Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2026
    • Rossi, A., Mooi, F. J., Aydeniz, E., Timmermans, T., Heines, S. J. H., van Rosmalen, F., de Kok, J., van der Horst, I. C. C., Sels, J. W. E. M., Bergmans, D. C. J. J., Giani, M., Citerio, G., van Bussel, B. C. T., & Driessen, R. G. H. (2026). Association of right ventricular dysfunction on electrocardiogram with outcomes and ventilatory response in patients monitored by electrical impedance tomography: A cohort study. Heart & Lung, 77, Article 102706. https://doi.org/10.1016/j.hrtlng.2025.102706
    • Aydeniz, E., van Bussel, B. C. T., van der Horst, I. C. C., Frerichs, I., & Bergmans, D. C. J. J. (2026). Sex-dependent differences in regional lung mechanics; A retrospective observational study. Journal of Critical Care, 92, Article 155366. https://doi.org/10.1016/j.jcrc.2025.155366
    • Spoormans, E. M., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., Stoel, M., ... Lemkes, J. S. (2026). Immediate vs Delayed Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: 5-Year Outcomes From the COACT Randomized Trial. Journal of the American College of Cardiology. Advance online publication. https://doi.org/10.1016/j.jacc.2025.12.018
  • 2025
    • Kishna, Y. S., Baars, S., van der Horst, I. C. C., Mess, W. H., Hendrix, R., Delnoij, T. S. R., & Aries, M. (2025). Cerebral monitoring responses to bedside physiological challenges in comatose post-cardiac arrest patients. Journal of Clinical Monitoring and Computing, (1). Advance online publication. https://doi.org/10.1007/s10877-025-01393-w
    • Verberght, H. C. R., Delnoij, T. S. R., Suverein, M. M., Lunsing, J., Hermanides, R. C., Otterspoor, L., Elzo Kraemer, C. V., Vlaar, A. P. J., Van Der Heijden, J. J., Scholten, E., Uil, C. A. D., Miranda, D. D. R., Akin, S., Metz, J. D., Van Der Horst, I. C. C., Mathot, B. J., De Jonge, J., Nijboer, M. W. N., De Meijer, V. E., ... Van De Poll, M. C. G. (2025). Organ Donor Potential After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest: A Post-Hoc Analysis of a Randomized Controlled Trial. Clinical Transplantation, 39(11), Article e70382. https://doi.org/10.1111/ctr.70382
    • Swinnen, B., Olsthoorn, J. R., Mihl, C., Smulders, M. W., Singh, S. K., van Brakel, T., van der Horst, I. C. C., Mingels, A. M. A., Myers, P. O., van 't Hof, A. W. J., Gorgels, A. P. M., Thielmann, M., De Caterina, R., Cerqueira, R. J., Bonaros, N., Oosterlinck, W., Jacobs, S., Lorusso, R., Bidar, E., ... Heuts, S. (2025). Periprocedural Myocardial Infarction After Coronary Artery Bypass Grafting: Current Clinical Practices and Future Perspectives. European Journal of Cardio-Thoracic Surgery, 67(10), Article ezaf344. https://doi.org/10.1093/ejcts/ezaf344
    • Klein, D. O., Waardenburg, S. F., Janssen, E. B. N. J., Wintjens, M. S. J. N., Imkamp, M., Heemskerk, S. C. M., Birnie, E., Bonsel, G. J., Warlé, M. C., Jacobs, L. M. C., Hemmen, B., Verbunt, J., van Bussel, B. C. T., van Santen, S., Kietelaer, B. L. J. H., Jansen, G., Klok, F. A., de Kruif, M. D., Vernooy, K., ... CAPACITY-COVID collaborative consortium (2025). Two years and counting: a prospective cohort study on the scope and severity of post-COVID symptoms across diverse patient groups in the Netherlands-insights from the CORFU study. BMJ Open, 15(9), Article e093639. https://doi.org/10.1136/bmjopen-2024-093639
    • Romeo, J. L., Vriesendorp, P. A., Gerritsen, K., Nader, M., Mahtab, E., Maessen, J. G., van 't Hof, A. W. J., Gollmann-Tepeköylü, C., van Rosmalen, F., van der Horst, I. C. C., Mingels, A. M. A., & Heuts, S. (2025). Modeling creatine-kinase MB concentrations following coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery, 170(3), 752-760.e3. https://doi.org/10.1016/j.jtcvs.2024.08.019
    • Gerardu, V. C. A., Mosch, L. K., Kloeze, C., de Kok, J. W. T. M., Herold, I. H. F., De Bie, A. J. R., Schnabel, R. M., Strauch, U., Dormans, T., Wunderlich, M. M., Bouwman, R. A., Balzer, F., van der Horst, I. C. C., van Bussel, B. C. T., Poncette, A.-S., Driessen, R. G. H., & Alarm Fatigue Study Group (2025). Measuring alarm fatigue in intensive care units: translation and validation of the Charité Alarm Fatigue Questionnaire. Journal of Critical Care, 91, Article 155223. https://doi.org/10.1016/j.jcrc.2025.155223
    • Saugel, B., Hapfelmeier, A., Flick, M., Rinehart, J., Thiele, R. H., Vistisen, S. T., Bartels, K., Cannesson, M., Cecconi, M., Chew, M. S., De Backer, D., Joosten, A., Khanna, A. K., Levy, J. H., Meidert, A. S., Messina, A., Monnet, X., Myatra, S. N., Pinsky, M. R., ... Kouz, K. (2025). Statistical Analysis and Reporting of Cardiac Output Method Comparison Studies (COMPARE) Statement. Anesthesiology, 143(3), 518-532. https://doi.org/10.1097/ALN.0000000000005559