, U., Fraser, J., Wiedemann, D., Belohlavek, J., ... Lorusso, R. (2024). Bilateral Femoral Cannulation Is Associated With Reduced Severe Limb Ischemia-Related Complications Compared With Unilateral Femoral Cannulation in Adult Peripheral Venoarterial Extracorporeal Membrane Oxygenation: Results From the Extracorporeal Life Support Registry. Critical Care Medicine, 52(1), 80-91. https://doi.org/10.1097/CCM.0000000000006040
    • Ubben, J. F. H., Suverein, M. M., Delnoij, T. S. R., Heuts, S., Winkens, B., Gabrio, A., van der Horst, I. C. C., Maessen, J. G., Lorusso, R., van de Poll, M. C. G., & INCEPTION-investigators (2024). Early extracorporeal CPR for refractory out-of-hospital cardiac arrest - A pre-planned per-protocol analysis of the INCEPTION-trial. Resuscitation, 194, Article 110033. https://doi.org/10.1016/j.resuscitation.2023.110033